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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
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Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Cressman, D. E., Greenbaum, L. E., Haber, B. A., & Taub, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43831-8 · Cited by 224
Cited by
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Self-citationMissing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citationAn Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Self-citationNF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090
Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022
Requirement for NF-κB in osteoclast and B-cell development
Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996
Nuclear factor-?B: its role in health and disease
Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666
Multilineage communication regulates human liver bud development from pluripotency
Camp, J. G., Sekine, K., Gerber, T., Loeffler-Wirth, H., Binder, H., Gac, M., Kanton, S., Kageyama, J., Damm, G., Seehofer, D., et al. (2017) · Nature · doi:10.1038/nature22796 · Cited by 621
The transcriptional control of hematopoiesis [see comments]
Shivdasani, R., & Orkin, S. (1996) · Blood · doi:10.1182/blood.v87.10.4025.bloodjournal87104025 · Cited by 560
Transcriptional Cross Talk between NF-κB and p53
Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598
Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585
Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
Catz, S. D., & Johnson, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204926 · Cited by 538
Yeh, W.-C., Itie, A., Elia, A. J., Ng, M., Shu, H.-B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D. V., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80214-9 · Cited by 515
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.
(2000) · PubMed Central · Cited by 489
Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice
Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479
Hepatocyte Death: A Clear and Present Danger
Malhi, H., Guicciardi, M. E., & Gores, G. J. (2010) · Physiological Reviews · doi:10.1152/physrev.00061.2009 · Cited by 477
Dondelinger, Y., Jouan-Lanhouet, S., Divert, T., Theatre, E., Bertin, J., Gough, P. J., Giansanti, P., Heck, A. J. R., Dejardin, E., Vandenabeele, P., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.032 · Cited by 431
Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399
NF-κB as a therapeutic target in chronic inflammation: recent advances
Makarov, S. S. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01814-1 · Cited by 379
Oxidative stress in anxiety and comorbid disorders
Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
Peng, W. C., Logan, C. Y., Fish, M., Anbarchian, T., Aguisanda, F., Álvarez-Varela, A., Wu, P., Jin, Y., Zhu, J., Li, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.012 · Cited by 331
Pfeffer, S. R., Yang, C. H., & Pfeffer, L. M. (2015) · Drug Development Research · doi:10.1002/ddr.21257 · Cited by 325
Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310
NF-κB signaling, liver disease and hepatoprotective agents
Sun, B., & Karin, M. (2008) · Oncogene · doi:10.1038/onc.2008.300 · Cited by 307
NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer
Grinberg-Bleyer, Y., Oh, H., Desrichard, A., Bhatt, D. M., Caron, R., Chan, T. A., Schmid, R. M., Klein, U., Hayden, M. S., & Ghosh, S. (2017) · Cell · doi:10.1016/j.cell.2017.08.004 · Cited by 297
Self-citationIncreased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
Kovalovich, K., DeAngelis, R. A., Li, W., Furth, E. E., Ciliberto, G., & Taub, R. (2000) · Hepatology · doi:10.1002/hep.510310123 · Cited by 298
IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα
Maeda, S., Chang, L., Li, Z.-W., Luo, J.-L., Leffert, H., & Karin, M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00301-7 · Cited by 286
Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C. (2012) · Genes & Development · doi:10.1101/gad.197954.112 · Cited by 276
Liu, S., Gallo, D. J., Green, A. M., Williams, D. L., Gong, X., Shapiro, R. A., Gambotto, A. A., Humphris, E. L., Vodovotz, Y., & Billiar, T. R. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3433-3442.2002 · Cited by 246
Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
Schmidt-Ullrich, R., Aebischer, T., Hülsken, J., Birchmeier, W., Klemm, U., & Scheidereit, C. (2001) · Development · doi:10.1242/dev.128.19.3843 · Cited by 216
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
González-Ramos, R., Van Langendonckt, A., Defrère, S., Lousse, J.-C., Colette, S., Devoto, L., & Donnez, J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.01.013 · Cited by 179
Crosstalk via the NF-κB signaling system
Basak, S., & Hoffmann, A. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.04.005 · Cited by 177
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168
Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways
Papa, S., Bubici, C., Zazzeroni, F., & Franzoso, G. (2009) · bchm · doi:10.1515/bc.2009.111 · Cited by 156
Trautwein, C., Rakemann, T., Brenner, D. A., Streetz, K., Licato, L., Manns, M. P., & Tiegs, G. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70324-5 · Cited by 147
DNA damage drives accelerated bone aging via an NF- κ B–dependent mechanism
Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J., & Ouyang, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1851 · Cited by 135
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
Götz, R., Wiese, S., Takayama, S., Camarero, G. C., Rossoll, W., Schweizer, U., Troppmair, J., Jablonka, S., Holtmann, B., Reed, J. C., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1524 · Cited by 133
The role of NF-κB/IκB proteins in cancer: implications for novel treatment strategies
Schwartz, S. A., Hernandez, A., & Mark Evers, B. (1999) · Surgical Oncology · doi:10.1016/s0960-7404(00)00012-8 · Cited by 132
Müller, M., Morotti, A., & Ponzetto, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1060-1072.2002 · Cited by 129
Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging · doi:10.18632/aging.102863 · Cited by 122
Oropeza, M., Petersen, B., Carnwath, J. W., Lucas‐Hahn, A., Lemme, E., Hassel, P., Herrmann, D., Barg‐Kues, B., Holler, S., Queisser, A., et al. (2009) · Xenotransplantation · doi:10.1111/j.1399-3089.2009.00556.x · Cited by 122
Anandamide Inhibits Nuclear Factor-κB Activation through a Cannabinoid Receptor-Independent Pathway
Sancho, R., Calzado, M. A., Di Marzo, V., Appendino, G., & Muñoz, E. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.429 · Cited by 120
Banerji, V., Frumm, S. M., Ross, K. N., Li, L. S., Schinzel, A. C., Hahn, C. K., Kakoza, R. M., Chow, K. T., Ross, L., Alexe, G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci46465 · Cited by 105
Met acts on Mdm2 via mTOR to signal cell survival during development
Moumen, A., Patané, S., Porras, A., Dono, R., & Maina, F. (2007) · Development · doi:10.1242/dev.02820 · Cited by 95
Edenberg, H. J., Xuei, X., Wetherill, L. F., Bierut, L., Bucholz, K., Dick, D. M., Hesselbrock, V., Kuperman, S., Porjesz, B., Schuckit, M. A., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm368 · Cited by 89
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Li, J., Ayoub, A., Xiu, Y., Yin, X., Sanders, J. O., Mesfin, A., Xing, L., Yao, Z., & Boyce, B. F. (2019) · Nature Communications · doi:10.1038/s41467-019-10677-0 · Cited by 86
Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
Teismann, P., Sathe, K., Bierhaus, A., Leng, L., Martin, H. L., Bucala, R., Weigle, B., Nawroth, P. P., & Schulz, J. B. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.006 · Cited by 75
Signal transduction during liver regeneration
BRENNER, D. (1998) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.1998.13.s1.93 · Cited by 72
JAK2 inhibition prevents innate immune responses and rescues animals from sepsis
Peña, G., Cai, B., Deitch, E. A., & Ulloa, L. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0628-z · Cited by 69
FIP200, a key signaling node to coordinately regulate various cellular processes
Gan, B., & Guan, J.-L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.021 · Cited by 67
Zhao, C., Xiu, Y., Ashton, J., Xing, L., Morita, Y., Jordan, C. T., & Boyce, B. F. (2012) · Stem Cells · doi:10.1002/stem.1050 · Cited by 65
NF-κB and STAT3 signaling hubs for lung innate immunity
Quinton, L. J., & Mizgerd, J. P. (2011) · Cell and Tissue Research · doi:10.1007/s00441-010-1044-y · Cited by 65
Longo, C. R., Patel, V. I., Shrikhande, G. V., Scali, S. T., Csizmadia, E., Daniel, S., Sun, D. W., Grey, S. T., Arvelo, M. B., & Ferran, C. (2005) · Hepatology · doi:10.1002/hep.20741 · Cited by 60
Recent Events in Alcoholic Liver Disease V. Effects of ethanol on liver regeneration
Diehl, A. M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00376.2004 · Cited by 59
Guerra, S., López-Fernández, L. A., García, M. A., Zaballos, A., & Esteban, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511983200 · Cited by 40
ME3738 protects from concanavalin A‐induced liver failure via an IL‐6‐dependent mechanism
Klein, C., Wüstefeld, T., Heinrich, P. C., Streetz, K. L., Manns, M. P., & Trautwein, C. (2003) · European Journal of Immunology · doi:10.1002/eji.200323651 · Cited by 27
Hareendran, S., Ramakrishna, B., & Jayandharan, G. R. (2016) · European Journal of Immunology · doi:10.1002/eji.201545867 · Cited by 10
Metadata
- Authors
- Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D.
- Venue
- Nature
- Published
- 1995-07
- Volume
- 376
- Issue
- 6536
- Pages
- 167-170
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1982062664
- Cited by
- 1,825
- References
- 3
- FWCI
- 29.90
- Type
- journal article
- Language
- en
- Open access
- closed
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