The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
Abstract
Objective To investigate whether delivery mode (vaginal versus by caesarean section), maternal pre-pregnancy body mass index (BMI) and early exposure to antibiotics (<6 months of age) influence child's risk of overweight at age 7 years, hence supporting the hypotheses that environmental factors influencing the establishment and diversity of the gut microbiota are associated with later risk of overweight.Design Longitudinal, prospective study with measure of exposures in infancy and follow-up at age 7 years.Methods A total of 28 354 mother-child dyads from the Danish National Birth Cohort, with information on maternal pre-pregnancy BMI, delivery mode and antibiotic administration in infancy, were assessed. Logistic regression analyses were performed with childhood height and weight at the 7-year follow-up as outcome measures.Results Delivery mode was not significantly associated with childhood overweight (odds ratio (OR):1.18, 95% confidence interval (CI): 0.95-1.47). Antibiotics during the first 6 months of life led to increased risk of overweight among children of normal weight mothers (OR: 1.54, 95% CI: 1.09-2.17) and a decreased risk of overweight among children of overweight mothers (OR: 0.54, 95% CI: 0.30-0.98). The same tendency was observed among children of obese mothers (OR: 0.85, 95% CI: 0.41-1.76).Conclusion The present cohort study revealed that a combination of early exposures, including delivery mode, maternal pre-pregnancy BMI and antibiotics in infancy, influences the risk of overweight in later childhood. This effect may potentially be explained by an impact on establishment and diversity of the microbiota.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The use of antibiotics in early life is associated with obesity in both people and mice”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [122]
Citations
Cites
Establishing a standard definition for child overweight and obesity worldwide: international survey
Cole, T. J. (2000) · BMJ · doi:10.1136/bmj.320.7244.1240 · Cited by 16,500
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity in children and young people: a crisis in public health
Lobstein, T., Baur, L., & Uauy, R. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00133.x · Cited by 3,801
Body mass index cut offs to define thinness in children and adolescents: international survey
Cole, T. J., Flegal, K. M., Nicholls, D., & Jackson, A. A. (2007) · BMJ · doi:10.1136/bmj.39238.399444.55 · Cited by 2,614
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
The Danish National Birth Cohort - its background, structure and aim
Olsen, J., Melbye, M., Olsen, S. F., Sørensen, T. I. A., Aaby, P., Andersen, A. N., Taxbøl, D., Hansen, K. D., Juhl, M., Schow, T. B., et al. (2001) · Scandinavian Journal of Public Health · doi:10.1177/14034948010290040201 · Cited by 1,071
Self-citationEarly differences in fecal microbiota composition in children may predict overweight
Kalliomäki, M. A., Collado, M. C., Salminen, S., & Isolauri, E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,056
The role of the gut microbiota in energy metabolism and metabolic disease
Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974
Cited by
Sorted by citations
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
Malfertheiner, P., Mégraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T. R., Bazzoli, F., Gasbarrini, A., Atherton, J. C., Graham, D. Y., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312288 · Cited by 3,023
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.052 · Cited by 1,859
“These findings are consistent with prior studies showing that early life changes in metabolism or exposure to antibiotics predict later adiposity in rodents (Knittle and Hirsch, 1968) and humans (Ajslev et al., 2011; Murphy et al., 2013; Trasande et al., 2013).”
BackgroundResultInfluentialThe microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances
Francino, M. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01543 · Cited by 990
“…is in line with the fact that long-term exposure to antibiotics is associated with increased body mass index, both in humans (Thuny et al., 2010; Ajslev et al., 2011; Angelakis et al., 2012) and in farm animals, where low-dose antibiotics have long been used to promote weight gain (Burch, 1996).”
BackgroundKeag, O. E., Norman, J. E., & Stock, S. J. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002494 · Cited by 921
“002, I(2) = 63%; 5 cohorts) [19,44,53,64], and at 20–28 years (1,250/ 7,759 cesarean delivery versus 3,105/25,342 vaginal delivery; OR 1.”
Risk Factors for Childhood Obesity in the First 1,000 Days
Baidal, J. W., Locks, L. M., Cheng, E. R., Blake‐Lamb, T., Perkins, M. E., & Taveras, E. M. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.11.012 · Cited by 951
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943
Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children
Korpela, K., Salonen, A., Virta, L. J., Kekkonen, R. A., Forslund, K., Bork, P., & de Vos, W. M. (2016) · Nature Communications · doi:10.1038/ncomms10410 · Cited by 698
Insights into the role of the microbiome in obesity and type 2 diabetes
Hartstra, A. V., Bouter, K. E. C., Bäckhed, F., & Nieuwdorp, M. (2015) · Diabetes Care · doi:10.2337/dc14-0769 · Cited by 641
“childhood overweight (71) are even more alarming but not surprising.”
BackgroundAntibiotics as deep modulators of gut microbiota: between good and evil
Ianiro, G., Tilg, H., & Gasbarrini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-312297 · Cited by 653
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573
“, 2011), obesity, (Ajslev et al., 2011) and asthma (Abrahamsson et al.”
Antibiotics in early life and obesity
Cox, L. M., & Blaser, M. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.210 · Cited by 554
Antibiotics, Pediatric Dysbiosis, and Disease
Vangay, P., Ward, T., Gerber, J. S., & Knights, D. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.006 · Cited by 556
Antibiotic Residues in Food: Extraction, Analysis, and Human Health Concerns
Chen, J., Ying, G., & Deng, W. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01334 · Cited by 515
Gérard, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2061-5 · Cited by 538
Infant antibiotic exposures and early-life body mass
Trasande, L., Blustein, J., Liu, M., Corwin, E. J., Cox, L. M., & Blaser, M. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.132 · Cited by 514
Fouhy, F., Guinane, C. M., Hussey, S., Wall, R., Ryan, C. A., Dempsey, E. M., Murphy, B. P., Ross, R. P., Fitzgerald, G. F., Stanton, C., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00789-12 · Cited by 518
“Regardless of the extent to which factors other than antibiotic administration influence these results, there is a concern that these short-term changes to the microbiota may in turn have long-term health consequences in the form of allergies, asthma, and obesity later in life (4, 13, 25).”
BackgroundAssociation of Antibiotics in Infancy With Early Childhood Obesity
Bailey, L. C., Forrest, C. B., Zhang, P., Richards, T. M., Livshits, A., & DeRusso, P. A. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.1539 · Cited by 504
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461
Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity
Mueller, N. T., Whyatt, R. M., Hoepner, L., Oberfield, S. E., Domínguez-Bello, M. G., Widen, E. M., Hassoun, A. A., Perera, F. P., & Rundle, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.180 · Cited by 501
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484
“Gut dysbiosis is reported in several conditions, such as immunological defects, Crohn’s disease, obesity, inflammatory bowel disease (IBD) and abnormal behaviours in children (including those with ASD) [27,38,51,52].”
BackgroundThe gut microbiota in human energy homeostasis and obesity
Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450
A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis
Kuzniewicz, M. W., Puopolo, K. M., Fischer, A. F., Walsh, E. M., Li, S. X., Newman, T. B., Kipnis, P., & Escobar, G. J. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.4678 · Cited by 463
Puopolo, K. M., Benitz, W. E., Zaoutis, T. E., Cummings, J. J., Juul, S. E., Hand, I. L., Eichenwald, E. C., Poindexter, B. B., Stewart, D. L., Aucott, S. W., et al. (2018) · PEDIATRICS · doi:10.1542/peds.2018-2894 · Cited by 462
“26 32 Although the biologic basis of such associations not firmly established, researchers suggest that neonatal – antibiotic administration alters the developing gut microbiome.”
BackgroundThe Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462
“Furthermore, dysbiosis of the gut microbiota is associated with several disorders in children, such as abnormal behaviors, Crohn’s disease, obesity and inflammatory bowel disease (IBD) (Ajslev et al., 2011; Cryan and Dinan, 2012; Jostins et al., 2012).”
BackgroundMicrobial contact during pregnancy, intestinal colonization and human disease
Rautava, S., Luoto, R., Salminen, S., & Isolauri, E. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.144 · Cited by 467
Heslehurst, N., Vieira, R., Akhter, Z., Bailey, H., Slack, E., Ngongalah, L., Pemu, A., & Rankin, J. M. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002817 · Cited by 440
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment
Nobel, Y. R., Cox, L. M., Kirigin, F. F., Bokulich, N. A., Yamanishi, S., Teitler, I., Chung, J., Sohn, J., Barber, C. M., Goldfarb, D. S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8486 · Cited by 389
“35,36 Four recent epidemiologic studies have shown increased adiposity in children who were exposed to antibiotics early in life 35,37-39 .”
Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 400
Antibiotic Exposure in Infancy and Risk of Being Overweight in the First 24 Months of Life
Saari, A., Virta, L. J., Sankilampi, U., Dunkel, L., & Saxén, H. (2015) · PEDIATRICS · doi:10.1542/peds.2014-3407 · Cited by 369
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 357
“Early exposure to oral antibiotics was found to be associated with overweight in children [114].”
BackgroundDogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Lee, Y. S., Yap, F. K. P., Chong, Y. S., et al. (2015) · mBio · doi:10.1128/mbio.02419-14 · Cited by 359
“In particular, disruption of the early microbiota by antibiotic use (14, 15) and a differential trajectory of microbiota acquisition following cesarean section (16, 17) is associated with increased adiposity later in life.”
BackgroundInfant antibiotic exposure and the development of childhood overweight and central adiposity
Azad, M. B., Bridgman, S. L., Becker, A. B., & Kozyrskyj, A. L. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.119 · Cited by 331
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326
Vallianou, N. G., Stratigou, T., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00352-2 · Cited by 325
Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
Moreno‐Indias, I., Cardona, F., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00190 · Cited by 325
“Several studies have indicated that some antibiotics are associated with weight gain in malnourished children, neonates, and adults (Ajslev et al., 2011; Trehan et al., 2013), but the precise mechanisms by which antibiotics improve weight are not well characterized.”
BackgroundHeiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304
The gut microbiota and metabolic disease: current understanding and future perspectives
Arora, T., & Bäckhed, F. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12508 · Cited by 312
Li, H.-T., Zhou, Y.-B., & Liu, J.-M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.195 · Cited by 301
Role of Gut Microbiota in the Aetiology of Obesity: Proposed Mechanisms and Review of the Literature
Khan, M. J., Gerasimidis, K., Edwards, C. A., & Shaikh, M. G. (2016) · Journal of Obesity · doi:10.1155/2016/7353642 · Cited by 315
Interindividual variability in gut microbiota and host response to dietary interventions
Healey, G. R., Murphy, R., Brough, L., Butts, C. A., & Coad, J. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux062 · Cited by 306
“Early life exposure to antibiotics is also associated with childhood overweight and obesity, which suggests that antibiotic-driven perturbation of the microbial balance at this critical time may have implications on host metabolic functionality.(40,41) In one study, the negative association between antibiotic exposure…”
Dzidic, M., Collado, M. C., Abrahamsson, T., Artacho, A., Stensson, M., Jenmalm, M. C., & Mira, A. (2018) · The ISME Journal · doi:10.1038/s41396-018-0204-z · Cited by 279
Association between caesarean section and childhood obesity: a systematic review and meta‐analysis
Kuhle, S., Tong, O. S., & Woolcott, C. G. (2015) · Obesity Reviews · doi:10.1111/obr.12267 · Cited by 285
“No study included in this review adjusted for gestational diabetes and few studies were able to adjust for pregnancy weight gain and breastfeeding simultaneously (7,27,33,34,36,38,39).”
BackgroundPathways in Microbe-Induced Obesity
Cox, L. M., & Blaser, M. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.004 · Cited by 272
“In particular, antibiotic exposure in early life, just when host adipocyte populations are developing (Greenwood and Hirsch, 1974), has been associated with the development of adiposity in humans (Ajslev et al., 2011; Trasande et al., 2013).”
Ronan, V., Yeasin, R., & Claud, E. C. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.065 · Cited by 278
“However, antibiotics were actually associated with a decreased risk of being overweight if the mothers were overweight or obese (35).”
BackgroundBrain–gut–microbiome interactions in obesity and food addiction
Gupta, A., Osadchiy, V., & Mayer, E. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0341-5 · Cited by 279
Zeißig, S., & Blumberg, R. S. (2014) · Nature Immunology · doi:10.1038/ni.2847 · Cited by 243
MECHANISMS IN ENDOCRINOLOGY: Gut microbiota in patients with type 2 diabetes mellitus
Allin, K. H., Nielsen, T., & Pedersen, O. B. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0874 · Cited by 243
Epigenetic mechanisms elicited by nutrition in early life
Canani, R. B., Costanzo, M. D., Leone, L., Bedogni, G., Brambilla, P., Cianfarani, S., Nobili, V., Pietrobelli, A., & Agostoni, C. V. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000102 · Cited by 237
“This effect may potentially be explained by an impact on establishment and diversity of the microbiota (59) .”
BackgroundComposition of the early intestinal microbiota
Fouhy, F., Ross, R. P., Fitzgerald, G. F., Stanton, C., & Cotter, P. D. (2012) · Gut Microbes · doi:10.4161/gmic.20169 · Cited by 245
The influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease
Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219
The Early Settlers: Intestinal Microbiology in Early Life
Scholtens, P. A. M. J., Oozeer, R., Martı́n, R., Amor, K. B., & Knol, J. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022811-101120 · Cited by 231
The health implications of birth by Caesarean section
Hyde, M. J., Mostyn, A., Modi, N., & Kemp, P. R. (2011) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2011.00195.x · Cited by 214
“(2) Body mass A recent, large population study, of children aged 7, found no difference in body mass between offspring born by CS or VD (Ajslev et al., 2011).”
BackgroundGut Microbiome and Obesity: A Plausible Explanation for Obesity
Sanmiguel, C. P., Gupta, A., & Mayer, E. A. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0152-0 · Cited by 210
Correlation between body mass index and faecal microbiota from children
Ignácio, A., Fernandes, M. R., Rodrigues, V. A. A., Groppo, F. C., Cardoso, A. L., Ávila-Campos, M. J., & Nakano, V. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.031 · Cited by 203
“Exogenous factors such as vaginal or caesarean delivery, breastfeeding and administration of antibiotics in infants can affect the intestinal microbial diversity; however, it is not clear if these factors might have an obesogenic effect [26].”
BackgroundYuan, C., Gaskins, A. J., Blaine, A. I., Zhang, C., Gillman, M. W., Missmer, S. A., Field, A. E., & Chavarro, J. E. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2385 · Cited by 200
Veterinary antibiotics in food, drinking water, and the urine of preschool children in Hong Kong
Li, N., Ho, W., Ying, G., & Deng, W. (2017) · Environment International · doi:10.1016/j.envint.2017.08.014 · Cited by 204
Human gut microbiota and healthy aging: Recent developments and future prospective
Kumar, M., Babaei, P., Ji, B., & Nielsen, J. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-150002 · Cited by 211
Mika, A., Van Treuren, W., González, A., Herrera, J. J., Knight, R., & Fleshner, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125889 · Cited by 197
“Similarly, previous work in humans has also detected a relationship between early life microbial composition and body mass later in life [25], as well as between early life microbial disruptions and obesity [26,27,71].”
BackgroundResultBifidobacteria and the infant gut: an example of co-evolution and natural selection
Turroni, F., Milani, C., Duranti, S., Ferrario, C., Lugli, G. A., Mancabelli, L., van Sinderen, D., & Ventura, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2672-0 · Cited by 214
Duong, Q. A., Pittet, L. F., Curtis, N. C., & Zimmermann, P. (2022) · Journal of Infection · doi:10.1016/j.jinf.2022.01.005 · Cited by 195
Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity
Scott, F. I., Horton, D. B., Mamtani, R., Haynes, K., Goldberg, D. S., Lee, D. Y., & Lewis, J. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.006 · Cited by 198
Weight gain by gut microbiota manipulation in productive animals
Angelakis, E. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.11.002 · Cited by 207
Related actions of probiotics and antibiotics on gut microbiota and weight modification
Angelakis, E., Merhej, V., & Raoult, D. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70179-8 · Cited by 190
Food additives, contaminants and other minor components: effects on human gut microbiota—a review
Roca-Saavedra, P., Mendez-Vilabrille, V., Miranda, J. M., Lamas, A., Nebot, C., Cardelle‐Cobas, A., Cepeda, A., & Cepeda, A. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0564-2 · Cited by 204
“As a general rule, it was reported that antibiotic intake in mice increased adiposity [3, 18, 30, 67, 81, 117], and thus favored the development of obesity and type II diabetes [79], besides affecting normal metabolic activity, hormonal and immune development.”
BackgroundGut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
Picca, A., Fanelli, F., Calvani, R., Mulè, G., Pesce, V., Sisto, A., Pantanelli, C., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/7026198 · Cited by 181
The developing gut microbiota and its consequences for health
Butel, M.-J., Waligora-Dupriet, A.-J., & Wydau-Dematteis, S. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000119 · Cited by 182
“Moreover, the risk of childhood overweight is increase in child born from women with a high gestational body mass index, women who have a gut microbiota enriched in Bacteroides, Clostridium and Staphylococcus.(64,65) This is in accordance with a transmission of obesogenic microbiota through vaginal delivery but was no…”
BackgroundResultAssociation of caesarean delivery with child adiposity from age 6 weeks to 15 years
Blustein, J., Attina, T., Liu, M., Ryan, A. M., Cox, L. M., Blaser, M. J., & Trasande, L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.49 · Cited by 211
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 190
“However, gut microbiota during infancy has been associated with rapid early growth and later overweight and obesity [14, 15], and numerous exposures known to impact the early gut microbiota, such as birth via cesarean section and antibiotics, have also been associated with increased obesity risk [16, 17].”
BackgroundAntibiotics detected in urines and adipogenesis in school children
Wang, H., Wang, N., Wang, B., Fang, H., Fu, C., Tang, C., Jiang, F., Zhou, Y., He, G., Zhao, Q., et al. (2016) · Environment International · doi:10.1016/j.envint.2016.02.005 · Cited by 173
Murphy, R., Stewart, A. W., Braithwaite, I. E., Beasley, R. W., Hancox, R. J., Mitchell, E. A., & the ISAAC Phase Three Study Group (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.218 · Cited by 169
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Iszatt, N., Dahl, C., Sontag, M. K., Knight, R. D., Lozupone, C., & Eggesbø, M. Å. (2018) · mBio · doi:10.1128/mbio.01751-18 · Cited by 179
Gomez-Arango, L. F., Barrett, H. L., McIntyre, H. D., Callaway, L. K., Morrison, M., & Nitert, M. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-03066-4 · Cited by 168
Antibiotics in the first year of life and subsequent neurocognitive outcomes
Slykerman, R. F., Thompson, J., Waldie, K. E., Murphy, R., Wall, C., & Mitchell, E. A. (2017) · Acta Paediatrica · doi:10.1111/apa.13613 · Cited by 166
“In animal models, antibiotic use in early life has been shown to increase risk of central adiposity and obesity in rodents (16), and this has more recently been shown in human studies (17,18).”
BackgroundHoen, A. G., Li, J., Moulton, L. A., O’Toole, G. A., Housman, M. L., Koestler, D. C., Guill, M. F., Moore, J. H., Hibberd, P. L., Morrison, H. G., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.02.049 · Cited by 167
ElRakaiby, M. T., Dutilh, B. E., Rizkallah, M. R., Boleij, A., Cole, J. N., & Aziz, R. K. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2014.0018 · Cited by 169
“Furthermore, the administration of antibiotics in early childhood has been associated with serious conditions such as Crohn’s disease (Virta et al., 2012), asthma (Risnes et al., 2011), and obesity (Ajslev et al., 2011).”
Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis
Słabuszewska-Jóźwiak, A., Szymański, J. K., Ciebiera, M., Sarecka‐Hujar, B., & Jakiel, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218031 · Cited by 162
“[72] Denmark Cohort Prospective 28,354 7 y Obesity”
BackgroundThe Infant Gut Microbiome: Evidence for Obesity Risk and Dietary Intervention
Koleva, P. T., Bridgman, S. L., & Kozyrskyj, A. L. (2015) · Nutrients · doi:10.3390/nu7042237 · Cited by 158
“Data from two large birth cohorts, the Danish National Birth Cohort and the UK Avon Longitudinal Study of Parents and Children, found modest increases in risk for overweight at age 7 years and 38 months, respectively, with antibiotic exposure before six months of life [43,47].”
Lee, P. C., Yacyshyn, B., & Yacyshyn, M. B. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13561 · Cited by 159
“Early exposure to antibiotics is correlated with an increased risk of overweight children from mothers with normal body weight and a decreased risk of child obesity from overweight mothers.(83) The timing of antibiotic exposure seems to be important.”
BackgroundEarly-onset Sepsis and Antibiotic Exposure in Term Infants
Fjalstad, J. W., Stensvold, H. J., Bergseng, H., Simonsen, G. S., Salvesen, B., Rønnestad, A. E., & Klingenberg, C. (2015) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000906 · Cited by 152
Vidal, A. C., Murphy, S. K., Murtha, A. P., Schildkraut, J. M., Soubry, A., Huang, Z., Neelon, S. E. B., Fuemmeler, B. F., Iversen, E. S., Wang, F., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.47 · Cited by 150
García‐Mantrana, I., Selma‐Royo, M., González, S., Llorca, A. P., Martínez‐Costa, C., & Collado, M. C. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730294 · Cited by 155
“Early exposure to antibiotic use, unbalanced diets, and the increased ratios of C-section deliveries could disrupt this adequate early infant colonization, which have been linked to the risk of childhood obesity.(14,15) Maternal overweight and obesity have an impact on the infant microbiota and can influence the risk…”
BackgroundLinking microbiota to human diseases: a systems biology perspective
Wu, H., Tremaroli, V., & Bäckhed, F. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.09.011 · Cited by 150
“to the development of obesity in humans [21], and mouse studies demonstrated that early administration of antibiotics decreases ileal expression of host immune genes by depleting the microbiota and induces obesity in adulthood, potentially by affecting host liver metabolism [22,23].”
BackgroundKuzniewicz, M. W., Walsh, E. M., Li, S. X., Fischer, A. F., & Escobar, G. J. (2016) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/s1553-7250(16)42030-1 · Cited by 148
Stinson, L. F., Payne, M. S., & Keelan, J. A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00135 · Cited by 154
“Aberrations in the establishment of this ecosystem in infants and children underpin the risk for immune-mediated diseases, such as asthma (18–21), allergies (22–25), and inflammatory bowel disease (26, 27), as well as metabolic conditions, such as obesity (28) and a variety of behavioral, cognitive, and mental health…”
BackgroundFactors influencing the gut microbiome in children: from infancy to childhood
Kumbhare, S. V., Patangia, D. V., Patil, R. H., Shouche, Y. S., & Patil, N. P. (2019) · Journal of Biosciences · doi:10.1007/s12038-019-9860-z · Cited by 143
“It is observed that antibiotic uptake during early life increases the risk of overweight and obesity in children in later life (Ajslev et al. 2011; Trasande et al. 2013; Bailey et al. 2018).”
BackgroundNormal neonatal microbiome variation in relation to environmental factors, infection and allergy
Madan, J. C., Farzan, S. F., Hibberd, P. L., & Karagas, M. R. (2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32835a1ac8 · Cited by 149
Pardon, B., Hostens, M., Duchateau, L., Dewulf, J., De Bleecker, K., & Deprez, P. (2013) · BMC Veterinary Research · doi:10.1186/1746-6148-9-79 · Cited by 138
“In human medicine, antimicrobial use at young age in infants from mothers with a normal body weight has been associated with an increased risk of overweight at the age of 7 [63].”
BackgroundRasmussen, S. H., Shrestha, S., Bjerregaard, L. G., Ängquist, L. H., Baker, J. L., Jess, T., & Allin, K. H. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13230 · Cited by 138
“arises from the fact that children who are prescribed antibiotics are inherently different from children who are not, and that these children may have a different risk of overweight than unexposed children independent of exposure to antibiotics.(3) This was not acknowledged by a recently published meta-analysis which…”
ResultSelf-citationImportance of gut microbiota in obesity
Cornejo-Pareja, I. M., Muñoz‐Garach, A., Clemente‐Postigo, M., & Tinahones, F. J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0306-8 · Cited by 147
Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use
Korpela, K., Zijlmans, M. A. C., Kuitunen, M., Kukkonen, A. K., Savilahti, E., Salonen, A., de Weerth, C., & de Vos, W. M. (2017) · Microbiome · doi:10.1186/s40168-017-0245-y · Cited by 143
Kan, H., Zhao, F., Zhang, X., Ren, H., & Gao, S. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b02990 · Cited by 132
Antibiotics, obesity and the link to microbes - what are we doing to our children?
Turta, O., & Rautava, S. (2016) · BMC Medicine · doi:10.1186/s12916-016-0605-7 · Cited by 132
“The clinical significance of this phenomenon is demonstrated by a recent systematic review and metaanalysis of epidemiological studies indicating that the risk of childhood obesity in infants born by CS is 1.34- fold (95 % CI 1.18–1.51) as compared to vaginally-born subjects even if maternal BMI is taken into consider…”
InfluentialCurrent understanding of antibiotic-associated dysbiosis and approaches for its management
Kesavelu, D., & Jog, P. P. (2023) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361231154443 · Cited by 156
Early life events influence whole-of-life metabolic health via gut microflora and gut permeability
Kerr, C. A., Grice, D. M., Tran, C. D., Bauer, D. C., Li, D., Hendry, P. L., & Hannan, G. N. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.837863 · Cited by 129
“For example, of all children treated with antibiotics in this study, those with mothers with a healthy pre-pregnancy BMI had an increased risk of developing obesity, whereas those of obese mothers were at decreased risk of developing obesity (Ajslev et al., 2011).”
BackgroundInfluential
Metadata
- Authors
- Ajslev, T. A., Andersen, C. S., Gamborg, M., Sørensen, T. I. A., & Jess, T.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Ajslev, T A
- Venue
- International Journal of Obesity
- Published
- 2011-03-08
- Volume
- 35
- Issue
- 4
- Pages
- 522-529
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2003202328
- Cited by
- 534
- References
- 36
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 36 · 2020: 51 · 2019: 54 · 2018: 51 · 2017: 51 · 2016: 54 · 2015: 59 · 2014: 32 · 2013: 33 · 2012: 21
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- childhood overweight, gut microbiota, mode of delivery, cesarean section, vaginal delivery, maternal pre-pregnancy BMI, maternal obesity, early antibiotic exposure, infancy, environmental risk factors
- MeSH terms
- Adolescent, Adult, Anti-Bacterial Agents, Cesarean Section, Child, Female, Humans, Infant, Newborn, Longitudinal Studies, Male, Mothers, Obesity, Pregnancy, Prospective Studies, Surveys and Questionnaires, Risk Factors, Body Mass Index, Delivery, Obstetric, Gastrointestinal Tract, Metagenome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
