Cited by 542Neuroscience and Neuropharmacology ResearchCellular transport and secretionNicotinic Acetylcholine Receptors Study

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Regulation of AMPA receptor lateral movements

Borgdorff, Aren J., Choquet, Daniel·2002·Nature

DOI 10.1038/nature00780

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Abstract

An essential feature in the modulation of the efficacy of synaptic transmission is rapid changes in the number of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors at post-synaptic sites on neurons. Regulation of receptor endo- and exocytosis has been shown to be involved in this process. Whether regulated lateral diffusion of receptors in the plasma membrane also participates in receptor exchange to and from post-synaptic sites remains unknown. We analysed the lateral mobility of native AMPA receptors containing the glutamate receptor subunit GluR2 in rat cultured hippocampal neurons, using single-particle tracking and video microscopy. Here we show that AMPA receptors alternate within seconds between rapid diffusive and stationary behaviour. During maturation of neurons, stationary periods increase in frequency and length, often in spatial correlation with synaptic sites. Raising intracellular calcium, a central element in synaptic plasticity, triggers rapid receptor immobilization and local accumulation on the neuronal surface. We suggest that calcium influx prevents AMPA receptors from diffusing, and that lateral receptor diffusion to and from synaptic sites acts in the rapid and controlled regulation of receptor numbers at synapses.

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Authors: Borgdorff, A. J., & Choquet, D.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Choquet, Daniel
ORCID: Choquet, Daniel
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-06
Volume: 417
Issue: 6889
Pages: 649-653
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature00780
OpenAlex: W1965202553
Cited by: 542
References: 29
Citations by year: 2026: 6 · 2025: 8 · 2024: 15 · 2023: 13 · 2022: 12 · 2021: 26 · 2020: 17 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 18 · 2015: 19 · 2014: 23 · 2013: 32 · 2012: 28
FWCI: 8.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: AMPA receptors, GluR2, receptor lateral diffusion, synaptic plasticity, intracellular calcium, receptor immobilization, synaptic transmission, hippocampal neurons, single-particle tracking
MeSH terms: Animals, Calcium, Cell Differentiation, Cells, Cultured, Diffusion, Hippocampus, Kinetics, Neurons, Photolysis, Synapses, Receptors, AMPA, Microscopy, Video, Protein Subunits, Protein Transport, Rats

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