Cited by 324Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerMarine Invertebrate Physiology and Ecology

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An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation

Wikramanayake, Athula H., Hong, Melanie, Lee, Patricia N., Pang, Kevin, Byrum, Christine A., Bince, Joanna M., Xu, Ronghui, Martindale, Mark Q.·2003·Nature

DOI 10.1038/nature02113

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Abstract

The human oncogene beta-catenin is a bifunctional protein with critical roles in both cell adhesion and transcriptional regulation in the Wnt pathway. Wnt/beta-catenin signalling has been implicated in developmental processes as diverse as elaboration of embryonic polarity, formation of germ layers, neural patterning, spindle orientation and gap junction communication, but the ancestral function of beta-catenin remains unclear. In many animal embryos, activation of beta-catenin signalling occurs in blastomeres that mark the site of gastrulation and endomesoderm formation, raising the possibility that asymmetric activation of beta-catenin signalling specified embryonic polarity and segregated germ layers in the common ancestor of bilaterally symmetrical animals. To test whether nuclear translocation of beta-catenin is involved in axial identity and/or germ layer formation in 'pre-bilaterians', we examined the in vivo distribution, stability and function of beta-catenin protein in embryos of the sea anemone Nematostella vectensis (Cnidaria, Anthozoa). Here we show that N. vectensis beta-catenin is differentially stabilized along the oral-aboral axis, translocated into nuclei in cells at the site of gastrulation and used to specify entoderm, indicating an evolutionarily ancient role for this protein in early pattern formation.

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A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
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Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167
Early animal evolution: emerging views from comparative biology and geology
Knoll, A. H., & Carroll, S. B. (1999) · Science · doi:10.1126/science.284.5423.2129 · Cited by 821
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Heasman, J., Crawford, A., Goldstone, K., Garner-Hamrick, P., Gumbiner, B., McCrea, P., Kintner, C., Noro, C., & Wylie, C. (1994) · Cell · doi:10.1016/0092-8674(94)90069-8 · Cited by 693
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Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
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β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos
Schneider, S., Steinbeißer, H., Warga, R. M., & Hausen, P. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00546-1 · Cited by 515

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Weitzel, H. E. & Ettensohn, C. A. beta-catenin is differentially degraded along the animal-vegetal axis of early sea urchin embryos in a GSK-3b-dependent manner. Dev. Biol. 247, 479a (2002)

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Authors: Wikramanayake, A. H., Hong, M., Lee, P. N., Pang, K., Byrum, C. A., Bince, J. M., Xu, R., & Martindale, M. Q.
Affiliations: University of Hawaiʻi at Mānoa (US)
Corresponding author: Wikramanayake, Athula H.
Martindale, Mark Q.
ORCID: Wikramanayake, Athula H.
Byrum, Christine A.
Xu, Ronghui
Martindale, Mark Q.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-11
Volume: 426
Issue: 6965
Pages: 446-450
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02113
OpenAlex: W2029609524
Cited by: 324
References: 29
Citations by year: 2026: 5 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 11 · 2021: 12 · 2020: 7 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 19 · 2015: 9 · 2014: 16 · 2013: 19 · 2012: 15
FWCI: 5.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Keywords: β-catenin, nuclear translocation, Wnt/β-catenin signaling, axial polarity, gastrulation, Nematostella vectensis, oral-aboral axis, cell adhesion, transcriptional regulation
MeSH terms: Animals, Cell Nucleus, Cytoskeletal Proteins, Gastrula, Germ Layers, Immunohistochemistry, Trans-Activators, Cell Polarity, Lithium Chloride, Active Transport, Cell Nucleus, Anthozoa, beta Catenin

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An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation

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