Blood stem cells emerge from aortic endothelium by a novel type of cell transition

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

Adult haematopoietic stem cell niches

Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712

Determinants of resident tissue macrophage identity and function

Blériot, C., Chakarov, S., & Ginhoux, F. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.014 · Cited by 507

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333

Stem cells living with a Notch

Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02492-2 · Cited by 278

The hematopoietic stem cell niche: from embryo to adult

Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247

Induction of a hemogenic program in mouse fibroblasts

Pereira, C.-F., Chang, B., Qiu, J., Niu, X., Papatsenko, D., Hendry, C. E., Clark, N. R., Nomura-Kitabayashi, A., Kovacic, J. C., Ma’ayan, A., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.024 · Cited by 216

RUNX transcription factors: orchestrators of development

Mevel, R., Draper, J. E., Lie-a-Ling, M., Kouskoff, V., & Lacaud, G. (2019) · Development · doi:10.1242/dev.148296 · Cited by 211

Perivascular support of human hematopoietic stem/progenitor cells

Corselli, M., Chin, C. J., Parekh, C., Sahaghian, A., Wang, W., Ge, S., Evseenko, D., Wang, X., Montelatici, E., Lazzari, L., et al. (2013) · Blood · doi:10.1182/blood-2012-08-451864 · Cited by 189

Development and homeostasis of “resident” myeloid cells: the case of the microglia

Gomez Perdiguero, E., Schulz, C., & Geissmann, F. (2013) · Glia · doi:10.1002/glia.22393 · Cited by 182

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J. Y., & Wen, Z. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.08.018 · Cited by 177

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175

Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium

Van Handel, B., Montel-Hagen, A., Sasidharan, R., Nakano, H., Ferrari, R., Boogerd, C. J., Schredelseker, J., Wang, Y., Hunter, S., Org, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.026 · Cited by 154

Targeting PAK4 to reprogram the vascular microenvironment and improve CAR‐T immunotherapy for glioblastoma

Ma, W., Wang, Y., Zhang, R., Yang, F., Zhang, D., Huang, M., Zhang, L., Dorsey, J. F., Binder, Z. A., O’Rourke, D. M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00147-8 · Cited by 143

SCL/TAL1: a multifaceted regulator from blood development to disease

Porcher, C., Chagraoui, H., & Kristiansen, M. S. (2017) · Blood · doi:10.1182/blood-2016-12-754051 · Cited by 135

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

Huang, M., Liu, T., Ma, P., Mitteer, R. A., Zhang, Z., Kim, H. J., Yeo, E., Zhang, D., Cai, P., Li, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84876 · Cited by 128

Hemogenic endothelium during development and beyond

Hirschi, K. K. (2012) · Blood · doi:10.1182/blood-2011-12-353466 · Cited by 124

Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis

Collins, A., Mitchell, C. A., & Passegué, E. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201545 · Cited by 111

Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny

Ganuza, M., Hall, T., Finkelstein, D., Chabot, A., Kang, G., & McKinney-Freeman, S. (2017) · Nature Cell Biology · doi:10.1038/ncb3607 · Cited by 94

The RUNX1–PU.1 axis in the control of hematopoiesis

Imperato, M. R., Cauchy, P., Obier, N., & Bonifer, C. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1762-8 · Cited by 94

Role of macrophages in the endocrine system

Rehman, A., Pacher, P., & Haskó, G. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.12.001 · Cited by 71

EGFR is required for Wnt9a/Fzd9b signalling specificity in haematopoietic stem cells

Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C. H., Wozniak, J. M., Barahona, R., Kamei, C. N., Houston, J., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0330-5 · Cited by 60

Stress and non-stress roles of inflammatory signals during HSC Emergence and maintenance

Clapes, T., Lefkopoulos, S., & Trompouki, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00487 · Cited by 62

High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations

Chen, M., Fu, R., Chen, Y., Li, L., & Wang, S.-W. (2025) · Nature Methods · doi:10.1038/s41592-024-02567-1 · Cited by 58

tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis

Mahony, C. B., Fish, R. J., Pasche, C., & Bertrand, J. Y. (2016) · Blood · doi:10.1182/blood-2016-04-710137 · Cited by 58

Hematopoietic stem cell engineering at a crossroads

Rivière, I., Dunbar, C. E., & Sadelain, M. (2012) · Blood · doi:10.1182/blood-2011-09-349993 · Cited by 54

Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment

Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52

ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development

Wareing, S., Eliades, A., Lacaud, G., & Kouskoff, V. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23825 · Cited by 46

Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model

Martin, C. S., Moriyama, A., & Zon, L. I. (2011) · Genome Medicine · doi:10.1186/gm299 · Cited by 29

Using the Zebrafish as a Genetic Model to Study Erythropoiesis

Zhang, Y., Chen, M., & Chen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910475 · Cited by 25