The genetics of ageing

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120

Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057

Signals from the reproductive system regulate the lifespan of C. elegans

Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014

FOXO3A genotype is strongly associated with human longevity

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983

The genetics of caloric restriction in Caenorhabditis elegans

Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 971

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7540 · Cited by 862

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 803

Genetic Analysis of Tissue Aging in Caenorhabditis elegans : A Role for Heat-Shock Factor and Bacterial Proliferation

Garigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

Grandison, R. C., Piper, M. D. W., & Partridge, L. (2009) · Nature · doi:10.1038/nature08619 · Cited by 785

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667

Two neurons mediate diet-restriction-induced longevity in C. elegans

Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643

Ovarian conservation at the time of hysterectomy and long-term health outcomes in the Nurses’ Health Study

Parker, W. H., Broder, M. S., Chang, E., Feskanich, D., Farquhar, C., Liu, Z., Shoupe, D., Berek, J. S., Hankinson, S., & Manson, J. E. (2009) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181a11c64 · Cited by 640

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 615

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 591

Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity

Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 578

Association of FOXO3A variation with human longevity confirmed in German centenarians

Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809594106 · Cited by 572

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M., Lu, T. A., Benzer, S., & Kapahi, P. (2009) · Cell · doi:10.1016/j.cell.2009.07.034 · Cited by 548

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532

Demography of Dietary Restriction and Death in Drosophila

Mair, W. B., Goymer, P., Pletcher, S. D., & Partridge, L. (2003) · Science · doi:10.1126/science.1086016 · Cited by 526

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

Stewart, J. B., Freyer, C., Elson, J. L., Wredenberg, A., Cansu, Z., Trifunović, A., & Larsson, N. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060010 · Cited by 525

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 513

A systematic RNAi screen for longevity genes in C. elegansPreprint

Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J., & Kapahi, P. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00266.x · Cited by 500

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.034 · Cited by 484

Tumours with PI3K activation are resistant to dietary restriction

Kalaany, N. Y., & Sabatini, D. M. (2009) · Nature · doi:10.1038/nature07782 · Cited by 468

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

Fan, W., Waymire, K. G., Narula, N., Li, P., Rocher, C., Coskun, P. E., Vannan, M. A., Narula, J., MacGregor, G. R., & Wallace, D. C. (2008) · Science · doi:10.1126/science.1147786 · Cited by 466

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.037 · Cited by 465

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 451

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

Tóth, M. L., Sigmond, T., Borsos, É., Barna, J., Erdélyi, P., Takács‐Vellai, K., Orosz, L., Kovács, A., Csikós, G., Sass, M., et al. (2008) · Autophagy · doi:10.4161/auto.5618 · Cited by 429

Resveratrol is not a direct activator of SIRT1 enzyme activity

Beher, D., Wu, J., Cumine, S., Kim, K. W., Lu, S., Atangan, L., & Wang, M. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2009.00901.x · Cited by 426

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 422

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

Viswanathan, M., Kim, S. K., Berdichevsky, A., & Guarente, L. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.017 · Cited by 420

A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans

Rea, S. L., Wu, D., Cypser, J. R., Vaupel, J. W., & Johnson, T. E. (2005) · Nature Genetics · doi:10.1038/ng1608 · Cited by 414

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

Wang, M. C., O’Rourke, E. J., & Ruvkun, G. (2008) · Science · doi:10.1126/science.1162011 · Cited by 412

Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

Libert, S., Zwiener, J., Chu, X., VanVoorhies, W., Roman, G., & Pletcher, S. D. (2007) · Science · doi:10.1126/science.1136610 · Cited by 410

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409

C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Berdichevsky, A., Viswanathan, M., Horvitz, H. R., & Guarente, L. (2006) · Cell · doi:10.1016/j.cell.2006.04.036 · Cited by 402

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

Lee, S., Murphy, C. T., & Kenyon, C. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.003 · Cited by 400

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans

Rea, S. L., Ventura, N., & Johnson, T. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050259 · Cited by 383

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

Pawlikowska, L., Hu, D., Huntsman, S., Sung, A., Chu, C., Chen, J., Joyner, A. H., Schork, N. J., Hsueh, W., Reiner, A. P., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00493.x · Cited by 358

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

Liu, B., Larsson, L., Caballero, A., Hao, X., Öling, D., Grantham, J., & Nyström, T. (2010) · Cell · doi:10.1016/j.cell.2009.12.031 · Cited by 351

Metformin slows down aging and extends life span of female SHR mice

Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Tyndyk, M. L., Yurova, M. V., Kovalenko, I. G., Poroshina, T. E., et al. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6625 · Cited by 348

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328 · cited 1×

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

Li, Y., Wang, W., Cao, H., Lu, J., Wu, C., Hu, F., Guo, J., Zhao, L., Yang, F., Zhang, Y.-X., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp459 · Cited by 323

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

Syntichaki, P., Troulinaki, K., & Tavernarakis, N. (2007) · Nature · doi:10.1038/nature05603 · Cited by 319

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, T., Min, K., D’Alterio, C., Villa-Cuesta, E., Cumbers, J. R., Lehmann, R., Jones, D. L., & Tatar, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709128105 · Cited by 310

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

Anselmi, C. V., Malovini, A. L., Roncarati, R., Novelli, V., Villa, F., Condorelli, G., Bellazzi, R., & Puca, A. A. (2009) · Rejuvenation Research · doi:10.1089/rej.2008.0827 · Cited by 310

Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice

Dell'Agnello, C., Leo, S., Agostino, A., Szabadkai, G., Tiveron, C., Zulian, A., Prelle, A., Roubertoux, P., Rizzuto, R., & Zeviani, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl477 · Cited by 308

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

Kappeler, L., Filho, C. D. D. M., Dupont, J., Leneuve, P., Cervera, P., Périn, L., Loudes, C., Blaise, A., Klein, R., Epelbaum, J., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060254 · Cited by 305

Dietary Restriction in Long-Lived Dwarf Flies

Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J., & Partridge, L. (2002) · Science · doi:10.1126/science.1069366 · Cited by 289

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Honjoh, S., Yamamoto, T., Uno, M., & Nishida, E. (2008) · Nature · doi:10.1038/nature07583 · Cited by 275

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

Medvedik, O., Lamming, D. W., Kim, K. D., & Sinclair, D. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050261 · Cited by 275

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

Wang, Y., & Tissenbaum, H. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.005 · Cited by 269

Antioxidant defense and aging in C. elegans : Is the oxidative damage theory of aging wrong?

Gems, D., & Doonan, R. (2009) · Cell Cycle · doi:10.4161/cc.8.11.8595 · Cited by 264

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans

Budovskaya, Y. V., Wu, K., Southworth, L. K., Jiang, M., Tedesco, P., Johnson, T. E., & Kim, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.05.044 · Cited by 253

Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth

Pinkston, J. M., Garigan, D., Hansen, M., & Kenyon, C. (2006) · Science · doi:10.1126/science.1121908 · Cited by 242

Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice

Lapointe, J., & Hekimi, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803287200 · Cited by 212

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Lunetta, K. L., D’Agostino, R. B., Karasik, D., Benjamin, E. J., Guo, C., Govindaraju, R., Kiel, D. P., Kelly‐Hayes, M., Massaro, J. M., Pencina, M. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s13 · Cited by 193

Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans

Murphy, C. T., Lee, S., & Kenyon, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709613104 · Cited by 186

Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans

Lee, S., & Kenyon, C. J. (2009) · Current Biology · doi:10.1016/j.cub.2009.03.041 · Cited by 184

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

Cristina, D., Cary, M., Lunceford, A., Clarke, C., & Kenyon, C. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000450 · Cited by 166

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

Sheaffer, K. L., Updike, D. L., & Mango, S. E. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.097 · Cited by 166

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

Kenyon, C. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05640.x · Cited by 163

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

Heidler, T., Hartwig, K., Daniel, H., & Wenzel, U. (2009) · Biogerontology · doi:10.1007/s10522-009-9239-x · Cited by 161

Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

Hull‐Thompson, J., Muffat, J., Sánchez, D., Walker, D. W., Benzer, S., Ganfornina, M. D., & Jasper, H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000460 · Cited by 152

Elimination of damaged proteins during differentiation of embryonic stem cells

Hernebring, M., Brolén, G., Aguilaniu, H., Semb, H., & Nyström, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510944103 · Cited by 146

The Posttranslational Processing of Prelamin A and Disease

Davies, B. S. J., Fong, L. G., Yang, S. H., Coffinier, C., & Young, S. G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082908-150150 · Cited by 145

Insulin and aging

Bartke, A. (2008) · Cell Cycle · doi:10.4161/cc.7.21.7012 · Cited by 141

Heat stress-induced life span extension in yeast

Shama, S., Lai, C.-Y., Antoniazzi, J. M., Jiang, J. C., & Jazwinski, S. M. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4279 · Cited by 135

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

Curran, S. P., Wu, X., Riedel, C. G., & Ruvkun, G. (2009) · Nature · doi:10.1038/nature08106 · Cited by 120

Mitochondrial Oxidative Phosphorylation Is Defective in the Long-lived Mutant clk-1

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Sir2 and calorie restriction in yeast: A skeptical perspective

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