Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Active Genes Are Tri-Methylated at K4 of Histone H3

Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138

Regulation of chromatin by histone modifications

Bannister, A. J., & Kouzarides, T. (2011) · Cell Research · doi:10.1038/cr.2011.22 · Cited by 6,012

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051

Gene-specific control of inflammation by TLR-induced chromatin modifications

Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

Ruthenburg, A. J., Allis, C. D., & Wysocka, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.014 · Cited by 1,147

REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

Ballas, N., Grunseich, C., Lu, D. D., Speh, J. C., & Mandel, G. (2005) · Cell · doi:10.1016/j.cell.2005.03.013 · Cited by 950

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

Vaquero, A., Scher, M., Lee, D., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.031 · Cited by 916

Histones: annotating chromatin

Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852

Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells

Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.047 · Cited by 660

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation

Edmunds, J. W., Mahadevan, L. C., & Clayton, A. L. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601967 · Cited by 547

Comparative studies of gene expression and the evolution of gene regulation

Romero, I. G., Ruvinsky, I., & Gilad, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3229 · Cited by 488

A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

Guenther, M. G., Frampton, G. M., Soldner, F., Hockemeyer, D., Mitalipova, M., Jaenisch, R., & Young, R. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.015 · Cited by 456

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352

Histone methylation makes its mark on longevity

Han, S., & Brunet, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.001 · Cited by 204

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

Baker, E. K., Johnstone, R. W., Zalcberg, J. R., & El-Osta, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208955 · Cited by 196

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes

Li, N., Li, Y., Lv, J., Zheng, X., Wen, H., Shen, H., Zhu, G., Chen, T.-Y., Dhar, S. S., Kan, P.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.035 · Cited by 141

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Hughes, A. L., Kelley, J. R., & Klose, R. J. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194567 · Cited by 139

Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis

Attema, J. L., Papathanasiou, P., Forsberg, E. C., Xu, J., Smale, S. T., & Weissman, I. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704468104 · Cited by 134

Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes

Wong, P., Hattangadi, S. M., Cheng, A. W., Frampton, G. M., Young, R. A., & Lodish, H. F. (2011) · Blood · doi:10.1182/blood-2011-03-341404 · Cited by 120

Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features

Lamb, A. N., Rosenfeld, J. A., Neill, N. J., Talkowski, M. E., Blumenthal, I., Girirajan, S., Keelean-Fuller, D., Fan, Z., Pouncey, J., Stevens, C., et al. (2012) · Human Mutation · doi:10.1002/humu.22037 · Cited by 107

RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction

Fong, N., Saldi, T., Sheridan, R. M., Cortazar, M. A., & Bentley, D. L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.016 · Cited by 98

Nrf2 Transcription Factor Can Directly Regulate mTOR

Bendavit, G., Aboulkassim, T., Hilmi, K., Shah, S., & Batist, G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.760249 · Cited by 95

Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes

Németh, A., Guibert, S., Tiwari, V. K., Ohlsson, R., & Längst, G. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.57 · Cited by 94

H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression

Cruceanu, C., Alda, M., Nagy, C., Freemantle, E., Rouleau, G. A., & Turecki, G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000363 · Cited by 93

Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

Attema, J. L., Pronk, C. J. H., Norddahl, G. L., Nygren, J. M., & Bryder, D. (2009) · Oncogene · doi:10.1038/onc.2009.94 · Cited by 72

Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE)

Allen, M. L., & Antoniou, M. (2007) · Epigenetics · doi:10.4161/epi.2.4.5231 · Cited by 62

Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin

Wijeweera, A., Haj, M., Feldman, A., Pnueli, L., Luo, Z., & Melamed, P. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.01.001 · Cited by 17

Regulation of genomic output and (pluri)potency in regeneration

Duncan, E. M., & Sánchez Alvarado, A. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043733 · Cited by 17

Analog epigenetic memory revealed by targeted chromatin editing

Palacios, S., Bruno, S., Weiss, R., Salibi, E., Kane, A., Ilia, K., & Del Vecchio, D. (2024) · doi:10.1101/2024.02.13.580200 · Cited by 13

Analog epigenetic memory revealed by targeted chromatin editing

(2025) · doi:10.1016/j.xgen.2025.100985 · Cited by 13

Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states

Murphy, A. E., Askarova, A., Lenhard, B., Skene, N. G., & Marzi, S. J. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkae1212 · Cited by 10

The Saccharomyces cerevisiae Cdk8 Mediator Represses AQY1 Transcription by Inhibiting Set1p-Dependent Histone Methylation

Law, M. J., & Finger, M. A. (2017) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.117.039586 · Cited by 6