IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F.-A., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E.-M., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,845

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay-Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,256

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Nivolumab plus Ipilimumab in Advanced Melanoma

Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099

Interleukin-12 and the regulation of innate resistance and adaptive immunity

Trinchieri, G. (2003) · Nature Reviews Immunology · doi:10.1038/nri1001 · Cited by 3,927

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00070-4 · Cited by 2,822

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593

Genetics of rheumatoid arthritis contributes to biology and drug discovery

the RACI consortium, Okada, Y., the GARNET consortium, Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., et al. (2014) · Nature · doi:10.1038/nature12873 · Cited by 2,310

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M., Florencia, E., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,176

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035

Secukinumab in plaque psoriasis—results of two phase 3 trials

Langley, R. G., Elewski, B. E., Lebwohl, M., Reich, K., Griffiths, C. E. M., Papp, K., Puig, L., Nakagawa, H., Spelman, L., Sigurgeirsson, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314258 · Cited by 1,997

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N., Guzzo, C., Wang, Y., Li, S., Dooley, L. T., & Gordon, K. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60725-4 · Cited by 1,874

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

Zheng, Y., Danilenko, D. M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 1,862

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669

Interferons, immunity and cancer immunoediting

Dunn, G. P., Koebel, C. M., & Schreiber, R. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1961 · Cited by 1,617

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial

Hueber, W., Sands, B. E., Lewitzky, S., Vandemeulebroecke, M., Reinisch, W., Higgins, P. D. R., Wehkamp, J., Feagan, B. G., Yao, M. D., Karczewski, M., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301668 · Cited by 1,547

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., Mckenzie, B., Kleinschek, M. A., Owyang, A., Mattson, J., Blumenschein, W., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,542

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465

Adaptive immunity maintains occult cancer in an equilibrium state

Koebel, C. M., Vermi, W., Swann, J. B., Zerafa, N., Rodig, S. J., Old, L. J., Smyth, M. J., & Schreiber, R. D. (2007) · Nature · doi:10.1038/nature06309 · Cited by 1,436

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

International Multiple Sclerosis Genetics Consortium (IMSGC) (2013) · Nature Genetics · doi:10.1038/ng.2770 · Cited by 1,386

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

Papp, K. A., Langley, R. G., Lebwohl, M., Krueger, G. G., Szapary, P., Yeilding, N., Guzzo, C., Hsu, M.-C., Wang, Y., Li, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60726-6 · Cited by 1,361

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D'Amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M., Latiano, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.764 · Cited by 1,320

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

Parham, C., Chirica, M., Timans, J., Vaisberg, E., Travis, M., Cheung, J., Pflanz, S., Zhang, R., Singh, K. P., Vega, F., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5699 · Cited by 1,296

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., & Levin, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352602 · Cited by 1,199

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191

Fate mapping of IL-17-producing T cells in inflammatory responses

Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

Sandborn, W. J., Gasink, C., Gao, L.-L., Blank, M. A., Johanns, J., Guzzo, C., Sands, B. E., Hanauer, S. B., Targan, S., Rutgeerts, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203572 · Cited by 1,134

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071

Late Developmental Plasticity in the T Helper 17 Lineage

Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 (2010) · Nature Genetics · doi:10.1038/ng.694 · Cited by 1,047

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024

IL-23 promotes tumour incidence and growth

Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature · doi:10.1038/nature04808 · Cited by 1,018

Genetic Dissection of Immunity to Mycobacteria: The Human Model

Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

Papp, K. A., Leonardi, C., Menter, A., Ortonne, J.-P., Krueger, J. G., Kricorian, G., Aras, G., Li, J., Russell, C. B., Thompson, E. H. Z., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109017 · Cited by 941

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

Leonardi, C., Matheson, R., Zachariae, C., Cameron, G., Li, L., Edson-Heredia, E., Braun, D., & Banerjee, S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109997 · Cited by 936

Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

Lee, E., Trepicchio, W. L., Oestreicher, J. L., Pittman, D., Wang, F., Chamian, F., Dhodapkar, M., & Krueger, J. G. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030451 · Cited by 899

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

Jouanguy, E., Altare, F., Lamhamedi, S., Revy, P., Emile, J.-F., Newport, M., Levin, M., Blanche, S., Seboun, E., Fischer, A., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352604 · Cited by 895

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

The Australo-Anglo-American Spondyloarthritis Consortium (TASC), Evans, D. M., the Wellcome Trust Case Control Consortium 2 (WTCCC2), Spondyloarthritis Research Consortium of Canada (SPARCC), Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Oppermann, U., et al. (2011) · Nature Genetics · doi:10.1038/ng.873 · Cited by 893

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Mannon, P. J., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D., Dolin, B., Goodman, N., Groden, C., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 848

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

Altare, F., Durandy, A., Lammas, D., Emile, J.-F., Lamhamedi, S., Le Deist, F., Drysdale, P., Jouanguy, E., Döffinger, R., Bernaudin, F., et al. (1998) · Science · doi:10.1126/science.280.5368.1432 · Cited by 845

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

Smyth, M. J., Thia, K. Y. T., Street, S. E. A., Cretney, E., Trapani, J. A., Taniguchi, M., Kawano, T., Pelikan, S. B., Crowe, N. Y., & Godfrey, D. I. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.4.661 · Cited by 829

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

Döffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A., Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., et al. (2001) · Nature Genetics · doi:10.1038/85837 · Cited by 828

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

Jong, R. D., Altare, F., Haagen, I.-A., Elferink, D. G., Boer, T. D., van Breda Vriesman, P. J. C., Kabel, P. J., Draaisma, J. M. T., van Dissel, J. T., Kroon, F. P., et al. (1998) · Science · doi:10.1126/science.280.5368.1435 · Cited by 821

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

McInnes, I. B., Kavanaugh, A., Gottlieb, A. B., Puig, L., Rahman, P., Ritchlin, C., Brodmerkel, C., Li, S., Wang, Y., Mendelsohn, A. M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60594-2 · Cited by 807

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

Liu, L., Okada, S., Kong, X.-F., Kreins, A. Y., Cypowyj, S., Abhyankar, A., Toubiana, J., Itan, Y., Audry, M., Nitschke, P., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110958 · Cited by 797

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Hepworth, M. R., Monticelli, L. A., Fung, T. C., Ziegler, C. G. K., Grunberg, S., Sinha, R., Mantegazza, A. R., Ma, H.-L., Crawford, A., Angelosanto, J. M., et al. (2013) · Nature · doi:10.1038/nature12240 · Cited by 778

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C.-C., & Caspi, R. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071258 · Cited by 721

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

Cooper, A. M., Magram, J., Ferrante, J., & Orme, I. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.39 · Cited by 715

Interleukin-12 in anti-tumor immunity and immunotherapy

Colombo, M. P., & Trinchieri, G. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00032-6 · Cited by 685

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

Bustamante, J., Boisson-Dupuis, S., Abel, L., & Casanova, J.-L. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.008 · Cited by 684

Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

Uhlig, H. H., McKenzie, B. S., Hue, S., Thompson, C., Joyce-Shaikh, B., Stepankova, R., Robinson, N., Buonocore, S., Tlaskalova-Hogenova, H., Cua, D. J., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.017 · Cited by 682

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

Chan, J. R., Blumenschein, W., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S., Lucian, L., Geissler, R., Brodie, S., Kimball, A. B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060244 · Cited by 680

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

The Australo-Anglo-American Spondyloarthritis Consortium (TASC) (2010) · Nature Genetics · doi:10.1038/ng.513 · Cited by 668

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

Liu, Y., Helms, C., Liao, W., Zaba, L. C., Duan, S., Gardner, J., Wise, C., Miner, A., Malloy, M. J., Pullinger, C. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000041 · Cited by 663

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

The NIDDK IBD Genetics Consortium, McGovern, D. P. B., Gardet, A., Törkvist, L., Goyette, P., Essers, J., Taylor, K. D., Neale, B. M., Ong, R. T. H., Lagacé, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.549 · Cited by 654

TH17 cells in tumour immunity and immunotherapy

Zou, W., & Restifo, N. P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2742 · Cited by 624

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

Baeten, D., Baraliakos, X., Braun, J., Sieper, J., Emery, P., van der Heijde, D., McInnes, I., van Laar, J. M., Landewé, R., Wordsworth, P., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61134-4 · Cited by 595

Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

Bogunovic, D., Byun, M., Durfee, L. A., Abhyankar, A., Sanal, O., Mansouri, D., Salem, S., Radovanovic, I., Grant, A. V., Adimi, P., et al. (2012) · Science · doi:10.1126/science.1224026 · Cited by 572

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L., & O'Shea, J. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00211.x · Cited by 572

Therapeutic opportunities of the IL-22–IL-22R1 system

Sabat, R., Ouyang, W., & Wolk, K. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4176 · Cited by 562

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

Libioulle, C., Louis, E., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D., Vermeire, S., Dewit, O., de Vos, M., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 560

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

Bending, D., De La Peña, H., Veldhoen, M., Phillips, J. M., Uyttenhove, C., Stockinger, B., & Cooke, A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37865 · Cited by 558

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

Chen, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25308 · Cited by 555

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.11.005 · Cited by 537

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

The UK IBD Genetics Consortium, & The Wellcome Trust Case Control Consortium 2 (2009) · Nature Genetics · doi:10.1038/ng.483 · Cited by 536

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

Segal, B. M., Constantinescu, C. S., Raychaudhuri, A., Kim, L., Fidelus-Gort, R., & Kasper, L. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70173-x · Cited by 479

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

Kortylewski, M., Xin, H., Kujawski, M., Lee, H., Liu, Y., Harris, T., Drake, C., Pardoll, D., & Yu, H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.018 · Cited by 474

IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available

Khader, S. A., Pearl, J. E., Sakamoto, K., Gilmartin, L., Bell, G. K., Jelley-Gibbs, D. M., Ghilardi, N., deSauvage, F., & Cooper, A. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.788 · Cited by 472

Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features

Filipe-Santos, O., Bustamante, J., Chapgier, A., Vogt, G., de Beaucoudrey, L., Feinberg, J., Jouanguy, E., Boisson-Dupuis, S., Fieschi, C., Picard, C., et al. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.07.010 · Cited by 464

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

de Beaucoudrey, L., Puel, A., Filipe-Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 439

Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung

Okamoto Yoshida, Y., Umemura, M., Yahagi, A., O’Brien, R. L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., & Matsuzaki, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903332 · Cited by 421

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up: Long-term ustekinumab safety in psoriasis

Papp, K. A., Griffiths, C. E. M., Gordon, K., Lebwohl, M., Szapary, P. O., Wasfi, Y., Chan, D., Hsu, M.-C., Ho, V., Ghislain, P. D., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12214 · Cited by 415

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

Altare, F., Lammas, D., Revy, P., Jouanguy, E., Döffinger, R., Lamhamedi, S., Drysdale, P., Scheel-Toellner, D., Girdlestone, J., Darbyshire, P., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4950 · Cited by 413

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.014 · Cited by 405

Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

Silverberg, M. S., Cho, J. H., Rioux, J. D., McGovern, D. P. B., Wu, J., Annese, V., Achkar, J.-P., Goyette, P., Scott, R., Xu, W., et al. (2009) · Nature Genetics · doi:10.1038/ng.275 · Cited by 396

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

Mease, P. J., Genovese, M. C., Greenwald, M. W., Ritchlin, C. T., Beaulieu, A. D., Deodhar, A., Newmark, R., Feng, J., Erondu, N., & Nirula, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315231 · Cited by 395

Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries

de Beaucoudrey, L., Samarina, A., Bustamante, J., Cobat, A., Boisson-Dupuis, S., Feinberg, J., Al-Muhsen, S., Jannière, L., Rose, Y., de Suremain, M., et al. (2010) · Medicine · doi:10.1097/md.0b013e3181fdd832 · Cited by 394

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

Kryczek, I., Lin, Y., Nagarsheth, N., Peng, D., Zhao, L., Zhao, E., Vatan, L., Szeliga, W., Dou, Y., Owens, S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.010 · Cited by 389

Essentials of Th17 cell commitment and plasticity

Muranski, P., & Restifo, N. P. (2013) · Blood · doi:10.1182/blood-2012-09-378653 · Cited by 383

Stat3 regulates genes common to both wound healing and cancer

Dauer, D. J., Ferraro, B., Song, L., Yu, B., Mora, L., Buettner, R., Enkemann, S., Jove, R., & Haura, E. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208469 · Cited by 380

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

Street, S. E. A., Trapani, J. A., MacGregor, D., & Smyth, M. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020063 · Cited by 375

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

Awasthi, A., Riol-Blanco, L., Jäger, A., Korn, T., Pot, C., Galileos, G., Bettelli, E., Kuchroo, V. K., & Oukka, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900732 · Cited by 364

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

Papp, K. A., Langley, R. G., Sigurgeirsson, B., Abe, M., Baker, D. R., Konno, P., Haemmerle, S., Thurston, H. J., Papavassilis, C., & Richards, H. B. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12110 · Cited by 360

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

McInnes, I. B., Sieper, J., Braun, J., Emery, P., van der Heijde, D., Isaacs, J. D., Dahmen, G., Wollenhaupt, J., Schulze-Koops, H., Kogan, J., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202646 · Cited by 343

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

Bradfield, J. P., Qu, H.-Q., Wang, K., Zhang, H., Sleiman, P. M., Kim, C. E., Mentch, F. D., Qiu, H., Glessner, J. T., Thomas, K. A., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002293 · Cited by 341

Psoriasis

Di Meglio, P., Villanova, F., & Nestle, F. O. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015354 · Cited by 317

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

Kugathasan, S., Baldassano, R. N., Bradfield, J. P., Sleiman, P. M. A., Imielinski, M., Guthery, S. L., Cucchiara, S., Kim, C. E., Frackelton, E. C., Annaiah, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.203 · Cited by 316

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

Puel, A., Cypowyj, S., Maródi, L., Abel, L., Picard, C., & Casanova, J.-L. (2012) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0b013e328358cc0b · Cited by 315

Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present

Cooper, A. M., Kipnis, A., Turner, J., Magram, J., Ferrante, J., & Orme, I. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1322 · Cited by 304

An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis

Boisson, B., Wang, C., Pedergnana, V., Wu, L., Cypowyj, S., Rybojad, M., Belkadi, A., Picard, C., Abel, L., Fieschi, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.002 · Cited by 293

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

Filipe-Santos, O., Bustamante, J., Haverkamp, M. H., Vinolo, E., Ku, C.-L., Puel, A., Frucht, D. M., Christel, K., von Bernuth, H., Jouanguy, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060085 · Cited by 282

The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

Di Meglio, P., Di Cesare, A., Laggner, U., Chu, C.-C., Napolitano, L., Villanova, F., Tosi, I., Capon, F., Trembath, R. C., Peris, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017160 · Cited by 262

Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)

Poddubnyy, D., Hermann, K.-G. A., Callhoff, J., Listing, J., & Sieper, J. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204248 · Cited by 260

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

Rich, P., Sigurgeirsson, B., Thaçi, D., Ortonne, J. ‐., Paul, C. F., Schopf, R. E., Morita, A., Roseau, K., Harfst, E., Guettner, A., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12112 · Cited by 244

The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases

Al-Muhsen, S., & Casanova, J.-L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.037 · Cited by 242

IL-17 and IL-22: siblings, not twins

Eyerich, S., Eyerich, K., Cavani, A., & Schmidt-Weber, C. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.004 · Cited by 236

Deciphering the role of Th17 cells in human disease

Wilke, C. M., Bishop, K., Fox, D. A., & Zou, W. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.08.003 · Cited by 234

A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection

Hölscher, C., Atkinson, R. A., Arendse, B., Brown, N., Myburgh, E., Alber, G., & Brombacher, F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6957 · Cited by 229

Regulation of interleukin‐12/interleukin‐23 production and the T‐helper 17 response in humans

Lyakh, L., Trinchieri, G., Provezza, L., Carra, G., & Gerosa, F. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00700.x · Cited by 227

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

Tonel, G., Conrad, C., Laggner, U., Di Meglio, P., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J.-Z., Xin, H., Oldham, E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001538 · Cited by 224

Tuberculosis in children and adults

Alcaïs, A., Fieschi, C., Abel, L., & Casanova, J.-L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20052302 · Cited by 223

IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46

Eisenring, M., vom Berg, J., Kristiansen, G., Saller, E., & Becher, B. (2010) · Nature Immunology · doi:10.1038/ni.1947 · Cited by 221

IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans

Kagami, S., Rizzo, H. L., Kurtz, S. E., Miller, L. S., & Blauvelt, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001153 · Cited by 216

Long‐term efficacy of ustekinumab in patients with moderate‐to‐severe psoriasis treated for up to 5 years in the PHOENIX 1 study

Kimball, A. B., Papp, K. A., Wasfi, Y., Chan, D., Bissonnette, R., Sofen, H., Yeilding, N., Li, S., Szapary, P., Gordon, K. B., et al. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12046 · Cited by 213

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

Raelson, J. V., Little, R. D., Ruether, A., Fournier, H., Paquin, B., Van Eerdewegh, P., Bradley, W. E. C., Croteau, P., Nguyen-Huu, Q., Segal, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706645104 · Cited by 213

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

vom Berg, J., Vrohlings, M., Haller, S., Haimovici, A., Kulig, P., Sledzinska, A., Weller, M., & Becher, B. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130678 · Cited by 213

A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

Genovese, M. C., Greenwald, M., Cho, C., Berman, A., Jin, L., Cameron, G. S., Benichou, O., Xie, L., Braun, D., Berclaz, P., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38617 · Cited by 211

Interleukin (IL)–12 and IL‐23 Are Key Cytokines for Immunity against Salmonella in Humans

MacLennan, C. A., Fieschi, C., Lammas, D. A., Pïcard, C., Dorman, S. E., Sanal, Ö., MacLennan, J. M., Holland, S. M., Ottenhoff, T. H. M., Casanova, J., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/425021 · Cited by 202

IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

Khader, S. A., Guglani, L., Rangel‐Moreno, J., Gopal, R., Junecko, B. A. F., Fountain, J. J., Martino, C. A., Pearl, J. E., Tighe, M. P., Lin, Y., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101377 · Cited by 201

Human genetics of tuberculosis: a long and winding road

Abel, L., Baghdadi, J. E., Bousfiha, A. A., Casanova, J., & Schurr, E. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0428 · Cited by 201

A 52-Week Trial Comparing Briakinumab with Methotrexate in Patients with Psoriasis

Reich, K., Langley, R. G. B., Papp, K. A., Ortonne, J. P., Unnebrink, K., Kaul, M., & Valdes, J. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1010858 · Cited by 198

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

and the IBSEN study group, Franke, A., Balschun, T., Sina, C., Ellinghaus, D., Häsler, R., Mayr, G., Albrecht, M., Wittig, M., Buchert, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.553 · Cited by 194

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

Sarin, R., Wu, X., & Abraham, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017854108 · Cited by 194

Th17 cells in cancer: help or hindrance?

Wilke, C. M., Kryczek, I., Wei, S., Zhao, E., Wu, K., Wang, G., & Zou, W. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr019 · Cited by 193

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study

Rich, P., Sigurgeirsson, B., Thaci, D. P., Ortonne, J.-P., Paul, C., Schopf, R. E., Morita, A., Roseau, K., Harfst, E., Guettner, A., et al. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12070 · Cited by 189

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

Yang, S.-K., Hong, M., Zhao, W., Jung, Y., Baek, J., Tayebi, N., Kim, K. M., Ye, B. D., Kim, K.-J., Park, S. H., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305193 · Cited by 184

Prostaglandin E2 induces IL‐23 production in bone marrow‐derived dendritic cells

Sheibanie, A. F., Tadmori, I., Jing, H., Vassiliou, E., & Ganea, D. (2004) · The FASEB Journal · doi:10.1096/fj.03-1367fje · Cited by 171

Inherited IL-12p40 Deficiency

Prando, C., Samarina, A., Bustamante, J. C., Boisson‐Dupuis, S., Cobat, A., Pïcard, C., Alsum, Z., Aljumaah, S., Al-Hajjar, S. H., Frayha, H. H., et al. (2013) · Medicine · doi:10.1097/md.0b013e31828a01f9 · Cited by 170

Interleukin‐12 Receptor β1 Deficiency in a Patient with Abdominal Tuberculosis

Altare, F., Ensser, A., Breiman, A., Reichenbach, J., Baghdadi, J. E., Fischer, A., Emile, J., Gaillard, J., Meinl, E., & Casanova, J. (2001) · The Journal of Infectious Diseases · doi:10.1086/321999 · Cited by 170

A Phase III, Randomized, Controlled Trial of the Fully Human IL-12/23 mAb Briakinumab in Moderate-to-Severe Psoriasis

Gordon, K. B., Langley, R. G., Gottlieb, A. B., Papp, K. A., Krueger, G. G., Strober, B. E., Williams, D. A., Gu, Y., & Valdes, J. M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.304 · Cited by 168

Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model

Nakajima, K., Kanda, T., Takaishi, M., Shiga, T., Miyoshi, K., Nakajima, H., Kamijima, R., Tarutani, M., Benson, J., Elloso, M. M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000148 · Cited by 167

IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis

Blumberg, H., Dinh, H., Dean, C., Trueblood, E. S., Bailey, K. L., Shows, D. M., Bhagavathula, N., Aslam, M. N., Varani, J., Towne, J. E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000313 · Cited by 163

Interleukin-23 Orchestrates Mucosal Responses to Salmonella enterica Serotype Typhimurium in the Intestine

Godinez, I., Raffatellu, M., Chu, H., Paixão, T. A., Haneda, T., Santos, R. L., Bevins, C. L., Tsolis, R. M., & Bäumler, A. J. (2009) · Infection and Immunity · doi:10.1128/iai.00933-08 · Cited by 163

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Kenny, E. E., Pe’er, I., Karban, A. A., Ozelius, L. J., Mitchell, A. A., Ng, S. M. E., Erazo, M., D, H. O. M., Abraham, C., Abreu, M. T., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002559 · Cited by 163

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

Teng, M. W. L., Andrews, D. M., McLaughlin, N. M., von Scheidt, B., Ngiow, S. F., Möller, A., Hill, G. R., Iwakura, Y., Oft, M., & Smyth, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003251107 · Cited by 161

Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients

He, S., Fei, M., Wu, Y., Zheng, D., Wan, D., Wang, L., & Li, D. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12117424 · Cited by 152

Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis

Strober, B. E., Crowley, J., Yamauchi, P. S., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10419.x · Cited by 146

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

Chan, I. H., JAIN, R. K., Tessmer, M. S., Gorman, D., Mangadu, R., Sathe, M., Vives, F., Moon, C., Penaflor, E., Turner, S. P., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.101 · Cited by 145

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

Filer, C., Ho, P., Smith, R., Griffiths, C. E. M., Young, H. S., Worthington, J., Bruce, I. N., & Barton, A. C. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24128 · Cited by 142

1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data

Huang, J., Ellinghaus, D., Franke, A., Howie, B., & Li, Y. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.3 · Cited by 134

IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity

Kopp, T., Lenz, P., Bello-Fernández, C., Kastelein, R. A., Kupper, T. S., & Stingl, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5438 · Cited by 133

IL-12Rβ1 Deficiency in Two of Fifty Children with Severe Tuberculosis from Iran, Morocco, and Turkey

Boisson‐Dupuis, S., Baghdadi, J. E., Parvaneh, N., Bousfiha, A. A., Bustamante, J. C., Feinberg, J. M., Samarina, A., Grant, A. V., Jannière, L., Hafidi, N. E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018524 · Cited by 131

Opposing Roles for IL-23 and IL-12 in Maintaining Occult Cancer in an Equilibrium State

Teng, M. W. L., Vesely, M. D., Duret, H., McLaughlin, N. M., Towne, J. E., Schreiber, R. D., & Smyth, M. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1337 · Cited by 128

Role of Neutrophils in IL-17–Dependent Immunity to Mucosal Candidiasis

Huppler, A. R., Conti, H. R., Hernández‐Santos, N., Darville, T. L., Biswas, P. S., & Gaffen, S. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302265 · Cited by 128

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Pidasheva, S., Trifari, S., Phillips, A., Hackney, J. A., Ma, Y., Smith, A., Sohn, S. J., Spits, H., Little, R. D., Behrens, T. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025038 · Cited by 123

Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis

Hüffmeier, U., Lascorz, J., Böhm, B. B., Lohmann, J., Wendler, J., Mößner, R., Reich, K., Traupe, H., Kurrat, W., Burkhardt, H., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.233 · Cited by 122

Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Schulz, S. M., Köhler, G., Schütze, N., Knauer, J., Straubinger, R. K., Chackerian, A. A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7891 · Cited by 118

A balance of interleukin-12 and -23 in cancer

Ngiow, S. F., Teng, M. W. L., & Smyth, M. J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.07.004 · Cited by 117

Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy

Airoldi, I. (2005) · Blood · doi:10.1182/blood-2005-05-2034 · Cited by 117

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

Martin, D. A., Churchill, M. A., Flores-Suárez, L. F., Cardiel, M. H., Wallace, D. J., Martin, R. W., Phillips, K., Kaine, J., Dong, H., Salinger, D. H., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4347 · Cited by 111

The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway

Yano, J., Kolls, J. K., Happel, K. I., Wormley, F. L., Wozniak, K. L., & Fidel, P. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046311 · Cited by 105

Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor β1 Deficiency

Ouederni, M., Sanal, Ö., İkincioğulları, A., Tezcan, İ., Doğu, F., Sologuren, I., Pedraza‐Sánchez, S., Emiroğlu, M., Tanır, G., Nieuwhof, C. M. G., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit722 · Cited by 103

Interleukin 23 Promotes Hepatocellular Carcinoma Metastasis via NF-Kappa B Induced Matrix Metalloproteinase 9 Expression

Li, J., Lau, G. K. K., Chen, L., Yuan, Y., Huang, J. C., Luk, J. M., Xie, D., & Guan, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046264 · Cited by 90

Mo2083 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease

Targan, S. R., Feagan, B. G., Vermeire, S., Panaccione, R., MELMED, G. Y., Blosch, C. M., Newmark, R., Zhang, N., Chon, Y., Lin, S., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.084 · Cited by 88

Distinct roles for interleukin‐12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene‐targeting

Farah, C. S., Hu, Y., Riminton, S., & Ashman, R. B. (2006) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2006.00288.x · Cited by 79

Immunology Taught by Human GeneticsPreprint

Casanova, J., Abel, L., & Quintana‐Murci, L. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.019968 · Cited by 77

Safety results from a pooled analysis of randomized, controlled phase II and III clinical trials and interim data from an open‐label extension trial of the interleukin‐12/23 monoclonal antibody, briakinumab, in moderate to severe psoriasis

Langley, R. G. B., Papp, K. A., Gottlieb, A. B., Krueger, G. G., Gordon, K. B., Williams, D., Valdes, J. M., Setze, C. M., & Strober, B. E. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04705.x · Cited by 70

Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?

Chiricozzi, A., Saraceno, R., Chimenti, M. S., Guttman‐Yassky, E., & Krueger, J. G. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.889686 · Cited by 67

A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis

Vollmer, T. L., Wynn, D. R., Alam, M. S., & Valdes, J. M. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510384496 · Cited by 65

The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients

Meglio, P. D., Villanova, F., Napolitano, L., Tosi, I., Barberio, M. T., Mak, R. K. H., Nutland, S. L., Smith, C. H., Barker, J. N. W. N., Todd, J. A., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.170 · Cited by 61

IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway

Zhang, L., Li, J., Li, L., Zhang, J., Wang, X., Yang, C., Li, Y., Lan, F., & Lin, P. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu017 · Cited by 59

Lethal Tuberculosis in a Previously Healthy Adult with IL-12 Receptor Deficiency

Tabarsi, P., Marjani, M., Mansouri, N., Farnia, P., Boisson‐Dupuis, S., Bustamante, J. C., Abel, L., Naghan, P. A., Casanova, J., & Mansouri, D. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9523-9 · Cited by 55

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease

Cayatte, C., Joyce-Shaikh, B., Vega, F., Boniface, K., Grein, J., Murphy, E., Blumenschein, W. M., Chen, S., Malinao, M.-C., Basham, B., et al. (2012) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2012.2 · Cited by 55

The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer

Alizadeh, D., Katsanis, E., & Larmonier, N. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/957878 · Cited by 55

Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor

Li, J., Zhang, L., Zhang, J., Wei, Y., Li, K., Huang, L., Zhang, S., Gao, B., Wang, X., & Lin, P. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs384 · Cited by 54

Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases

Teng, M. W. L., von Scheidt, B., Duret, H., Towne, J. E., & Smyth, M. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3994 · Cited by 54

Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation

Carvalho, A., Cunha, C., Ianni, M. D., Pitzurra, L., Aloisi, T., Falzetti, F., Carotti, A., Bistoni, F., Aversa, F., & Romani, L. R. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2010.28 · Cited by 51

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300

Julià, A., Domènech, E., Ricart, E., Tortosa, R., García-Sánchez, V., Gisbert, J. P., Mateu, P. N., Gutiérrez, A., Gomollón, F., Mendoza, J. L., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302865 · Cited by 46

Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis

Zhu, K., Zhu, C., Shi, G., & Fan, Y. (2012) · Inflammation Research · doi:10.1007/s00011-012-0509-8 · Cited by 44

Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases

von Scheidt, B., Leung, P. S. K., Yong, M. C. R., Zhang, Y. X., Towne, J. E., Smyth, M. J., & Teng, M. W. L. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1646 · Cited by 43

Clinical significance of circulating interleukin‐23 as a prognostic factor in breast cancer patients

Gangemi, S., Minciullo, P. L., Adamo, B., Franchina, T., Ricciardi, G. R. R., Ferraro, M., Briguglio, R., Toscano, G., Saitta, S., & Adamo, V. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24083 · Cited by 42

Elevated Serum Level of IL-23 Correlates with Expression of VEGF in Human Colorectal Carcinoma

Ljujić, B., Radosavljevic, G. D., Jovanović, I., Pavlovic, S. M., Zdravkovic, N. S., Milovanović, M., Aćimović, L., Knežević, M., Banković, D., Zdravkovic, D., et al. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.02.009 · Cited by 42

Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway

Chen, D., Li, W., Liu, S., Su, Y., Han, G., Xu, C., Liu, H., Zheng, T., Zhou, Y., & Mao, C. (2015) · Scientific Reports · doi:10.1038/srep08604 · Cited by 39

Does IL-17 suppress tumor growth?

Ngiow, S. F., Smyth, M. J., & Teng, M. W. L. (2010) · Blood · doi:10.1182/blood-2009-11-254607 · Cited by 34

Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation

Wermke, M., Maiwald, S., Schmelz, R., Thiede, C., Schetelig, J., Ehninger, G., Bornhäuser, M., & Waßmuth, R. (2010) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2010.06.001 · Cited by 23

Gamma Interferon-Independent Effects of Interleukin-12 on Immunity toSalmonella entericaSerovar Typhimurium

Price, J. D., Simpfendorfer, K. R., Mantena, R. K. R., Holden, J. A., Heath, W. R., van Rooijen, N., Strugnell, R. A., & Wijburg, O. L. C. (2007) · Infection and Immunity · doi:10.1128/iai.00971-07 · Cited by 21

Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23

Awoniyi, M., Miller, S. I., Wilson, C. B., Hajjar, A. M., & Smith, K. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037311 · Cited by 19

Expression of interleukin-23 and its receptors in human squamous cell carcinoma of the oral cavity

Fukuda (2009) · Molecular Medicine Reports · doi:10.3892/mmr_00000223 · Cited by 11

Activation and effector functions of human RORC+ innate lymphoid cells

Cornelissen, F., Aparicio‐Domingo, P., Reijmers, R. M., & Cupedo, T. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.03.002 · Cited by 10

Interpreting noncoding genetic variation in complex traits and human disease

Ward, L. D., & Kellis, M. (2012) · Nature Biotechnology · doi:10.1038/nbt.2422 · Cited by 6

Targeting the IL-12/IL-23 axis

Smyth, M. J., & Teng, M. W. L. (2014) · OncoImmunology · doi:10.4161/onci.28964 · Cited by 6

IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer

Baird, A., Leonard, J. M., Naicker, K. M., Kilmartin, L., O'Byrne, K. J., & Gray, S. G. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.10.003

NF-κB signaling in inflammation

Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791

Mechanisms of Disease: Inflammatory Bowel Diseases

Ramos, G. P., & Papadakis, K. A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.09.013 · Cited by 1,021

Combination cancer immunotherapies tailored to the tumour microenvironment

Smyth, M. J., Ngiow, S. F., Ribas, A., & Teng, M. W. L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.209 · Cited by 944

Kinase inhibition in autoimmunity and inflammation

Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431

Moving towards personalized treatments of immune-related adverse events

Esfahani, K., Elkrief, A., Calabrese, C., Lapointe, R., Hudson, M., Routy, B., Miller, W. H., & Calabrese, L. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0352-8 · Cited by 351