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PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2
Open accessAbstract
Postsynaptic density protein 95 (PSD-95) is essential for synaptic maturation and plasticity. Although its synaptic regulation has been widely studied, the control of PSD-95 cellular expression is not understood. We found that Psd-95 was controlled post-transcriptionally during neural development. Psd-95 was transcribed early in mouse embryonic brain, but most of its product transcripts were degraded. The polypyrimidine tract binding proteins PTBP1 and PTBP2 repressed Psd-95 (also known as Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay. The loss of first PTBP1 and then of PTBP2 during embryonic development allowed splicing of exon 18 and expression of PSD-95 late in neuronal maturation. Re-expression of PTBP1 or PTBP2 in differentiated neurons inhibited PSD-95 expression and impaired the development of glutamatergic synapses. Thus, expression of PSD-95 during early neural development is controlled at the RNA level by two PTB proteins whose sequential downregulation is necessary for synapse maturation.
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“The highest enrichment was observed in the developing brain, germinal matrix, cortex-derived neurospheres, and embryonic stem cell (ESC)-derived neurons, consistent with ASD as a neurodevelopmental disorder with largely prenatal origins, as supported by data from analysis of rare de novo variants 76 .”
From Identification of common genetic risk variants for autism spectrum disorder (2019) · cites this paper as [76]
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“Interestingly, both common and rare variation in ASD preferentially affects genes expressed during corticogenesis 76 , highlighting a potential spatiotemporal convergence of genetic risk on this specific developmental epoch, despite the disorder's profound genetic heterogeneity.”
From Identification of common genetic risk variants for autism spectrum disorder (2019) · cites this paper as [76]
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“Overexpression of either PTBP1 or PTBP2 in mature neurons inhibits exon 18 inclusion, PSD95 protein expression and excitatory synapse formation67.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [67]
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“Thus the high expression of PTBP2 during early development extends the expression of the embryonic splicing programme until late in neuronal maturation.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [67]
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Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
The Nonsense-Mediated Decay RNA Surveillance Pathway
Chang, Y.-F., Imam, J. S., & Wilkinson, M. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.050106.093909 · Cited by 1,326
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160
Self-citationStargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003
Woods, D. F., & Bryant, P. J. (1991) · Cell · doi:10.1016/0092-8674(81)90009-x · Cited by 898
Mendell, J. T., Sharifi, N., Meyers, J. L., Martínez-Murillo, F., & Dietz, H. C. (2004) · Nature Genetics · doi:10.1038/ng1429 · Cited by 880
Qin, F. X.-F., An, D. S., Chen, I. S. Y., & Baltimore, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232688199 · Cited by 701
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
Lareau, L. F., Inada, M., Green, R. E., Wengrod, J., & Brenner, S. E. (2007) · Nature · doi:10.1038/nature05676 · Cited by 685
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Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, Grove, J., BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23andMe Research Team, Ripke, S., Als, T. D., Mattheisen, M., Walters, R. K., Won, H., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0344-8 · Cited by 2,421
Context-dependent control of alternative splicing by RNA-binding proteins
Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044
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Vaquero-Garcia, J., Barrera, A., Gazzara, M. R., González-Vallinas, J., Lahens, N. F., Hogenesch, J. B., Lynch, K. W., & Barash, Y. (2016) · eLife · doi:10.7554/elife.11752 · Cited by 488
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562
Raj, B., & Blencowe, B. J. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.004 · Cited by 475
Lin, N., Chang, K., Li, Z., Gates, K. P., Rana, Z. A., Dang, J. W., Zhang, D., Han, T., Yang, C., Cunningham, T. J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.021 · Cited by 405
Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)
Huang, J., Zhou, N., Watabe, K., Zhao, L., Wu, F., Xu, M., & Mo, Y.-Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.541 · Cited by 382
Ramos, A. D., Andersen, R. E., Liu, S. J., Nowakowski, T. J., Hong, S. J., Gertz, C. C., Salinas, R. D., Zarabi, H., Kriegstein, A. R., & Lim, D. A. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.02.007 · Cited by 359
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Vuong, C. K., Black, D. L., & Zheng, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.27 · Cited by 340
Self-citationYap, K., Lim, Z. Q., Khandelia, P., Friedman, B., & Makeyev, E. V. (2012) · Genes & Development · doi:10.1101/gad.188037.112 · Cited by 286
Loera-Valencia, R., Goikolea, J., Parrado-Fernandez, C., Merino-Serrais, P., & Maioli, S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.003 · Cited by 214
The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function
Gehman, L. T., Meera, P., Stoilov, P., Shiue, L., O'Brien, J. E., Meisler, M. H., Ares, M., Otis, T. S., & Black, D. L. (2012) · Genes & Development · doi:10.1101/gad.182477.111 · Cited by 213
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Colak, D., Ji, S., Porse, B. T., & Jaffrey, S. R. (2013) · Cell · doi:10.1016/j.cell.2013.04.056 · Cited by 214
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The changing paradigm of intron retention: regulation, ramifications and recipes
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Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
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Hanse, E., Seth, H., & Riebe, I. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3642 · Cited by 184
Li, Q., Zheng, S., Han, A., Lin, C.-H., Stoilov, P., Fu, X.-D., & Black, D. L. (2014) · eLife · doi:10.7554/elife.01201 · Cited by 174
Self-citationYap, K., Mukhina, S., Zhang, G., Tan, J. S. C., Ong, H. S., & Makeyev, E. V. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.041 · Cited by 162
Linares, A. J., Lin, C.-H., Damianov, A., Adams, K. L., Novitch, B. G., & Black, D. L. (2015) · eLife · doi:10.7554/elife.09268 · Cited by 159
Self-citationNonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease
Jaffrey, S. R., & Wilkinson, M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0079-z · Cited by 147
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Zhu, W., Zhou, B., Rong, L., Li, Y., Xu, H., Zhou, Y., Yan, X., Liu, W., Zhu, B., Wang, L., et al. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900422 · Cited by 160
Jolly, L. A., Homan, C. C., Jacob, R. P., Barry, S. C., & Gécz, J. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt315 · Cited by 148
PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing
Vuong, J. K., Lin, C.-H., Zhang, M., Chen, L., Black, D. L., & Zheng, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.034 · Cited by 143
Self-citationIntrons in UTRs: why we should stop ignoring them
Bicknell, A. A., Cenik, C., Chua, H. N., Roth, F. P., & Moore, M. J. (2012) · BioEssays · doi:10.1002/bies.201200073 · Cited by 133
Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system
Hsia, H., Tüshaus, J., Brummer, T., Zheng, Y., Scilabra, S. D., & Lichtenthaler, S. F. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03173-7 · Cited by 148
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Raj, B., Irimia, M., Braunschweig, U., Sterne-Weiler, T., O’Hanlon, D., Lin, Z.-Y., Chen, G. I., Easton, L. E., Ule, J., Gingras, A.-C., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.011 · Cited by 132
“, 2009), which is thought to contribute to neural exon inclusion (Makeyev et al., 2007; Zheng et al., 2012), Ptbp2 expression is not sufficient for the activation of nSR100 target exons.”
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Xue, Y., Qian, H., Hu, J., Zhou, B., Zhou, Y., Hu, X., Karakhanyan, A., Pang, Z., & Fu, X.-D. (2016) · Nature Neuroscience · doi:10.1038/nn.4297 · Cited by 118
Alternative pre-mRNA splicing in neurons: growing up and extending its reach
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Risher, M., Fleming, R. L., Risher, W. C., Miller, K. M., Klein, R. C., Wills, T., Acheson, S. K., Moore, S. D., Wilson, W. A., Eroglu, C., et al. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12725 · Cited by 104
Blechman, J., & Levkowitz, G. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00055 · Cited by 105
Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function
Norris, A. D., & Calarco, J. A. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00122 · Cited by 100
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Vallejo, D., Codocedo, J. F., & Inestrosa, N. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9745-1 · Cited by 97
Ifrim, M. F., Williams, K. R., & Bassell, G. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2802-14.2015 · Cited by 97
Common risk variants identified in autism spectrum disorder
Grove, J., Ripke, S., Als, T. D., Mattheisen, M., Walters, R., Won, H., Pallesen, J., Agerbo, E., Andreassen, O. A., Anney, R., et al. (2017) · doi:10.1101/224774 · Cited by 89
Chao, H.-W., Tsai, L.-Y., Lu, Y.-L., Lin, P.-Y., Huang, W.-H., Chou, H.-J., Lu, W.-H., Lin, H.-C., Lee, P.-T., & Huang, Y.-S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3043-13.2013 · Cited by 80
Zhang, M., Ergin, V., Lin, L., Stork, C., Chen, L., & Zheng, S. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.022 · Cited by 92
Self-citationPTB/nPTB: master regulators of neuronal fate in mammals
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Han, A., Stoilov, P., Linares, A. J., Zhou, Y., Fu, X., & Black, D. L. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003442 · Cited by 84
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Self-citationDukhinova, M., Kuznetsova, I. S., Kopeikina, E., Veniaminova, E. A., Yung, A. W. Y., Veremeyko, T., Levchuk, K., Barteneva, N. S., Wing-Ho, K. K., Yung, W., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.009 · Cited by 63
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Aygün, N., Elwell, A. L., Liang, D., Lafferty, M. J., Cheek, K. E., Courtney, K. P., Mory, J. T., Hadden-Ford, E., Krupa, O., de la Torre-Ubieta, L., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.07.011 · Cited by 57
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Grassi, E., Santoro, R., Umbach, A., Grosso, A., Oliviero, S., Neri, F., Conti, L., Ala, U., Provero, P., Cunto, F. D., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00518 · Cited by 56
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Self-citationYeom, K., Mitchell, S. A., Linares, A. J., Zheng, S., Lin, C.-H., Wang, X., Hoffmann, A., & Black, D. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809609115 · Cited by 49
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Potter, K. M., Holden, K. R., Cathey, S. S., Dwivedi, A., DuPont, B. R., & Lyons, M. J. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36708 · Cited by 45
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Metadata
- Authors
- Zheng, S., Gray, E. E., Chawla, G., Porse, B. T., O'Dell, T. J., & Black, D. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, Los Angeles (US)
- University of Copenhagen (DK)
- Corresponding author
- Black, Douglas L
- Venue
- Nature Neuroscience
- Published
- 2012-01-15
- Volume
- 15
- Issue
- 3
- Pages
- 381-388
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3288398
- OpenAlex
- W2026441189
- Cited by
- 254
- References
- 50
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 29 · 2023: 18 · 2022: 14 · 2021: 21 · 2020: 15 · 2019: 14 · 2018: 21 · 2017: 14 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 20 · 2012: 5
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Lundbeckfonden (R5-2006-99)
- National Institute of Mental Health (F32 MH84562, R01MH060919, F31MH085462)
- National Institute of General Medical Sciences (R01GM049662)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- PSD-95, PTBP1, PTBP2, polypyrimidine tract-binding protein, alternative splicing, nonsense-mediated mRNA decay, post-transcriptional regulation, synapse maturation, glutamatergic synapses, neuronal maturation, embryonic brain development
- MeSH terms
- Disks Large Homolog 4 Protein, Empty Spiracles Homeobox Proteins, Age Factors, Animals, Carrier Proteins, Cell Differentiation, Cells, Cultured, Cerebral Cortex, Dendrites, Electric Stimulation, Embryo, Mammalian, Exons, Hippocampus, Membrane Proteins, Mice, Transgenic, Neuroblastoma, Neurons, RNA Splicing, RNA, Messenger, Transcription Factors, Transfection, RNA-Binding Proteins, Homeodomain Proteins, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Excitatory Postsynaptic Potentials, Electrophoretic Mobility Shift Assay, RNA, Small Interfering, Polypyrimidine Tract-Binding Protein, Green Fluorescent Proteins, Mice, Guanylate Kinases, Neurogenesis, Neural Stem Cells, RNA Isoforms
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