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Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

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Mendelian Randomization: Concepts and Scope

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Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

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Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization

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Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

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Genetic drug target validation using Mendelian randomisation

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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

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Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

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Using Mendelian Randomization to Improve the Design of Randomized Trials

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The use of two-sample methods for Mendelian randomization analyses on single large datasets

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Deconstructing the sources of genotype-phenotype associations in humans

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Quantifying genetic effects on disease mediated by assayed gene expression levels

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Mendel’s laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues

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Type 2 Diabetes and Hypertension: A Study on Bidirectional Causality

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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

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Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits

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Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms

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Causal inference with observational data: the need for triangulation of evidence

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Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?

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Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

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Locus for severity implicates CNS resilience in progression of multiple sclerosis

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An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

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Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

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The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

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DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits

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Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis

Rosoff, D. B., Smith, G. D., & Lohoff, F. W. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.3554 · Cited by 186 · see citing works

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Hill, W. D., Davies, N. M., Ritchie, S. J., Skene, N., Bryois, J., Bell, S., Angelantonio, E. D., Roberts, D. J., Shen, X., Davies, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13585-5 · Cited by 178 · see citing works

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates

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A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity

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Understanding the assumptions underlying Mendelian randomization

de Leeuw, C., Savage, J. E., Bucur, I. G., Heskes, T., & Posthuma, D. (2022) · European Journal of Human Genetics · doi:10.1038/s41431-022-01038-5 · Cited by 169 · see citing works

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

Taylor, D. L., Jackson, A., Narisu, N., Hemani, G., Erdos, M. R., Chines, P. S., Swift, A. J., Idol, J., Didion, J. P., Welch, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814263116 · Cited by 167 · see citing works

Within family Mendelian randomization studies

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Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N. R., Vaez, A., Agbessi, M. D. T., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., et al. (2021) · Nature Human Behaviour · doi:10.1038/s41562-021-01135-3 · Cited by 158 · see citing works

Causal associations between modifiable risk factors and the Alzheimer's phenome

Andrews, S. J., Fulton‐Howard, B., O'Reilly, P., Marcora, E., Goate, A. M., & collaborators of the Alzheimer's Disease Genetics Consortium (2021) · Annals of Neurology · doi:10.1002/ana.25918 · Cited by 156 · see citing works

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study

Anderson, E. L., Howe, L. D., Wade, K. H., Ben‐Shlomo, Y., Hill, W. D., Deary, I. J., Sanderson, E. C. M., Zheng, J., Korologou‐Linden, R., Stergiakouli, E., et al. (2020) · International Journal of Epidemiology · doi:10.1093/ije/dyz280 · Cited by 148 · see citing works

Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression

Yao, S., Zhang, M., Dong, S., Wang, J.-H., Zhang, K., Guo, J., Guo, Y., & Yang, T. (2022) · Nature Human Behaviour · doi:10.1038/s41562-022-01412-9 · Cited by 143 · see citing works

A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure

Yu, Z., Coresh, J., Qi, G., Grams, M., Boerwinkle, E., Snieder, H., Teumer, A., Pattaro, C., Köttgen, A., Chatterjee, N., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.04.044 · Cited by 135 · see citing works

Educational attainment, structural brain reserve and Alzheimer’s disease: a Mendelian randomization analysis

Seyedsalehi, A., Warrier, V., Bethlehem, R. A. I., Perry, B. I., Burgess, S., & Murray, G. K. (2022) · Brain · doi:10.1093/brain/awac392 · Cited by 137 · see citing works

Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

Yuan, Z., Zhu, H., Zeng, P., Yang, S., Sun, S., Yang, C., Liu, J., & Zhou, X. (2020) · Nature Communications · doi:10.1038/s41467-020-17668-6 · Cited by 134 · see citing works

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Cho, Y., Haycock, P., Sanderson, E. C. M., Gaunt, T. R., Zheng, J., Morris, A. P., Smith, G. D., & Hemani, G. (2020) · Nature Communications · doi:10.1038/s41467-020-14452-4 · Cited by 134 · see citing works

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

Gormley, M., Dudding, T., Sanderson, E. C. M., Martin, R. M., Thomas, S. J., Tyrrell, J., Ness, A., Brennan, P., Munafo, M. R., Pring, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19822-6 · Cited by 133 · see citing works

Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure

Haas, M. E., Aragam, K. G., Emdin, C. A., Bick, A. G., Hemani, G., Smith, G. D., & Kathiresan, S. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.08.004 · Cited by 132 · see citing works

Debiased inverse-variance weighted estimator in two-sample summary-data Mendelian randomization

Ye, T., Shao, J., & Kang, H. (2021) · The Annals of Statistics · doi:10.1214/20-aos2027 · Cited by 131 · see citing works

Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

Hu, X., Zhao, J., Lin, Z., Wang, Y., Peng, H., Zhao, H., Wan, X., & Yang, C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106858119 · Cited by 128 · see citing works

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Kavousi, M., Bos, M. M., Barnes, H. J., Cardenas, C. L. L., Wong, D., Lu, H., Hodonsky, C. J., Landsmeer, L. P. L., Turner, A. W., Kho, M., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01518-4 · Cited by 123 · see citing works

Triangulating Evidence through the Inclusion of Genetically Informed Designs

Munafò, M. R., Higgins, J. P. T., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040659 · Cited by 125 · see citing works

Polygenic Mendelian RandomizationPreprint

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The use of negative control outcomes in Mendelian randomization to detect potential population stratification

Sanderson, E., Richardson, T. G., Hemani, G., & Davey Smith, G. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyaa288 · Cited by 115 · see citing works

C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study

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Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

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Coffee Consumption and Kidney Function: A Mendelian Randomization Study

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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study

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Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

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Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids

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Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci

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Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization

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Association Between Plasma Proteome and Childhood Neurodevelopmental Disorders: A Two-Sample Mendelian Randomization Analysis

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Evaluating the impact of metformin targets on the risk of osteoarthritis: a mendelian randomization study

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Testing the association between tobacco smoking, alcohol consumption, and risk of periodontitis: A Mendelian randomization study

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