Shaping the nuclear action of NF-κB

NF-κB regulation in the immune system

Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007

NF-κB: a key role in inflammatory diseases

Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638

DNA damage activates p53 through a phosphorylation–acetylation cascade

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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB

Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

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Regulation of activity of the transcription factor GATA-1 by acetylation

Boyes, J., Byfield, P., Nakatani, Y., & Ogryzko, V. (1998) · Nature · doi:10.1038/25166 · Cited by 694

Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism

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Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

Almawi, W., & Melemedjian, O. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0280069 · Cited by 242

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,494

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350

Crosstalk in NF-κB Signaling Pathways

Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942

Mechanisms of Cell Protection by Heme Oxygenase-1

Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241

CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

Su, S., Chen, J., Yao, H., Liu, J., Yu, S., Lao, L., Wang, M., Luo, M., Xing, Y., Chen, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.009 · Cited by 1,230

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1

Abe, T., & Barber, G. N. (2014) · Journal of Virology · doi:10.1128/jvi.00037-14 · Cited by 767

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762

S100A8 and S100A9 in inflammation and cancer

Gebhardt, C., Németh, J., Angel, P., & Hess, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.05.017 · Cited by 696

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation

Giridharan, S., & Srinivasan, M. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s140188 · Cited by 686

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

Lee, H., Herrmann, A., Deng, J.-H., Kujawski, M., Niu, G., Li, Z., Forman, S., Jove, R., Pardoll, D. M., & Yu, H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.015 · Cited by 683

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581

Good cop, bad cop: the different faces of NF-κB

Perkins, N. D., & Gilmore, T. D. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401838 · Cited by 489

NF-κB RelA Phosphorylation Regulates RelA Acetylation

Chen, L.-F., Williams, S. A., Mu, Y., Nakano, H., Duerr, J. M., Buckbinder, L., & Greene, W. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.7966-7975.2005 · Cited by 438

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

Albensi, B. C. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00154 · Cited by 341

Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes

Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K. (2007) · Endocrinology · doi:10.1210/en.2006-0687 · Cited by 334

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

Ros-Bernal, F., Hunot, S., Herrero, M. T., Parnadeau, S., Corvol, J.-C., Lu, L., Alvarez-Fischer, D., Carrillo-de Sauvage, M. A., Saurini, F., Coussieu, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017820108 · Cited by 231

The nuclear-envelope protein and transcriptional repressor LAP2β interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation

Somech, R., Shaklai, S., Geller, O., Amariglio, N., Simon, A. J., Rechavi, G., & Gal-Yam, E. N. (2005) · Journal of Cell Science · doi:10.1242/jcs.02521 · Cited by 223

The c‐myc Promoter: Still MysterY and Challenge

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Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease

Plant, P. J., Brooks, D., Faughnan, M., Bayley, T., Bain, J., Singer, L., Correa, J., Pearce, D., Binnie, M., & Batt, J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0382oc · Cited by 190

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.11.002 · Cited by 163

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00107-6 · Cited by 145

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

Silva, G., Jeney, V., Chora, Â., Larsen, R., Balla, J., & Soares, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045344 · Cited by 137

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9

Luo, K.-W., Chen, W., Lung, W.-Y., Wei, X.-Y., Cheng, B.-H., Cai, Z.-M., & Huang, W.-R. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.004 · Cited by 137

Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury

Oakley, F., Mann, J., Nailard, S., Smart, D. E., Mungalsingh, N., Constandinou, C., Ali, S., Wilson, S. J., Millward-Sadler, H., Iredale, J. P., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62291-2 · Cited by 123

The intracellular domain of CD44 promotes the fusion of macrophages

Cui, W. (2006) · Blood · doi:10.1182/blood-2005-05-1902 · Cited by 110

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04883-5 · Cited by 82

Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-κB System

Ökvist, A., Johansson, S., Kuzmin, A., Bazov, I., Merino-Martinez, R., Ponomarev, I., Mayfield, R. D., Harris, R. A., Sheedy, D., Garrick, T., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000930 · Cited by 84

Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior

Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78

Nuclear Factor κB-Dependent Histone Acetylation is Specifically Involved in Persistent Forms of Memory

Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., & Romano, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4181-12.2013 · Cited by 73

Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels

Fekete, C., Sarkar, S., Christoffolete, M. A., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.021 · Cited by 54

TRα Protects Against Atherosclerosis in Male Mice: Identification of a Novel Anti-Inflammatory Property for TRα in Mice

Billon, C., Canaple, L., Fleury, S., Deloire, A., Beylot, M., Dombrowicz, D., del Carmine, P., Samarut, J., & Gauthier, K. (2014) · Endocrinology · doi:10.1210/en.2014-1098 · Cited by 45

CRH inhibits NF-κB signaling in human melanocytes

Zbytek, B., Pfeffer, L. M., & Slominski, A. T. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.017 · Cited by 45

Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features

Weiss, R., Schilling, E., Grahnert, A., Kölling, V., Dorow, J., Ceglarek, U., Sack, U., & Hauschildt, S. (2015) · Innate Immunity · doi:10.1177/1753425915602545 · Cited by 41

UVB-Induced Activation of NF-κb Is Regulated by the IGF-1R and Dependent on P38 MAPK

Lewis, D. A., & Spandau, D. F. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701127 · Cited by 41

The EDA/EDAR/NF-κB pathway in non-syndromic tooth agenesis: A genetic perspective

Gao, Y., Jiang, X., Wei, Z., Long, H., & Lai, W. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1168538 · Cited by 33

NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression

Tanaka, T., Hozumi, Y., Iino, M., & Goto, K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.06.021 · Cited by 24

Functional investigations of p53 acetylation enabled by heterobifunctional molecules

Chen, L.-Y., Singha Roy, S. J., Jadhav, A. M., Wang, W. W., Chen, P.-H., Bishop, T., Erb, M. A., & Parker, C. G. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00438 · Cited by 18