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Modulation of innate immunity by Toxoplasma gondii virulence effectors

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Hunter, Christopher A., Sibley, L. David·2012·Nature Reviews Microbiology
DOI 10.1038/nrmicro2858
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Abstract

Toxoplasma gondii is a common parasite of animals and humans and can cause serious opportunistic infections. However, the majority of infections are asymptomatic, possibly because the organism has co-evolved with its many vertebrate hosts and has developed multiple strategies to persist asymptomatically for the lifetime of the host. Over the past two decades, infection studies in the mouse, combined with forward-genetics approaches aimed at unravelling the molecular basis of infection, have revealed that T. gondii virulence is mediated, in part, by secretion of effector proteins into the host cell during invasion. Here, we review recent advances that illustrate how these virulence factors disarm innate immunity and promote survival of the parasite.

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Cited by

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Metadata

Authors
Hunter, C. A., & Sibley, L. D.
Venue
Nature Reviews Microbiology
Publisher
Springer Science and Business Media LLC
Published
2012-10-16
Volume
10
Issue
11
Pages
766-778
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
DOI
10.1038/nrmicro2858
OpenAlex
W2031029755
Cited by
570
References
2
FWCI
3.75
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Modulation of innate immunity by Toxoplasma gondii virulence effectors. https://app.cochat.ai/papers/10.1038/nrmicro2858
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Hunter, C. A., & Sibley, L. D. (2012). Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro2858

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