Disease and the brain's dark energy

Control of goal-directed and stimulus-driven attention in the brain

Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881

A default mode of brain function

Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190

Complex brain networks: graph theoretical analysis of structural and functional systems

Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812

The Brain's Default Network: Anatomy, Function, and Relevance to Disease

Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761

Dissociable intrinsic connectivity networks for salience processing and executive control

Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700

Functional connectivity in the resting brain: a network analysis of the default mode hypothesis

Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358

Consistent resting-state networks across healthy subjects

Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326

Mapping the structural core of human cerebral cortex

Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173

The influence of head motion on intrinsic functional connectivity MRI

Van Dijk, K. R. A., Sabuncu, M. R., & Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.044 · Cited by 2,344

The role of the posterior cingulate cortex in cognition and disease

Leech, R., & Sharp, D. J. (2014) · Brain · doi:10.1093/brain/awt162 · Cited by 2,247

Prediction of individual brain maturity using fMRI

Dosenbach, N. U. F., Nardos, B., Cohen, A. L., Fair, D. A., Power, J. D., Church, J. A., Nelson, S. M., Wig, G. S., Vogel, A. C., Lessov-Schlaggar, C. N., et al. (2010) · Science · doi:10.1126/science.1194144 · Cited by 2,183

Large-scale cortical correlation structure of spontaneous oscillatory activity

Hipp, J. F., Hawellek, D. J., Corbetta, M., Siegel, M., & Engel, A. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3101 · Cited by 1,113

The brain's default network and its adaptive role in internal mentation

Andrews-Hanna, J. R. (2012) · The Neuroscientist · doi:10.1177/1073858411403316 · Cited by 1,114

Two views of brain function

Raichle, M. E. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.008 · Cited by 1,111

Opportunities and limitations of intrinsic functional connectivity MRI

Buckner, R. L., Krienen, F. M., & Yeo, B. T. T. (2013) · Nature Neuroscience · doi:10.1038/nn.3423 · Cited by 912

Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder

Zhang, J., Wang, J., Wu, Q., Kuang, W., Huang, X., He, Y., & Gong, Q. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.018 · Cited by 951

Large-scale brain systems in ADHD: beyond the prefrontal–striatal model

Castellanos, F. X., & Proal, E. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.007 · Cited by 831

The restless brain

Raichle, M. E. (2011) · Brain Connectivity · doi:10.1089/brain.2011.0019 · Cited by 672

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Fox, M. D., Buckner, R. L., Liu, H., Chakravarty, M. M., Lozano, A. M., & Pascual-Leone, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405003111 · Cited by 617

Graph-based network analysis of resting-state functional MRI

Wang, J. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00016 · Cited by 614

Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s disease progression

Brier, M. R., Thomas, J. B., Snyder, A. Z., Benzinger, T. L., Zhang, D., Raichle, M. E., Holtzman, D. M., Morris, J. C., & Ances, B. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5698-11.2012 · Cited by 595

Resting state functional connectivity in preclinical Alzheimer’s disease

Sheline, Y. I., & Raichle, M. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.028 · Cited by 509

Functional network disruption in the degenerative dementias

Pievani, M., de Haan, W., Wu, T., Seeley, W. W., & Frisoni, G. B. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70158-2 · Cited by 481

The restless brain: How intrinsic activity organizes brain function

Raichle, M. E. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0172 · Cited by 433

Graph theoretical analysis of functional brain networks: test-retest evaluation on short- and long-term resting-state functional MRI data

Wang, J.-H., Zuo, X.-N., Gohel, S., Milham, M. P., Biswal, B. B., & He, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021976 · Cited by 416

Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS)

Fox, M. D., Halko, M. A., Eldaief, M. C., & Pascual-Leone, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.035 · Cited by 395

Increased Functional Connectivity Between Subcortical and Cortical Resting-State Networks in Autism Spectrum Disorder

Cerliani, L., Mennes, M., Thomas, R. M., Di Martino, A., Thioux, M., & Keysers, C. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0101 · Cited by 339

Clinical applications of the functional connectome

Castellanos, F. X., Di Martino, A., Craddock, R. C., Mehta, A. D., & Milham, M. P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.083 · Cited by 312

Long-term effects of marijuana use on the brain

Filbey, F. M., Aslan, S., Calhoun, V. D., Spence, J. S., Damaraju, E., Caprihan, A., & Segall, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415297111 · Cited by 249

Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity

Zhang, Z., Liu, Y., Jiang, T., Zhou, B., An, N., Dai, H., Wang, P., Niu, Y., Wang, L., & Zhang, X. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.049 · Cited by 255

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease

Ossenkoppele, R., Cohn‐Sheehy, B. I., La Joie, R., Vogel, J. W., Möller, C., Lehmann, M., van Berckel, B. N. M., Seeley, W. W., Pijnenburg, Y. A., Gorno‐Tempini, M. L., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22927 · Cited by 243

Resting-state networks predict individual differences in common and specific aspects of executive function

Reineberg, A. E., Andrews-Hanna, J. R., Depue, B. E., Friedman, N. P., & Banich, M. T. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.045 · Cited by 206

Emotion-dependent functional connectivity of the default mode network in adolescent depression

Ho, T. C., Connolly, C. G., Henje Blom, E., LeWinn, K. Z., Strigo, I. A., Paulus, M. P., Frank, G., Max, J. E., Wu, J., Chan, M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.002 · Cited by 227

Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms

Hemington, K. S., Wu, Q., Kucyi, A., Inman, R. D., & Davis, K. D. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1161-1 · Cited by 220

Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study

Zhao, X., Liu, Y., Wang, X., Liu, B., Xi, Q., Guo, Q., Jiang, H., Jiang, T., & Wang, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033540 · Cited by 215

The brain's default network: origins and implications for the study of psychosis

Buckner, R. L. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.3/rbuckner · Cited by 196

Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum

Yang, L., Yan, Y., Wang, Y., Hu, X., Lu, J., Chan, P., Yan, T., & Han, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00975 · Cited by 182

Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain

Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P., & Holtzman, D. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5845-11.2012 · Cited by 181

Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder

Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B. (2012) · Psychological Medicine · doi:10.1017/s0033291712000323 · Cited by 176

Changes in Community Structure of Resting State Functional Connectivity in Unipolar Depression

Lord, A., Horn, D., Breakspear, M., & Walter, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041282 · Cited by 174

Functional segregation of the human dorsomedial prefrontal cortex

Eickhoff, S. B., Laird, A. R., Fox, P. T., Bzdok, D., & Hensel, L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhu250 · Cited by 159

Resting-state neuroimaging studies: a new way of identifying differences and similarities among the anxiety disorders?

Peterson, A., Thome, J., Frewen, P., & Lanius, R. A. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900602 · Cited by 156

Electrophysiological Low-Frequency Coherence and Cross-Frequency Coupling Contribute to BOLD Connectivity

Wang, L., Saalmann, Y. B., Pinsk, M. A., Arcaro, M. J., & Kastner, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.033 · Cited by 158

Post-traumatic stress influences the brain even in the absence of symptoms: a systematic, quantitative meta-analysis of neuroimaging studies

Stark, E. A., Parsons, C. E., Van Hartevelt, T. J., Charquero-Ballester, M., McManners, H., Ehlers, A., Stein, A., & Kringelbach, M. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.007 · Cited by 152

Modulating the default mode network using hypnosis

Deeley, Q., Oakley, D. A., Toone, B., Giampietro, V., Brammer, M. J., Williams, S. C. R., & Halligan, P. W. (2012) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2012.648070 · Cited by 146

Self-projection and the default network in frontotemporal dementia

Irish, M., Piguet, O., & Hodges, J. R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.11 · Cited by 140

Social fearfulness in the human brain

Miskovic, V., & Schmidt, L. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.002 · Cited by 126

Hyper-connectivity of subcortical resting state networks in social anxiety disorder

Arnold Anteraper, S., Triantafyllou, C., Sawyer, A. T., Hofmann, S. G., Gabrieli, J. D., & Whitfield-Gabrieli, S. (2014) · Brain Connectivity · doi:10.1089/brain.2013.0180 · Cited by 101

Individual classification of ADHD patients by integrating multiscale neuroimaging markers and advanced pattern recognition techniques

Cheng, W., Ji, X., Zhang, J., & Feng, J. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00058 · Cited by 97

A behavioral neuroenergetics theory of ADHD

Killeen, P. R., Russell, V. A., & Sergeant, J. A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.011 · Cited by 97

Prenatal lead exposure impacts cross-hemispheric and long-range connectivity in the human fetal brain

Thomason, M. E., Hect, J. L., Rauh, V. A., Trentacosta, C., Wheelock, M. D., Eggebrecht, A. T., Espinoza-Heredia, C., & Burt, S. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.02.017 · Cited by 94

Alterations in Default Mode Network Connectivity During Pain Processing in Borderline Personality Disorder

Kluetsch, R. C., Schmahl, C., Niedtfeld, I., Densmore, M., Calhoun, V. D., Daniels, J., Kraus, A., Ludaescher, P., Bohus, M., & Lanius, R. A. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.476 · Cited by 91

Brain functional connectivity correlates of coping styles

Santarnecchi, E., Sprugnoli, G., Tatti, E., Mencarelli, L., Neri, F., Momi, D., Di Lorenzo, G., Pascual-Leone, A., Rossi, S., & Rossi, A. (2018) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-0583-7 · Cited by 85

Default mode network connectivity in children with a history of preschool onset depression

Gaffrey, M. S., Luby, J. L., Botteron, K., Repovš, G., & Barch, D. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02552.x · Cited by 78

Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI

Gorges, M., Roselli, F., Müller, H.-P., Ludolph, A. C., Rasche, V., & Kassubek, J. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00200 · Cited by 76

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa

Sanders, N., Smeets, P. A. M., van Elburg, A. A., Danner, U. N., van Meer, F., Hoek, H. W., & Adan, R. A. H. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00046 · Cited by 72

Origin of slow spontaneous resting-state neuronal fluctuations in brain networks

Krishnan, G. P., González, O. C., & Bazhenov, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715841115 · Cited by 73

Structure-function relationships behind the phenomenon of cognitive resilience in neurology: insights for neuroscience and medicine.

Rudrauf, D. (2014) · Advances in Neuroscience · doi:10.1155/2014/462765 · Cited by 74

Differentially disrupted functional connectivity of the subregions of the inferior parietal lobule in Alzheimer’s disease

Wang, Z., Xia, M., Dai, Z., Liang, X., Song, H., He, Y., & Li, K. (2015) · Brain Structure and Function · doi:10.1007/s00429-013-0681-9 · Cited by 73

Amygdala–cingulate intrinsic connectivity is associated with degree of social inhibition

Blackford, J. U., Clauss, J. A., Avery, S. N., Cowan, R. L., Benningfield, M. M., & VanDerKlok, R. M. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.02.003 · Cited by 67

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

Raber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62

Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment

Wang, J., Liu, J., Wang, Z., Sun, P., Li, K., & Liang, P. (2019) · Aging · doi:10.18632/aging.102380 · Cited by 59

Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span

Yin, D., Liu, W., Zeljic, K., Wang, Z., Lv, Q., Fan, M., Cheng, W., & Wang, Z. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1476-16.2016 · Cited by 43

Neuroelectrical Decomposition of Spontaneous Brain Activity Measured with Functional Magnetic Resonance Imaging

Liu, Z., de Zwart, J. A., Chang, C., Duan, Q., van Gelderen, P., & Duyn, J. H. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht164 · Cited by 22

Functional dynamic network connectivity differentiates biological patterns in the Alzheimer’s disease continuum

Pini, L., Brusini, L., Griffa, A., Cruciani, F., Allali, G., Frisoni, G. B., Corbetta, M., Menegaz, G., & Boscolo Galazzo, I. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106866 · Cited by 11

Connections, Tracts, Fractals, and the Rest: A Working Guide to Network and Connectivity Studies in Neurosurgery

Hart, M. G., Romero-Garcia, R., Price, S. J., Santarius, T., & Suckling, J. (2020) · World Neurosurgery · doi:10.1016/j.wneu.2020.03.116 · Cited by 7