Acetyl-CoA metabolism in cancer

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Tang, Z., Li, C., Kang, B., Gao, G., Li, C., & Zhang, Z. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx247 · Cited by 9,849

Ferroptosis: mechanisms, biology and role in disease

Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298

Targeting Ferroptosis as a Vulnerability in Cancer

Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Mao, C., Liu, X., Zhang, Y., Lei, G., Yan, Y., Lee, H., Koppula, P., Wu, S., Zhuang, L., Fang, B., et al. (2021) · Nature · doi:10.1038/s41586-021-03539-7 · Cited by 2,028

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., et al. (2011) · Science · doi:10.1126/science.1208347 · Cited by 1,377

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328

The growing landscape of lysine acetylation links metabolism and cell signalling

Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3841 · Cited by 1,324

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2229-5 · Cited by 1,240

Energy-stress-mediated AMPK activation inhibits ferroptosis

Lee, H., Zandkarimi, F., Zhang, Y., Meena, J. K., Kim, J., Zhuang, L., Tyagi, S., Ma, L., Westbrook, T. F., Steinberg, G. R., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0461-8 · Cited by 1,157

Adipose-tissue plasticity in health and disease

Sakers, A. P., Siqueira, M. K. D., Seale, P., & Villanueva, C. J. (2022) · Cell · doi:10.1016/j.cell.2021.12.016 · Cited by 1,124

ATP citrate lyase inhibition can suppress tumor cell growth

Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.008 · Cited by 1,086

Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease

Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069

Cell-programmed nutrient partitioning in the tumour microenvironment

Reinfeld, B. I., Madden, M. Z., Wolf, M. M., Chytil, A. M., Bader, J. E., Patterson, A. R., Sugiura, A., Cohen, A. S., Ali, A., Do, B. T., et al. (2021) · Nature · doi:10.1038/s41586-021-03442-1 · Cited by 1,062

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Amaravadi, R. K., Kimmelman, A. C., & Debnath, J. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0292 · Cited by 928

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S.-H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.017 · Cited by 865

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604392103 · Cited by 792

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O. (2016) · Science · doi:10.1126/science.aaf6284 · Cited by 787

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Ringel, A. E., Drijvers, J. M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.009 · Cited by 780

Mitochondrial Metabolism as a Target for Cancer Therapy

Vasan, K., Werner, M., & Chandel, N. S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.019 · Cited by 762

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.025 · Cited by 760

Branched Chain Amino Acids

Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 757

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Veldhoven, P. P. V., Waltregny, D., Daniëls, V. W., Machiels, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3871 · Cited by 723

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

Mayers, J. R., Wu, C. H., Clish, C. B., Kraft, P. L., Torrence, M. E., Fiske, B. P., Yuan, C., Bao, Y., Townsend, M. K., Tworoger, S. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3686 · Cited by 672

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

Sutendra, G., Kinnaird, A. S., Dromparis, P., Paulin, R., Stenson, T. H., Haromy, A., Hashimoto, K., Zhang, N., Flaim, E., & Michelakis, E. D. (2014) · Cell · doi:10.1016/j.cell.2014.04.046 · Cited by 633

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

Calvisi, D. F., Wang, C., Ho, C., Ladu, S., Lee, S. A., Mattu, S., Destefanis, G., Delogu, S., Zimmermann, A., Ericsson, J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.006 · Cited by 611

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

Hardie, D. G., & Pan, D. A. (2002) · Biochemical Society Transactions · doi:10.1042/bst0301064 · Cited by 574

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Zhao, S., Jang, C., Liu, J., Uehara, K., Gilbert, M., Izzo, L., Zeng, X., Trefely, S., Fernandez, S., Carrer, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2101-7 · Cited by 553

Caloric restriction mimetics enhance anticancer immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.016 · Cited by 542

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208773 · Cited by 537

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Svensson, R. U., Parker, S. J., Eichner, L. J., Kolar, M. J., Wallace, M., Brun, S. N., Lombardo, P. S., Van Nostrand, J. L., Hutchins, A., Vera, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4181 · Cited by 536

Adipocyte‐derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer

Bochet, L., Lehuédé, C., Dauvillier, S., Wang, Y. Y., Dirat, B., Laurent, V., Dray, C., Guiet, R., Maridonneau-Parini, I., Le Gonidec, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0530 · Cited by 529

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

Neinast, M. D., Jang, C., Hui, S. T., Murashige, D., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.013 · Cited by 522

GSK-3 as potential target for therapeutic intervention in cancer

McCubrey, J. A., Steelman, L. S., Bertrand, F. E., Davis, N. M., Sokolosky, M. L., Abrams, S. L., Montalto, G., D’Assoro, A. B., Libra, M., Nicoletti, F., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2037 · Cited by 521

Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids

Smith, U., & Kahn, B. B. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12540 · Cited by 514

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Li, X., Egervári, G., Wang, Y., Berger, S. L., & Lu, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0029-7 · Cited by 501

Regulation of autophagy by cytosolic acetyl-coenzyme A

Mariño, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.016 · Cited by 500

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Pinkosky, S. L., Newton, R. S., Day, E. A., Ford, R. J., Lhotak, S., Austin, R. C., Birch, C. M., Smith, B. K., Filippov, S., Groot, P. H. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13457 · Cited by 498

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Gao, X. J., Lin, S., Ren, F., Li, J.-T., Chen, J.-J., Yao, C.-B., Yang, H., Jiang, S.-X., Yan, G.-Q., Wang, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11960 · Cited by 494

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Covarrubias, A. J., Aksoylar, H., Yu, J., Snyder, N. W., Worth, A. J., Iyer, S. S., Wang, J., Ben‐Sahra, I., Byles, V., Polynne-Stapornkul, T., et al. (2016) · eLife · doi:10.7554/elife.11612 · Cited by 469

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

Moon, S.-H., Huang, C., Houlihan, S. L., Regunath, K., Freed-Pastor, W. A., Morris, J. P., Tschaharganeh, D. F., Kastenhuber, E. R., Barsotti, A. M., Culp‐Hill, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.011 · Cited by 447

Regulation of acetyl-CoA carboxylase

Brownsey, R. W., Boone, A. N., Elliott, J. E., Kulpa, J. E., & Lee, W. M. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060223 · Cited by 444

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.040 · Cited by 438

Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors

Lengyel, E. R., Makowski, L., DiGiovanni, J., & Kolonin, M. G. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.03.004 · Cited by 436

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

García‐Bermúdez, J., Baudrier, L., Bayraktar, E. C., Shen, Y., La, K., Guarecuco, R., Yücel, B., Fiore, D., Tavora, B., Freinkman, E., et al. (2019) · Nature · doi:10.1038/s41586-019-0945-5 · Cited by 435

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

Sugden, M. C., & Holness, M. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00526.2002 · Cited by 428

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

Liu, X., Cooper, D. E., Cluntun, A. A., Warmoes, M. O., Zhao, S., Reid, M. A., Liu, J., Lund, P. J., Lopes, M. D. C., Garcia, B. A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.040 · Cited by 421

Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation

Kim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Ruddy, M., Chakravarthy, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.009 · Cited by 419

Lipogenesis inhibitors: therapeutic opportunities and challenges

Batchuluun, B., Pinkosky, S. L., & Steinberg, G. R. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00367-2 · Cited by 419

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

Stacpoole, P. W. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx071 · Cited by 418

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Lally, J., Ghoshal, S., DePeralta, D. K., Moaven, O., Wei, L., Masia, R., Erstad, D. J., Fujiwara, N., Leong, V., Houde, V. P., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.020 · Cited by 417

Statins: a repurposed drug to fight cancer

Jiang, W., Hu, J.-W., He, X.-R., Jin, W.-L., & He, X.-Y. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02041-2 · Cited by 417

ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer

Migita, T., Narita, T., Nomura, K., Miyagi, E., Inazuka, F., Matsuura, M., Ushijima, M., Mashima, T., Seimiya, H., Satoh, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1235 · Cited by 403

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

Störz, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.12 · Cited by 401

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20080557 · Cited by 396

ATP-citrate lyase controls a glucose-to-acetate metabolic switch

Zhao, S., Torres, A., Henry, R. A., Trefely, S., Wallace, M., Lee, J. V., Carrer, A., Sengupta, A., Campbell, S. L., Kuo, Y.-M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.069 · Cited by 394

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Lin, R., Tao, R., Gao, X., Li, T., Zhou, X., Guan, K.-L., Xiong, Y., & Lei, Q.-Y. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.002 · Cited by 384

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

Berwick, D. C., Hers, I., Heesom, K. J., Moule, S. K., & Tavareá, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204681200 · Cited by 383

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

Li, X., Yu, W., Qian, X., Xia, Y., Zheng, Y., Lee, J.-H., Li, W., Lyu, J., Rao, G., Zhang, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.026 · Cited by 378

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

Sivanand, S., Viney, I. A., & Wellen, K. E. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.11.004 · Cited by 374

High-fructose corn syrup enhances intestinal tumor growth in mice

Goncalves, M. D., Lu, C., Tutnauer, J., Hartman, T. E., Hwang, S.-K., Murphy, C. J., Pauli, C., Morris, R., Taylor, S., Bosch, K., et al. (2019) · Science · doi:10.1126/science.aat8515 · Cited by 374

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

Akella, N. M., Ciraku, L., & Reginato, M. J. (2019) · BMC Biology · doi:10.1186/s12915-019-0671-3 · Cited by 374

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

White, P. J., McGarrah, R. W., Grimsrud, P. A., Tso, S.-C., Yang, W.-H., Haldeman, J. M., Grenier-Larouche, T., An, J., Lapworth, A. L., Astapova, I., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.015 · Cited by 365

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

DeBose‐Boyd, R. A., & Ye, J. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.01.005 · Cited by 363

Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation

Nagaraj, R., Sharpley, M. S., Chi, F., Braas, D., Zhou, Y., Kim, R., Clark, A. T., & Banerjee, U. K. (2017) · Cell · doi:10.1016/j.cell.2016.12.026 · Cited by 352

Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent

Heymsfield, S. B., Allison, D. B., Vasselli, J. R., Pietrobelli, A., Greenfield, D., & Nunez, C. (1998) · JAMA · doi:10.1001/jama.280.18.1596 · Cited by 344

Acetate Promotes T Cell Effector Function during Glucose Restriction

Qiu, J., Villa, M., Sanin, D. E., Buck, M. D., O’Sullivan, D., Ching, R., Matsushita, M., Grzes, K. M., Winkler, F., Chang, C.-H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.022 · Cited by 342

Fructose stimulated de novo lipogenesis is promoted by inflammation

Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0261-2 · Cited by 328

Low glycaemic diets alter lipid metabolism to influence tumour growth

Lien, E. C., Westermark, A. M., Zhang, Y., Yuan, C., Li, Z., Lau, A. N., Sapp, K. M., Wolpin, B. M., & Heiden, M. G. V. (2021) · Nature · doi:10.1038/s41586-021-04049-2 · Cited by 323

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism

Walsh, C. T., Tu, B. P., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00510 · Cited by 315

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0567 · Cited by 313

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

Liu, M., O’Connor, R. S., Trefely, S., Graham, K. L., Snyder, N. W., & Beatty, G. L. (2019) · Nature Immunology · doi:10.1038/s41590-018-0292-y · Cited by 300

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Sivanand, S., Rhoades, S., Jiang, Q., Lee, J. V., Benci, J., Zhang, J., Yuan, S., Viney, I., Zhao, S., Carrer, A., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.008 · Cited by 295

Lactate supports a metabolic-epigenetic link in macrophage polarization

Noe, J. T., Rendon, B. E., Geller, A. E., Conroy, L. R., Morrissey, S. M., Young, L. E. A., Bruntz, R. C., Kim, E. J., Wise, A. D., Rizzo, M. B. D. S., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi8602 · Cited by 295

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Harriman, G., Greenwood, J., Bhat, S., Huang, X., Wang, R., Paul, D., Tong, L., Saha, A. K., Westlin, W. F., Kapeller, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520686113 · Cited by 287

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

García, M. R., Steinbauer, B., Srivastava, K., Singhal, M., Mattijssen, F., Maida, A., Christian, S., Hess‐Stumpp, H., Augustin, H. G., Müller‐Decker, K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.018 · Cited by 281

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Seki, T., Yang, Y., Sun, X., Lim, S., Xie, S., Guo, Z., Xiong, W., Kuroda, M., Sakaue, H., Hosaka, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05030-3 · Cited by 277

Compartmentalised acyl-CoA metabolism and roles in chromatin regulation

Trefely, S., Lovell, C. D., Snyder, N. W., & Wellen, K. E. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.005 · Cited by 272

NAFLD‐related hepatocellular carcinoma: The growing challenge

Shah, P. A., Patil, R., & Harrison, S. A. (2022) · Hepatology · doi:10.1002/hep.32542 · Cited by 270

Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: Citrate oxaloacetate lyase

Watson, J. A., Fang, M., & Lowenstein, J. M. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90532-3 · Cited by 268

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

Abu-Elheiga, L. A., Matzuk, M. M., Kordari, P., Oh, W. K., Shaiken, T. E., Gu, Z., & Wakil, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505714102 · Cited by 266

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

Bulusu, V., Tumanov, S., Michalopoulou, E., van den Broek, N. J. F., Mackay, G., Nixon, C., Dhayade, S., Schug, Z. T., Voorde, J. V., Blyth, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.055 · Cited by 263

Chemistry and Biochemistry of (−)-Hydroxycitric Acid from Garcinia

Jena, B. S., Jayaprakasha, G. K., Singh, R. P., & Sakariah, K. K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010753k · Cited by 259

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

Dai, X., Bu, X., Gao, Y., Guo, J., Hu, J., Jiang, C., Zhang, Z., Xu, K., Duan, J., He, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.037 · Cited by 257

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Li, J., Yin, M., Wang, D., Wang, J., Lei, M., Zhang, Y., Liu, Y., Zhang, L., Zou, S., Hu, L.-P., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0455-6 · Cited by 248

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

He, A., Chen, X., Tan, M., Chen, Y., Lu, D., Zhang, X., Dean, J. M., Razani, B., & Lodhi, I. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.007 · Cited by 243

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

Pinkosky, S. L., Filippov, S. I., Srivastava, R. A. K., Hanselman, J. C., Bradshaw, C. D., Hurley, T. R., Cramer, C. T., Spahr, M. A., Brant, A. F., Houghton, J. L., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m030528 · Cited by 241

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice #

Wang, Q. A., Jiang, L., Wang, J., Li, S., Yu, Y., You, J., Zeng, R., Gao, X., Rui, L., Li, W., et al. (2008) · Hepatology · doi:10.1002/hep.22774 · Cited by 215

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

Lee, J., Walsh, M. C., Hoehn, K. L., James, D. E., Wherry, E. J., & Choi, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302985 · Cited by 215

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

Kondo, A., Yamamoto, S., Nakaki, R., Shimamura, T., Hamakubo, T., Sakai, J., Kodama, T., Yoshida, T., Aburatani, H., & Osawa, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.006 · Cited by 205

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Verschueren, K. H. G., Blanchet, C. E., Félix, J., Dansercoer, A., Vos, D. E. D., Bloch, Y., BEEUMEN, J. V., Svergun, D. I., Gutsche, I., Savvides, S. N., et al. (2019) · Nature · doi:10.1038/s41586-019-1095-5 · Cited by 205

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Chen, J., Guccini, I., Mitri, D. D., Brina, D., Revandkar, A., Sarti, M., Pasquini, E., Alajati, A., Pinton, S., Losa, M., et al. (2018) · Nature Genetics · doi:10.1038/s41588-017-0026-3 · Cited by 202

Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

Morrow, M. R., Batchuluun, B., Wu, J., Ahmadi, E., Leroux, J. M., Mohammadi-Shemirani, P., Desjardins, E. M., Wang, Z., Tsakiridis, E. E., Lavoie, D. C. T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.004 · Cited by 199

Statins as Anticancer Agents in the Era of Precision Medicine

Longo, J., van Leeuwen, J. E., Elbaz, M., Branchard, E., & Penn, L. Z. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1967 · Cited by 196

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Ning, Z., Guo, X., Liu, X., Lu, C., Wang, A., Wang, X., Wang, W., Chen, H., Qin, W., Liu, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29846-9 · Cited by 196

The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth

Gouw, A. M., Margulis, K., Liu, N. S., Raman, S. J., Mancuso, A., Toal, G. G., Tong, L., Mosley, A. R., Hsieh, A. L., Sullivan, D. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.012 · Cited by 195

Metabolic Signaling to the Nucleus in Cancer

Campbell, S. L., & Wellen, K. E. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.015 · Cited by 186

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Jia, W., Leit, S. M., Kuai, J., Therrien, É., Rafi, S. B., Harwood, H. J., DeLaBarre, B., & Tong, L. (2019) · Nature · doi:10.1038/s41586-019-1094-6 · Cited by 186

Phosphorylation of Recombinant Human ATP:Citrate Lyase by cAMP-Dependent Protein Kinase Abolishes Homotropic Allosteric Regulation of the Enzyme by Citrate and Increases the Enzyme Activity. Allosteric Activation of ATP:Citrate Lyase by Phosphorylated Sugars

Potapova, I. A., El‐Maghrabi, M. R., Doronin, S. V., & Benjamin, W. B. (2000) · Biochemistry · doi:10.1021/bi992159y · Cited by 176

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

Alkhouri, N., Lawitz, E., Noureddin, M., DeFronzo, R., & Shulman, G. I. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1668374 · Cited by 162

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

Calejman, C. M., Trefely, S., Entwisle, S. W., Luciano, A. K., Jung, S., Hsiao, W., Torres, A., Hung, C. M., Li, H., Snyder, N. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14430-w · Cited by 161

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

Huang, Z., Zhang, M., Plec, A. A., Estill, S. J., Cai, L., Repa, J. J., McKnight, S. L., & Tu, B. P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806635115 · Cited by 160

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

German, N. J., Yoon, H., Yusuf, R. Z., Murphy, J. P., Finley, L. W. S., Laurent, G., Haas, W., Satterstrom, F. K., Guarnerio, J., Zaganjor, E., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.014 · Cited by 156

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Talebi, A., Dehairs, J., Rambow, F., Rogiers, A., Nittner, D., Derua, R., Vanderhoydonc, F., Duarte, J. A. G., Bosisio, F., Van den Eynde, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04664-0 · Cited by 155

ATP-Citrate Lyase Deficiency in the Mouse

Beigneux, A. P., Kosinski, C., Gavino, B. J., Horton, J. D., Skarnes, W. C., & Young, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310512200 · Cited by 154

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Sangineto, M., Villani, R., Cavallone, F., Romano, A. D., Loizzi, D., & Serviddio, G. (2020) · Cancers · doi:10.3390/cancers12061419 · Cited by 153

Macrophages are metabolically heterogeneous within the tumor microenvironment

Geeraerts, X., Fernández-García, J., Hartmann, F. J., de Goede, K. E., Martens, L., Elkrim, Y., Debraekeleer, A., Stijlemans, B., Vandekeere, A., Rinaldi, G., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110171 · Cited by 151

ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition

Lü, M., Zhu, W., Wang, X., Tang, J.-J., Zhang, K., Yu, G., Shao, W., Lin, Z., Wang, S.-H., Lu, L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.019 · Cited by 150

Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

Madiraju, P., Pande, S. V., Prentki, M., & Madiraju, S. R. M. (2009) · Epigenetics · doi:10.4161/epi.4.6.9767 · Cited by 147

The IKKβ‐USP30‐ACLY Axis Controls Lipogenesis and Tumorigenesis

Gu, L., Zhu, Y., Lin, X., Lu, B., Zhou, X., Zhou, F., Zhao, Q., Prochownik, E. V., & Li, Y. (2020) · Hepatology · doi:10.1002/hep.31249 · Cited by 147

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Pinkosky, S. L., Scott, J. W., Desjardins, E. M., Smith, B. K., Day, E. A., Ford, R. J., Langendorf, C. G., Ling, N. X. Y., Nero, T. L., Loh, K., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0245-2 · Cited by 145

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids

PEARCE, N. J., Yates, J. W., Berkhout, T. A., Jackson, B., Tew, D. G., Boyd, H., Camilleri, P., Sweeney, P. J., Gribble, A. D., Shaw, A. N., et al. (1998) · Biochemical Journal · doi:10.1042/bj3340113 · Cited by 144

The Use ofGarciniaExtract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

Onakpoya, I., Hung, S. K., Perry, R. E., Wider, B., & Ernst, E. (2010) · Journal of Obesity · doi:10.1155/2011/509038 · Cited by 143

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Ye, C., & Tu, B. P. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.06.002 · Cited by 142

Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progressionPreprint

Zhang, C., Liu, J., Huang, G., Zhao, Y., Yue, X., Wu, H., Li, J., Zhu, J., Shen, Z., Haffty, B. G., et al. (2016) · Genes & Development · doi:10.1101/gad.283283.116 · Cited by 140

Quantitative Sub-Cellular Acyl-Coa Analysis Reveals Distinct Nuclear Regulation

Trefely, S., Huber, K., Liu, J., Noji, M., Stransky, S., Singh, J. P., Doan, M. T., Lovell, C. D., von Krusenstiern, E. V., Jiang, H., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.11.006 · Cited by 139

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Baardman, J., Verberk, S. G. S., van der Velden, S., Gijbels, M. J., van Roomen, C. P. A. A., Sluimer, J. C., Broos, J. Y., Griffith, G. R., Prange, K. H. M., van Weeghel, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20141-z · Cited by 134

Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice

Harada, N., Oda, Z., Hara, Y., Fujinami, K., Okawa, M., Ohbuchi, K., Yonemoto, M., Ikeda, Y., Ohwaki, K., Aragane, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01122-06 · Cited by 132

Older than genes: the acetyl CoA pathway and origins

Martin, W. F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00817 · Cited by 132 · cited 1×

Serine catabolism generates liver NADPH and supports hepatic lipogenesis

Zhang, Z., TeSlaa, T. A., Xu, X., Zeng, X., Yang, L., Xing, G., Tesz, G. J., Clasquin, M. F., & Rabinowitz, J. D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00487-4 · Cited by 130

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

Pomatto, L. C. D., Bodogai, M., Bosompra, O., Kato, J. I., Wong, S., Carpenter, M., Duregon, E., Chowdhury, D., Krishna, P., Ng, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26431-4 · Cited by 126

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca 2+ –NFAT signalingPreprint

Lee, J. V., Berry, C. T., Kim, K., Sen, P., Kim, T., Carrer, A., Trefely, S., Zhao, S., Fernandez, S., Barney, L. E., et al. (2018) · Genes & Development · doi:10.1101/gad.311027.117 · Cited by 121

Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma

Torrini, C., Nguyen, T. T. T., Shu, C., Mela, A., Humala, N., Mahajan, A., Seeley, E., Zhang, G., Westhoff, M., Karpel‐Massler, G., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.06.030 · Cited by 117

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response

McGregor, G. H., Campbell, A. D., Fey, S. K., Tumanov, S., Sumpton, D. P., Blanco, G. R., Mackay, G., Nixon, C., Vázquez, A., Sansom, O. J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0644 · Cited by 116

Cancer‐associated adipocytes promote pancreatic cancer progression through SAA1 expression

Takehara, M., Sato, Y., Kimura, T., Noda, K., Miyamoto, H., Fujino, Y., Miyoshi, J., Nakamura, F., Wada, H., Bando, Y., et al. (2020) · Cancer Science · doi:10.1111/cas.14527 · Cited by 115

Identification of multifunctional ATP-citrate lyase kinase as the α-isoform of glycogen synthase kinase-3

Hughes, K., Ramakrishna, S., Benjamin, W. B., & Woodgett, J. R. (1992) · Biochemical Journal · doi:10.1042/bj2880309 · Cited by 113

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

Chow, J. D. Y., Lawrence, R., Healy, M. E., Dominy, J. E., Liao, J. A., Breen, D. S., Byrne, F. L., Kenwood, B. M., Lackner, C., Okutsu, S., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.004 · Cited by 111

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

Li, Z., Liu, H., He, J., Wang, Z., Yin, Z., You, G., Wang, Z., Davis, R. E., Lin, P., Bergsagel, P. L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.011 · Cited by 110

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

Pandyra, A. A., Mullen, P., Kalkat, M., Yu, R., Pong, J. T., Li, Z., Trudel, S., Lang, K. S., Minden, M. D., Schimmer, A. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0130 · Cited by 109

AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability

Jonas, M. C., Pehar, M., & Puglielli, L. (2010) · Journal of Cell Science · doi:10.1242/jcs.068841 · Cited by 108

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Cai, L., Ruddy, M., Chakravarthy, M. V., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.011 · Cited by 105

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Miller, K. D., Pniewski, K. A., Perry, C. E., Papp, S. B., Shaffer, J. D., Velasco‐Silva, J. N., Casciano, J. C., Aramburu, T. M., Srikanth, Y. V. V., Cassel, J. A., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1847 · Cited by 103

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

Longo, J., Mullen, P., Yu, R., van Leeuwen, J. E., Masoomian, M., Woon, D. T. S., Wang, Y. Z., Chen, E. X., Hamilton, R. J., Sweet, J., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.003 · Cited by 100

Adipocyte mesenchymal transition contributes to mammary tumor progression

Zhu, Q., Zhu, Y., Hepler, C., Zhang, Q., Park, J., Gliniak, C. M., Henry, G. H., Crewe, C., Bu, D., Zhang, Z., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111362 · Cited by 99

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Nelson, M. E., Lahiri, S., Chow, J. D. Y., Byrne, F. L., Hargett, S. R., Breen, D. S., Olzomer, E. M., Wu, L. E., Cooney, G. J., Turner, N. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14689 · Cited by 93

ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia

Burke, A. C., & Huff, M. W. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000390 · Cited by 91

Incorporation of radioactive citrate into fatty acids

Srere, P. A., & Bhaduri, A. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90205-6 · Cited by 87 · cited 1×

ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection

Vysochan, A., Sengupta, A., Weljie, A. M., Alwine, J. C., & Yu, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614268114 · Cited by 86

Nature and Nurture: What Determines Tumor Metabolic Phenotypes?

Mayers, J. R., & Heiden, M. G. V. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0165 · Cited by 86

The incorporation of citrate carbon into fatty acids

Bhaduri, A., & Srere, P. A. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)90747-9 · Cited by 85

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Shah, S., Carriveau, W. J., Li, J., Campbell, S. L., Kopinski, P. K., Lim, H., Daurio, N. A., Trefely, S., Won, K., Wallace, D. C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9666 · Cited by 85

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Broadfield, L. A., Duarte, J. A. G., Schmieder, R., Broekaert, D., Veys, K., Planque, M., Vriens, K., Karasawa, Y., Napolitano, F., Fujita, S., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1954 · Cited by 85

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Fernandez, S., Viola, J. M., Torres, A., Wallace, M., Trefely, S., Zhao, S., Affronti, H. C., Gengatharan, J. M., Guertin, D. A., Snyder, N. W., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.112 · Cited by 80

MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex

Zervopoulos, S. D., Boukouris, A. E., Saleme, B., Haromy, A., Tejay, S., Sutendra, G., & Michelakis, E. D. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.003 · Cited by 75

Purification and Physicochemical Properties of ATP Citrate (pro‐3S) Lyase from Lactating Rat Mammary Gland and Studies of Its Reversible Phosphorylation

Guy, P. S., Cohen, P., & Hardie, D. G. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05160.x · Cited by 73

IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R

Qiao, C., Huang, W., Chen, J., Feng, W., Zhang, T., Wang, Y., Liu, D., Ji, X., Xie, M., Sun, M., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03833-2 · Cited by 71

Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites

Mendoza, M. R., Egervári, G., Sidoli, S., Donahue, G., Alexander, D. C., Sen, P., Garcia, B. A., & Berger, S. L. (2022) · Science Advances · doi:10.1126/sciadv.abj5688 · Cited by 65

The Bidirectional Relationship Between Cancer Epigenetics and Metabolism

Izzo, L., Affronti, H. C., & Wellen, K. E. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070820-035832 · Cited by 64

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

Jung, S. M., Doxsey, W. G., Le, J., Haley, J. D., Mazuecos, L., Luciano, A. K., Li, H., Jang, C., & Guertin, D. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109459 · Cited by 63

Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K–AKT Pathway and Activating the AMPK–ROS Pathway

Wei, X., Shi, J., Lin, Q., Ma, X., Pang, Y., Mao, H., Li, R., Lü, W., Wang, Y., & Liu, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.642229 · Cited by 60

NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions

Kumar, A., Cordes, T., Thalacker‐Mercer, A. E., Pajor, A. M., Murphy, A. N., & Metallo, C. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109701 · Cited by 60

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

Ciraku, L., Bacigalupa, Z. A., Ju, J., Moeller, R. A., Minh, G. L., Lee, R. H., Smith, M. D., Ferrer, C. M., Trefely, S., Izzo, L., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02237-6 · Cited by 60

Molecular basis for acetyl-CoA production by ATP-citrate lyase

Wei, X., Schultz, K. C., Bazilevsky, G. A., Vogt, A. D., & Marmorstein, R. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0351-6 · Cited by 58

Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells

Chowdhury, S., Kar, A., Bhowmik, D., Gautam, A., Basak, D., Sarkar, I., Ghosh, P., Sarkar, D., Deka, A., Chakraborty, P., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-4052 · Cited by 58

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

Dieterich, I. A., Lawton, A. J., Peng, Y., Yu, Q., Rhoads, T. W., Overmyer, K. A., Cui, Y., Armstrong, E. A., Howell, P. R., Burhans, M. S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11945-9 · Cited by 55

ACLY: A biomarker of recurrence in breast cancer

Chen, Y., Li, K., Gong, D., Zhang, J., Li, Q., Zhao, G., & Lin, P. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153076 · Cited by 53

ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p‐eIF2α/ATF4/CHOP axis

Zheng, Y., Zhou, Q., Zhao, C., Li, J., Yu, Z., & Zhu, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16235 · Cited by 53

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes

Huber, K., Hofer, D., Trefely, S., Pelzmann, H. J., Madreiter‐Sokolowski, C. T., Duta-Mare, M., Schlager, S., Trausinger, G., Stryeck, S., Graier, W. F., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.08.017 · Cited by 49

Global Profiling of Acetyltransferase Feedback Regulation

Montgomery, D. C., Garlick, J. M., Kulkarni, R. A., Kennedy, S., Allali‐Hassani, A., Kuo, Y., Andrews, A. J., Wu, H., Vedadi, M., & Meier, J. L. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b03036 · Cited by 48

Should we consider subcellular compartmentalization of metabolites, and if so, how do we measure them?

Wellen, K. E., & Snyder, N. W. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000580 · Cited by 48

Decreased expression of acetyl‐CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma

Sun, L., Kong, Y., Cao, M., Zhou, H., Li, H., Cui, Y., Fang, F., Zhang, W., Li, J., Zhu, X., et al. (2017) · Cancer Science · doi:10.1111/cas.13252 · Cited by 47

Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma

Bae, J. M., Kim, J. H., Oh, H. J., Park, H. E., Lee, T. H., Cho, N., & Kang, G. H. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.172 · Cited by 44

Low expression of ACLY associates with favorable prognosis in acute myeloid leukemia

Wang, J., Ye, W., Yan, X., Guo, Q., Ma, Q., Lin, F., Huang, J., & Jin, J. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1884-5 · Cited by 43

Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer

Senapati, P., Kato, H., Lee, M., Leung, A., Thai, C., Sanchez, A., Gallagher, E. J., LeRoith, D., Seewaldt, V. L., Ann, D. K., et al. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0290-9 · Cited by 43

Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA

Adina-Zada, A., Zeczycki, T. N., Maurice, M. S., Jitrapakdee, S., Cleland, W. W., & Attwood, P. V. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120041 · Cited by 42

AMPK β1 reduces tumor progression and improves survival in p53 null mice

Houde, V. P., Donzelli, S., Sacconi, A., Galić, S., Hammill, J. A., Bramson, J. L., Foster, R. A., Tsakiridis, T. K., Kemp, B. E., Grasso, G., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12079 · Cited by 41

Rat mammary gland ATP‐citrate lyase is phosphorylated by cyclic AMP‐dependent protein kinase

Guy, P. S., Cohen, P., & Hardie, D. G. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)81087-8 · Cited by 38

Advances into understanding metabolites as signaling molecules in cancer progression

Liu, J. Y., & Wellen, K. E. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.01.013 · Cited by 38

The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease

Park, G. S. H., Jung, S., Wellen, K. E., & Jang, C. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00614-x · Cited by 37

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

Yenilmez, B., Kelly, M., Zhang, G., Wetoska, N., Ilkayeva, O., Min, K., Rowland, L. A., DiMarzio, C., He, W., Raymond, N., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102401 · Cited by 36

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

Longo, J., Smirnov, P., Li, Z., Branchard, E., van Leeuwen, J. E., Licht, J. D., Haibe‐Kains, B., Andrews, D. W., Keats, J. J., Pugh, T. J., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0962-2 · Cited by 33

Acetyl-CoA synthetase 2 enhances tumorigenesis and is indicative of a poor prognosis for patients with renal cell carcinoma

Zhang, S., He, J., Jia, Z., Yan, Z., & Yang, J. (2018) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2018.01.013 · Cited by 31

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

Trefely, S., Liu, J., Huber, K., Doan, M. T., Jiang, H., Singh, J. P., von Krusenstiern, E. V., Bostwick, A., Xu, P. J., Bogner‐Strauß, J. G., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.004 · Cited by 28

A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks

Levy, M. J., Montgomery, D. C., Sardiu, M. E., Montaño, J. L., Bergholtz, S. E., Nance, K. D., Thorpe, A. L., Fox, S. D., Lin, Q., Andrésson, Þ., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.11.011 · Cited by 27

Comparison of phospho- and dephospho-ATP citrate lyase

Ranganathan, N. S., Srere, P. A., & Linn, T. C. (1980) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(80)90006-5 · Cited by 26

ACLY is the Novel Signaling Target of PIP 2/PIP 3 and Lyn in Cancer

Basappa, J., Citir, M., Zhang, Q., Wang, H. Y., Liu, X., Melnikov, O., Yahya, H. A., Stein, F., Müller, R., Traynor‐Kaplan, A., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03910 · Cited by 26

Effects of phosphorylation on the kinetic properties of rat liver ATP-citrate lyase

Houston, B., & Nimmo, H. G. (1985) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(85)90095-3 · Cited by 24

Structure of ACLY in complex with CoA

Wei, X., & Marmorstein, R. (2019) · Worldwide Protein Data Bank · doi:10.2210/pdb6poe/pdb · Cited by 24

Effect of Oxaloacetate and Phosphorylation on ATP-Citrate Lyase Activity

Pentyala, S., & Benjamin, W. B. (1995) · Biochemistry · doi:10.1021/bi00035a001 · Cited by 20

Identification and integrative analysis of ACLY and related gene panels associated with immune microenvironment reveal prognostic significance in hepatocellular carcinoma

Xu, Y., Zhang, Z., Xu, D., Yang, X. L., Zhou, L., & Zhu, Y. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02108-2 · Cited by 20

NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma

Odera, J. O., Xiong, Z., Huang, C. D., Gu, N., Yang, W., Githanga, J. N., Odera, E. O., Paiboonrungruang, C., & Chen, X. L. (2020) · Biochemical Journal · doi:10.1042/bcj20200452 · Cited by 16

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies

Liefwalker, D. F., Gabay, M., Wang, Z., Pathak, K. V., Plaisier, S. B., Shah, V. M., Babra, B., Dewson, G. S., Lai, I. K., Mosley, A. R., et al. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00263-8 · Cited by 12

Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth

de Goede, K. E., Verberk, S. G. S., Baardman, J., Harber, K. J., van Kooyk, Y., de Winther, M. P. J., Schetters, S. T. T., & den Bossche, J. V. (2021) · Cancers · doi:10.3390/cancers13123054 · Cited by 10

Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms

Steinberg, G. R., Valvano, C. M., De Nardo, W., & Watt, M. J. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.02.033 · Cited by 240

Metabolic reprogramming, sensing, and cancer therapy

Mao, Y., Xia, Z., Xia, W., & Jiang, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115064 · Cited by 180

The emerging role of protein l-lactylation in metabolic regulation and cell signalling

Ren, H., Tang, Y., & Zhang, D. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01259-0 · Cited by 159

Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis

Izzo, L., Trefely, S., Demetriadou, C., Drummond, J. M., Mizukami, T., Kuprasertkul, N., Farria, A. T., Nguyen, P. T., Murali, N., Reich, L. N., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf0115 · Cited by 140

MASH: the nexus of metabolism, inflammation, and fibrosis

Steinberg, G. R., Carpentier, A. C., & Wang, D. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186420 · Cited by 135

Acetyl-CoA metabolism as a therapeutic target for cancer

Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54

Acetyl-CoA: an interplay between metabolism and epigenetics in cancer

Hao, Y., Yi, Q., XiaoWu, X., WeiBo, C., GuangChen, Z., & XueMin, C. (2022) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2022.1044585 · Cited by 26

Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer

He, W., Li, Q., & Li, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188837 · Cited by 182

Acetyl-CoA carboxylase-a as a novel target for cancer therapy

Cao, D. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s82 · Cited by 91

Abstract IA24: Acetyl-CoA metabolism, gene regulation, and stress management

Wellen, K. E. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-ia24