Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382

AMPK: guardian of metabolism and mitochondrial homeostasis

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A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

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The mechanisms of action of metformin

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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

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Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

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Lactate in the brain: from metabolic end-product to signalling molecule

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Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

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Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke

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The role of mitochondrial genome abundance in Alzheimer's disease

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Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease

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Enhancing healthy aging with small molecules: A mitochondrial perspective

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Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

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Multi-omics analysis revealed the brain dysfunction induced by energy metabolism in Pelteobagrus vachelli under hypoxia stress

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Aging-related modifications to G protein-coupled receptor signaling diversity

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The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.

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Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis

Nelson, A. T., & Trotti, D. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01262-3 · Cited by 31

Raman Spectroscopy on Brain Disorders: Transition from Fundamental Research to Clinical Applications

Ranasinghe, J. C., Wang, Z., & Huang, S. (2022) · Biosensors · doi:10.3390/bios13010027 · Cited by 34

New insight of metabolomics in ocular diseases in the context of 3P medicine

Zhang, Q., Wang, N., Rui, Y., Yang, X., Xiong, S., & Xia, X. (2023) · The EPMA Journal · doi:10.1007/s13167-023-00313-9 · Cited by 29

Metabolomic Footprint of Disrupted Energetics and Amino Acid Metabolism in Neurodegenerative Diseases: Perspectives for Early Diagnosis and Monitoring of Therapy

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Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy

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Epidemiological and genetic overlap among biological aging clocks: New challenges in biogerontology

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Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

González, L. F., Bevilacqua, L. E., & Naves, R. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122055 · Cited by 31

Metabolomics in aging research: aging markers from organs

Fang, W., Chen, S., Jin, X., Liu, S., Cao, X., & Liu, B. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1198794 · Cited by 30

Neuroprotective effect of short‐chain fatty acids against oxidative stress‐induced SH‐SY5Y injury via GPR43 ‐dependent pathway

Saikachain, N., Sungkaworn, T., Muanprasat, C., & Asavapanumas, N. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15827 · Cited by 31

Nervonic acid improves liver inflammation in a mouse model of Parkinson's disease by inhibiting proinflammatory signaling pathways and regulating metabolic pathways

Wang, X., Liang, T., Mao, Y. Q., Li, Z., Li, X., Zhu, X., Cao, F., & Zhang, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154911 · Cited by 30

Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease

Lian, P., Cai, X., Wang, C., Liu, K., Yang, X., Wu, Y., Zhang, Z., Ma, Z., Cao, X., & Xu, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04324-y · Cited by 29

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00690-9 · Cited by 30

Intermittent fasting and neurodegenerative diseases: Molecular mechanisms and therapeutic potential

Lv, R., Liu, B., Jiang, Z., Zhou, R., Liu, X., Lu, T., Bao, Y., Huang, C., Zou, G., Zhang, Z., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156104 · Cited by 34

Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging

Souder, D. C., McGregor, E. R., Clark, J. P., Rhoads, T. W., Porter, T. J., Eliceiri, K. W., Moore, D. L., Puglielli, L., & Anderson, R. M. (2025) · Nature Communications · doi:10.1038/s41467-025-57363-y · Cited by 30

Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders

Mansoor, M. A., Ibrahim, A., Hamide, A., Tran, T., Candreva, E., & Baltaji, J. (2025) · Physiologia · doi:10.3390/physiologia5020013 · Cited by 38

Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate

Chen, W., Xiaoxia, S., Zhan, L., Zhou, W., & Bi, T. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.767560 · Cited by 28

A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment

Roy, M., Fortier, M., Rheault, F., Edde, M., Croteau, É., Castellano, C., Langlois, F., St-Pierre, V., Cuenoud, B., Bocti, C., et al. (2021) · medRxiv · doi:10.1002/trc2.12217 · Cited by 31

Microbiota from Exercise Mice Counteracts High-Fat High-Cholesterol Diet-Induced Cognitive Impairment in C57BL/6 Mice

Li, R., Liu, R., Chen, L., Wang, G., Qin, L., Yu, Z., & Wan, Z. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/2766250 · Cited by 30

Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity

Schreiber, S., Bernal, J., Arndt, P., Schreiber, F., Müller, P., Morton, L., Braun-Dullaeus, R. C., Hernández, M. V., Duarte, R., Wardlaw, J. M., et al. (2023) · Cells · doi:10.3390/cells12060957 · Cited by 30

Brain insulin resistance linked Alzheimer’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation

Kakoty, V., Sarathlal, K. C., Kumari, S., Yang, C., Dubey, S. K., Sahebkar, A., Kesharwani, P., & Taliyan, R. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01187-z · Cited by 30

Systematic review of 31P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer's disease

Jett, S., Boneu, C., Zarate, C., Carlton, C., Kodancha, V., Nerattini, M., Battista, M., Pahlajani, S. S., Williams, S., Dyke, J. P., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1183228 · Cited by 30

Neurodegenerative disorders, metabolic icebergs, and mitohormesis

Phillips, M. C. L., & Picard, M. A. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00435-8 · Cited by 31

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29

Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson’s Patients, Using In Vivo 31P MRS-Based Metabolic Imaging at 7T

Zhu, X.-H., Lee, B., Tuite, P., Coles, L. D., Sathe, A. G., Chen, C., Cloyd, J. C., Low, W. C., Steer, C. J., & Chen, W. (2021) · Metabolites · doi:10.3390/metabo11030145 · Cited by 27

Brain energy metabolism and neurodegeneration: hints from CSF lactate levels in dementias

Bonomi, C. G., Lucia, V. D., Mascolo, A. P., Assogna, M., Motta, C., Scaricamazza, E., Sallustio, F., Mercuri, N. B., Koch, G., & Martorana, A. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.05.011 · Cited by 30

Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00705-2 · Cited by 30

Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation?

Grimm, A. (2021) · Cells · doi:10.3390/cells10102531 · Cited by 26

Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice

Li, Z., Meng, X., Ma, G., Liu, W., Li, W., Cai, Q., Wang, S., Huang, G., & Zhang, Y. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01092-7 · Cited by 29

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications

Wei, X., He, Y., Yu, Y., Tang, S., Liu, R., Guo, J., Jiang, Q., Zhi, X., Wang, X., & Meng, D. (2025) · Advanced Science · doi:10.1002/advs.202412850 · Cited by 27

Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis

Chen, H., Zhang-Brotzge, X., Morozov, Y. M., Li, Y., Wang, S., Zhang, H. H., Kuan, I. S., Fugate, E. M., Mao, H. Z., Sun, Y., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.140173 · Cited by 28

Subcellular delivery of lipid nanoparticles to endoplasmic reticulum and mitochondria

Shi, Y., Luo, Z., & You, J. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1803 · Cited by 30

Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome

Martini, A. C., Gross, T. J., Head, E., & Mapstone, M. E. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.001 · Cited by 26

β-Hydroxybutyrate and Medium-Chain Fatty Acids are Metabolized by Different Cell Types in Mouse Cerebral Cortex Slices

Andersen, J. V., Westi, E. W., Neal, E. S., Aldana, B. I., & Borges, K. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03726-6 · Cited by 27

Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer’s Disease

Ameen, A. O., Freude, K., & Aldana, B. I. (2022) · Biomedicines · doi:10.3390/biomedicines10112778 · Cited by 29

Kai-Xin-San protects against mitochondrial dysfunction in Alzheimer’s disease through SIRT3/NLRP3 pathway

Su, S., Chen, G., Gao, M., Zhong, G., Zhang, Z., Wei, D., Luo, X., & Wang, Q. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00722-y · Cited by 27

Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes)

de la Monte, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230555 · Cited by 28

Beta-Hydroxybutyrate (BHB), Glucose, Insulin, Octanoate (C8), and Decanoate (C10) Responses to a Medium-Chain Triglyceride (MCT) Oil with and without Glucose: A Single-Center Study in Healthy Adults

Heidt, C., Fobker, M., Newport, M. T., Feldmann, R., Fischer, T. W., & Marquardt, T. (2023) · Nutrients · doi:10.3390/nu15051148 · Cited by 25

Effect of Exercise and Oral Niacinamide Mononucleotide on Improving Mitochondrial Autophagy in Alzheimer’s Disease

Wu, W., Yuan, S., Tang, Y., Meng, X., Peng, M., Hu, Z., & Liu, W. (2023) · Nutrients · doi:10.3390/nu15132851 · Cited by 33

Investigating the Therapeutic Potential of the Ketogenic Diet in Modulating Neurodegenerative Pathophysiology: An Interdisciplinary Approach

Shabbir, I., Liu, K., Riaz, B., Rahim, M. F., Zhong, S., Aweya, J. J., & Cheong, K. (2025) · Nutrients · doi:10.3390/nu17071268 · Cited by 26

The key roles of organelles and ferroptosis in Alzheimerʼs disease

Long, H., Cheng, Y., Zhou, Z., Luo, H., Wen, D., & Gao, L. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25033 · Cited by 28

Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Ondaro, J., Hernández-Eguiazu, H., Garciandia-Arcelus, M., Loera‐Valencia, R., Rodríguez-Gómez, L., Jiménez-Zúñiga, A., Goikolea, J., Rodriguez‐Rodriguez, P., Ruiz‐Martínez, J., Moreno, F., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.836196 · Cited by 28

Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive‐Like Disorders by Promoting ATP Production

Zhang, H., Liu, S., Qin, Q., Xu, Z., Qu, Y., Wang, Y., Wang, J., Du, Z., Yuan, S., Hong, S., et al. (2022) · Advanced Science · doi:10.1002/advs.202204463 · Cited by 28

Protein glycosylation and glycoinformatics for novel biomarker discovery in neurodegenerative diseases

Costa, J., Hayes, C. A., & Lisacek, F. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101991 · Cited by 25

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses

Acevedo, A., Torres, F., Kiwi, M., Baeza‐Lehnert, F., Barros, L. F., Lee‐Liu, D., & González-Billault, C. E. (2023) · Aging · doi:10.18632/aging.204663 · Cited by 27

Low-dose BPA-induced neuronal energy metabolism dysfunction and apoptosis mediated by PINK1/parkin mitophagy pathway in juvenile rats

Meng, L., Ouyang, Z., Chen, Y., Huang, C., Yu, Y., & Fan, R. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172655 · Cited by 26

Metformin and cyanidin 3- O -galactoside from Aronia melanocarpa synergistically alleviate cognitive impairment in SAMP8 mice

Wen, H., Tian, H., Liu, C., Zhang, X., Peng, Y., Yang, X., Chen, F., & Li, J. (2021) · Food & Function · doi:10.1039/d1fo02122b · Cited by 25

A Machine Learning-Based Holistic Approach to Predict the Clinical Course of Patients within the Alzheimer’s Disease Spectrum

Massetti, N., Russo, M., Franciotti, R., Nardini, D., Mandolini, G. M., Granzotto, A., Bomba, M., Pizzi, S. D., Mosca, A., Scherer, R., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210573 · Cited by 25

Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses

Kabiraj, P., Grund, E. M., Clarkson, B. D. S., Johnson, R. K., LaFrance‐Corey, R. G., Lucchinetti, C. F., & Howe, C. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-07024-7 · Cited by 26

The associations of serum valine with mild cognitive impairment and Alzheimer’s disease

Xiong, Y., Therriault, J., Ren, S., Jing, X., & Zhang, H. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02120-0 · Cited by 21

Creatine as a Therapeutic Target in Alzheimer's Disease

Smith, A. N., Morris, J. K., Carbuhn, A. F., Herda, T. J., Keller, J. E., Sullivan, D. K., & Taylor, M. K. (2023) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2023.102011 · Cited by 31

Conquering Insulin Network Dysfunctions in Alzheimer’s Disease: Where Are We Today?

de la Monte, S. M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240069 · Cited by 28

Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma

Liu, X., Wang, Q., Shao, Z., Zhang, S., Hou, M., Jiang, M., Du, M., Li, J., & Yuan, H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab099 · Cited by 24

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts

Gerou, M., Hall, B., Woof, R., Allsop, J., Kolb, S. J., Meyer, K., Shaw, P. J., & Allen, S. P. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.013 · Cited by 26

Serum proBDNF Is Associated With Changes in the Ketone Body β-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults

Norgren, J., Daniilidou, M., Kåreholt, I., Sindi, S., Akenine, U., Nordin, K., Rosenborg, S., Ngandu, T., Kivipelto, M., & Matton, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.716594 · Cited by 24

Pericytes: Intrinsic Transportation Engineers of the CNS Microcirculation

Eltanahy, A. M., Koluib, Y. A., & Gonzales, A. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.719701 · Cited by 27

Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice

Li, T., Li, X., Huang, X., Yu, H., Li, S., Zhang, Z., Xie, Y., Song, X., Liu, J., Yang, X., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108899 · Cited by 24

Cyanidin 3-O-β-Galactoside Alleviated Cognitive Impairment in Mice by Regulating Brain Energy Metabolism During Aging

Fan, Z., Wen, H., Zhang, X., Li, J., & Zang, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06240 · Cited by 24

A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment

Roy, M., Edde, M., Fortier, M., Croteau, É., Castellano, C., St‐Pierre, V., Vandenberghe, C., Rheault, F., Dadar, M., Duchesne, S., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.04.005 · Cited by 25

A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice

Saito, E. R., Warren, C. E., Hanegan, C. M., Larsen, J. G., du Randt, J. D., Cannon, M. E., Saito, J. Y., Campbell, R. J., Kemberling, C. M., Miller, G., et al. (2022) · Metabolites · doi:10.3390/metabo12111019 · Cited by 24

Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions

Westi, E. W., Andersen, J. V., & Aldana, B. I. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106145 · Cited by 23

Association between triglyceride glucose index and cognitive decline: A meta-analysis

Liu, Y., Yang, X., Gao, J., Xie, C., Tian, C., & Gao, T. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.049 · Cited by 24

Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease

Pan, C., Mao, S., Xiong, Z., Chen, Z., & Xu, N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175733 · Cited by 23

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms

Khan, S., Bano, N., Ahamad, S., John, U., Dar, N. J., & Bhat, S. A. (2024) · Aging and Disease · doi:10.14336/ad.2024.0125-1 · Cited by 27

Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications

Yan, B., Zhou, J., Yan, F., Gao, M., Tang, J., Huang, L., & Luo, Y. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241311695 · Cited by 24

Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain

Zilberter, Y., & Zilberter, T. (2020) · eNeuro · doi:10.1523/eneuro.0303-20.2020 · Cited by 23

Glycolysis: The Next Big Breakthrough in Parkinson’s Disease

Naeem, U., Arshad, A. R., Jawed, A., Eqbal, F., Imran, L., Khan, Z., & Ijaz, F. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00579-3 · Cited by 23

Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance

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