Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382

AMPK: guardian of metabolism and mitochondrial homeostasis

Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

Mercuri, E., Darras, B. T., Chiriboga, C. A., Day, J. W., Campbell, C., Connolly, A. M., Iannaccone, S. T., Kirschner, J., Kuntz, N. L., Saito, K., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1710504 · Cited by 1,433

Lactate in the brain: from metabolic end-product to signalling molecule

Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173

Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty

Okinaka, Y., Suda, Y., Matsumoto, T., Kuroda, R., Shinagawa, Y., Gul, S., Claussen, C., Matsui, I., Matsui, Y., & Taguchi, A. (2025) · Aging · doi:10.18632/aging.206256 · Cited by 1

A machine learning-based holistic and age-dependent approach for the diagnosis within the Alzheimer's disease spectrum

Massetti, N., Granzotto, A., Bomba, M., Pizzi, S. D., Mosca, A., Scherer, R., ONOFRJ, M. C., Sensi, S. L., & (ADNI), F. T. A. D. N. I. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.119015 · Cited by 1

Effect of caloric restriction on aging and neurodegenerative diseases

Анатольевна, Ф. Ю., & Мурашев, Б. Ю. (2022) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2022.03.166-176 · Cited by 1

Identification of Genetic Markers and Immune Infiltration Characteristics of Alzheimer’s Disease Through Weighted Gene Co-expression Network AnalysisPreprint

Zhang, Q., Duan, K., Miao, Y., & Tan, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1113029/v1 · Cited by 1

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in micePreprint

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.06.479307 · Cited by 2

Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATPPreprint

Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-927236/v1 · Cited by 2

Small-molecule ketone esters treat brain network abnormalities in an Alzheimer’s disease mouse modelPreprint

Newman, J. C., Ma, K., Kroll, F., Higgins, E., Ulrich, S. M., Palop, J. J., & Verdin, E. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.24.509337 · Cited by 1

Transcriptional Coordination between Mitochondrial and Nuclear Genomes for Oxidative Phosphorylation Is Disrupted in Alzheimer’s BrainPreprint

Shang, Y., Yin, F., & Brinton, R. D. (2022) · Research Square · doi:10.21203/rs.3.rs-2122232/v1 · Cited by 1

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transportPreprint

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2859584/v1 · Cited by 1

Brain Target Engagement by CNM-Au8 in Parkinson’s Disease and Multiple Sclerosis: Integrated Imaging Results from the REPAIR-PD and REPAIR-MS Phase 2 Clinical TrialsPreprint

Ren, J., Dewey, R. B., Rynders, A., Evan, J., Evan, J., Ligozio, S., Ho, K. S., Sguigna, P. V., Glanzman, R., Hotchkin, M. T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3168496/v1 · Cited by 1

Editorial: Dietary polysaccharides and brain health

Liu, Z., Liu, Q., & Qi, G. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1249498 · Cited by 1

Curcumin extends the lifespan of aging postmitotic cells with mitochondrial dysfunctionPreprint

Naaz, A., Zhang, Y., Faidzinn, N. A., Yogasundaram, S., & Alfatah, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.06.556469 · Cited by 1

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in micePreprint

Makhijani, P., Emani, R., Aguirre, C. G., Mu, W., Rane, A., Ng, J. H. Y., Valentino, T. R., Manwaring-Mueller, M., Tan, C. R., Du, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.27.573841 · Cited by 1

Editorial: The role and mechanism of metabolic dysfunction in the development of neurodegenerative disease

Henderson, S. T. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1373532 · Cited by 1

BHB promotes the proliferation of neural stem cells by activating the Erk1/2- MAPK pathway and changing histone modification patternsPreprint

Wang, L., Zhao, T., Shang, S., & Lu, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4566991/v1 · Cited by 1

Ketosis Elevates Antioxidants and Enhances Neural Function Through Improved Bioenergetics: A 1 H MR Spectroscopy StudyPreprint

van Nieuwenhuizen, H., Antal, B. B., Hone‐Blanchet, A., Lithen, A., McMahon, L., Nikolaidou, S., Kuang, Z., Clarke, K., Jenkins, B. G., Rothman, D. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619722 · Cited by 1

Microglia coordinate activity-dependent protein synthesis in neurons through metabolic couplingPreprint

Adler, D. I., Martín‐Ávila, A., Cheng, E., Oliveira, M. M., Zhang, M., Evans, H. T., Yuan, D., Sam, R., Zhang, N., Sellés, M. C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.29.685332 · Cited by 1

LRRK2 I1371V Impairs Astrocytic Glucose Metabolism and Triggers Multi-Organellar Dysfunction in PDPreprint

Banerjee, R., Santhoshkumar, R., Holla, V. V., Kamble, N. L., Yadav, R., Pal, P. K., & Datta, I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700314 · Cited by 1

Requirement for oxidation of neuronal ketone bodies in aging and neurodegenerationPreprint

Yang, J. L., Nomura, M., Meng, J. X., Garcia, T. Y., Matsuura, T. R., Kelly, D. P., Nakamura, K.-I., & Newman, J. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.24.712448 · Cited by 1

Meta analysis of glucose metabolism across Alzheimer’s, Parkinson’s and ALS Reveals emergence of adaptive brain glucometabolic responses and associated neurological functional profilesPreprint

Raikes, A., Garza, M., Murrell, A. N., & Brinton, R. D. (2026) · medRxiv · doi:10.64898/2026.04.07.26350339 · Cited by 1

Mitochondrial Complex I Modulator Restores Network Resilience in Advanced Alzheimer’s Disease Through Metabolic ReprogrammingPreprint

Gabal, E., Nguyen, T. K. O., Kovalenko, T., Gao, H., Rappaport, N., Funk, C. C., Baloni, P., & Trushina, E. V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.14.732179 · Cited by 1

Mitochondriomics reveals the underlying neuoprotective mechanism of TrkB receptor agonist R13 in the 5×FAD micePreprint

Li, X., Li, T., Yu, H., Li, S., Zhang, Z., Xie, Y., Song, X., Liu, J., Yang, X., & Liu, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.08.430227

Visualizing an convergence of three mitochondrial molecule mRNAs for DRP1/MFN2/UCP4 on soma of cerebellar Purkinje cells by RNAscopePreprint

Liu, H., Luo, T., Wu, F., Guo, B., Zhang, K.-L., Li, S., Li, X., Wang, R., Chen, J., Wang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-818426/v1

Visualizing a Convergence of Three Mitochondrial Molecule mRNAs for Drp1/Mfn2/Ucp4 on Soma of Cerebellar Purkinje Cells by RNAscopePreprint

Liu, H., Luo, T., Wu, F., Guo, B., Zhang, K.-L., Li, S., Li, X., Wang, R., Chen, J., Wang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1159900/v1

Antidementia Medications: Pharmacology and Biochemistry

Eckert, A., Grimm, A., & Müller, W. E. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_192-1

Regional changes with global brain hypometabolism indicates a physiological triage phenomenon and can explain shared pathophysiological events in Alzheimer's & small vessel diseases and delirium.

Gupta, S. K., Rutherford, N. K., Dolja‐Gore, X., Watson, T., & Nair, B. (2021) · PubMed Central

New therapeutic opportunities for Alzheimer disease

Jang, J. (2022) · Journal of Geriatric Neurology · doi:10.53991/jgn.2021.00017

Proteomic Comparison of Aged and OPTN E50K Retina in the Development of Normal Tension GlaucomaPreprint

Liu, X., Wang, Q., Shao, Z., Zhang, S., Hou, M., Jiang, M., Du, M., Li, J., & Yuan, H. (2021) · Research Square · doi:10.21203/rs.3.rs-141353/v1

Ketotherapeutics to Rescue Brain Energy Deficits

Myette‐Côté, É., Castellano, C., Fortier, M., St‐Pierre, V., & Cunnane, S. C. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780197501207.003.0017

Potencial neurotrófico e neuroprotetor do fitoquímico carvacrol contra a neurotoxicidade induzida pela acroleína em células PC12

Sisti, F. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2021.tde-22032022-075600

Visualizing an convergence of three mitochondrial molecule mRNAs for DRP1/MFN2/UCP4 on soma of cerebellar Purkinje cells by RNAscopePreprint

Liu, H., Luo, T., Wu, F., Guo, B., Zhang, K.-L., Li, S., Li, X., Wang, R., Chen, J., Wang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-818426/v2

Proteomic Comparison of Aged and OPTN E50K Retina in The Development of Normal Tension GlaucomaPreprint

Liu, X., Wang, Q., Shao, Z., Zhang, S., Hou, M., Jiang, M., Du, M., Li, J., & Yuan, H. (2021) · Research Square · doi:10.21203/rs.3.rs-179540/v1

Effects of Allanblackia floribunda stem-bark Extracts on Oxidative stress and Mitochondrial Dysfunction in Rats Exposed to Crude Oil

Olubodun, S. O., & Ikponmwosa-Eweka, O. (2022) · Caliphate Journal of Science and Technology · doi:10.4314/cajost.v4i2.10

Gene dosage determines the behavioural phenotype in the 5xFAD mouse model of Alzheimer’s disease: analysis of the contribution of brain insulin signalling and gut microbiotaPreprint

Vera, D. M., Zambrana-Infantes, E. N., López-Gambero, A. J., Gonzalez-Jimenez, A., Navarro, J. A., Pavón, F. J., Baixerás, E., Santín, L. J., Suárez, J., Rosell‐Valle, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2087511/v1

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosisPreprint

Matsuyama, M., Ortega, J. T., Fedorov, Y., Scott-McKean, J. J., Muller-Greven, J., Buck, M., Adams, D., Jastrzębska, B., Greenlee, W. J., & Matsuyama, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.12.511987

Nodweddu effaith signalu ghrelin-GHS-R ar awtoffagi niwronaidd

Roberts, L. D. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.62285

Análisis de la relación entre estido de vida mediterráneo, dieta y glaucoma en el proyecto SUN (Seguimiento Universidad de Navarra)

Gándara, E. (2022) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · doi:10.15581/10171/65682

Time-dependent changes in the glycolytic pathway in activated T cells are independent of tumor burden or anti-cancer chemotherapy

Khalil, S. M., Eltaramsy, A., Hegazi, M. M., Mohamed, T. M., Alwasel, S. H., & Salem, M. L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110622

Identification of Shared Pathogenetic Genes in Parkinson’s Disease and Type 2 DiabetesPreprint

Chen, L., Wang, Y., Hu, B., Huang, J., & Huang, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3166035/v1

Editorial: The legacy of Dr. Candance Pert: recent advances in the neuropeptides and neuroreceptors research

Anacleto, P. Z., & Joviano‐Santos, J. V. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1295240

review of variable risk factors affecting the development of mild cognitive impairment in older adults

Zhang, C., Fan, H., & Li, M. (2023) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2023.12.123

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairmentPreprint

Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., et al. (2023) · eLife · doi:10.7554/elife.89376.2

EXPLORING COGNITIVE TRAILS: A REVIEW ON THE BENEFITS OF SUPPLEMENTATION ON COGNITION AND MENTAL PERFORMANCE

Carvalho, J. C. M., Pacheco, G. M. F., de Moura, M. F., Aguiar, R. S., Guizardi, L. F., de Lima, L. P., Barboza, M. M., da Costa, M. N., Campagna, L. N., Landi, G. R., et al. (2024) · International Journal of Health Science · doi:10.22533/at.ed.159432409013

Coconut Oil: Nutrition and Health

Dayrit, F. M. (2024) · Botany, production and uses. · doi:10.1079/9781789249736.0011

Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular couplingPreprint

Deery, H. A., Liang, E., Paolo, R. D., Voigt, K., Murray, G., Siddiqui, M. N., Egan, G. F., Moran, C., & Jamadar, S. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.07.579389

Age-related disease: Eyes

Dow, C. T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00007-4

Eating Behavior and Mental Health during the COVID-19 Pandemic

Silva, J. A. D., & da Silveira, J. A. C. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-4638-3

Brain Energy Problem

Satoh, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-54150-6_2

Neuron World

Satoh, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-54150-6_1

Cardiometabolic state links neurovascular burden with brain structure and function across age: evidence from EEG and MRIPreprint

Franco-O’Byrne, D., Laguardia, A. M. C., Delgado, C., Shine, J. M., Huepe, D., Tagliazucchi, E., Campo, C. G., Ibáñez, A. M., & Medel, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.31.596817

Protein Restriction in Aging and Disease

Brandhorst, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_2

Microwave Radiation Caused Dynamic Metabolic Fluctuations in the Mammalian Hippocampus

Yu, X., Guan, S., Ren, K., Wang, H., Dong, J., Wang, H., Zhang, J., Xu, X., Yao, B., Zhao, L., et al. (2024) · Metabolites · doi:10.3390/metabo14070354

A Comprehensive Review on Alzheimer’s Disease; Pathophysiology and Treatment

Nandini, N., & Cyriac, K. S. (2024) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2024.v84i06.007

Nutrients for Cognitive Function

Sikarwar, R., Gupta, G. D., Srivastava, V., & Saxena, R. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-2947-4.ch018

Brain Glucose Metabolism and COMT Val 158 Met Polymorphism in Female Patients with Work-Related Stress

Madsen, S. S., Andersen, T. L., Pihl‐Thingvad, J., Brandt, L. P. A., Olsen, B. B., Gerke, O., & Videbech, P. (2024) · Diagnostics · doi:10.3390/diagnostics14161730

Prevalence of Cognitive Impairment in Dialysis Patients in Gauteng Province, South Africa

Tebogo, N., Repsold, L., Kwazi, N., & Albert, M. (2024) · Journal of Clinical Nephrology · doi:10.29328/journal.jcn.1001136

Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer’s disease mouse modelsPreprint

M’Bra, P. E. H., Hamilton, L. K., Moquin‐Beaudry, G., Aubin, M., Mangahas, C. L., Pratesi, F., Brunet‐Ratnasingham, E., Castonguay, A., Mailloux, S., Galoppin, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.04.610637

The aging brain, mitochondria, and neurodegenerative disorders

Amin, S. N., Alhanaktah, B., Mohd, O. B., & ShamsEldeen, A. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00003-8

Creatine and TBI

Memudu, A. E., Alex, G. S., & Ihunwo, A. O. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-6341-2_9

The role of cholesterol during remyelination for multiple sclerosis: advances in metabolic regulation, potential therapeutic targets, <?A3B2 pi6?>and drug research

ZHANG, Y., Du, X., Liu, L., Lina, Y. A. N. G., Zhang, J., KeShan, D. O. N. G., YuJie, L. I., Yang, Q., Chen, Y., Zhu, X., et al. (2025) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0208

Ketogenic interventions prevent alterations of the gut microbiome in transgenic Alzheimer’s Disease micePreprint

M’Bra, P. E. H., Avino, M., Lim, E. N. K., Mayhue, M., Balthazar, P., Aumont, A., Prévost, K., Massé, É., & Fernandes, K. J. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.25.640129

Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model

Croteau, É., Richard, G. M., Prud’Homme, P., Rousseau, É., Cunnane, S. C., Dumulon‐Perreault, V., Sarrhini, O., Phoenix, S., Tremblay, S., Guérin, B., et al. (2025) · EJNMMI Research · doi:10.1186/s13550-025-01215-9 · Cited by 1

Metabolic Regulation as a Potential Therapeutic Approach for Alzheimer's Disease

Zhong, J., Sun, J., & Zhou, B. (2025) · Current Alzheimer Research · doi:10.2174/0115672050379410250421065857

Investigating Qi-Centered Interventions for Neurodegenerative Disorders: Trends in Patents and Academic Literature

Lim, H.-S., & Park, G. (2025) · Journal of Environmental Science International · doi:10.5322/jesi.2025.34.4.223

Mitochondrial Dysfunction and Its Impact on Cellular Metabolism in Degenerative Diseases

Safi, S. Z. (2024) · Premier Journal of Neuroscience · doi:10.70389/pjn.100002

A Drosophila model of prion disease and its metabolic changes in the brain

Wang, D., Sun, Z., Wen, P., Zhao, M., He, Y., Gou, F., Wang, J., Fan, Q., Li, X., Ma, T., et al. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70048

Insulin-Enhanced Biological Visual Rehabilitation in Neuroretinal Degeneration Patients Treated with Mesenchymal Cell-Derived Secretome

Limoli, P. G., Limoli, C., & Nebbioso, M. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070901

Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19

Couly, S., Yasui, Y., Grammatikakis, I., Kimura, Y., Hinkle, J. J., Gomez, J. L., Wu, H.-E., Paritosh, G., Lal, A., Michaelides, M., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116092

Variants in glycine decarboxylase activate mechanisms of mitochondrial energy metabolism in the brainPreprint

Lopez‐Ramirez, A., Worth, A. J., Wang, Z., Yılmaz, S., Hayes, S., Farris, J. D., Alam†, M. S., Padmanabhan, P. K., & Haldar, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.12.664515

Systems biology approach in the detection of neuronal disorders

Rao, D., Yadav, S., Chandra, N., Muthamma, T., Sivamani, Y., Pokkuluri, K. S., & Elayaperumal, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33351-4.00016-7

Dietary nutrition and neurological disorders: a review

Li, F., Feng, Z., Li, J., Ma, L., Li, M., Li, S., Liu, S., & Tang, C. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250714

Safety and Preliminary Effectiveness of a Natural, Multi-modal Therapeutic in Postmenopausal Women with ObesityPreprint

Thompson, T., Tanwar, V., Hoskinson, W., Peterson, K. R., SOTHERN, M. S., McKibbin, C. L., Missikpode, C., Kapahi, P., & Dhar, S. (2025) · medRxiv · doi:10.1101/2025.09.04.25335119

Impact Induces Phagocytic Defect in Reactive MicrogliaPreprint

Yu, R., Rogers, E. A., Manchanda, P., Beveridge, C. H., Randolph, C. E., Beauclair, T., Jethava, K. P., Shi, R., & Chopra, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.14.676171

Absolute quantification of brain deuterium metabolic imaging in healthy volunteers and glioblastoma patients at 7TPreprint

Karkouri, J., Novoselova, M., Miller, S., Zhang, M., Constantinou, A., Graf, C., Atkinson, D., Tramm, B., Schillak, S., Mair, R. J., et al. (2025) · medRxiv · doi:10.1101/2025.10.08.25337571

Oxidative brain injury ascending from DMBA: Metabolomics and BRAF3/FKBR/A2m molecular signaling crosstalk

Megeed, R. M. A., Kadry, M. O., Abdel‐Hamid, A. Z., Afifi, S. M., & Ammar, N. M. (2025) · OpenNano · doi:10.1016/j.onano.2025.100261

Clinical Improvements in Autism Spectrum Disorder with Novel Pulsatile Insulin Therapy

Mahajan, P. V. (2025) · doi:10.46889/jrmbr.2025/6303

Autophagy and Brain Longevity

Vijay, A., & Varshney, R. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2790-8_3

An Update Review on Probiotics Against Alzheimer’s Disease: Protective Mechanisms, Current Limitations, and Future Opportunities

Cheng, N., Li, W., Yang, T., Peng, F., Lou, W., & Huang, Z. L. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2587828

Direct Measure of DNA Damage in Huntington Disease Reveals Elevated Oxidative Genotoxic Stress and Dysfunctional DNA RepairPreprint

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Additional file 1 of Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

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Additional file 2 of Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

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Additional file 2 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease

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Additional file 4 of Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

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Additional file 1 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease

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Additional file 3 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease

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Additional file 3 of Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

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Additional file 4 of Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

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Additional file 2 of Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

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Additional file 3 of Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

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Additional file 1 of Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

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