Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382

AMPK: guardian of metabolism and mitochondrial homeostasis

Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

Mercuri, E., Darras, B. T., Chiriboga, C. A., Day, J. W., Campbell, C., Connolly, A. M., Iannaccone, S. T., Kirschner, J., Kuntz, N. L., Saito, K., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1710504 · Cited by 1,433

Lactate in the brain: from metabolic end-product to signalling molecule

Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173

Lactate Contributes to Remote Ischemic Preconditioning–Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase–Mammalian Target of Rapamycin–Transcription Factor EB–Connexin 43 Axis

Yang, Z., Zhang, W., Jin, Q.-Q., Wu, Z.-R., Du, Y.-Y., Shi, H., Qu, Z.-S., Han, X., & Jiang, L. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.005 · Cited by 13

Recent Advances of Mitochondrial Alterations in Alzheimer’s Disease: A Perspective of Mitochondrial Basic Events

Wei, W., Jiang, Y. Y., Hu, G., He, Y., & Chen, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240092 · Cited by 13

Mild cognitive impairment: when nutrition helps brain energy rescue—a report from the EuGMS 2020 Congress

Cunnane, S. C., Sieber, C. C., Swerdlow, R. H., & Cruz-Jentoft, A. J. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00534-z · Cited by 13

No Effect of Calorie Restriction or Dietary Patterns on Spatial Working Memory During a 2-Year Intervention: A Secondary Analysis of the CALERIE Trial

Silver, R. E., Roberts, S. B., Kramer, A. F., Chui, K. K. H., & Das, S. K. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.019 · Cited by 15

Gastrodin Attenuates Cerebral Ischemia–Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the AMPK ‐ OPA1 Signaling Pathway

Liu, Z., Han, Z., Bao, W., Guo, Y., Yuan, Y., Cheng, J., Zhang, J., & Hu, Y. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70559 · Cited by 12

Diabetic encephalopathy: metabolic reprogramming as a potential driver of accelerated brain aging and cognitive decline

Huai, J., Chang, E.-E., Zhu, Y., Ma, W., Lv, T.-S., Sun, J., & Zhou, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1701406 · Cited by 15

Interplay between aging and metabolic diseases: from molecular mechanisms to therapeutic horizons

Zhong, D., Sun, Y., Zhao, L., Hu, Z., Li, G., Li, H., & Xie, Z. (2025) · Medical Review · doi:10.1515/mr-2025-0047 · Cited by 16

Optimization of measurement of mitochondrial electron transport activity in postmortem human brain samples and measurement of susceptibility to rotenone and 4-hydroxynonenal inhibition

Benavides, G. A., Mueller, T., Darley-Usmar, V. M., & Zhang, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102241 · Cited by 12

Exerkines: A Crosstalk between Lactate Production, Exercise and Mental Health

Filho, A. S. S., Barsanulfo, S. R., Faria, S. S., Inácio, P. A., Tafti, F. A., & Machado, S. E. D. C. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273250928231009054658 · Cited by 12

Rational construction and evaluation of a dual-functional near-infrared fluorescent probe for the imaging of Amyloid-β and mitochondrial viscosity

Cao, Y., Xu, S., Liu, J., Zhao, S., & Yan, J. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.123564 · Cited by 12

Neuronal aerobic glycolysis exacerbates synapse loss in aging mice

Zhou, W., Yang, X., Wang, H., Yao, W., Chu, D., & Wu, F. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114590 · Cited by 13

A Brief Review of Low-Level Light Therapy in Depression Disorder

Shirkavand, A., Tavakoli, M. A., & Ebrahimpour, Z. (2023) · Journal of lasers in medical sciences · doi:10.34172/jlms.2023.55 · Cited by 12

Promotion of mature angiogenesis in ischemic stroke by Taohong Siwu decoction through glycolysis activation

Tang, L., Liu, Z., Ji, Z., Zhang, X., Zhao, M., Peng, D., & Han, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1395167 · Cited by 12

Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease

Cohen, B. M., & Sonntag, K. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105238 · Cited by 13

Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction

Naaz, A., Zhang, Y., Faidzinn, N. A., Yogasundaram, S., Dorajoo, R., & Alfatah, M. (2024) · Cells · doi:10.3390/cells13171470 · Cited by 14

Decreased cold‐inducible RNA ‐binding protein ( CIRP ) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure

Jiang, H., Lu, C., Wu, H., Ding, J. M., Li, J., Ding, J., Gao, Y., Wang, G., & Luo, Q. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70059 · Cited by 12

Glucose Metabolic Abnormality: A Crosstalk between Depression and Alzheimer’s Disease

Yang, S., Li, Y., Tang, Q., Zhang, Y., & Shao, T. (2024) · Current Neuropharmacology · doi:10.2174/011570159x343281240912190309 · Cited by 12

Spatiotemporal control of kinases and the biomolecular tools to trace activity

Burton, J. C., Royer, F. T., & Grimsey, N. J. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107846 · Cited by 13

The Impact of HIV on Early Brain Aging—A Pathophysiological (Re)View

Lazăr, M., Moroti, R., Barbu, E. C., Chițu, C. E., Tilişcan, C., Erculescu, T. M., Rosca, R. R., Frasila, S., Schmilevschi, E. T., Simion, V., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237031 · Cited by 12

High‐intensity interval exercise is more efficient than medium intensity exercise at inducing neurogenesis

Lambertus, M., Geiseler, S. J., & Morland, C. (2024) · The Journal of Physiology · doi:10.1113/jp287328 · Cited by 13

Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model

Carrasco, M., Guzman, L., Olloquequi, J., Cano, A. C., Fortuna, A. C., Vázquez‐Carrera, M., Verdaguer, E., Auladell, C., Ettcheto, M., & Camins, A. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01106-8 · Cited by 12

Microalgae as an emerging alternative raw material of docosahexaenoic acid and eicosapentaenoic acid – a review

Sharma, T., Das, N., Kakkar, P. M., Mohapatra, R. K., Pamidimarri, S. D. V. N., Singh, R. K., Kumar, M., Guldhe, A., & Nayak, M. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2486267 · Cited by 14

Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease

Viel, C., Brandtner, A. T., Weißhaar, A., Lehto, A., Fuchs, M., & Klein, J. (2021) · Pharmaceuticals · doi:10.3390/ph14121218 · Cited by 13

Genome-wide Survival Study Identifies PARL as a Novel Locus for Clinical Progression and Neurodegeneration in Alzheimer’s Disease

Chen, S.-D., Zhang, W., Feng, Y., Wu, B., Liu, Y., Zhang, Y., Wang, H.-F., Guo, Y., Deng, Y., Feng, J., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.02.992 · Cited by 13

Interactions between estradiol, diabetes, and brain aging and the risk for cognitive impairment

Hugenschmidt, C. E., Duran, T., & Espeland, M. A. (2021) · Climacteric · doi:10.1080/13697137.2021.1877652 · Cited by 13

Increased RNA Transcription of Energy Source Transporters in Circulating White Blood Cells of Aged Mice

Takeuchi, Y., Saino, O., Okinaka, Y., Ogawa, Y., Akamatsu, R., Kikuchi-Taura, A., Kataoka, Y., Maeda, M., Gul, S., Claussen, C., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.759159 · Cited by 11

Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ

Hemmerich, M., Malorny, N., Lewen, A., Hollnagel, J., Chausse, B., & Kann, O. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577881 · Cited by 11

Fibroblast growth factor 21 exerts a protective effect on diabetes-induced cognitive decline by remodeling cerebral glucose and neurotransmitter metabolism in mice

Zhang, X., Zheng, H. X., Ni, Z., Shen, Y., Wang, D., Li, W., Zhao, L., Li, C., & Gao, H. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhad502 · Cited by 11

Improving mitochondrial function for alleviating memory decline of aging mice via dual-delivering lycopene nanoparticles

Xia, X., Li, H., Xu, X., Wang, Z., Zhao, G., & Du, M. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102132 · Cited by 11

Dietary sn-2 palmitate influences cognitive behavior by increasing the transport of liver-produced lysophosphatidylcholine VLCPUFAs to the brain

Wei, T., He, Y., Tan, D., Zeng, X., Hou, Y., Wang, J., Jiang, H., Deng, Z., & Li, J. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140955 · Cited by 12

Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy

Tian, H., Yao, J., Ba, Q., Meng, Y., Cui, Y., Quan, L., Gong, W., Wang, Y., Yang, Y., Yang, M., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.058 · Cited by 12

Decoding the influence of mitochondrial Ca2+ regulation on neurodegenerative disease progression

Sun, J., Gao, G., Wang, S., Liu, H., & Tang, T.-S. (2025) · Mitochondrial Communications · doi:10.1016/j.mitoco.2025.01.001 · Cited by 11

Withania somnifera Regulates Mitochondrial Biogenesis and Energetics in Rat Cortical Neurons: Role of BDNF and SIRT1

Fanibunda, S. E., Kukkemane, K., Ghai, U., Kolthur‐Seetharam, U., Hingorani, L., Vaidya, A. D. B., & Vaidya, V. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04920-7 · Cited by 14

PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1 mice

Zhang, Z., Guo, X., Liu, Y., Ke, P., Meng, Y., Gu, J., Hu, L.-Q., Yuan, Z., Duan, R., Luo, J., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.012 · Cited by 11

Applications and Challenges of Machine Learning Methods in Alzheimer's Disease Multi-Source Data Analysis

Li, X., Qiu, Y., Zhou, J. H., & Xie, Z. (2021) · Current Genomics · doi:10.2174/1389202923666211216163049 · Cited by 11

Glycolytic metabolism supports microglia training during age-related neurodegeneration

Camacho‐Morales, A. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00363-2 · Cited by 11

Microglial autophagy in cerebrovascular diseases

Chen, M., Zhang, H., Chu, Y., Tang, Y., Pang, X., Qin, C., & Tian, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1023679 · Cited by 11

Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease

Bosworth, A., Loh, V., Stranahan, B. N., & Palmer, C. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1085512 · Cited by 14

In Vivo Investigation of Glucose Metabolism in Idiopathic and PRKN‐Related Parkinson's Disease

Borsche, M., Märtens, A., Hörmann, P., Brückmann, T., Lohmann, K., Tunç, S., Klein, C., Hiller, K., & Balck, A. (2023) · Movement Disorders · doi:10.1002/mds.29333 · Cited by 10

Stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice

McNair, L. F., Andersen, J. V., & Waagepetersen, H. S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105626 · Cited by 11

The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?

Daalen, J. M. J., Koopman, W. J. H., Saris, C. G. J., Meinders, M. J., Thijssen, D. H. J., & Bloem, B. R. (2023) · Movement Disorders · doi:10.1002/mds.29688 · Cited by 11

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes

Nelson, A. T., Cicardi, M. E., Markandaiah, S. S., Han, J. Y., Philp, N. J., Welebob, E. M., Haeusler, A. R., Pasinelli, P., Manfredi, G., Kawamata, H., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00140-7 · Cited by 11

A Genome-Wide Association Study in Human Lymphoblastoid Cells Supports Safety of Mitochondrial Complex I Inhibitor

Gao, H.-Y., Tripathi, U., Trushin, S., Okromelidze, L., Pichurin, N. P., Wei, L., Zhuang, Y.-X., Wang, L.-W., & Trushina, E. (2021) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2021.02.005 · Cited by 11

Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β

Hamilton, K., Morrow, K., Markantoni, E., & Harvey, J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15980 · Cited by 10

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

Makhijani, P., Valentino, T. R., Manwaring-Mueller, M., Emani, R., Mu, W., Aguirre, C. G., Tan, C. R., Rane, A., Wilson, K. A., Kifle, A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116109 · Cited by 13

Astrocytes as Metabolic Sensors Orchestrating Energy‐Driven Brain Vulnerability in Alzheimer's Disease

de Muniain, L. S., Escalada, P., Ramírez, M. J., & Solas, M. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70252 · Cited by 11

Intracellular spatiotemporal metabolism in connection to target engagement

Zhang, J., Qiu, Z., Zhang, Y. J., Wang, G., & Hao, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115024 · Cited by 10

Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of Alzheimer’s Disease

Abghari, M., Vu, J. T. C. M., Eckberg, N., Aldana, B. I., & Kohlmeier, K. A. (2023) · Biomolecules · doi:10.3390/biom13101461 · Cited by 12

Ropinirole reverses the effects of neuroinflammation, and cellular demise by downregulating the MARK4-NFκβ signaling system in Alzheimer's disease

Neha, N., Anwar, S., Pinky, P., Hassan, M. I., & Parvez, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132425 · Cited by 10

The Evolving Use of Gold Nanoparticles as a Possible Reversal Agent for the Symptoms of Neurodegenerative Diseases: A Narrative Review

Kaye, A. D., Sala, K. R., Dethloff, D. R., Norton, M., Moss, C., Plessala, M. J., Derouen, A. G., Torres, Y. L., Kim, J. S., Tirumala, S. R., et al. (2024) · Cureus · doi:10.7759/cureus.64846 · Cited by 12

Metabolic preferences of astrocytes: Functional metabolic mapping reveals butyrate outcompetes acetate

Ameen, A. O., Nielsen, S. W., Kjær, M. W., Andersen, J. V., Westi, E. W., Freude, K., & Aldana, B. I. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241270457 · Cited by 13

Cytoskeleton dysfunction of motor neuron in spinal muscular atrophy

Shi, T., Zhou, Z., Xiang, T., Suo, Y., Shi, X., Li, Y., Zhang, P., Dai, J., & Sheng, L. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12724-3 · Cited by 10

Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer’s disease

Guo, H., Ou, H., Yu, J., Rosa, J. M., Formolo, D. A., Cheng, T., Yau, S., & Tsang, H. W. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-00943 · Cited by 11

Intranuclear TCA and mitochondrial overload: The nascent sprout of tumors metabolism

Yuan, W., Lu, G., Zhao, Y., He, X., Liao, S., Wang, Z., Lei, X., Xie, Z., Yang, X., Tang, S., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217527 · Cited by 13

The polysaccharides from Hemerocallis citrina Baroni alleviate cognitive impairment in high-fat diet/streptozocin-induced type 2 diabetic mice

Liu, X., Wu, Y., Jiang, W., Ma, K., Du, J., & Li, J. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106701 · Cited by 10

Systemic Neuroprotection by Chlorogenic Acid: Antioxidant and Anti-inflammatory Evaluation in Early Neurodegeneration Induced by 3-Nitropropionic Acid in Mice

Cantero-Téllez, A., Moreno‐Fierros, L., Gutiérrez‐Ospina, G., Santiago-Prieto, A. C., Juárez, I., Rodríguez‐Sosa, M., & Hernández, E. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04356-4 · Cited by 10

Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration

Chen, X., Zhou, Y., Yao, W., Gao, C., Sha, Z., Yi, J., Wang, J., Liu, X., Dai, C., Zhang, Y., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00411-6 · Cited by 19

Gastrodin alleviates Aβ25–35-induced glycolytic dysfunction via activating PI3K/AKT/BACH1 signaling in Alzheimer's disease models

Liu, T., Yang, X., Lei, H.-P., Hu, Y., Wu, L.-N., Wei, A., Ji, X., Liu, J., Jin, H. J., Shi, J., et al. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115225 · Cited by 10

The thermodynamic hypothesis of protein aggregation

Vendruscolo, M. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101364 · Cited by 12

The Interplay between the Gut and Ketogenic Diets in Health and Disease

Mu, C., Rho, J. M., & Shearer, J. (2025) · Advanced Science · doi:10.1002/advs.202504249 · Cited by 11

Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?

Nagpal, D., Nema, S., Nagpal, S., Pandey, M. M., Kaushik, D. K., & Kathuria, H. (2025) · Antioxidants · doi:10.3390/antiox14091078 · Cited by 13

Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain

Pourmajidian, M., Hansen, J. Y., Shafiei, G., Mišić, B., & Dagher, A. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003619 · Cited by 11

Nutrition-Based Approaches in Clinical Trials Targeting Cognitive Function: Highlights of the CTAD 2020

Giudici, K. V. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2021.6 · Cited by 10

Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models

Hasan, M. F., & Trushina, E. V. (2022) · Brain Sciences · doi:10.3390/brainsci12050552 · Cited by 10

COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence

Wang, Z., Ma, Y., Chen, Z., Yang, R., Liu, Q., Pan, J., Wang, J., Liu, Y., Zhou, M., Zhang, Y., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.981471 · Cited by 10

Adiposity and Insulin Resistance Moderate the Links between Neuroelectrophysiology and Cognitive Functions

Larsen, B. A., Klinedinst, B. S., Wolf, T., McLimans, K. E., Wang, Q., Pollpeter, A., Li, T., Mohammadiarvejeh, P., Fili, M., Grundy, J. G., et al. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114321 · Cited by 14

Relevant Aspects of Combined Protocols for Prevention of N(M)AFLD and Other Non‐Communicable Diseases

Videla, L. A., Valenzuela, R., Zúñiga‐Hernández, J., & del Campo, A. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400062 · Cited by 10

Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer’s Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study

Zhang, L., Xu, J., Guo, J., Wang, Y., & Wang, Q. (2023) · Molecules · doi:10.3390/molecules28155846 · Cited by 11

ROCK Inhibitor Fasudil Attenuates Neuroinflammation and Associated Metabolic Dysregulation in the Tau Transgenic Mouse Model of Alzheimer’s Disease

Ouyang, X., Collu, R., Benavides, G. A., Tian, R., Darley-Usmar, V. M., Xia, W., & Zhang, J. (2024) · Current Alzheimer Research · doi:10.2174/0115672050317608240531130204 · Cited by 9

Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exercise

Seferi, G., Mjønes, H. S., Havik, M., Reiersen, H., Dalen, K. T., Nordengen, K., & Morland, C. (2024) · Life Science Alliance · doi:10.26508/lsa.202302239 · Cited by 9

Exercise preconditioning mitigates Ischemia-Reperfusion injury in rats by enhancing mitochondrial respiration

Liang, R., Hou, X., Zhou, D., Zhu, L., Teng, L., Song, W., & Tang, Q. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.045 · Cited by 9

Lactate supplementation after hypoglycemia alleviates cognitive dysfunction induced by recurrent non-severe hypoglycemia in diabetic mice

Wu, Y., Gao, R., Huang, Q., Huang, C., Wang, L., Lin, L., He, G., Wu, K., Liu, X., Liu, X., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115037 · Cited by 9

Fasting the brain for mental health

Pérez‐Kast, R. C., & Camacho‐Morales, A. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.11.041 · Cited by 10

The mitochondrial function of peripheral blood cells in cognitive frailty patients

Li, Q., Huang, T., Zhang, D., Wei, L., Li, G., Zhu, Q., Tong, Q., Ding, G., & Liu, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1503246 · Cited by 9

Rock inhibitors in Alzheimer’s disease

Zheng, C., Xia, W., & Zhang, J. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1547883 · Cited by 11

Gastrodin alleviates mitochondrial energy metabolism dysfunction via activating β-catenin/c-Myc/MCT2 signaling in Alzheimer's disease models

Lei, H.-P., Yang, X., Hu, Y., Wu, L.-N., Wei, A., Yu, L., Liu, T., Ji, X., Liu, J., Jin, H. J., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120548 · Cited by 9

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Seo, D. H., Kim, M., Cho, Y., Ahn, S. H., Hong, S., & Kim, S. H. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154386 · Cited by 11

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Inoue, Y., Wang, H., Heckman, M. G., Ren, Y., White, L. J., Lü, W., Wang, P., Julia, T. C. W., Koga, S., Alnobani, A., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02949-5 · Cited by 9

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