Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

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AMPK: guardian of metabolism and mitochondrial homeostasis

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A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

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The mechanisms of action of metformin

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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

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Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

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Lactate in the brain: from metabolic end-product to signalling molecule

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Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

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mTOR-Mediated Immunometabolic Reprogramming Nanomodulators Enable Sensitive Switching of Energy Deprivation-Induced Microglial Polarization for Alzheimer’s Disease Management

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L ‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA 1

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Ketogenic diet uncovers differential metabolic plasticity of brain cells

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Mitochondria Transfer in Brain Injury and Disease

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Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age

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Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions

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Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease

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Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression

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Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions

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Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease

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Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

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Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling

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Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention

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Deuterium Metabolic Imaging of the Healthy and Diseased Brain

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Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials

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Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

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Mitochondrial Sirtuins in Parkinson’s Disease

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Chlorogenic Acid Ameliorates High-Fat and High-Fructose Diet-Induced Cognitive Impairment via Mediating the Microbiota–Gut–Brain Axis

Zhang, S. Q., Tian, D., Hu, C. Y., & Meng, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07479 · Cited by 54

The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming

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Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

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Role of primary aging hallmarks in Alzheimer´s disease

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The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

Dogaru, B. G., & Munteanu, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612555 · Cited by 51

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice

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Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

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Sex differences in Alzheimer’s disease: metabolic reprogramming and therapeutic intervention

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Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice

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Mode and Mechanism of Action of Omega-3 and Omega-6 Unsaturated Fatty Acids in Chronic Diseases

Xu, R., Molenaar, A. J., Chen, Z., & Yuan, Y. (2025) · Nutrients · doi:10.3390/nu17091540 · Cited by 64

Memory and eating: A bidirectional relationship implicated in obesity

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Lower brain glucose metabolism in normal ageing is predominantly frontal and temporal: A systematic review and pooled effect size and activation likelihood estimates meta‐analyses

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Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

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The Legend of ATP: From Origin of Life to Precision Medicine

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Recent advances in metal oxide affinity chromatography materials for phosphoproteomics

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Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

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Fasting for 20 h does not affect exercise‐induced increases in circulating BDNF in humans

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The Role of Acyl-CoA β-Oxidation in Brain Metabolism and Neurodegenerative Diseases

Szrok-Jurga, S., Turyn, J., Hebanowska, A., Świerczyński, J., Czumaj, A., Śledziński, T., & Stelmańska, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813977 · Cited by 49

Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice

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Can Natural Products Exert Neuroprotection without Crossing the Blood–Brain Barrier?

Leclerc, M., Dudonné, S., & Calon, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073356 · Cited by 50

Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease

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Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?

Anitha, A., Thanseem, I., Iype, M., & Thomas, S. V. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.01.002 · Cited by 47

Adaptive Metabolic Responses Facilitate Blood‐Brain Barrier Repair in Ischemic Stroke via BHB‐Mediated Epigenetic Modification of ZO‐1 Expression

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Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors

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Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of TCA cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice

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Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease

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Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists

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Predictive metabolic networks reveal sex‐ and APOE genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease

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Ketogenic interventions in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease: A systematic review and critical appraisal

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Targeting PDK2 rescues stress-induced impaired brain energy metabolism

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Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations

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The blood-brain barrier, a key bridge to treat neurodegenerative diseases

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PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues

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Astrocytes in depression and Alzheimer’s disease

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Ketones: potential to achieve brain energy rescue and sustain cognitive health during ageing

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Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation

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The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction

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Lower GLUT1 and unchanged MCT1 in Alzheimer’s disease cerebrovasculature

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Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation

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Exercise improves choroid plexus epithelial cells metabolism to prevent glial cell-associated neurodegeneration

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Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

Mutalib, N. A., Mohamad, S. A. S., Jusril, N. A., Hasbullah, N. I., Amin, M. C. I. M., & Ismail, N. H. (2023) · Pharmaceuticals · doi:10.3390/ph16050712 · Cited by 47

Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review

Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15143106 · Cited by 46

Impact of supplementation with vitamins B6 , B12 , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review

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Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function

Li, Y., Yang, L., Hu, F., Xu, J., Ye, J., Liu, S., Wang, L., Zhuo, M., Ran, B., Zhang, H., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c04341 · Cited by 40

Maintenance of mitochondrial homeostasis for Alzheimer's disease: Strategies and challenges

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Decoding metabolic signatures in Alzheimer’s disease: a mitochondrial perspective

Bano, D., Ehninger, D., & Bagetta, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01732-3 · Cited by 41

Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment

Poor, S. R., Ettcheto, M., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Olloquequi, J., Camins, A., & Javan, M. (2021) · Pharmaceuticals · doi:10.3390/ph14090890 · Cited by 41

Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

Долгачева, Л. П., Зинченко, В. П., & Goncharov, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113043 · Cited by 43

Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics

Avgerinos, K. I., Mullins, R. J., Vreones, M. P., Mustapić, M., Chen, Q., Melvin, D. L., Kapogiannis, D., & Egan, J. M. (2022) · Cells · doi:10.3390/cells11213372 · Cited by 41

Therapeutic Potential of Targeting Mitochondria for Alzheimer’s Disease Treatment

Atlante, A., Amadoro, G., Latina, V., & Valenti, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226742 · Cited by 40

A comprehensive perspective of Huntington’s disease and mitochondrial dysfunction

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The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review

Kuang, G., Halimitabrizi, M., Edziah, A.-A., Salowe, R., & O’Brien, J. M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1184060 · Cited by 44

Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation

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Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches

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Mitochondrial transplantation in brain disorders: Achievements, methods, and challenges

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Cross-sectional investigation of insulin resistance in youths with autism spectrum disorder. Any role for reduced brain glucose metabolism?

Manco, M., Guerrera, S., Ravà, L., Atti, M. L. C. D., Vara, S. D., Valeri, G., & Vicari, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01345-3 · Cited by 38

Glucose uptake by GLUT1 in photoreceptors is essential for outer segment renewal and rod photoreceptor survival

Daniele, L. L., Han, J. Y. S., Samuels, I. S., Komirisetty, R., Mehta, N. K., McCord, J. L., Yu, M., Wang, Y., Boesze‐Battaglia, K., Bell, B. A., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200369r · Cited by 38

The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease

Hamilton, K., & Harvey, J. (2021) · Pharmaceuticals · doi:10.3390/ph14010052 · Cited by 36

The role of ApoE-mediated microglial lipid metabolism in brain aging and disease

Yen, J.-H. J., & Yu, I.-C. I. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000018 · Cited by 38

Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts

Ma, Q., Lei, J., Pang, Y., Yu, S., & Zhang, T. (2025) · Environment & Health · doi:10.1021/envhealth.5c00087 · Cited by 43

Dual-acting agents for improving cognition and real-world function in Alzheimer’s disease: Focus on 5-HT6 and D3 receptors as hubs

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