Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382

AMPK: guardian of metabolism and mitochondrial homeostasis

Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

Mercuri, E., Darras, B. T., Chiriboga, C. A., Day, J. W., Campbell, C., Connolly, A. M., Iannaccone, S. T., Kirschner, J., Kuntz, N. L., Saito, K., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1710504 · Cited by 1,433

Lactate in the brain: from metabolic end-product to signalling molecule

Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173

New horizons: disrupted brain energy metabolism as a driver of delirium

Sabharwal, M., Boyd, G., & Cunningham, C. M. (2026) · Age and Ageing · doi:10.1093/ageing/afag024 · Cited by 2

Cerebral capillary computation

Longden, T. A. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2026 · Cited by 2

Responsive nanoparticles modulating microglia lactate transport alleviate M1-type polarization and neuroinflammation for brain injury therapy

Ma, Y., Chen, G., Xu, P., Wang, B., Teng, T., Zheng, Y., Liu, Y., Zhang, Q., Lai, T., Wang, Z., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04355-9 · Cited by 2

Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline

Alameen, A. A. M., Al‐kuraishy, H. M., Fawzy, M. N., & Batiha, G. E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05309-6 · Cited by 4

The Glymphatic system: A dynamic regulator of brain health and therapeutic target

Wang, X., Gao, M., Sui, S., Liu, F., Tian, W., Wu, S., Ding, J., Chao, X., Xie, X., Gu, M., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115825 · Cited by 3

Targeting mitochondrial dysfunction to quell neuroinflammation in central nervous system (CNS): a new strategy for treating CNS disease with nanomedicines

Wang, S., Liu, M., Shi, X., Xiong, T., Li, R., Zheng, W., Huang, Q., Nan, Y., & Ai, K. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.05.020 · Cited by 2

Alzheimer's disease biological domain sub‐stratification enhances the precision of functional analyses

Cary, G. A., Ganesh, S. S. A., Heath, L. M., Leal, K., Kampmann, M., Longo, F. M., Butler, R. R., Levey, A. I., Carter, G. W., & Wiley, J. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71403 · Cited by 2

Decoding lactate signals in Alzheimer’s disease: redox control, receptor pharmacology, lactylation chemistry, and neuroglial vulnerability

Zaman, W., Ayaz, A., & Ullah, A. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118275 · Cited by 2

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Li, W., Rimal, S., Bhurtel, S., Yeung, L., Lu, B. G., Grinberg, L. T., Spina, S., Cobos, I., Seeley, W. W., Guo, S., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.07.012 · Cited by 2

Noninvasive Delivery of Biologicals to the Brain

Jordan, S., Zielinski, M. A., Kortylewski, M., Kuhn, T. P., & Bystritsky, A. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20210028 · Cited by 2

New Tiaoxin Recipe Alleviates Energy Metabolism Disorders in an APPswe/PS1DE9 Mouse Model of Alzheimer’s Disease

Hu, Y., Xing, S., Huang, Y., Chen, C., Shen, D., & Chen, J. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230428112358 · Cited by 2

Alteration of metabolic profile during the progression of Alzheimer’s disease

Yu, W., Li, X., Han, T.-L., Lü, Y., Long, F., Hu, C., Yu, W., & Lü, Y. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.061193 · Cited by 2

Accumulation of Prion Triggers the Enhanced Glycolysis via Activation of AMKP Pathway in Prion-Infected Rodent and Cell Models

Fan, Q., Xiao, K., Ruhan, A., Gao, L., Wu, Y.-Z., Chen, D., Hu, C., Jia, X.-X., Liu, C.-M., Liu, X., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03621-3 · Cited by 2

Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models

Weber, F. B., Santos, C. L., da Silva, A., Schmitz, I., Rezena, E., Gonçalves, C., Quincozes‐Santos, A., & Bobermin, L. D. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-00896-1 · Cited by 2

Identification of biomarkers of Alzheimer's disease and their characterization of immune function

Lin, M., Zhou, Y., Liang, P., Zheng, R., Du, M., Ke, X., Zhang, W., & Shang, P. (2024) · Archives of Medical Science · doi:10.5114/aoms/188721 · Cited by 2

Study of the immune disorder and metabolic dysregulation underlying mental abnormalities caused by exposure to narrow confined spaces

Zhang, X., Qiao, Y., Wang, M., Liang, X., Wei, L., Zhang, M., Bi, H., & Gao, T. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149101 · Cited by 2

Challenges and Frontiers in Computational Metabolic Psychiatry

Chesebro, A. G., Antal, B. B., Weistuch, C., & Mujica-Parodi, L. R. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.10.011 · Cited by 2

Mitigating the Impact of High-Fat Diet: The Role of Metformin and Exercise Interventions in Alleviating Autism-Like Behaviors and Insulin Resistance in Mice

Ebrahimi, A., Sabaghi, A., Nedaei, S. E., & Yousofvand, N. (2025) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-024-00323-7 · Cited by 2

Suppression of PCK1 attenuates neuronal injury and improves post-resuscitation outcomes

Xu, R., Li, J., Zhu, J. F., Guo, F., Zhang, C., Chen, K., & Xu, J. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167674 · Cited by 2

Role of Liposomes in the Treatment of Neurodegenerative Disorders: A Comprehensive Review

Garg, N., Dhankhar, S., Dhariya, A., Parkash, C., Chauhan, S., & Singh, T. G. (2025) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249342585241230065557 · Cited by 2

Mechanism of action of synaptic mitochondrial damage in delayed cognitive recovery

Miao, H., Liu, Q., Liu, Y., Yan, B.-B., Jiao, X., Wang, H., Zhou, C.-H., Li, T., Xie, Z., & Wu, Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01126 · Cited by 3

Seizure and redox rescue in a model of glucose transport deficiency

Coggan, J. S., Shichkova, P., Markram, H., & Keller, D. X. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012959 · Cited by 2

Fueling Brain Inhibition: Integrating GABAergic Neurotransmission and Energy Metabolism

Walls, A. B., Andersen, J. V., Waagepetersen, H. S., & Bak, L. K. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04384-0 · Cited by 3

Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms

Rodríguez‐Casado, A., Álvarez, M., Merino, J. J., Tolédano, A., & Tolédano, A. (2025) · Current Alzheimer Research · doi:10.2174/0115672050375461250325074826 · Cited by 3

Association between ketone metabolism and the risk of depression: An observational and Mendelian randomization study

Dong, X., Aveyard, P. N., Guess, N. D., Huang, N., Huang, T., & Gao, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119594 · Cited by 2

Nucleoredoxin-like 2 metabolic signaling impairs its potential contribution to neurodegenerative diseases

Corsi, M., Jaillard, C., & Léveillard, T. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346476 · Cited by 2

Weight loss in a cardiovascular trial population identifies people at future risk of dementia

van der Veere, P. J., Hammami, I., Buck, G. A. N., Greenland, M., Offer, A. R., Nunn, M., Whiteley, W. N., Bulbulia, R. A., Collins, R., Armitage, J., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12352 · Cited by 2

Anti-dementia Medications: Pharmacology and Biochemistry

Eckert, A., Grimm, A., & Müller, W. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_192 · Cited by 2

Purine and lipid metabolism in rats with a rotenone model of Parkinson’s disease under the influence of methanindiazenone

Shtanova, L. Y., Veselsky, S. P., Yanchuk, P. I., Tsymbalyuk, О. V., Москвина, В. С., Shablykina, O. V., Moroz, O. F., Vovkun, T. V., Kravchenko, О. V., & Khilya, V. P. (2022) · Fìzìologìčnij žurnal · doi:10.15407/fz68.06.018 · Cited by 2

Ethics of therapeutic foods consumption for Neurodegenerative Diseases and Hormesis-Based Anti-Aging Strategies

Olaniran, A. F., Taiwo, A. E., Alike-Peter, M. E., Okonkwo, C. E., Sanusi, A., Olaniran, O. D., & Erinle, O. C. (2023) · International Conference on Science, Engineering and Business for Sustainable Development Goals (SEB-SDG) · doi:10.1109/seb-sdg57117.2023.10124581 · Cited by 2

Effects of acute exercise of different modalities and durations on interference control and response inhibition in healthy young adults

Tian, S., Mou, H., & Qiu, F. (2023) · International Journal of Sport and Exercise Psychology · doi:10.1080/1612197x.2023.2216207 · Cited by 2

Research Progress of Mitophagy in Alzheimer's Disease

Yao, J., Kan, B., Dong, Z., & Tang, Z. (2023) · Current Alzheimer Research · doi:10.2174/0115672050300063240305074310 · Cited by 2

Association of diabetes mellitus with dementia‐ and non‐dementia‐related mortality amongst women: a secondary competing risks analysis of the California Teachers Study

Morgan, C., Annegers, B., Taylor, M., Fox, S. S., & Titcomb, T. J. (2024) · European Journal of Neurology · doi:10.1111/ene.16294 · Cited by 2

Molecular Regulation of Fetal Brain Development in Inbred and Congenic Mouse Strains Differing in Longevity

Islam, M., & Behura, S. K. (2024) · Genes · doi:10.3390/genes15050604 · Cited by 2

Energy Metabolism | Brain Energy Metabolism

Panov, A. V., & Dikalov, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00323-6 · Cited by 3

Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytesPreprint

Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M. C., Ludlam, A., Allen, S. L., Prosser, S., Chen, R. E., Martínez‐Jarquín, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.23.554346 · Cited by 2

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalancePreprint

Irmen, R. E., Turner, S. M., Snipes, J. A., Williams, H. C., Velmurugan, G. V., Hunt, J. B., Li, J., Sullivan, P. G., Lee, D. C., Johnson, L. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.25.666872 · Cited by 2

The Effect of Exogenous Ketone Bodies on Cognition in Patients with Mild Cognitive Impairment, Alzheimer’s Disease and in Healthy Adults: A Systematic Review and Meta-AnalysisPreprint

Bonnechère, B., Stephens, E. B., Boileau, A. C., Ducker, M., & Stubbs, B. J. (2025) · medRxiv · doi:10.1101/2025.09.17.25335999 · Cited by 2

Ketone body β-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanismPreprint

Rossitto, L.-A. M., Foo, J., Silvestri, J. M. D., Lehmann, L. M., Brunelli, M., Nie, Y., Muñoz-Mayorga, D., Xiao, Q., Dai-Liu, A. Y., Jati, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.30.702936 · Cited by 2

[Forsythiaside B inhibits cerebral ischemia/reperfusion-induced oxidative stress injury in mice via the AMPK/DAF-16/FOXO3 pathway].

Chen, X., WANG, K.-F., Chu, D., Zhu, Y., Zhang, W., Cao, H., Xie, W., Lu, C., & Li, X. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.02.06 · Cited by 1

Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing

Zilberter, Y., & Zilberter, T. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00013 · Cited by 1

Does enhanced cognitive performance reduce fracture risk? a Mendelian randomization study

Luo, S., Deng, L., Chen, Y., Zhou, W., Canavese, F., & Li, L. (2023) · Aging · doi:10.18632/aging.205325 · Cited by 1

Multifunctional Tasks and an Energy Crisis are Crucial Players in Determining the Vulnerability of the Entorhinal Cortex to Early Damage in Alzheimer’s Disease

Sivanesan, S., Howell, M. D., Kaushik, V., Rajadas, J., Pari, S. S., & Goyal, P. (2024) · Current Alzheimer Research · doi:10.2174/0115672050324909240823104209 · Cited by 1

An introduction to neurodegenerative disorders: Pathophysiology, hallmarks, and mechanisms at a glance

Dilawari, R., Barik, M., & Singh, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00003-9 · Cited by 1

Impacts of aging on brain metabolism

Rodrigues, B. A., Santiago, T. C., & Silva, J. D. N. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.05.009 · Cited by 2

Brain glucose and ketone metabolism in first-episode psychosis: Neuroimaging and brain metabolism before and after antipsychotic treatment: The protocol for the CAST-ATP study

Zemmour, K., Samson, G.-O., Fortier, M., Parent, E., Leus, A., Grignon, S., Carrier, J., Whittingstall, K., Danielsen, A. A., Köhler‐Forsberg, O., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325489 · Cited by 1

Ketosis Elevates Antioxidants and Markers of Energy Metabolism: A Proton Magnetic Resonance Spectroscopy Study

van Nieuwenhuizen, H., Antal, B. B., Hone‐Blanchet, A., Lithen, A., McMahon, L., Nikolaidou, S., Kuang, Z., Clarke, K., Jenkins, B. G., Rothman, D. L., et al. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.06.009 · Cited by 1

Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson's disease

Zampese, E., Moran, J., & Surmeier, D. J. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00039-6 · Cited by 1

Selective resilience in brain aging: challenging the scope of the disposable soma theory

Feltes, B. C. (2025) · Biogerontology · doi:10.1007/s10522-025-10292-1 · Cited by 1

The mechanisms in glucose metabolism of aging hippocampus

He, R., Zhao, F., Yang, Z., Wang, T., Zhang, Y., Quan, J., & Zhu, G. (2025) · Ibrain · doi:10.1002/ibra.12201 · Cited by 1

Impact of O ‐ GlcNAcylation Elevation on Mitophagy and Glia in the Dentate Gyrus

Kramer, J., Fu, S. Y., Ouyang, X., Rohwer, E., Chatham, J. C., Young, M. E., Darley-Usmar, V. M., & Zhang, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70205 · Cited by 1

Potential therapeutic benefit of exogenous ketone ester administration in delirium: a narrative review

Smith, R. J., Harrison, F. E., Bastarache, J. A., Roberson, S. W., Zaganjor, E., Pandharipande, P. P., Rice, T. W., & Ely, W. (2025) · Critical Care · doi:10.1186/s13054-025-05680-5 · Cited by 1

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles ( Lasiopodomys brandtii ): Behavioral and Transcriptomic Insights

Li, M., Qiao, C., Li, X., Huang, M., Wang, Z., & Shi, L. (2025) · Integrative Zoology · doi:10.1111/1749-4877.70010 · Cited by 1

Connexin 43 hemichannel-mediated ATP release in depression: recent advances and mechanistic insights

Wang, Y.-C., Chen, N., & Wang, Z. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124047 · Cited by 1

Early structural hub disruption leads to premature functional adaption in multiple sclerosis

Stellmann, J., Maarouf, A., Nicolescu, M., Boutière, C., Rico, A., Zaaraoui, W., Guye, M., Pelletier, J., Ranjeva, J., & Audoin, B. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-03023-2 · Cited by 1

Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue

Asadipour, B., Morizet, J. M., Ronzano, R., Zhang, X., Aigrot, M., Mahou, P., Solinas, X., Phan, M.-S., Chessel, A., Stankoff, B., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09192-4 · Cited by 2

Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study

Stubbs, B. J., Stephens, E. B., Mansfield, T. A., Senadheera, C., Diaz, S. R., Peralta, S., Alexander, L. E. C., Silverman-Martin, W., Kurtzig, J., Fernando, B., et al. (2025) · The Journal of Frailty & Aging · doi:10.1016/j.tjfa.2025.100106 · Cited by 1

Therapeutic Potential of Leptin in Neurodegenerative Disease

Harvey, J. (2025) · Biomedicines · doi:10.3390/biomedicines13122969 · Cited by 1

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Liu, F., Tang, Y., Zhang, Z., Tan, Y., Lin, S., Wang, N., Li, J., Pan, Z., Li, J., Huang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202506695 · Cited by 1

Brain aging: molecular targets of geroprotection and prevention strategies

Chukanova, E. I., & Сергеевна, Ч. А. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2025125111132 · Cited by 1

Differential Left and Right Carotid Artery Blood Flow and Altered Hippocampal Mitochondrial Function After Transverse Aortic Constriction in Aging Rats

Pena, G. S., Liu, Y., Silva, M. C. D., Ranadive, S. M., Smith, J. C., & Kuzmiak‐Glancy, S. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.041233 · Cited by 1

Age at type 2 diabetes onset and risk of dementia: The modifying role of genetic susceptibility and mitochondrial function

Dong, W., Yuan, Q., Wu, B., Gao, S., Zhang, Y., Pan, Y., Zhou, K. S., & Jiang, H. (2026) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2026.100780 · Cited by 1

Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy

Bertino, F., Venturini, D. I. Z., Grasso, E., Kopecka, J., Salio, C., Gnutti, B., Basnet, R. M., Bellini, S., Mignani, L., Zhao, B., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09691-y · Cited by 1

Mitochondrial complex-derived ROS induces lysosomal dysfunction and impairs autophagic flux in human cells carrying the APOE4 allele

Niño, S. A., Barrios-Camus, O., Silva-Pavez, E. E., Cárdenas, J. C., & González-Billault, C. E. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168211 · Cited by 1

Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism

Ayala, D. A., Hall, G. M., Das, D., Tijerina, E., Villagran, L. L., Khan, Z., Paliwal, D., Anand, A., Rimer, M., & Srinivasan, R. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01713-x · Cited by 1

Ferulic acid inhibits Tau-441 liquid-liquid phase separation to restore glycolytic metabolism

Lin, W.-J., Li, C., Shi, W., Liu, T.-A., Wang, Y.-J., & Li, Y.-J. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151806 · Cited by 2

Potential crosstalk between Parkinson's disease and glucose metabolism

Li, Y., He, X., Lan, J., Bai, L., Huang, T., & Zhang, X. (2026) · Journal of Biomedical Research · doi:10.7555/jbr.39.20250499 · Cited by 1

The Roles of Macrophage Lineage Cells ( MLC s) in Brain Aging

Qin, Q., Zhang, L., Guo, M., Lu, D., Liu, Y., Wang, Z., Hu, M., Wang, S., Kang, X., Yi, H., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70873 · Cited by 1

Association of TyG index and obesity indicators with cognitive function: a cross - sectional study from Chinese health check-up centers

Wei, J., Wu, X., Chen, L., Wang, Y., Zhao, Y., Zhang, L., Cao, X., Chen, L., Ge, X. T., Lu, Y., et al. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02280-4 · Cited by 1

Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline

Qi, W., Liu, Q., Dong, N., Sun, X., Wu, P., Zhou, J., Sun, R., Liu, Y., Han, Q., & Wang, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02652-1 · Cited by 1

Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI

Jaroszynski, K. M., Dindarian, S., Lee, H., Detre, J. A., & Wehrli, F. W. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121967 · Cited by 1

Retinal vessel imaging in inflammatory disease: From endothelial dysfunction to clinical evidence and translation

Wallraven, T., Günthner, R., Ribeiro, A., Alnemer, M. S., Kotliar, K. E., Lech, M., Bleidißel, N., Wicklein, R., Hauser, C., Streese, L., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101472 · Cited by 1

Special packaging enables effective mitochondrial delivery

Jerred, C., Hatzfeld, J., & Prigione, A. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.04.005 · Cited by 1

Frogs Uncouple Neural Activity From Oxygen Consumption After Hibernation

Yaseen, H., & Santin, J. M. (2026) · Acta Physiologica · doi:10.1111/apha.70247 · Cited by 2

Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming

Ma, R., Wang, C., Qin, W., Yan, C., Zhang, M., Li, Y., Liang, Y., Zhang, J., & Niu, Q. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120301 · Cited by 2

APOE4 accelerates menopause-associated brain metabolic shift and disrupts bioenergetic adaptation

Wang, T., Shang, Y., McLean, J. W., Yin, F., & Brinton, R. D. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1796680

AAV-mediated FGF21 gene therapy promotes health span extension by whole-body tissue-specific adaptations

Jiménez, V., Sacristan, V., García, M., Jambrina, C., Casana, E., MUÑOZ, S. A., Vilà, L., Grass, I., Jaén, M. L., Roca, C., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.05.025 · Cited by 2

Nutrients and bioactive compounds as modifiers of neurodegenerative trajectories: molecular mechanisms, translational barriers, and precision nutrition

Singh, G., Singh, G., Shreya, Kumari, A., & Aran, K. R. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1819432 · Cited by 1

Effet de 3 mois de régime cétogène sur l’euthymie dans un trouble bipolaire de type II : étude de cas

Rioux, C., Cholette-Tétrault, S., Dumas, V., Cunnane, S. C., & Zemmour, K. (2026) · Santé mentale au Québec · doi:10.7202/1125480ar · Cited by 1

Ketone metabolism at the interface of atherosclerosis and brain dysfunction

Kim, Y., & Song, J. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108301 · Cited by 1

Biomaterials for Treatments of Neurodegenerative Disorders

Yu, Y. P., & Ding, J. (2026) · Engineering · doi:10.1016/j.eng.2026.06.006 · Cited by 1

Distinct roles of AdipoR1 and AdipoR2 in modulating neuronal firing homeostasis in response to adiponectin and AdipoRon

Jia, X., Zheng, C., Gong, Q., Hu, Y., Ali, T., Wei, S., Huang, J., Wang, Z., Xiao, P., Li, S., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03049-x · Cited by 1

JAK/STAT signaling pathway inhibitors in neurodegenerative diseases: current status and future perspectives

Yang, H., Su, B.-W., Bao, Y.-N., Wang, W.-H., Lao, J.-Y., Ji, H.-Y., Han, S., Cui, X.-H., Ren, H.-W., & Luan, Z.-L. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1880374 · Cited by 1

Targeting Sirtuin Signaling in Parkinson’s Disease and Neurodegeneration: Molecular Insights and Translational Potential

Kumari, S., Singh, H., Kamiya, A., & Taliyan, R. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06062-w · Cited by 2

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Zhang, N., Chen, W. H., & Wang, M. (2026) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70262 · Cited by 1

Metabolic reprogramming-driven neuroimmunoregulation: Key mechanisms and therapeutic opportunities and challenges in central nervous system disorders

Li, N., Wu, Y., Feng, H., Jian, X., Yang, Z., Wang, X., Li, X., Yin, Y., & Long, Y. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103291 · Cited by 1

Transforming neural activity to operate without glucose metabolism using brain-derived ketone bodies

Yaseen, H., Cisneros, K., Wright, R., Bueschke, N., & Santin, J. M. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2613981123 · Cited by 1

Micro- and nanoencapsulation of omega-3 and other nutritional fatty acids: challenges and novel solutions

Ren, X., Liu, Y., Wu, W., Lim, L., Zhang, W., & Wangn, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821683-5.00007-8 · Cited by 1

Neural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment

Sharma, K., Puranik, N., & Yadav, D. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230512121416 · Cited by 1

The Neuroprotective Role of Purslane in a chronic model of Depression Induced By reserpine in mice: Prevention of Behavioral, Mitochondrial and Neuro Dysfunction.

محمد, ب. ا. ف. ا., & محمد, س. ا. ف. ا. (2022) · Journal of Pure & Applied Sciences · doi:10.51984/jopas.v21i4.2132 · Cited by 1

A Review on Metabolic Dysfunction Hypothesis of Alzheimer's Disease

Majd, S. (2023) · International Journal of Research Publication and Reviews · doi:10.55248/gengpi.4.1223.123424 · Cited by 1

Glucose handling by the brain and its implication in metabolic syndrome

Mukhopadhyay, R., Chowdhury, A. S., & Palui, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00083-9 · Cited by 1

Neuron Foundry Mach 8: A Concept of Multi-modal Neuro-supportive Energy Therapy Device for Treating Neurodegenerative Disorders

McGlynn, C., Dermawan, D., & Canonizado, G. M. (2024) · Brain Science Advances · doi:10.26599/bsa.2023.9050026 · Cited by 1

Supply of Energy Substrate to the Brain

Satoh, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-54150-6_5 · Cited by 1

Cellular Adaptations to Intermittent Fasting with Emphasis on the Brain

Mattson, M. P. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_7 · Cited by 2

A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study

Vandenberghe, C., Hardy, E., Morin, M. C., St‐Pierre, V., Groulx, K., Fortier, M., Tessier, D., Leclerc, P., & Cunnane, S. C. (2024) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2024-0277 · Cited by 1

Food for thought: implications of exercise‐induced changes to cerebral glucose metabolism in ageing and Alzheimer's disease

Mladen, S. P. S., Bone, J., Renwick, J. R. M., & Rourke, A. J. (2024) · The Journal of Physiology · doi:10.1113/jp287696 · Cited by 1

Recent advances in neurodegenerative disease research

Singh, E., & Dilawari, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00014-3 · Cited by 1

Pathways toward and away from a metabolic cliff during brain aging

Mattson, M. P. (2025) · Frontiers in Science · doi:10.3389/fsci.2025.1571009 · Cited by 1

Potential threat of environmental toxin palytoxin to cerebral nerves: A mechanism study in vitro and in vivo.

Zhang, X., Huang, L., Liu, Y., Li, X., Zhou, H.-Y., Qin, K., Li, S., Ren, S.-Y., Jia, X.-X., & Gao, Z.-X. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118150 · Cited by 1

Ketones: potential to achieve brain energy rescue and sustain cognitive health during ageing

Myette‐Côté, É., Soto-Mota, A., & Cunnane, S. C. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003883 · Cited by 44

Metabolic therapeutic targets in Alzheimer’s disease

Ignatius Raymond Peter, L., Chatterjee, D., Chrishone, A. F., & Francis, D. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.05.010

Brain glucose and ketone utilization in brain aging and neurodegenerative diseases

Kapogiannis, D., & Avgerinos, K. I. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.015 · Cited by 64

Therapeutic targeting of brain bioenergetics in Alzheimer’s disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction

Jangra, J., Mahindru, I., & Kumar, R. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.05.005

Glucose, glycolysis, and neurodegenerative disorders

Coelho, P., & Rego, A. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91704-9.00012-4 · Cited by 2