New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Targeting the IL-6/JAK/STAT3 signalling axis in cancer

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IL-6 as a keystone cytokine in health and disease

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Primary liver cancer: Worldwide incidence and trends

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Genomic atlas of the human plasma proteome

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

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Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

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Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

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Impaired immune and acute-phase responses in interleukin-6-deficient mice

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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

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Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

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Liver regeneration

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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

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Interleukin-6-deficient mice develop mature-onset obesity

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Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

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Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

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Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

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Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

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Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

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Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

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Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity

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Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.

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The role of hepatocytes and oval cells in liver regeneration and repopulation

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Interleukin-6: designing specific therapeutics for a complex cytokine

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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

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A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

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Disruption of the CNTF gene results in motor neuron degeneration

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Interleukin-6: Biology, signaling and strategies of blockade

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The soluble interleukin‐6 receptor is generated by shedding

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Common variants at five new loci associated with early-onset inflammatory bowel disease

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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

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Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial

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Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

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Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent

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STAT3 Plays a Critical Role in KRAS -Induced Pancreatic Tumorigenesis

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IL-6 is required for the development of Th1 cell-mediated murine colitis

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Plasticity and cross-talk of Interleukin 6-type cytokines

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Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice

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Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

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Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials

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STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

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Regulation of Adipose Tissue Inflammation by Interleukin 6

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Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

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Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

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Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn’s Disease

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

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CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

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Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

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Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

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Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease

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Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor

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IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

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Systematic review of the association between circulating interleukin-6 (IL-6) and cancer

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Activation Pattern of Signal Transducers and Activators of Transcription (STAT) Factors in Inflammatory Bowel Diseases

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