Cellular senescence: the good, the bad and the unknown

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J., & Toussaint, O. (2009) · Nature Protocols · doi:10.1038/nprot.2009.191 · Cited by 1,668

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell · doi:10.1111/acel.12445 · Cited by 1,148

Senolytic CAR T cells reverse senescence-associated pathologies

Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915

Mitochondria are required for pro-ageing features of the senescent phenotype

Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701

Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κ B activation

Moiseeva, O., Deschênes‐Simard, X., St‐Germain, E., Igelmann, S., Huot, G., Cadar, A. E., Bourdeau, V., Pollak, M. N., & Ferbeyre, G. (2013) · Aging Cell · doi:10.1111/acel.12075 · Cited by 654

The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Adams, J. M., & Cory, S. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.161 · Cited by 530

Chronic Oxidative Stress Compromises Telomere Integrity and Accelerates the Onset of Senescence in Human Endothelial Cells

Kurz, D. J., Decary, S., Hong, Y., Trivier, E., Akhmedov, A., & Erusalimsky, J. D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01097 · Cited by 499

Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion

Liu, D., & Hornsby, P. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3452 · Cited by 499

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis

Sarkisian, C. J., Keister, B. A., Stairs, D. B., Boxer, R. B., Moody, S. E., & Chodosh, L. A. (2007) · Nature Cell Biology · doi:10.1038/ncb1567 · Cited by 490

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

Bernadotte, A., Mikhelson, V. M., & Spivak, I. M. (2016) · Aging · doi:10.18632/aging.100871 · Cited by 466

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W., & Raulet, D. H. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130783 · Cited by 414

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Ogrodnik, M., Evans, S. A., Fielder, E., Victorelli, S., Kruger, P., Salmonowicz, H., Weigand, B. M., Patel, A. D., Pirtskhalava, T., Inman, C. L., et al. (2021) · Aging Cell · doi:10.1111/acel.13296 · Cited by 405

Biomarkers of cellular senescence and skin aging

Wang, A. S., & Dreesen, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00247 · Cited by 404

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

Turinetto, V., & Giachino, C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv061 · Cited by 393

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

Zhou, L., Li, Y., Zhou, D. F., Tan, R. J., & Liu, Y. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012080865 · Cited by 379

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374

Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?

Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

Wang, R., Yu, Z., Sunchu, B., Shoaf, J., Dang, I., Zhao, S., Caples, K., Bradley, L., Beaver, L. M., Ho, E., et al. (2017) · Aging Cell · doi:10.1111/acel.12587 · Cited by 360

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03555-8 · Cited by 350

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

Yang, G., Rosen, D. G., Zhang, Z., Bast, R. C., Mills, G. B., Colacino, J. A., Mercado-Uribe, I., & Liu, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605752103 · Cited by 341

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Xu, Q., Fu, Q., Li, Z., Liu, H., Wang, Y., Lin, X., He, R., Zhang, X., Ju, Z., Campisi, J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00491-8 · Cited by 341

Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism

Lutz, C. T., & Quinn, L. S. (2012) · Aging · doi:10.18632/aging.100482 · Cited by 339

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

Xiao, X., Xu, M., Yu, H., Wang, L., Li, X., Rak, J. W., Wang, S., & Zhao, R. C. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00765-3 · Cited by 302

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

Gewirtz, D. A., Holt, S. E., & Elmore, L. W. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.06.024 · Cited by 301

Senescence from G2 arrest, revisited

Gire, V., & Dulić, V. (2015) · Cell Cycle · doi:10.1080/15384101.2014.1000134 · Cited by 300

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

Özcan, S., Alessio, N., Acar, M. B., Mert, E., Omerli, F., Peluso, G., & Galderisi, U. (2016) · Aging · doi:10.18632/aging.100971 · Cited by 295

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Rawlings, T. M., Makwana, K., Taylor, D. M., Molè, M. A., Fishwick, K. J., Tryfonos, M., Odendaal, J., Hawkes, A., Zernicka‐Goetz, M., Hartshorne, G. M., et al. (2021) · eLife · doi:10.7554/elife.69603 · Cited by 279

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

Luo, C., Zhou, S., Zhou, Z., Liu, Y., Yang, L., Liu, J., Zhang, Y., Li, H., Liu, Y., Hou, F. F., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017050574 · Cited by 277

Metformin as Anti-Aging Therapy: Is It for Everyone?

Soukas, A. A., Hao, H., & Wu, L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.015 · Cited by 266

TAp63 induces senescence and suppresses tumorigenesis in vivo

Guo, X., Keyes, W. M., Papazoglu, C., Zuber, J. A., Li, W., Lowe, S. W., Vogel, H. S., & Mills, A. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1988 · Cited by 251

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

Terlecki‐Ζaniewicz, L., Lämmermann, I., Latreille, J., Bobbili, M. R., Pils, V., Schosserer, M., Weinmüllner, R., Dellago, H., Skalicky, S., Pum, D., et al. (2018) · Aging · doi:10.18632/aging.101452 · Cited by 249

Small molecule compounds that induce cellular senescence.

Petrova, N. V., Velichko, A. K., Razin, S. V., & Kantidze, O. L. (2016) · Aging Cell · doi:10.1111/acel.12518 · Cited by 240

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.007 · Cited by 237

Immunosenescence Study of T Cells: A Systematic Review

Rodríguez, I. J., Lalinde-Ruiz, N., León, M. L., Martínez-Enriquez, L. C., Velásquez, M. D. P. M., Aguirre, J. P. O., Bohórquez, O. M. R., Vargas, E. A. V., Hernández-Álvarez, E. D., & Parra-López, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604591 · Cited by 229

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Mylonas, K. J., O’Sullivan, E. D., Humphries, D., Baird, D. P., Docherty, M.-H., Neely, S. A., Krimpenfort, P. J., Melk, A., Schmitt, R., Ferreira-Gonzalez, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0203 · Cited by 219

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Shao, Z., Wang, B., Shi, Y., Xie, C., Huang, C., Chen, B., Zhang, H.-S., Zeng, G., Liang, H., Wu, Y., et al. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.11.006 · Cited by 216

Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1–Mediated Activation of Two GC-Rich Promoter Elements

Dasari, A., Bartholomew, J. N., Volonté, D., & Galbiati, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1236 · Cited by 215

Cellular senescence in cancer: from mechanisms to detection

Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 208

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

Olivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2012) · AGE · doi:10.1007/s11357-012-9440-8 · Cited by 206

KLRG1—more than a marker for T cell senescence

Henson, S. M., & Akbar, A. N. (2009) · AGE · doi:10.1007/s11357-009-9100-9 · Cited by 204

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression

Pazolli, E., Alspach, E., Milczarek, A., Prior, J., Piwnica-Worms, D., & Stewart, S. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3386 · Cited by 192

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

Guccini, I., Revandkar, A., D'Ambrosio, M., Colucci, M., Pasquini, E., Mosole, S., Troiani, M., Brina, D., Sheibani-Tezerji, R., Elia, A. R., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.10.012 · Cited by 185

In senescence, age‐associated B cells secrete TNF α and inhibit survival of B‐cell precursors*

Ratliff, M., Alter, S., Frasca, D., Blomberg, B. B., & Riley, R. L. (2013) · Aging Cell · doi:10.1111/acel.12055 · Cited by 183

Senescence promotes in vivo reprogramming through p16INK4a and IL‐6

Mosteiro, L., Pantoja, C., de Martino, A., & Serrano, M. (2018) · Aging Cell · doi:10.1111/acel.12711 · Cited by 182

p38MAPK plays a crucial role in stromal-mediated tumorigenesis

Alspach, E., Flanagan, K. C., Luo, X., Ruhland, M. K., Huang, H., Pazolli, E., Donlin, M. J., Marsh, T., Piwnica-Worms, D., Monahan, J., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0743 · Cited by 167

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

Rossiello, F., Herbig, U., Longhese, M. P., Fumagalli, M., & di Fagagna, F. D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.06.009 · Cited by 163

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

Alimbetov, D., Davis, T., Brook, A. J. C., Cox, L. S., Faragher, R. G. A., Nurgozhin, T., Zhumadilov, Z., & Kipling, D. (2016) · Biogerontology · doi:10.1007/s10522-015-9610-z · Cited by 162

PAI-1 Regulation of TGF-β1–induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages

Rana, T., Jiang, C., Liu, G., Miyata, T., Antony, V. B., Thannickal, V. J., & Liu, R.-M. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0071oc · Cited by 161

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

Liu, T., Yang, Q., Zhang, X., Qin, R., Shan, W., Zhang, H., & Chen, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118116 · Cited by 161

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

Conley, S. M., Hickson, L. J., Kellogg, T. A., McKenzie, T. J., Heimbach, J. K., Taner, T., Tang, H. J., Jordan, K. L., Saadiq, I. M., Woollard, J. R., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00197 · Cited by 160

Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease

Sis, B., Tasanarong, A., Khoshjou, F., Dadras, F., Solez, K., & Halloran, P. F. (2007) · Kidney International · doi:10.1038/sj.ki.5002039 · Cited by 159

Similarities and interplay between senescent cells and macrophages

Behmoaras, J., & Gil, J. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202010162 · Cited by 158

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

Xie, H., Ma, K., Zhang, K., Zhou, J., Li, L., Yang, W., Gong, Y., Cai, L., & Gong, K. (2021) · Cell Death & Disease · doi:10.1038/s41419-020-03229-8 · Cited by 155

Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts

Dulić, V., Beney, G.-E., Frebourg, G., Drullinger, L. F., & Stein, G. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6741-6754.2000 · Cited by 149

High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

Chang, T.-C., Hsu, M., & Wu, K. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126537 · Cited by 141

A Study of Serum Immunoglobulin Levels in Elderly Persons That Provides New Insights into B Cell Immunosenescence

Listı̀, F., Candore, G., Modica, M. A., Russo, M., Lorenzo, G. D., Esposito-Pellitteri, M., Colonna‐Romano, G., Aquino, A., Bulati, M., Lio, D., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.013 · Cited by 140

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Carracedo, J., Alique, M., Vida, C., Bodega, G., Ceprián, N., Morales, E., Praga, M., de Sequera, P., & Ramı́rez, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00185 · Cited by 140

Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury

Westhoff, J. H., Schildhorn, C., Jacobi, C., Hömme, M., Hartner, A., Braun, H., Kryzer, C., Wang, C., von Zglinicki, T., Kränzlin, B., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009010072 · Cited by 139

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X.-Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L. J., et al. (2019) · Translational Research · doi:10.1016/j.trsl.2019.07.005 · Cited by 139

Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2

Wilkinson, H. N., Clowes, C., Banyard, K. L., Matteuci, P., Mace, K. A., & Hardman, M. J. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.005 · Cited by 138

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker

Poblocka, M., Bassey, A. L., Smith, V. M., Falcicchio, M., Manso, A. S., Althubiti, M., Sheng, X., Kyle, A., Barber, R., Frigerio, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99852-2 · Cited by 137

Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide

Chen, Q. M., Tu, V. C., Catania, J. M., Burton, M., Toussaint, O., & Dilley, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.4087 · Cited by 136

Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

de Bourcy, C. F. A., Angel, C. J. L., Vollmers, C., Dekker, C. L., Davis, M. M., & Quake, S. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617959114 · Cited by 132

Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?

de Mera‐Rodríguez, J. A., Álvarez‐Hernán, G., Gañán, Y., Martín‐Partido, G., Rodríguez‐León, J., & Francisco‐Morcillo, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.623175 · Cited by 132

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Sharma, A. K., Roberts, R. L., Benson, R. D., Pierce, J. L., Yu, K., Hamrick, M. W., & McGee-Lawrence, M. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00354 · Cited by 131

Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans

Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129

Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling

Alimirah, F., Pulido, T., Valdovinos, A., Alptekin, S., Chang, E., Jones, E., Diaz, D. A., Flores, J., Velarde, M. C., Demaria, M., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0108 · Cited by 128

CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury

DiRocco, D. P., Bisi, J., Roberts, P. J., Strum, J. C., Wong, K., Sharpless, N. E., & Humphreys, B. D. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00475.2013 · Cited by 127

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

Tonnessen-Murray, C. A., Frey, W. D., Rao, S. G., Shahbandi, A., Ungerleider, N. A., Olayiwola, J. O., Murray, L. B., Vinson, B. T., Chrisey, D. B., Lord, C. J., et al. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201904051 · Cited by 127

Immunology of the ageing kidney

Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126

Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence

Jiang, Y.-H., Jiang, L., Wang, Y.-C., Ma, D., & Li, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00512 · Cited by 126

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Poulsen, R. C., Watts, A. C., Murphy, R., Snelling, S. J. B., Carr, A. J., & Hulley, P. A. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-203146 · Cited by 125

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Zhang, E., Guo, Q., Gao, H., Xu, R., Teng, S., & Wu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143814 · Cited by 125

Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence

Li, C., Shen, Y., Huang, L., Liu, C., & Wang, J. (2020) · The FASEB Journal · doi:10.1096/fj.202001855rr · Cited by 124

Gadd45a Suppresses Ras-Driven Mammary Tumorigenesis by Activation of c-Jun NH2-Terminal Kinase and p38 Stress Signaling Resulting in Apoptosis and Senescence

Tront, J. S., Hoffman‐Liebermann, B., & Liebermann, D. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2013 · Cited by 120

Impact of er stress-regulated atf4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

Liu, J., Yang, J.-R., Chen, X.-M., Cai, G.-Y., Lin, L.-R., & He, Y.-N. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00096.2014 · Cited by 117

Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

Zhang, C., Грубер, Ф., Ni, C., Mildner, M., Koenig, U., Karner, S., Barresi, C., Rossiter, H., Narzt, M., Nagelreiter, I., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.439 · Cited by 116

Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells

Bertolo, A., Baur, M., Guerrero, J., Pötzel, T., & Stoyanov, J. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-38546-2 · Cited by 116

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Barinda, A. J., Ikeda, K., Nugroho, D. B., Wardhana, D. A., Sasaki, N., Honda, S., Urata, R., Matoba, S., Hirata, K., & Emoto, N. (2020) · Nature Communications · doi:10.1038/s41467-020-14387-w · Cited by 115

Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice

Yokozawa, T., Satoh, A., & Cho, E. J. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022449 · Cited by 114

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Xiao, Y.-Z., Yang, M., Xiao, Y., Guo, Q., Huang, Y., Li, C., Cai, D., & Luo, X. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.002 · Cited by 112

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice

Rodríguez, M. I., Carretero, M., Escames, G., López, L. C., y Aibar, M. D. M., Tan, D., Reiter, R. J., & Acuña-Castroviejo, D. (2006) · Free Radical Research · doi:10.1080/10715760600936359 · Cited by 111

Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients

Crépin, T., Legendre, M., Carron, C., Vachey, C., Courivaud, C., Rebibou, J.-M., Ferrand, C., Laheurte, C., Vauchy, C., Gaiffe, É., et al. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy276 · Cited by 111

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

(2019) · doi:10.1101/604306 · Cited by 110

T‐cell Immunoglobulin and ITIM Domain Contributes to CD 8+ T‐cell Immunosenescence

Song, Y., Wang, B., Song, R., Yu, H., Wang, D., Li, Y., Jiang, Y. Y., Xu, L., Ma, Y., Zheng, H., et al. (2018) · Aging Cell · doi:10.1111/acel.12716 · Cited by 109

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Lei, J., Jiang, X., Li, W., Ren, J., Wang, D., Ji, Z., Wu, Z., Cheng, F., Cai, Y., Yu, Z., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00860-9 · Cited by 109

Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

Rodríguez, J. A., Marigorta, U. M., Hughes, D. A., Spataro, N., Bosch, E., & Navarro, A. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-016-0055 · Cited by 108

Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy

Kim, S. R., Puranik, A. S., Jiang, K., Chen, X., Zhu, X., Taylor, I., Khodadadi‐Jamayran, A., Lerman, A., Hickson, L. J., Childs, B. G., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020091373 · Cited by 108

Challenges and opportunities for stem cell therapy in patients with chronic kidney disease

Hickson, L. J., Eirin, A., & Lerman, L. O. (2016) · Kidney International · doi:10.1016/j.kint.2015.11.023 · Cited by 106

Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo

Song, X., Narzt, M., Nagelreiter, I., Hohensinner, P. J., Terlecki‐Ζaniewicz, L., Tschachler, E., Grillari, J., & Грубер, Ф. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.015 · Cited by 105

Regulation of senescence and the SASP by the transcription factor C/EBPβ

Salotti, J., & Johnson, P. F. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110752 · Cited by 103

Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.

Trost, T. M., Lausch, E., Fees, S. A., Schmitt, S., Enklaar, T., Reutzel, D., Brixel, L., Schmidtke, P., Maringer, M., Schiffer, I., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.840.65.3 · Cited by 99

Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC–MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

Gan, W., Nie, B., Shi, F., Xu, X., Qian, J., Takagi, Y., Hayakawa, H., Sekiguchi, M., & Cai, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.016 · Cited by 99

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury

Castellano, G., Franzin, R., Sallustio, F., Stasi, A., Banelli, B., Romani, M., Palma, G. D., Lucarelli, G. T., Divella, C., Battaglia, M., et al. (2019) · Aging · doi:10.18632/aging.102059 · Cited by 98

Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

Malaise, O., Tachikart, Y., Constantinides, M., Mumme, M., Ferreira, R., Noack, S., Krettek, C., Noël, D., Wang, J., Jørgensen, C., et al. (2019) · Aging · doi:10.18632/aging.102379 · Cited by 96

BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake

Wang, H., Fu, H., Zhu, R., Wu, X., Ji, X., Li, X., Jiang, H., Lin, Z., Tang, X., Sun, S., et al. (2020) · Aging · doi:10.18632/aging.103200 · Cited by 96

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

Liu, J., Ju-rong, Y., He, Y., Cai, G., Zhang, J., Lin, L.-R., Zhan, J., Zhang, J.-H., & Xiao, H.-S. (2011) · Translational research · doi:10.1016/j.trsl.2011.11.008 · Cited by 95

Autophagy and Immune Senescence

Zhang, H., Puleston, D. J., & Simon, A. K. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.001 · Cited by 95

COX2 regulates senescence secretome composition and senescence surveillance through PGE2

Gonçalves, S., Yin, K., Ito, Y., Chan, A., Olan, I., Gough, S., Cassidy, L., Serrao, E., Smith, S., Young, A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108860 · Cited by 95

Telomerase deficiency delays renal recovery in mice after ischemia–reperfusion injury by impairing autophagy

Cheng, H., Fan, X., Lawson, W. E., Paueksakon, P., & Harris, R. C. (2015) · Kidney International · doi:10.1038/ki.2015.69 · Cited by 89

Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

Rodrigues, C. E., Capcha, J. M. C., de Bragança, A. C., Sanches, T. R., Gouveia, P. Q., de Oliveira, P. A. F., Malheiros, D. M. A. C., Volpini, R. A., Santinho, M. A. R., Santana, B. A., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0475-8 · Cited by 89

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging · doi:10.18632/aging.203560 · Cited by 88

Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

Gannon, H. S., Donehower, L. A., Lyle, S., & Jones, S. N. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.02.007 · Cited by 87

ATF6α regulates morphological changes associated with senescence in human fibroblasts

Druelle, C., Drullion, C., Deslé, J., Martin, N., Saas, L., Cormenier, J., Malaquin, N., Huot, L., Slomianny, C., Bouali, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11505 · Cited by 87

Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes

Parish, S. T., Wu, J. E., & Effros, R. B. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9449-7 · Cited by 85

Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

Son, M. J., Kwon, Y., Son, T., & Cho, Y. S. (2016) · Stem Cells · doi:10.1002/stem.2460 · Cited by 85

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Martı́n-Castillo, B., Joven, J., Vellón, L., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100407 · Cited by 84

Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling

Wang, Z., Wang, L., Jiang, R., Li, C., Chen, X., Xiao, H., Hou, J., Hu, L., Huang, C., & Wang, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.007 · Cited by 84

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.

López-Domínguez, J. A., Rodríguez-López, S., Ahumada-Castro, U., Desprez, P.-Y., Konovalenko, M., Laberge, R.-M., Cárdenas, C., Villalba, J. M., & Campisi, J. (2021) · Aging · doi:10.18632/aging.203110 · Cited by 83

Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling

Dong, D. F., Cai, G., Ning, Y., Wang, J., Lv, Y., Hong, Q., Cui, S., Fu, B., Guo, Y.-N., & Chen, X. (2017) · Oncotarget · doi:10.18632/oncotarget.14884 · Cited by 81

Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1

Cohen, C., Le Goff, O., Soysouvanh, F., Vasseur, F., Tanou, M., Nguyen, C., Amrouche, L., Le Guen, J., Saltel‐Fulero, O., Meunier, T., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114146 · Cited by 79

Irreversible spectrin‐haemoglobin crosslinking in vivo: a marker for red cell senescence

Snyder, L. M., Leb, L., Piotrowski, J., et al. (1983) · British Journal of Haematology · doi:10.1111/j.1365-2141.1983.tb02038.x · Cited by 77

Invariant natural killer T cells coordinate removal of senescent cells

Arora, S., Thompson, P. J., Wang, Y., Bhattacharyya, A., Apostolopoulou, H., Hatano, R., Naikawadi, R. P., Shah, A., Wolters, P. J., Koliwad, S., et al. (2021) · Med · doi:10.1016/j.medj.2021.04.014 · Cited by 77

NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system

Alonso‐Arias, R., Moro‐García, M. A., López‐Vázquez, A., Rodrigo, L., Baltar, J., García, F. M. S., Jaurrieta, J. J. S., & López‐Larrea, C. (2011) · AGE · doi:10.1007/s11357-010-9200-6 · Cited by 76

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Gong, W., Luo, C., Peng, F., Xiao, J., Zeng, Y., Yin, B., Chen, X., Li, S., He, X., Liu, Y., et al. (2021) · Clinical Science · doi:10.1042/cs20210447 · Cited by 75

Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

McCarthy, D. A., Clark, R. R., Bartling, T. R., Trebak, M., & Melendez, J. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.493841 · Cited by 73

Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype ( SASP ) in human fetal lung fibroblast cells

Yu, S., Wang, X., Geng, P., Tang, X.-D., Xiang, L., Lu, X., Li, J., Ruan, Z., Chen, J., Xie, G., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12405 · Cited by 72

D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation

Okada, A., Nangaku, M., Jao, T., Maekawa, H., Ishimono, Y., Kawakami, T., & Inagi, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-11049-8 · Cited by 72

Nuclear Accumulation of Globular Actin as a Cellular Senescence Marker

Kwak, I. H., Kim, H. S., Choi, O. R., Ryu, M. S., & Lim, I. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1856 · Cited by 70

Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrPC‐dependent enhancement of the mitochondrial function

Han, Y., Kim, S. M., Lee, J. H., Jung, S. K., Noh, H., & Lee, S. H. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12535 · Cited by 70

INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury

Lee, D. H., Wolstein, J. M., Pudasaini, B., & Plotkin, M. D. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00407.2011 · Cited by 69

Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells

Trzonkowski, P., Dębska-Ślizień, A. M., Jankowska, M., Wardowska, A., Carvalho‐Gaspar, M., Hak, Ł., Moszkowska, G., Bzoma, B., Mills, N., Wood, K. J., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.006 · Cited by 68

Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

Hou, J., Cui, C.-H., Kim, S., Sung, C. K., & Choi, C. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.002 · Cited by 68

Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes

Bitar, M. S., Abdel‐Halim, S. M., & Al‐Mulla, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2013 · Cited by 66

S-Phase-specific Activation of PKCα Induces Senescence in Non-small Cell Lung Cancer Cells

Oliva, J. L., Caino, M. C., Senderowicz, A. M., & Kazanietz, M. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707576200 · Cited by 66

The role of replicative senescence in chronic allograft nephropathy

Ferlicot, S., Dürrbach, A., Bâ, N., Desvaux, D., Bédossa, P., & Paradis, V. (2003) · Human Pathology · doi:10.1016/s0046-8177(03)00340-x · Cited by 65

Drug-Induced Kidney Injury in the Elderly

Khan, S. F., Loi, V., & Rosner, M. H. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0484-4 · Cited by 65

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Wang, X., Qu, M., Li, J., Danielson, P., Yang, L., & Zhou, Q. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-26983 · Cited by 64

Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

Bian, X., Griffin, T. P., Zhu, X., Islam, M. N., Conley, S. M., Eirin, A., Tang, H. J., O’Shea, P. M., Palmer, A. K., McCoy, R. G., et al. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000720 · Cited by 64

Reduced EBF expression underlies loss of B‐cell potential of hematopoietic progenitors with age

Lescale, C., Dias, S., Maës, J., Cumano, A., Szabo, P., Charron, D. J., Weksler, M. E., Dosquet, C., Vieira, P., & Goodhardt, M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00566.x · Cited by 63

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

Yasaei, H., Gilham, E., Pickles, J. C., Roberts, T. P. L., O’Donovan, M. R., & Newbold, R. F. (2012) · Oncogene · doi:10.1038/onc.2012.45 · Cited by 63

Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy

Sasaki, N., Itakura, Y., & Toyoda, M. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00533-w · Cited by 63

The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro

Favetta, L. A., Madan, P., Mastromonaco, G. F., John, E. S., King, W. A., & Betts, D. H. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-132 · Cited by 62

Cellular Senescence

Li, Y., & Lerman, L. O. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14594 · Cited by 62

Lifestyle exercise attenuates immunosenescence; flow cytometry analysis

Tylutka, A., Morawin, B., Gramacki, A., & Zembroń-Łacny, A. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02128-7 · Cited by 61

Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells

Corpet, A., & Stucki, M. (2014) · Chromosoma · doi:10.1007/s00412-014-0469-6 · Cited by 60

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

Berkenkamp, B., Susnik, N., Baisantry, A., Kuznetsova, I., Jacobi, C., Sörensen-Zender, I., Broecker, V., Haller, H. G., Melk, A., & Schmitt, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088071 · Cited by 60

Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin‐1 production

Olmos, G., Miguel, P. M., Alcalde‐Estévez, E., Medrano, D. R., Sosa, P., Rodríguez‐Mañas, L., Naves‐Díaz, M., Rodrı́guez-Puyol, D., Ruiz‐Torres, M. P., & López‐Ongil, S. (2017) · Aging Cell · doi:10.1111/acel.12664 · Cited by 59

Autophagy inhibits the mesenchymal stem cell aging induced by D‐galactose through ROS/JNK/p38 signalling

Zhang, D., Chen, Y., Xu, X., Xiang, H., Shi, Y., Gao, Y., Wang, X., Jiang, X., Li, N., & Pan, J. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13207 · Cited by 59

Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease

Schroth, J., Thiemermann, C., & Henson, S. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.564461 · Cited by 59

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

Jia, Y., Kang, X., Tan, L., Ren, Y., Qu, L., Tang, J., Liu, G., Wang, S., Xiong, Z., & Yang, L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.649547 · Cited by 59

Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways

Rinaldi, S., Maioli, M., Pigliaru, G., Castagna, A., Santaniello, S., Basoli, V., Fontani, V., & Ventura, C. (2014) · Scientific Reports · doi:10.1038/srep06373 · Cited by 58

Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells

Hu, J., Guan, W., Liu, P., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.07.009 · Cited by 58

Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

Blokland, K. E. C., Waters, D. W., Schuliga, M. J., Read, J. M., Pouwels, S. D., Grainge, C., Jaffar, J., Westall, G. P., Mutsaers, S. E., Prêle, C. M., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040389 · Cited by 58

Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease

Zhang, L., Zhu, X.-Y., Zhao, Y., Eirin, A., Liu, L., Ferguson, C. M., Tang, H. J., Lerman, A., & Lerman, L. O. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-019-0772-8 · Cited by 57

Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–Sirt1 signaling

Pi, C., Yang, Y. J., Sun, Y., Wang, H., Sun, H., Ma, M., Lin, L., Shi, Y., Li, Y., Li, Y., et al. (2019) · Aging · doi:10.18632/aging.101993 · Cited by 56

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification

Zuccolo, E., Badi, I., Scavello, F., Gambuzza, I., Mancinelli, L., Macrì, F., Tedesco, C. C., Veglia, F., Bonfigli, A. R., Olivieri, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124454 · Cited by 56

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

Schwenger, P., Alpert, D. R., Skolnik, E. Y., & ek, J. V. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199904)179:1 · Cited by 55

Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress‐induced premature senescence

Volonté, D., & Galbiati, F. (2009) · EMBO Reports · doi:10.1038/embor.2009.215 · Cited by 54

Microglia senescence occurs in both substantia nigra and ventral tegmental area

Shaerzadeh, F., Phan, L. T., Miller, D. R., Dacquel, M. V., Hachmeister, W., Hansen, C. A., Bechtle, A. R., Tu, D., Martcheva, M., Foster, T. C., et al. (2020) · Glia · doi:10.1002/glia.23834 · Cited by 54

Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis

Cheng, T., Ding, S., Liu, S., Li, Y., & Sun, L. (2020) · Theranostics · doi:10.7150/thno.48080 · Cited by 53

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High‐Fat Diet: Role of Angiogenesis

Yu, S., Kim, S. R., Jiang, K., Ogrodnik, M. B., Zhu, X. Y., Ferguson, C. M., Tchkonia, T., Lerman, A., Kirkland, J. L., & Lerman, L. O. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8875729 · Cited by 53

miR‐152 induces human dental pulp stem cell senescence by inhibiting SIRT 7 expression

Gu, S., Ran, S., Liu, B., & Liang, J. (2016) · FEBS Letters · doi:10.1002/1873-3468.12138 · Cited by 52

Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation

Sadhu, S., Decker, C., Sansbury, B. E., Marinello, M., Seyfried, A. N., Howard, J. E., Mori, M., Hosseini, Z., Arunachalam, T., Finn, A. V., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100284 · Cited by 52

HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis

Chen, Y., Pan, K., Wang, P., Cao, Z., Wang, W., Wang, S., Hu, N., Xue, J., Li, H., Jiang, W., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.714147 · Cited by 51

Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients

Mancini, Ö. K., Acevedo, M., Fazez, N., Cuillerier, A., Ruiz, A. F., Huynh, D. N., Burelle, Y., Ferbeyre, G., Baron, M. G., & Servant, M. J. (2021) · Rheumatology · doi:10.1093/rheumatology/keab477 · Cited by 51

The Splicing Factor SRSF1 as a Marker for Endothelial Senescence

Blanco, F. J., & Bernabéu, C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00054 · Cited by 50

Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia

Sosa, P., Alcalde‐Estévez, E., Plaza, P., Troyano, N., Alonso, C., Martínez‐Arias, L., Aroeira, A. E. D. M., Rodrı́guez-Puyol, D., Olmos, G., López‐Ongil, S., et al. (2018) · Aging and Disease · doi:10.14336/ad.2017.1214 · Cited by 50

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S., & Lerman, L. O. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012584 · Cited by 50

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a

Xu, M., Su, X., Xiao, X., Yu, H., Li, X., Keating, A., Wang, S., & Zhao, R. C. (2021) · Aging and disease · doi:10.14336/ad.2020.0624 · Cited by 50

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

Muñoz-Galván, S., Lucena-Cacace, A., Pérez, M., Otero-Albiol, D., Gómez-Cambronero, J., & Carnero, A. (2018) · Oncogene · doi:10.1038/s41388-018-0527-2 · Cited by 49

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial

Wong, G. C. L., Ng, T. K. S., Lee, J. L., Lim, P. Y., Chua, S. K. J., Tan, C. T. Y., Chua, M., Tan, J. S. H., Lee, S. M., Sia, A., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa271 · Cited by 49

C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice

Zhang, L., Zhou, F., Yu, X., Zhu, Y., Zhou, Y., Liu, J., Liu, Y., Ma, Q., Zhang, Y., Wang, W., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1933-2 · Cited by 48

Senescent cell accumulation mechanisms inferred from parabiosis

Karin, O., & Alon, U. (2021) · GeroScience · doi:10.1007/s11357-020-00286-x · Cited by 48

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

Vindrieux, D., Devailly, G., Augert, A., Calvé, B. L., Ferrand, M., Pigny, P., Payen, L. F., Lambeau, G. J., Perrais, M., Aubert, S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1681 · Cited by 47

Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells

Menicacci, B., Laurenzana, A., Chillà, A., Margheri, F., Peppicelli, S., Tanganelli, E., Fibbi, G., Giovannelli, L., Rosso, M. D., & Mocali, A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw336 · Cited by 47

Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence

Cho, J., Shen, H., Yu, H. M., Li, H., Cheng, T., Lee, S. B., & Lee, B. C. (2010) · Blood · doi:10.1182/blood-2010-04-279349 · Cited by 46

Occludin‐mediated premature senescence is a fail‐safe mechanism against tumorigenesis in breast carcinoma cells

Osanai, M., Murata, M., Nishikiori, N., Chiba, H., Kojima, T., & Sawada, N. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00494.x · Cited by 46

Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells

Bourdens, M., Jeanson, Y., Taurand, M., Juin, N., Carrière, A., Clément, F., Casteilla, L., Bulteau, A., & Planat‐Benard, V. (2019) · Scientific Reports · doi:10.1038/s41598-019-45191-2 · Cited by 46

Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes

Márquez‐Expósito, L., Tejedor-Santamaria, L., Santos‐Sanchez, L., Valentijn, F. A., Cantero‐Navarro, E., Rayego‐Mateos, S., Rodrigues-Díez, R. R., Tejera‐Muñoz, A., Marchant, V. A., Sanz, A. B., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662020 · Cited by 46

Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF‐ κ B during Pseudomonas aeruginosa Infection

Li, H., Luo, Y.-F., Wang, Y.-S., Yang, Q., Xiao, Y.-L., Cai, H.-R., & Xie, C.-M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9741838 · Cited by 45

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2

Cho, A., Park, S.-R., Kim, S., Nam, S., Lim, S., Park, C. H., Lee, H., & Hong, I. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.04.019 · Cited by 45

Cell senescence in liver diseases: pathological mechanism and theranostic opportunity

Sanfeliu-Redondo, D., Gibert-Ramos, A., & Gracia-Sancho, J. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00913-4 · Cited by 117

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease

Millar, C. L., Iloputaife, I., Baldyga, K., Norling, A. M., Boulougoura, A., Vichos, T., Tchkonia, T., Deisinger, A., Pirtskhalava, T., Kirkland, J. L., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105612 · Cited by 88

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions

Wang, J., Zhou, X., Yu, P., Yao, J., Guo, P., Xu, Q., Zhao, Y., Wang, G., Li, Q., Zhu, X., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00886-2 · Cited by 28

The life and times of cellular senescence in skeletal muscle: Friend or foe for homeostasis and adaptation?

Dungan, C. M., Wells, J. M., & Murach, K. A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00553.2022 · Cited by 21

Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells

Ellison, D. D., Munden, A. L., & Levchenko, A. (2009) · Molecular BioSystems · doi:10.1039/b905602e · Cited by 41

Autocrine/Paracrine Function of Parathyroid Hormone-Related Peptide in Rat Osteoblast-like Cells

Enomoto, H., Yamashita, S., Usa, T., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1353 · Cited by 16

Renal Autocrine and Paracrine Signaling: A Story of Self-protection

Leipziger, J., & Prætorius, H. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00014.2019 · Cited by 28

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

Dias, S., Hattori, K., Heissig, B., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191117498 · Cited by 268

The possible role of IL—1 autocrine and paracrine in mesangial cell(MSc)

Zi, Z. (1992) · Zhongguo mianyixue zazhi