The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin
Open accessAbstract
The mRNA expression patterns of the androgen receptor and the androgen metabolizing enzymes 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase, 17beta-hydroxysteroid dehydrogenase, 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase were investigated in three different cell populations originating from human skin, SZ95 sebocytes, HaCaT keratinocytes, and MeWo melanoma cells, by means of reverse transcription polymerase chain reaction. Restriction analysis of cDNA fragments was performed to identify isozymes of 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase and 3alpha-hydroxysteroid dehydrogenase. In addition, 3H-dihydroepiandrosterone and 3H-testosterone were used as substrates to determine the metabolic activity of these enzymes in SZ95 sebocytes, primary sebocyte cultures, and HaCaT keratinocytes. Furthermore, the effects of the selective 5alpha-reductase type 1 and 2 inhibitors, 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one and dihydrofinasteride, respectively, and of the 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase inhibitor cyproterone acetate on androgen metabolism were investigated. Androgen receptor mRNA was detected in SZ95 sebocytes and HaCaT keratinocytes but not in MeWo melanoma cells, whereas 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase isotype 1 mRNA and metabolic activity were only found in SZ95 sebocytes. The enzyme activity could be inhibited by cyproterone acetate. Type 2 17beta-hydroxysteroid dehydrogenase, type 1 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase mRNA were expressed in all three cell populations tested, whereas type 3 17beta-hydroxysteroid dehydrogenase mRNA could only be detected in SZ95 sebocytes. The major metabolic steps of testosterone in SZ95 sebocytes, primary sebocyte cultures, and HaCaT keratinocytes were its conversion to androstenedione by 17beta-hydroxysteroid dehydrogenase and further to 5alpha-androstanedione by 5alpha-reductase. The type 1 5alpha-reductase selective inhibitor 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one, but not the type 2 selective inhibitor dihydrofinasteride, inhibited 5alpha-reductase at low concentrations in SZ95 sebocytes and HaCaT keratinocytes. 5alpha-androstanedione was degraded to androsterone by 3alpha-hydroxysteroid dehydrogenase, which exhibited a stronger activity in HaCaT keratinocytes than in SZ95 sebocytes and in primary sebocyte cultures. Lower levels of 5alpha-dihydrotestosterone and 5alpha-androstanediol were also detected in all cells tested. Our investigations show that specific enzyme expression and activity in cultured sebocytes and keratinocytes seem to allocate different duties to these cells in vitro. Sebocytes are able to synthesize testosterone from adrenal precursors and to inactivate it in order to maintain androgen homeostasis, whereas keratinocytes are responsible for androgen degradation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A prominent androgen is 5α-dihydrotestosterone (5α-DHT), as sebocytes are able to convert testosterone to 5α-DHT with the enzyme 5α-reductase type I68.”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [68]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Both testosterone and 5α-DHT increase sebaceous proliferation, however, they do not affect lipid synthesis.68,69”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [68]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Both testosterone and 5α-DHT increase sebaceous proliferation, however, they do not affect lipid synthesis.68,69”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [68]
Experimental — accuracy not yet measuredIn the citing paper
“Greater activity of the 17βHSD types 3 and 5 was detected in sebaceous glands of facial skin than in other, non-acne prone skin areas, suggesting the in situ more potent androgen formation in these areas [74, 101].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [101]
In the citing paper
“Functional comparison of different epidermal cell types hint at differential functions for androgen biosynthesis and inactivation (Fritsch et al., 2001).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Fritsch et al., 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., & Fusenig, N. E. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.761 · Cited by 4,170
Steroid 5α-reductase: two genes/two enzymes
Russell, D. W., & Wilson, J. D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000325 · Cited by 1,105
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480
Grino, P. B., Griffin, J. E., & Wilson, J. D. (1990) · Endocrinology · doi:10.1210/endo-126-2-1165 · Cited by 442
Wu, L., Einstein, M., Geissler, W. M., Chan, H. K., Elliston, K. O., & Andersson, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31480-7 · Cited by 437
Establishment and Characterization of an Immortalized Human Sebaceous Gland Cell Line (SZ95)1
Zouboulis, C. C., Seltmann, H., Orfanos, C. E., & Neitzel, H. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00771.x · Cited by 363
Self-citationSansone, G., & Reisner, R. M. (1971) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12261252 · Cited by 300
Martel, C., Rhéaume, E., Takahashi, M., Trudel, C., Couët, J., Luu-The, V., Simard, J., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90390-5 · Cited by 231
Research works printed but not linked: 2
- Orfanos, 1982, Antiandrogenos en dermatologia, Arch Argent Dermat, 32, 51
- Puerto, 1990, Regional differences of the androgenic metabolic pattern in subjects affected by male pattern baldness, Rev Esp Fisiol, 46, 289
Cited by
Sorted by citations
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
Payne, A. H., & Hales, D. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0030 · Cited by 1,766
Gollnick, H. P. M., Cunliffe, W. J., Berson, D. S., Dréno, B., Finlay, A. Y., Leyden, J. J., Shalita, A. R., & Thiboutot, D. M. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.618 · Cited by 818
Acne and sebaceous gland function
Zouboulis, C. C. (2004) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2004.03.004 · Cited by 561
Self-citationPrevalence of Dry Eye Disease among US Men: Estimates from the Physicians’ Health Studies
Schaumberg, D., Dana, R., Buring, J., & Sullivan, D. (2009) · A M A Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.103 · Cited by 627
Androgenetic alopecia: a review
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., & Lombardo, F. P. (2017) · Endocrine · doi:10.1007/s12020-017-1280-y · Cited by 582
Ito, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., & Paus, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-1968fje · Cited by 498
Zouboulis, C., Chen, W.-C., Thornton, M., Qin, K., & Rosenfield, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961807 · Cited by 379
Self-citationSteroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369
Self-citationThiboutot, D., Gilliland, K., Cong, Z., Jabara, S., McAllister, J. M., Sivarajah, A., & Clawson, G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12244.x · Cited by 301
An update on the role of the sebaceous gland in the pathogenesis of acne
Makrantonaki, E., Gancevičienė, R., & Zouboulis, C. C. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.1.13900 · Cited by 312
Self-citationAcne is an inflammatory disease and alterations of sebum composition initiate acne lesions
Zouboulis, C. C., Jourdan, E., & Picardo, M. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12298 · Cited by 286
Self-citationMan, M., Xin, S. J., Song, S. P., Cho, S., Zhang, X. J., Tu, C. X., Feingold, K. R., & Elias, P. M. (2009) · Skin Pharmacology and Physiology · doi:10.1159/000231524 · Cited by 285
Cutaneous androgen metabolism: basic research and clinical perspectives
Chen, W., Thiboutot, D., & Zouboulis, C. C. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00613.x · Cited by 273
Self-citationCorticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes
Zouboulis, C. C., Seltmann, H., Hiroi, N., Chen, W., Young, M., Oeff, M., Scherbaum, W. A., Orfanos, C. E., McCann, S. M., & Bornstein, S. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102180999 · Cited by 290
Self-citationChronological ageing and photoageing of the human sebaceous gland
Zouboulis, C. C., & Boschnakow, A. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00894.x · Cited by 226
Self-citationIntracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217
The Pathobiology of Skin Aging
Russell-Goldman, E. E., & Murphy, G. F. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.03.007 · Cited by 224
The role of androgen and androgen receptor in skin-related disorders
Lai, J.-J., Chang, P., Lai, K.-P., Chen, L., & Chang, C. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1265-x · Cited by 207
Frontiers in sebaceous gland biology and pathology
Zouboulis, C. C., Baron, J. M., Böhm, M., Kippenberger, S., Kurzen, H., Reichrath, J., & Thielitz, A. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00725.x · Cited by 205
Self-citationThe Hair Follicle as an Estrogen Target and Source
Ohnemus, U., Uenalan, M., Inzunza, J., Gustafsson, J.-A., & Paus, R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0020 · Cited by 205
Androgen actions on the human hair follicle: perspectives
Inui, S., & Itami, S. (2012) · Experimental Dermatology · doi:10.1111/exd.12024 · Cited by 202
Clinical and biological impact of the exposome on the skin
Passeron, T., Krutmann, J., Andersen, M. L., Katta, R., & Zouboulis, C. C. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16614 · Cited by 205
Self-citationRegulation of Human Sebaceous Glands
Thiboutot, D. M. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2004.t01-2-.x · Cited by 191
The human skin as a hormone target and an endocrine gland
Zouboulis, C. C. (2004) · HORMONES · doi:10.14310/horm.2002.11109 · Cited by 184
Self-citationAndrogen action on human skin – from basic research to clinical significance
Zouboulis, C. C., & Degitz, K. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00255.x · Cited by 184
Self-citationHuman skin: an independent peripheral endocrine organ
Zouboulis, C. C. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053265 · Cited by 183
Self-citationHomeostasis of the sebaceous gland and mechanisms of acne pathogenesis
Clayton, R. W., Göbel, K., Niessen, C. M., Paus, R., Steensel, M. A. M. V., & Lim, X. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17981 · Cited by 187
Otberg, N., Finner, A. M., & Shapiro, J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.004 · Cited by 175
Beyond acne: Current aspects of sebaceous gland biology and function
Zouboulis, C. C., Picardo, M., Ju, Q., Kurokawa, I., Törőcsik, D., Bíró, T., & Schneider, M. R. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9389-5 · Cited by 174
Self-citationNeuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne
Zouboulis, C. C., & Böhm, M. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00254.x · Cited by 161
Self-citationUpdate and Future of Systemic Acne Treatment
Zouboulis, C. C., & Piquero-Martín, J. (2003) · Dermatology · doi:10.1159/000067821 · Cited by 155
Self-citationDisorders of the Sebaceous Glands
Simpson, N. B., & Cunliffe, W. J. (2004) · doi:10.1002/9780470750520.ch43 · Cited by 155
Acne: hormonal concepts and therapy
Thiboutot, D. (2004) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2004.03.010 · Cited by 155
Sebaceous-immunobiology is orchestrated by sebum lipids
Lovászi, M., Szegedi, A., Zouboulis, C. C., & Törőcsik, D. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1375636 · Cited by 151
“Both testosterone and 5a-DHT increase sebaceous proliferation, however, they do not affect lipid synthesis.(68,69)”
BackgroundSelf-citationDevelopment and homeostasis of the sebaceous gland
Niemann, C., & Horsley, V. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.010 · Cited by 151
Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris
Gancevičienė, R., Gražienë, V., Fimmel, S., & Zouboulis, C. C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08959.x · Cited by 146
Self-citationSakai, S., Kikuchi, K., Satoh, J., Tagami, H., & Inoue, S. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06756.x · Cited by 131
The mechanism of skin lipids influencing skin status
Jia, Y., Gan, Y., He, C., Chen, Z., & Zhou, C. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.11.006 · Cited by 131
Zouboulis, C. C., Coenye, T., He, L., Kabashima, K., Kobayashi, T., Niemann, C., Nomura, T., Oláh, A., Picardo, M., Quist, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029818 · Cited by 143
Self-citationŠtecová, J., Mehnert, W., Blaschke, T., Kleuser, B., Sivaramakrishnan, R., Zouboulis, C. C., Seltmann, H., Körting, H. C., Kramer, K. D., & Schäfer‐Korting, M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9225-9 · Cited by 126
Self-citationExpert Committee Recommendations for Acne Management
Zaenglein, A. L., & Thiboutot, D. M. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2022 · Cited by 120
Makrantonaki, E., & Zouboulis, C. C. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07671.x · Cited by 117
Self-citationAdult-onset acne: prevalence, impact, and management challenges
Rocha, M., & Bagatin, E. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s137794 · Cited by 110
Lunenfeld, B., Saad, F., & Hoesl, C. E. (2005) · The Aging Male · doi:10.1080/13685530500163416 · Cited by 108
The skin as an endocrine organ
Zouboulis, C. C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.5.9499 · Cited by 106
Self-citationZouboulis, C. C., Schagen, S., & Alestas, T. (2008) · Archives of Dermatological Research · doi:10.1007/s00403-008-0879-5 · Cited by 105
Self-citationUpdate on etiopathogenesis and treatment of Acne
Bhat, Y. J., Latief, I., & Hassan, I. (2017) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.199581 · Cited by 100
Correlation between Endocrinological Parameters and Acne Severity in Adult Women
Cannavò, S. P., Vaccaro, M., Guarneri, B., Borgia, F., Cannavò, S., & Guarneri, F. (2004) · Acta Dermato Venereologica · doi:10.1080/00015550410023248 · Cited by 96
Orfanos, C. E., Adler, Y. D., & Zouboulis, C. C. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053267 · Cited by 92
Self-citationZouboulis, C. C., & Bettoli, V. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13639 · Cited by 90
Self-citationDisorders of the Sebaceous Glands
Layton, A. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch42 · Cited by 87
Skin and brain age together: The role of hormones in the ageing process
Makrantonaki, E., Schönknecht, P., Hossini, A. M., Kaiser, E., Katsouli, M.-M., Adjaye, J., Schröder, J., & Zouboulis, C. C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.005 · Cited by 88
Self-citationMakrantonaki, E., & Zouboulis, C. C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.002 · Cited by 87
Self-citationLXRα Enhances Lipid Synthesis in SZ95 Sebocytes
Hong, I., Lee, M.-H., Na, T.-Y., Zouboulis, C. C., & Lee, M.-O. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701134 · Cited by 77
Self-citationZouboulis, C. C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.7804 · Cited by 77
Self-citationUrysiak-Czubatka, I., Kmieć, M. L., & Broniarczyk-Dyła, G. (2014) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.40925 · Cited by 77
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76
Self-citationEndocrinology and immunology of acne: Two sides of the same coin
Zouboulis, C. C. (2020) · Experimental Dermatology · doi:10.1111/exd.14172 · Cited by 78
Self-citationKarčiauskienė, J., Valiukevičienė, S., Gollnick, H. P. M., & Stang, A. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12160 · Cited by 74
“Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands
Tóth, B. I., Oláh, A., Szöllősi, A. G., Czifra, G., & Bíró, T. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0941-6 · Cited by 76
A practical guide for the study of human and murine sebaceous glands in situ
Hinde, E., Haslam, I. S., Schneider, M. R., Langan, E. A., Kloepper, J. E., Schramm, C., Zouboulis, C. C., & Paus, R. (2013) · Experimental Dermatology · doi:10.1111/exd.12207 · Cited by 72
Self-citationOzolins, M., Eady, E. A., Avery, A. J., Cunliffe, W. J., O'Neill, C., Simpson, N., & Williams, H. C. (2005) · Health Technology Assessment · doi:10.3310/hta9010 · Cited by 69
Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 66
Genetic architecture of acne vulgaris
Lichtenberger, R., Simpson, M. A., Smith, C. H., Barker, J. N., & Navarini, A. A. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14385 · Cited by 63
Androgens and ageing of the skin
Makrantonaki, E., & Zouboulis, C. C. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832b71dc · Cited by 62
Self-citationEndocrinologic Aspects of Hidradenitis Suppurativa
Karagiannidis, I., Nikolakis, G. D., & Zouboulis, C. C. (2015) · Dermatologic Clinics · doi:10.1016/j.det.2015.08.005 · Cited by 61
Self-citationAesthetic Treatment of Bruxism.
Aguilera, S. B., Brown, L., & Perico, V. (2017) · Europe PMC (PubMed Central) · Cited by 75
Zhang, C., Chinnappan, M., Prestwood, C. A., Edwards, M., Artami, M., Thompson, B. M., Eckert, K. M., do Vale, G. D., Zouboulis, C. C., McDonald, J. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100749118 · Cited by 59
Self-citationSelective non-steroidal inhibitors of 5α-reductase type 1
Occhiato, E. G., Guarna, A., Danza, G., & Serio, M. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.10.004 · Cited by 59
Alsantali, A., & Shapiro, J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832b100a · Cited by 61
Ridha, Z., Fabi, S. G., Zubair, R., & Dayan, S. H. (2024) · Aesthetic Surgery Journal · doi:10.1093/asj/sjae132 · Cited by 62
Hormonal Therapy of Intrinsic Aging
Zouboulis, C. C., & Makrantonaki, E. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1249 · Cited by 58
Self-citationIs hormonal treatment still an option in acne today?
Bettoli, V., Zauli, S., & Virgili, A. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13681 · Cited by 52
Barrault, C., Garnier, J., Pedretti, N., Cordier-Dirikoc, S., Ratineau, E., Deguercy, A., & Bernard, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.04.005 · Cited by 51
Recent advances in the endocrinology of the sebaceous gland
Szöllősi, A. G., Oláh, A., Bíró, T., & Tóth, B. I. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1361576 · Cited by 51
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone
Chen, W., Tsai, S., Sheu, H., Tsai, J., & Zouboulis, C. C. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00996.x · Cited by 48
Self-citationKoseki, J., Matsumoto, T., Matsubara, Y., Tsuchiya, K., Mizuhara, Y., Sekiguchi, K., Nishimura, H., Watanabe, J. A., Kaneko, A., Hattori, T., et al. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/853846 · Cited by 47
Azzi, L., Elalfy, M., & Labrie, F. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06847.x · Cited by 47
Schneider, M. R., & Zouboulis, C. C. (2018) · Experimental Dermatology · doi:10.1111/exd.13513 · Cited by 48
Self-citationSteroid hormone influence on melanomagenesis
Mitkov, M. V., Joseph, R. W., & Copland, J. A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.020 · Cited by 47
Samson, M., Labrie, F., Zouboulis, C. C., & Luu-The, V. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.225 · Cited by 42
Self-citationZouboulis, C. C. (2010) · Der Hautarzt · doi:10.1007/s00105-009-1894-y · Cited by 44
Self-citationZouboulis, C. C. (2003) · Der Hautarzt · doi:10.1007/s00105-003-0581-7 · Cited by 42
Self-citationGender Differences in Skin Aging and the Changing Profile of the Sex Hormones with Age
Farage, M. A. (2012) · Journal of Steroids & Hormonal Science · doi:10.4172/2157-7536.1000109 · Cited by 42
Sebaceous Gland in Human Skin - The Fantastic Future of a Skin Appendage
Zouboulis, C. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12263.x · Cited by 41
Self-citationDoxorubicin-Induced Alopecia Is Associated with Sebaceous Gland Degeneration
Selleri, S., Seltmann, H., Gariboldi, S., Shirai, Y. F., Balsari, A., Zouboulis, C. C., & Rumio, C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700175 · Cited by 41
Self-citationUlmann, L., Rodeau, J., Danoux, L., Contet‐Audonneau, J., Pauly, G., & Schlichter, R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.018 · Cited by 39
Pathogenesis of Androgenetic Alopecia
Kidangazhiathmana, A., & Santhosh, P. (2022) · Clinical Dermatology Review · doi:10.4103/cdr.cdr_29_21 · Cited by 36
Acne as an altered dermato‐endocrine response problem
Briganti, S., Flori, E., Mastrofrancesco, A., & Ottaviani, M. (2020) · Experimental Dermatology · doi:10.1111/exd.14168 · Cited by 39
Expression of steroidogenic enzymes in human sebaceous glands
Inoue, T., Miki, Y., Kakuo, S., Hachiya, A., Kitahara, T., Aiba, S., Zouboulis, C. C., & Sasano, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0323 · Cited by 36
Self-citationAnti-acne drugs in phase 1 and 2 clinical trials
Zouboulis, C. C., Dessinioti, C., Tsatsou, F., & Gollnick, H. P. M. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1337745 · Cited by 35
Self-citationBharti, S., & Vadlamudi, H. C. (2020) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2020.1805626 · Cited by 43
Anti‐Aging Data and Support Claims – Consensus Statement
Elsner, P. L., Fluhr, J. W., Gehring, W., Kerscher, M. J., Krutmann, J., Lademann, J. M., Makrantonaki, E., Wilhelm, K., & Zouboulis, C. C. (2011) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0379.2011.07746.x · Cited by 36
Self-citationRosati, F., Danza, G., Guarna, A., Cini, N., Racchi, M. L., & Serio, M. (2002) · Endocrinology · doi:10.1210/en.2002-220649 · Cited by 34
Therapie der Akne mit Antiandrogenen – Eine evidenzbasierte Übersicht
Zouboulis, C. C. (2003) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1046/j.1610-0387.2003.03011.x · Cited by 34
Self-citationOverview of the Treatment of Acne Vulgaris with Topical Retinoids
Hsu, P., Litman, G. I., & Brodell, R. T. (2011) · Postgraduate Medicine · doi:10.3810/pgm.2011.05.2294 · Cited by 33
Kapoor, A., Lubach, G. R., Hedman, C. J., Ziegler, T. E., & Coe, C. L. (2014) · Pediatric Research · doi:10.1038/pr.2014.1 · Cited by 33
The pathophysiology of acne vulgaris in children and adolescents, Part 1.
Bergfeld, W. F. (2004) · PubMed · Cited by 33
Ultraviolet B irradiation increases the expression of inflammatory cytokines in cultured sebocytes
Lee, W. J., Park, K. H., Sohn, M. Y., Lee, W. C., Lee, S., & Kim, D. W. (2013) · The Journal of Dermatology · doi:10.1111/1346-8138.12330 · Cited by 32
Azmahani, A., Nakamura, Y., Felizola, S. J. A., Ozawa, Y., Ise, K., Inoue, T., McNamara, K. M., Doi, M., Okamura, H., Zouboulis, C. C., et al. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.07.010 · Cited by 31
Self-citation
Metadata
- Authors
- Fritsch, M., Orfanos, C. E., & Zouboulis, C. C.
- Affiliations
- Freie Universität Berlin (DE)
- Corresponding author
- Zouboulis, Christos C.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 116
- Issue
- 5
- Pages
- 793-800
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2094557019
- Cited by
- 232
- References
- 61
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 4 · 2015: 14 · 2014: 19 · 2013: 8 · 2012: 8
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- sebocytes, androgen receptor, 17β-hydroxysteroid dehydrogenase, 5α-reductase, 3α-hydroxysteroid dehydrogenase, testosterone metabolism, dihydrotestosterone, androstenedione, cyproterone acetate
- MeSH terms
- Androgens, Cell Line, Dehydroepiandrosterone, Enzyme Inhibitors, Homeostasis, Humans, Hydroxysteroid Dehydrogenases, Oxidoreductases, Receptors, Androgen, RNA, Messenger, Sebum, Skin Physiological Phenomena, Testosterone, Cyproterone Acetate, Reverse Transcriptase Polymerase Chain Reaction, Cholestenone 5 alpha-Reductase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
