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Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation
Open accessAbstract
Background & aims In fecal samples from patients with chronic constipation, the microbiota differs from that of healthy subjects. However, the profiles of fecal microbiota only partially replicate those of the mucosal microbiota. It is not clear whether these differences are caused by variations in diet or colonic transit, or are associated with methane production (measured by breath tests). We compared the colonic mucosal and fecal microbiota in patients with chronic constipation and in healthy subjects to investigate the relationships between microbiota and other parameters.Methods Sigmoid colonic mucosal and fecal microbiota samples were collected from 25 healthy women (controls) and 25 women with chronic constipation and evaluated by 16S ribosomal RNA gene sequencing (average, 49,186 reads/sample). We assessed associations between microbiota (overall composition and operational taxonomic units) and demographic variables, diet, constipation status, colonic transit, and methane production (measured in breath samples after oral lactulose intake).Results Fourteen patients with chronic constipation had slow colonic transit. The profile of the colonic mucosal microbiota differed between constipated patients and controls (P < .05). The overall composition of the colonic mucosal microbiota was associated with constipation, independent of colonic transit (P < .05), and discriminated between patients with constipation and controls with 94% accuracy. Genera from Bacteroidetes were more abundant in the colonic mucosal microbiota of patients with constipation. The profile of the fecal microbiota was associated with colonic transit before adjusting for constipation, age, body mass index, and diet; genera from Firmicutes (Faecalibacterium, Lactococcus, and Roseburia) correlated with faster colonic transit. Methane production was associated with the composition of the fecal microbiota, but not with constipation or colonic transit.Conclusions After adjusting for diet and colonic transit, the profile of the microbiota in the colonic mucosa could discriminate patients with constipation from healthy individuals. The profile of the fecal microbiota was associated with colonic transit and methane production (measured in breath), but not constipation.
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“In a study of adults with chronic constipation, overall composition of the colonic mucosa-associated microbiota could discriminate patients with constipation from control subjects independent of transit time157.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [157]
In the citing paper
“There is evidence supporting an association between the altered mucosal and fecal microbiota and chronic constipation156, 157.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [157]
In the citing paper
“The other explanation is that the ref lexivity of metabolites of various gut microbiota (especially the bacteria attached to the intestinal mucosa) causes intestinal smooth muscle contraction [14,17].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
In the citing paper
“One explanation suggests that the gut microbiota can regulate the expression of genes involved in intestinal peristalsis.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
In the citing paper
“When the concentration of SCFAs surpasses a certain threshold, they can stimulate electrolyte absorption, inhibit the secretion of mucin, and lead to the occurrence and development of constipation;”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
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“SCFAs, especially butyric acid, exhibit a biphasic effect on the secretion of mucin by colonic epithelial cells.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
In the citing paper
“conversely, they can stimulate mucin secretion, regulate the neurochemical phenotype, and enhance the excitability of choline acetyltransferase-positive neurons, thereby improving constipation [17,33,34].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
In the citing paper
“On the other hand, one study reported that in patients with FC, methane production was associated with the gut microbial composition, but not with constipation or colonic transit [ 77 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [77]
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Citations
Cites
Breiman, L. (2001) · Machine Learning · doi:10.1023/a:1010933404324 · Cited by 133,538
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,770
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Self-citationFastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Shekhar, C., Monaghan, P. J., Morris, J., Issa, B., Whorwell, P. J., Keevil, B. G., & Houghton, L. A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.014 · Cited by 2,891
Lozupone, C., Hamady, M., Kelley, S. T., & Knight, R. D. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01996-06 · Cited by 2,717
Flagged first, then by citations
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Roseburia Spp.: A Marker of Health?
Tamanai‐Shacoori, Z., Smida, I., Bousarghin, L., Loréal, O., Meuric, V., Fong, S. B., Bonnaure‐Mallet, M., & Jolivet‐Gougeon, A. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0130 · Cited by 767
Mechanisms, evaluation, and management of chronic constipation
Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655
Self-citationGlobal burden of irritable bowel syndrome: trends, predictions and risk factors
Black, C. J., & Ford, A. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0286-8 · Cited by 666
Sex differences in gut microbiota
Kim, Y. S., Unno, T., Kim, B.-Y., & Park, M.-S. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.190009 · Cited by 610
Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., Tong, T., Yang, Y., & Wang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.757718 · Cited by 515
Oscillospira - a candidate for the next-generation probiotics
Yang, J., Li, Y., Wen, Z., Liu, W., Meng, L., & Huang, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1987783 · Cited by 484
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468
Tang, R., Wei, Y., Li, Y., Chen, W., Chen, H., Wang, Q., Yang, F., Miao, Q., Xiao, X., Zhang, H., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313332 · Cited by 434
Oscillospira and related bacteria – From metagenomic species to metabolic features
Gophna, U., Konikoff, T., & Nielsen, H. B. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13658 · Cited by 409
Prebiotics and Probiotics in Digestive Health
Quigley, E. M. M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.028 · Cited by 404
Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
Nishiwaki, H., Ito, M., Ishida, T., Hamaguchi, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., et al. (2020) · Movement Disorders · doi:10.1002/mds.28119 · Cited by 370
Gut Microbiota and Chronic Constipation: A Review and Update
Ohkusa, T., Koido, S., Nishikawa, Y., & Sato, N. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00019 · Cited by 364
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359
Self-citationAdvancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 349
Gut microbiota diversity across ethnicities in the United States
Brooks, A. W., Priya, S., Blekhman, R., & Bordenstein, S. R. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006842 · Cited by 304
Constipation and risk of death and cardiovascular events
Sumida, K., Molnar, M. Z., Potukuchi, P. K., Thomas, F., Lü, J., Yamagata, K., Kalantar‐Zadeh, K., & Kovesdy, C. P. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.021 · Cited by 296
Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243
Bharucha, A. E., & Wald, A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.031 · Cited by 238
Self-citationGe, X., Zhao, W., Ding, C., Tian, H., Xu, L., Wang, H., Ni, L., Jiang, J., Gong, J., Zhu, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00612-y · Cited by 232
Black, C. J., & Ford, A. C. (2018) · The Medical Journal of Australia · doi:10.5694/mja18.00241 · Cited by 231
The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls
Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020433 · Cited by 219
Race-dependent association of sulfidogenic bacteria with colorectal cancer
Yazici, C., Wolf, P. G., Kim, H., Cross, T.-W. L., Vermillion, K., Carroll, T., Augustus, G. J., Mutlu, E., Tussing-Humphreys, L., Braunschweig, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313321 · Cited by 215
Self-citationBlue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, F., Leeming, E. R., Dimidi, E., Mazidi, M., Franks, P. W., Khatib, H. A., Valdes, A. M., Davies, R., Bakker, E., Francis, L., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323877 · Cited by 208
Intestinal microbiota and chronic constipation
Zhao, Y., & Yu, Y. (2016) · SpringerPlus · doi:10.1186/s40064-016-2821-1 · Cited by 216
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 229
Fang, Z., Li, L., Zhang, H., Zhao, J., Lu, W., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720393 · Cited by 200
Role of gut microbiota in functional constipation
Zhang, S., Wang, R., Li, D., Zhao, L., & Zhu, L. (2021) · Gastroenterology Report · doi:10.1093/gastro/goab035 · Cited by 175
Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., Nouvenne, A., Meschi, T., van Sinderen, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10663-w · Cited by 182
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163
Gut physiology and environment explain variations in human gut microbiome composition and metabolism
Procházková, N., Laursen, M. F., Barbera, G. L., Tsekitsidi, E., Jørgensen, M. S., Rasmussen, M. A., Raes, J., Licht, T. R., Dragsted, L. O., & Roager, H. M. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01856-x · Cited by 189
The effect of gut microbiome on tolerance to morphine mediated antinociception in mice
Kang, M., Mischel, R. A., Bhave, S., Komla, E., Cho, A., Huang, C., Dewey, W. L., & Akbarali, H. I. (2017) · Scientific Reports · doi:10.1038/srep42658 · Cited by 154
Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149
Sumida, K., Yamagata, K., & Kovesdy, C. P. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.11.002 · Cited by 153
A potential role for the gut microbiome in substance use disorders
Meckel, K. R., & Kiraly, D. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05232-0 · Cited by 146
Body Mass Index and Sex Affect Diverse Microbial Niches within the Gut
Borgo, F., Garbossa, S., Riva, A., Severgnini, M., Luigiano, C., Benetti, A., Pontiroli, A. E., Morace, G., & Borghi, E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00213 · Cited by 145
Understanding the physiology of human defaecation and disorders of continence and evacuation
Heitmann, P. T., Vollebregt, P. F., Knowles, C. H., Lunniss, P. J., Dinning, P. G., & Scott, S. M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00487-5 · Cited by 156
Characterization of Microbiota in Children with Chronic Functional Constipation
de Meij, T. G. J., de Groot, E. F. J., Eck, A., Budding, A. E., Kneepkens, C. M. F., Benninga, M. A., Bodegraven, A. A. V., & Savelkoul, P. H. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164731 · Cited by 141
Tian, H., Ge, X., Nie, Y., Yang, L., Ding, C., McFarland, L. V., Zhang, X., Chen, Q., Gong, J., & Li, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171308 · Cited by 131
The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127
Liu, Y., Liu, B., Li, D., Hu, Y., Zhao, L., Zhang, M., Ge, S., Pang, J., Li, Y., Wang, R., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001157 · Cited by 125
Zhang, X., Yang, H., Zheng, J., Jiang, N., Sun, G., Bao, X., Lin, A., & Liu, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117218 · Cited by 121
Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 121
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 127
Hu, T., Wen, P., Fu, H.-Z., Guangyue, L., Liao, S., & Zou, Y. (2019) · Food & Function · doi:10.1039/c9fo00132h · Cited by 107
Carco, C., Young, W., Gearry, R. B., Talley, N. J., McNabb, W. C., & Roy, N. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00468 · Cited by 105
Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation
Wang, J.-K., & Yao, S.-K. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/5560310 · Cited by 98
Wang, J., Liang, Q., Zhao, Q., Tang, Q., Ahmed, A. F., Zhang, Y., & Kang, W. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112305 · Cited by 96
Fruits and their impact on the gut microbiota, gut motility and constipation
Katsirma, Z., Dimidi, E., Rodriguez‐Mateos, A., & Whelan, K. (2021) · Food & Function · doi:10.1039/d1fo01125a · Cited by 96
Dimidi, E., Scott, S. M., & Whelan, K. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000934 · Cited by 90
Next‐Generation Probiotics: Microflora Intervention to Human Diseases
Zhang, H., Duan, Y., Cai, F., Cao, D., Wang, L., Qiao, Z., Hong, Q., Li, N., Zheng, Y., Su, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/5633403 · Cited by 99
Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice
Jing, Y., Yang, D., Bai, F., Zhang, C., Qin, C., Li, D., Wang, L., Yang, M., Chen, Z., & Li, J. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6012 · Cited by 88
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R., Dimidi, E., Fikree, A., Ford, A. C., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14050 · Cited by 97
The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy
Engen, P. A., Dodiya, H. B., Naqib, A. D., Forsyth, C. B., Green, S. J., Voigt, R. M., Kordower, J. H., Mutlu, E., Shannon, K. M., & Keshavarzian, A. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-160991 · Cited by 84
Altomare, A., Putignani, L., CHIERICO, F. D., Cocca, S., Angeletti, S., Ciccozzi, M., Tripiciano, C., Piccola, B. D., Cicala, M., & Guarino, M. P. L. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.11.021 · Cited by 86
Zhang, Y., Yu, X., Yu, E., Wang, N., Cai, Q.-C., Shuai, Q., Yan, F., Jiang, L., Wang, H., Liu, J., et al. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1232-6 · Cited by 82
Wang, L., Wang, L., Tian, P., Wang, B., Cui, S., Zhao, J., Zhang, H., Qian, L., Wang, Q., Chen, W., et al. (2022) · Food & Function · doi:10.1039/d1fo03896f · Cited by 81
The gut–kidney–heart axis in chronic kidney disease
Sumida, K., & Kovesdy, C. P. (2019) · Physiology International · doi:10.1556/2060.106.2019.19 · Cited by 80
Johnston, D. G. W., Williams, M. A., Thaiss, C. A., Cabrera‐Rubio, R., Raverdeau, M., McEntee, C. P., Cotter, P. D., Elinav, E., O'Neill, L. A. J., & Corr, S. C. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy038 · Cited by 77
Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B. R., Shen, B., Liao, Q., Xie, Z., & Hong, Y. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110569 · Cited by 74
Gut microbiota: a new avenue to reveal pathological mechanisms of constipation
Yang, L., Wang, Y., Zhang, Y. L., Li, W., Jiang, S., Qian, D., & Duan, J. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12197-2 · Cited by 75
Constipation and Fecal Incontinence in the Elderly
Deb, B., Prichard, D. O., & Bharucha, A. E. (2020) · Current Gastroenterology Reports · doi:10.1007/s11894-020-00791-1 · Cited by 81
Self-citationHori, T., Matsuda, K., & Oishi, K. (2020) · Microorganisms · doi:10.3390/microorganisms8091401 · Cited by 76
Xu, Y., Shao, M., Fang, X., Tang, W., Zhou, C., Hu, X., Zhang, X., & Su, K. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.014 · Cited by 72
Chu, J. R., Kang, S.-Y., Kim, S.-E., Lee, S.-J., Lee, Y., & Sung, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i40.6129 · Cited by 72
Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation
Tian, H., Chen, Q., Yang, B., Qin, H., & Li, N. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06500-2 · Cited by 68
Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment
Xu, Y., Amdanee, N., & Zhang, X. (2021) · CNS Drugs · doi:10.1007/s40263-021-00859-0 · Cited by 73
Effects of Prebiotics and Synbiotics on Functional Constipation
Yu, T., Zheng, Y., Tan, J., Xiong, W.-J., Wang, Y., & Lin, L. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.09.014 · Cited by 69
Martoni, C. J., Evans, M., Chow, C. T., Chan, L. S., & Leyer, G. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12797 · Cited by 67
Ding, C., Fan, W., Gu, L., Tian, H., Ge, X., Gong, J., Nie, Y., & Li, N. (2018) · Gastroenterology report · doi:10.1093/gastro/gox036 · Cited by 65
Flux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 70
Intestinal Microbiota Predicts Lung Cancer Patients at Risk of Immune-Related Diarrhea
Liu, T., Xiong, Q., Li, L., & Hu, Y. (2019) · Immunotherapy · doi:10.2217/imt-2018-0144 · Cited by 64
Guo, M., Yao, J., Yang, F. H., Liu, W., Bai, H., Ma, J., Ma, X., Zhang, J., Fang, Y., Miao, Y., et al. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0283 · Cited by 63
Zhang, X., Tian, H., Gu, L., Nie, Y., Ding, C., Ge, X., Yang, B. K., Gong, J., & Li, N. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9229-1 · Cited by 65
Characterization of gut contractility and microbiota in patients with severe chronic constipation
Рашидовна, Я. Д., Ulfatovich, S. M., Андреевич, С. К., Arzamastseva, A. A., Shaidullov, I. F., Markelova, M., Grigoryeva, T. V., Karpukhin, O. Y., & Ситдикова, Г. Ф. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235985 · Cited by 62
Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice
Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 65
Zhang, X., Zheng, J., Jiang, N., Sun, G., Bao, X., Kong, M., Cheng, X., Lin, A., & Liu, H. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105676 · Cited by 61
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Thomas, M. S., Blesso, C. N., Calle, M. C., Chun, O. K., Puglisi, M. J., & Fernández, M. L. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0131 · Cited by 66
Gu, Y., Qin, X., Zhou, G., Wang, C., Mu, C., Liu, X., Zhong, W., Xu, X. J., Wang, B., Jiang, K., et al. (2022) · Food & Function · doi:10.1039/d2fo01900k · Cited by 61
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
Yang, L., Wan, Y., Li, W., Liu, C., Li, H., Dong, Z., Zhu, K., Jiang, S., Shang, E., Qian, D., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11813-5 · Cited by 59
Hollister, E. B., Cain, K. C., Shulman, R. J., Jarrett, M. E., Burr, R. L., Ko, C. W., Zia, J. K., Han, C. J., & Heitkemper, M. M. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001107 · Cited by 61
Ma, T., Yang, N., Xie, Y., Li, Y., Xiao, Q., Li, Q., Jin, H., Zheng, L., Sun, Z., Zuo, K., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106755 · Cited by 66
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Li, H., Chen, J., Ren, X., Yang, C., Liu, S., Bai, X., Shan, S., & Dong, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.557515 · Cited by 58
Self-citationGhaffari, P., Shoaie, S., & Nielsen, L. K. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03365-z · Cited by 60
Ghoshal, U. C., Srivastava, D., & Misra, A. (2018) · Indian Journal of Gastroenterology · doi:10.1007/s12664-018-0901-6 · Cited by 59
Chai, M., Wang, L., Li, X., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2021) · Food & Function · doi:10.1039/d1fo00559f · Cited by 58
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Sumida, K., Lau, W. L., Kovesdy, C. P., Kalantar‐Zadeh, K., & Kalantar‐Zadeh, K. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000661 · Cited by 57
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Panarese, A., Pesce, F., Porcelli, P., Riezzo, G., Iacovazzi, P. A., Leone, C. M., Carne, M. D., Rinaldi, C. M., & Shahini, E. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i14.1729 · Cited by 56
Mars, R. A. T., Frith, M., & Kashyap, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.10.058 · Cited by 53
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“Parthasarathy et al. also demonstrated the correlation between a more rapid transit time and increased concentrations of Actinobacteria , Bacteroides , and Lactococcus [182].”
Yang, C., Hu, T., Xue, X., Su, X., Zhang, X., Fan, Y., Shen, X., & Dong, X. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03123-1 · Cited by 57
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Ge, X., Tian, H., Ding, C., Gu, L., Yao, W., Gong, J., Zhu, W., Li, N., & Li, J. (2016) · Archives of Medical Research · doi:10.1016/j.arcmed.2016.06.005 · Cited by 52
Tian, H., Cui, J., Ye, C., Zhao, J., Yang, B. K., Xu, Y., Ji, S., Wang, L., Lv, X., Ma, C., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236362 · Cited by 51
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Metadata
- Authors
- Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E.
- Affiliations
- Mayo Clinic (US)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Bharucha, Adil E.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 150
- Issue
- 2
- Pages
- 367-379.e1
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4727996
- OpenAlex
- W1915385926
- Cited by
- 396
- References
- 66
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 51 · 2023: 52 · 2022: 60 · 2021: 41 · 2020: 44 · 2019: 37 · 2018: 20 · 2017: 21 · 2016: 9
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health (UL1TR000135, TR000135)
- National Cancer Institute (R01CA179243)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK78924, R01DK078924, P30DK084567)
- National Center for Advancing Translational Sciences (TR000135)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- chronic constipation, fecal microbiota, colonic transit, methane production, breath test, Bacteroidetes, Firmicutes, Faecalibacterium, Roseburia, Lactococcus, women, 16S rRNA gene sequencing
- MeSH terms
- Gastrointestinal Microbiome, Adult, Algorithms, Bacteria, Breath Tests, Chronic Disease, Colon, Constipation, Feces, Female, Gastrointestinal Transit, Humans, Intestinal Mucosa, Methane, Middle Aged, Phylogeny, Multivariate Analysis, Case-Control Studies, Nonlinear Dynamics, Ribotyping
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