Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
Abstract
Background: PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. Objectives: To identify gut dysbiosis in PD across countries. Methods: We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta‐analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method. Results: After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol‐O‐methyl transferase inhibitor), genera Akkermansia and Catabacter , as well as families Akkermansiaceae , were increased, whereas genera Roseburia , Faecalibacterium , and Lachnospiraceae ND3007 group were decreased in PD. Catechol‐O‐methyl transferase inhibitor intake markedly increased family Lactobacillaceae . Inspection of these bacteria in 12 datasets that were not included in the meta‐analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short‐chain fatty acid metabolisms in our dataset. Conclusions: We report that intestinal mucin layer‐degrading Akkermansia is increased and that short‐chain fatty acid–producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society
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Gut dysbacteriosis is prevalent among PD patients and may be related to motor symptoms.
“gut dysbacteriosis is prevalent among PD patients and may be related to motor symptoms [16]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [16]
Several studies have reported a higher abundance of Akkermansia in PD patients compared to healthy controls.
“Several studies have reported a higher abundance of Akkermansia in PD patients compared to healthy controls [16, 53]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [16]
Parkinson's disease patients are characterized by an overgrowth of the genera Bifidobacterium, Lactobacillus, Akkermansia and of the opportunistic pathogens Porphyromonas and Corynebacterium, together with a decreased abundance of the SCFAs producers Prevotellaceae, Lachnospiraceae and Faecalibacterium.
“meta-analysis and systematic reviews report that PD patients are characterized by an overgrowth of the genera Bifidobacterium, Lactobacillus, Akkermansia and of the opportunistic pathogens Porphyromonas and Corynebacterium, together with a decreased abundance of the SCFAs producers Prevotellaceae, Lachnospiraceae and Faecalibacterium [52,53,54,55,56]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [52]
A meta-analysis of gut microbiota in 223 patients with Parkinson's disease and 137 healthy controls from five different countries revealed that Parkinson's disease is frequently associated with increased genus Akkermansia, which increases intestinal permeability, and decreased SCFA-producing bacteria of genera Roseburia and Faecalibacterium.
“A meta-analysis of gut microbiota in 223 patients with Parkinson's disease and 137 healthy controls from five different countries revealed that Parkinson's disease is frequently associated with increased genus Akkermansia which increases intestinal permeability and decreased SCFA-producing bacteria of genera Roseburia and Faecalibacterium [417].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [417]
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- Authors
- Nishiwaki, H., Ito, M., Ishida, T., Hamaguchi, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., Kurokawa, K., Katsuno, M., Hirayama, M., & Ohno, K.
- Affiliations
- Nagoya University (JP)
- Iwate Medical University (JP)
- Department of Neurology Okayama Kyokuto Hospital Okayama Japan
- Fukuoka University (JP)
- National Institute of Genetics (JP)
- Corresponding author
- Hirayama, Masaaki
- Ohno, Kinji
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2020-06-18
- Volume
- 35
- Issue
- 9
- Pages
- 1626-1635
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W3036274992
- Cited by
- 370
- References
- 83
- Citations by year
- 2026: 49 · 2025: 62 · 2024: 58 · 2023: 58 · 2022: 83 · 2021: 47 · 2020: 13
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Grants-in-Aid from the Japan Society for the Promotion of Science (JP17K07094, JP19K16516)
- he National Center of Neurology and Psychiatry (29-4)
- the Hori Sciences and Arts Foundation
- the Smoking Research Foundation;
- the Japan Agency for Medical Research and Development (JJP19gm1010002, JP19bm0804005, JP19ek0109230, JP19ek0109281)
- the Ministry of Health, Labour and Welfare of Japan (H29-Nanchi-Ippan-030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut dysbiosis, gut microbiota, Akkermansia, Roseburia, Faecalibacterium, Lactobacillaceae, catechol-O-methyltransferase inhibitors, short-chain fatty acid metabolism, mucin-degrading bacteria, cross-national comparison
- MeSH terms
- Gastrointestinal Microbiome, Catechol O-Methyltransferase, Feces, Finland, Germany, Humans, Parkinson Disease, Dysbiosis
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