The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Identification of Intermediates and Enzymes Involved in the Early Steps of Artemisinin Biosynthesis in Artemisia annua
Open accessAbstract
An important group of antimalarial drugs consists of the endoperoxide sesquiterpene lactone artemisinin and its derivatives. Only little is known about the biosynthesis of artemisinin in Artemisia annua L., particularly about the early enzymatic steps between amorpha-4,11-diene and dihydroartemisinic acid. Analyses of the terpenoids from A. annua leaves and gland secretory cells revealed the presence of the oxygenated amorpha-4,11-diene derivatives artemisinic alcohol, dihydroartemisinic alcohol, artemisinic aldehyde, dihydroartemisinic aldehyde and dihydroartemisinic acid. We also demonstrated the presence of a number of biosynthetic enzymes such as the amorpha-4,11-diene synthase and the--so far unknown--amorpha-4,11-diene hydroxylase as well as artemisinic alcohol and dihydroartemisinic aldehyde dehydrogenase activities in both leaves and glandular trichomes. From these results, we hypothesise that the early steps in artemisinin biosynthesis involve amorpha-4,11-diene hydroxylation to artemisinic alcohol, followed by oxidation to artemisinic aldehyde, reduction of the C11-C13 double bond to dihydroartemisinic aldehyde and oxidation to dihydroartemisinic acid.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Collectively, these metabolites suggested the presence of two interlinked pathways for the conversion of amorpha-4,11-diene (451) to either dihydroartemisinic acid (480) or artemisinic acid (473), as is shown in Scheme 11 [135].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [135]
In the citing paper
“Interestingly, there is now some evidence for such a route to dihydroartemisinic acid (480), which involves two oxidations at C-12 of amorpha-4,11-diene (451), producing artemisinic aldehyde (460) via artemisinic alcohol (458); followed by reduction of the Δ11,13 double bond in (460) to dihydroartemisinic aldehyde (483); and, finally, oxidation of (483) at C-12 to yield dihydroartemisinic acid (”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [135]
In the citing paper
“In 2005, artemisinic alcohol (458), artemisinic aldehyde (460), dihydroartemisinic alcohol (482) and dihydroartemisinic aldehyde (483) were all isolated as natural products from A. annua [135].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
March's Advanced Organic Chemistry
Smith, M. B., & March, J. (2006) · Wiley eBooks · doi:10.1002/0470084960 · Cited by 3,906
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720
Lange, B. M., Wildung, M. R., Stauber, E. J., Sanchez, C., Pouchnik, D. J., & Croteau, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2934 · Cited by 311
Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., & Brodelius, P. E. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1962 · Cited by 283
Self-citationAmorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis
Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266
Self-citationArtemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production
Abdin, M. Z., Israr, M., Rehman, R. U., & Jain, S. K. (2003) · Planta Medica · doi:10.1055/s-2003-38871 · Cited by 252
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183
de Kraker, J., Franssen, M. C. R., Joerink, M., de Groot, C. P. G. M., & Bouwmeester, H. J. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.010957 · Cited by 139
Self-citationWallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., & Quax, W. J. (1999) · Journal of Natural Products · doi:10.1021/np980370p · Cited by 129
de Kraker, J., Franssen, M. C. R., Dalm, M. C. F., de Groot, C. P. G. M., & Bouwmeester, H. J. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.4.1930 · Cited by 91
Self-citation
Research works printed but not linked: 5
- Ridley RG. Chemotherapeutic hope on the horizon for Plasmodium vivax malaria?.Proc Natl Acad Sci 2002; 21: 13 362 ± 4
- Maurer B, Grieder A. Sesquiterpenoids from costus root oil (Saussurea lappa Clarke). Helv Chim Acta 1977; 60: 2177 ± 190
- Zänglein A. Untersuchungen phytochemischer, morphologischer und anatomischer Merkmale und ihrer Variabilität an ausgewählten ¾therischölpflanzen und Drogen unter besonderen Aspekten der Dro- genbeurteilung und der Erkennung von Verfälschungen. PhD thesis, 1993 University of Würzburg, Würzburg, Germany: 13
- Gang DR, Wang J, Dudareva N, Nam KH, Simon JE, Lewinshom E, Pi- cherski E. An investigation of the storage and biosynthesis of phenyl- propanes in sweet basil. Plant Phys 2001; 125: 539 ± 55
- Mihaliak CA, Karp F, Croteau R. Cytochrome P450 terpene hydroxyla- ses. In: PJ Lea, editor. Methods in plant biochemistry; Enzymes of sec- ondary metabolism; Vol 9 Academic Press, London:: pp 261 ± 279 1993
Cited by
Sorted by citations
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
High-level semi-synthetic production of the potent antimalarial artemisinin
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060
Jan, R., Asaf, S., Numan, M., Lubna, & Kim, K. (2021) · Agronomy · doi:10.3390/agronomy11050968 · Cited by 893
Westfall, P. J., Pitera, D. J., Lenihan, J. R., Eng, D., Woolard, F. X., Regentin, R., Horning, T., Tsuruta, H., Melis, D. J., Owens, A. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110740109 · Cited by 726
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3240 · Cited by 675
Bohlmann, J., & Keeling, C. I. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03449.x · Cited by 524
Volatile science? Metabolic engineering of terpenoids in plants
Aharoni, A., Jongsma, M. A., & Bouwmeester, H. J. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.10.005 · Cited by 428
Self-citationMedically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action
Bergman, M. E., Davis, B. B., & Phillips, M. A. (2019) · Molecules · doi:10.3390/molecules24213961 · Cited by 425
Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., & Covello, P. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.065 · Cited by 409
Production of isoprenoid pharmaceuticals by engineered microbes
Chang, M. C. Y., & Keasling, J. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio836 · Cited by 398
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P. G., Khan, A. M., et al. (2010) · Science · doi:10.1126/science.1182612 · Cited by 348
Ma, D., Pu, G., Lei, C., Ma, L., Wang, H., Guo, Y., Chen, J., Du, Z., Wang, H., Li, G., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp149 · Cited by 333
Abbas, F., Ke, Y., Yu, R., Yue, Y., Amanullah, S., Jahangir, M., & Fan, Y. (2017) · Planta · doi:10.1007/s00425-017-2749-x · Cited by 323
Zhang, Y., Teoh, K. H., Reed, D. W., Maes, L., Goossens, A., Olson, D. J. H., Ross, A. R. S., & Covello, P. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803090200 · Cited by 312
Biosynthesis and engineering of isoprenoid small molecules
Withers, S. T., & Keasling, J. D. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0593-1 · Cited by 297
Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 275
Teoh, K. H., Polichuk, D. R., Reed, D. W., & Covello, P. S. (2009) · Botany · doi:10.1139/b09-032 · Cited by 251
Olsson, M. E., Olofsson, L. M., Lindahl, A.-L., Lundgren, A., Brodelius, M., & Brodelius, P. E. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.07.009 · Cited by 241
Maes, L., Van Nieuwerburgh, F. C. W., Zhang, Y., Reed, D. W., Pollier, J., Vande Casteele, S. R. F., Inzé, D., Covello, P. S., Deforce, D. L. D., & Goossens, A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03466.x · Cited by 240
Huang, W., Wang, Y., Tian, W., Cui, X., Tu, P., Li, J., Shi, S., & Liu, X. (2022) · Antibiotics · doi:10.3390/antibiotics11101380 · Cited by 270
Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing
Wang, W., Wang, Y., Zhang, Q., Qi, Y., & Guo, D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-465 · Cited by 224
Nicotiana benthamiana as a Production Platform for Artemisinin Precursors
van Herpen, T. W. J. M., Cankar, K., Nogueira, M., Bosch, D., Bouwmeester, H. J., & Beekwilder, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014222 · Cited by 212
Self-citationZhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183
Dietrich, J. A., Yoshikuni, Y., Fisher, K. J., Woolard, F. X., Ockey, D., McPhee, D. J., Renninger, N. S., Chang, M. C. Y., Baker, D., & Keasling, J. D. (2009) · ACS Chemical Biology · doi:10.1021/cb900006h · Cited by 186
Ji, Y., Xiao, J., Shen, Y., Ma, D., Li, Z., Pu, G., Li, X., Huang, L., Liu, B., Ye, H., et al. (2014) · Plant and Cell Physiology · doi:10.1093/pcp/pcu090 · Cited by 172
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.
Pu, G., Ma, D., Chen, J.-L., Ma, L., Wang, H., Li, G., Ye, H., & Liu, B. (2009) · Plant Cell Reports · doi:10.1007/s00299-009-0713-3 · Cited by 172
Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
Liu, C., Zhao, Y., & Wang, Y. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0452-0 · Cited by 158
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study
Schramek, N., Wang, H., Römisch-Margl, W., Keil, B., Radykewicz, T., Winzenhörlein, B., Beerhues, L., Bacher, A., Rohdich, F., Gershenzon, J., et al. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2009.10.015 · Cited by 150
Functional genomics and the biosynthesis of artemisinin
Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.02.016 · Cited by 152
Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution
Nett, R. S., Montanares, M., Marcassa, A., Lu, X., Nagel, R., Charles, T. C., Hedden, P., Rojas, M. C., & Peters, R. J. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2232 · Cited by 141
Bertea, C. M., Voster, A., Verstappen, F. W. A., Maffei, M., Beekwilder, J., & Bouwmeester, H. J. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.02.026 · Cited by 134
Self-citationCytochromes P450 for Terpene Functionalisation and Metabolic Engineering
Pateraki, I., Heskes, A. M., & Hamberger, B. (2015) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2014_301 · Cited by 136
Plant single-cell and single-cell-type metabolomics
Misra, B. B., Assmann, S. M., & Chen, S. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2014.05.005 · Cited by 120
Functional Genomics and the Biosynthesis of Artemisinin
Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · ChemInform · doi:10.1002/chin.200742266 · Cited by 121
Combinatorial biosynthesis of medicinal plant secondary metabolites
Julsing, M. K., Koulman, A., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2006) · Biomolecular Engineering · doi:10.1016/j.bioeng.2006.08.001 · Cited by 116
Malhotra, K., Subramani, M., Rawat, K., Kalamuddin, M., Qureshi, M. I., Malhotra, P., Mohmmed, A., Cornish, K., Daniell, H., & Kumar, S. B. (2016) · Molecular Plant · doi:10.1016/j.molp.2016.09.013 · Cited by 115
Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua
Soetaert, S. S., Van Neste, C. M., Vandewoestyne, M. L., Head, S. R., Goossens, A., Van Nieuwerburgh, F. C., & Deforce, D. L. (2013) · BMC Plant Biology · doi:10.1186/1471-2229-13-220 · Cited by 109
Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes
Weitzel, C., & Simonsen, H. T. (2013) · Phytochemistry Reviews · doi:10.1007/s11101-013-9280-x · Cited by 109
The Yin and Yang of traditional Chinese and Western medicine
Fu, R., Li, J., Yu, H., Zhang, Y., Xu, Z., & Martin, C. R. (2021) · Medicinal Research Reviews · doi:10.1002/med.21793 · Cited by 108
Ma, C., Wang, H., Lu, X., Xu, G., & Liu, B. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.09.023 · Cited by 103
In vivo transformations of artemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.062 · Cited by 100
Wang, H., Ma, C., Li, Z., Ma, L., Wang, H., Ye, H., Xu, G., & Liu, B. (2009) · Industrial Crops and Products · doi:10.1016/j.indcrop.2009.10.008 · Cited by 98
Weathers, P. J., Elkholy, S., & Wobbe, K. K. (2006) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1079/ivp2006782 · Cited by 97
Biosynthesis of fungal terpenoids
Luo, P., Huang, J.-H., Lv, J., Wang, G., Hu, D., & Gao, H. (2024) · Natural Product Reports · doi:10.1039/d3np00052d · Cited by 96
Appalasamy, S., Lo, K. Y., Ch’ng, S., Nornadia, K., Othman, A. S., & Keng, C. L. (2014) · BioMed Research International · doi:10.1155/2014/215872 · Cited by 92
Production of artemisinin by genetically-modified microbes
Zeng, Q.-P., Qiu, F., & Yuan, L. (2007) · Biotechnology Letters · doi:10.1007/s10529-007-9596-y · Cited by 87
Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment
Banyai, W., Mii, M., & Supaibulwatana, K. (2010) · Plant Growth Regulation · doi:10.1007/s10725-010-9510-9 · Cited by 89
Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.
Liu, B., Wang, H., Du, Z., Li, G., & Ye, H. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0967-9 · Cited by 82
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae
Lindahl, A.-L., Olsson, M. E., Mercke, P., Tollbom, Ö., Schelin, J., Brodelius, M., & Brodelius, P. E. (2006) · Biotechnology Letters · doi:10.1007/s10529-006-0015-6 · Cited by 82
The production of artemisinin precursors in tobacco
Zhang, Y., Nowak, G., Reed, D. W., & Covello, P. S. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2010.00556.x · Cited by 81
Ma, C., Wang, H., Lu, X., Li, H., Liu, B., & Xu, G. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.080 · Cited by 80
Plant Single-Cell Metabolomics—Challenges and Perspectives
de Souza, L. P., Borghi, M., & Fernie, A. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238987 · Cited by 79
Ahlawat, S., Saxena, P., Alam, P., Wajid, S., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.949885 · Cited by 78
Ma, C., Wang, H., Lu, X., Wang, H., Xu, G., & Liu, B. (2009) · Metabolomics · doi:10.1007/s11306-009-0170-6 · Cited by 76
Ting, H., Wang, B., Rydén, A., Woittiez, L. S., van Herpen, T. W. J. M., Verstappen, F. W. A., Ruyter-Spira, C. P., Beekwilder, J., Bouwmeester, H. J., & van der Krol, A. R. (2013) · New Phytologist · doi:10.1111/nph.12274 · Cited by 73
Self-citationAn Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
Demiray, M., Tang, X., Wirth, T., Faraldos, J. A., & Allemann, R. K. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201609557 · Cited by 68
Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues
Mora‐Pale, M., Sánchez-Rodríguez, S. P., Linhardt, R. J., Dordick, J. S., & Koffas, M. A. G. (2013) · Plant Science · doi:10.1016/j.plantsci.2013.05.005 · Cited by 67
Guo, X.-X., Yang, X., Yang, R., & Zeng, Q.-P. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.01.014 · Cited by 66
Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis
Rasool, S., & Mohamed, R. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0884-4 · Cited by 63
Fraga, B. M. (2006) · Natural Product Reports · doi:10.1039/b507870a · Cited by 62
Tsunematsu, Y., Ishiuchi, K., Hotta, K., & Watanabe, K. (2013) · Natural Product Reports · doi:10.1039/c3np70037b · Cited by 59
Shinyuy, L. M., Loe, G. E., Jansen, O., Mamede, L., Ledoux, A., Noukimi, S. F., Abenwie, S. N., Ghogomu, S. M., Souopgui, J., Robert, A. R., et al. (2023) · Metabolites · doi:10.3390/metabo13050613 · Cited by 58
A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua
Polichuk, D. R., Zhang, Y., Reed, D. W., Schmidt, J. F., & Covello, P. S. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.04.026 · Cited by 57
Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts
Muntendam, R., Melillo, E., Rydén, A., & Kayser, O. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2150-1 · Cited by 57
Zhu, X., Yang, L., Li, Y. J., Zhang, D., Chen, Y., Kostecká, P., Kmonı́èková, E., & Zídek, Z. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71016-8 · Cited by 55
Zhao, Y., Cheng, Q., Su, P., Chen, X., Wang, X., Gao, W., & Huang, L. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5496-3 · Cited by 56
Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production
Pulice, G., Pelaz, S., & Matías-Hernández, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00329 · Cited by 53
Sesquiterpene lactones with unusual structure. Their biogenesis and biological activity
Adekenov, S. M. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.05.017 · Cited by 52
Yang, K., Monafared, R. S., Wang, H., Lundgren, A., & Brodelius, P. E. (2015) · Plant Molecular Biology · doi:10.1007/s11103-015-0284-3 · Cited by 50
Ye, V. M., & Bhatia, S. K. (2011) · Biotechnology Journal · doi:10.1002/biot.201100289 · Cited by 47
Ahmad, A., Ali, H., Khan, H., Begam, A., Khan, S., Ali, S. S., Ahmad, N., Fazal, H., Ali, M., Hano, C., et al. (2020) · Plants · doi:10.3390/plants9040420 · Cited by 44
Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.
Li, Y., Yang, Y., Li, L., Tang, K., Hao, X., & Kai, G. (2024) · Horticulture Research · doi:10.1093/hr/uhad292 · Cited by 42
Ghaffari, Z., Rahimmalek, M., & Sabzalian, M. R. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111592 · Cited by 42
Yang, R.-Y., Feng, L.-L., Yang, X.-Q., Yin, L.-L., Xu, X.-L., & Zeng, Q.-P. (2008) · Planta Medica · doi:10.1055/s-2008-1081333 · Cited by 41
Yang, R.-Y., Zeng, X.-M., Lu, Y.-Y., Lu, W.-J., Feng, L.-L., Yang, X.-Q., & Zeng, Q.-P. (2010) · Planta Medica · doi:10.1055/s-0029-1240620 · Cited by 40
Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39
Kalalagh, K. F., Kashkooli, A. B., Babaei, A., Rezaei, A., & van der Krol, A. R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.780257 · Cited by 40
Trichome Specific Expression: Promoters and Their Applications
Tissier, A. F. (2012) · InTech eBooks · doi:10.5772/32101 · Cited by 37
Verdian-rizi, M. (2008) · African Journal of Plant Science · doi:10.5897/ajps.9000256 · Cited by 33
Essential oils of petal, leaf and stem of the antimalarial plant Artemisia annua
Goel, D., Singh, V., Ali, M., Mallavarupu, G. R., & Kumar, S. (2007) · Journal of Natural Medicines · doi:10.1007/s11418-006-0112-9 · Cited by 32
Biosynthesis of Terpenoid–Pyrrolobenzoxazine Hybrid Natural Product CJ‐12662
Cheng, W., Chen, M., Ōhashi, M., & Tang, Y. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202116928 · Cited by 30
Li, X., Ma, D., Chen, J., Pu, G., Ji, Y., Lei, C., Du, Z., Liu, B., Ye, H., & Wang, H. (2012) · Plant Science · doi:10.1016/j.plantsci.2012.05.011 · Cited by 30
Yu, Z., Wang, B., Yang, F., Sun, Q., Zhan-nan, Y., & Zhu, L. (2011) · Europe PMC (PubMed Central) · Cited by 29
Wang, Y., Yang, K., Jing, F., Li, M., Deng, T., Huang, R.-Z., Wang, B., Wang, G., Sun, X., & Tang, K. (2011) · Molecular Biology · doi:10.1134/s0026893311040145 · Cited by 28
Larson, T. R., Branigan, C., Harvey, D., Penfield, T., Bowles, D., & Graham, I. A. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.12.004 · Cited by 27
Investigation of Glandular Trichome Proteins in Artemisia annua L. Using Comparative Proteomics
Wu, T., Wang, Y., & Guo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041822 · Cited by 27
Co-overexpression of the HMGR and FPS genes enhances artemisinin content in Artemisia annua L.
Wang, Y., Jing, F., Yu, S., Chen, Y., Wang, T., Pin, L., Wang, G., Sun, X., & Tang, K. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000369 · Cited by 26
Heterologous biosynthesis of artemisinic acid in Saccharomyces cerevisiae
Li, C., Li, J., Wang, G., & Li, X. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13044 · Cited by 28
Kiani, B. H., Suberu, J., & Mirza, B. (2016) · Malaria Journal · doi:10.1186/s12936-016-1312-8 · Cited by 27
Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26
Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes ofArtemisia annua
Wang, H., Ma, C., Ma, L., Du, Z., Wang, H., Ye, H., Li, G., Liu, B., & Xu, G. (2009) · Planta Medica · doi:10.1055/s-0029-1185814 · Cited by 26
Genetic engineering of artemisinin biosynthesis: prospects to improve its production
Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25
Tian, N., Tang, Y., Xiong, S., Tian, D., Chen, Y., Wu, D., Liu, Z., & Liu, S. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.08.049 · Cited by 25
Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 25
Nekoei, M., Mohammadhosseini, M., & Akhlaghi, H. (2012) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2012.10662595 · Cited by 24
Choe, D., Olson, C. A., Szubin, R., Yang, H., Sung, J., Feist, A. M., & Palsson, B. Ø. (2024) · Nature Communications · doi:10.1038/s41467-024-46486-3 · Cited by 25
Chemotype-dependent Metabolic Response to Methyl Jasmonate Elicitation inArtemisia annua
Wu, W., Yuan, M., Zhang, Q., Zhu, Y., Li, Y., Wang, W., Yan, Q., & Guo, D. (2011) · Planta Medica · doi:10.1055/s-0030-1250744 · Cited by 24
Komori, A., Suzuki, M., Seki, H., Nishizawa, T., Meyer, J. J. M., Shimizu, H., Yokoyama, S., & Muranaka, T. (2013) · FEBS Letters · doi:10.1016/j.febslet.2012.11.031 · Cited by 24
Metadata
- Authors
- Bertea, C. M., Freije, J. R., van der Woude, H., Verstappen, F. W., Perk, L., Marquez, V., De Kraker, J.-W., Posthumus, M. A., Jansen, B. J., de Groot, A., Franssen, M. C., & Bouwmeester, H. J.
- Affiliations
- Wageningen University & Research (NL)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2005-01
- Volume
- 71
- Issue
- 1
- Pages
- 40-47
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2061459669
- Cited by
- 205
- References
- 13
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 14 · 2012: 21
- FWCI
- 5.77
- Type
- journal article
- Language
- de
- Open access
- bronze
- doi.org
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Keywords
- artemisinin biosynthesis, Artemisia annua, dihydroartemisinic acid, amorpha-4,11-diene synthase, sesquiterpene lactones, glandular trichomes, antimalarial drugs
- MeSH terms
- Antimalarials, Humans, Gas Chromatography-Mass Spectrometry, Phytotherapy, Plant Leaves, Artemisia annua, Artemisinins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review