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Concordance for Islet Autoimmunity among Monozygotic Twins
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To the Editor: The risk of type 1 diabetes among the monozygotic twins of patients with type 1 diabetes is reported to be as low as 30%; this percentage is usually based on the ascertainment of dat...
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“Type 1 diabetes is a heritable polygenic disease with identical twin concordance of 30–70%,20 sibling risk of 6–7%, and a risk of 1–9% for children who have a parent with diabetes.21”
From Type 1 diabetes (2018) · cites this paper as [20]
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“In the United States, individuals with a first-degree relative with T1D have a 1 in 20 lifetime risk of developing T1D, compared to a 1 in 300 lifetime risk for the general population46.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [46]
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Self-citationNovel Insights into the Immunotherapy-Based Treatment Strategy for Autoimmune Type 1 Diabetes
Rathod, S. (2022) · Diabetology · doi:10.3390/diabetology3010007 · Cited by 33
Metadata
- Authors
- Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S., & Orban, T.
- ORCID
- Redondo, Maria J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-12-25
- Volume
- 359
- Issue
- 26
- Pages
- 2849-2850
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1995177998
- Cited by
- 353
- References
- 5
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 21 · 2023: 17 · 2022: 29 · 2021: 25 · 2020: 20 · 2019: 18 · 2018: 21 · 2017: 15 · 2016: 23 · 2015: 13 · 2014: 19 · 2013: 15 · 2012: 25
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 50964)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK32083)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet autoimmunity, monozygotic twins, concordance, type 1 diabetes, twin discordance, disease risk
- MeSH terms
- Adolescent, Adult, Autoantibodies, Child, Child, Preschool, Diabetes Mellitus, Type 1, Diseases in Twins, Humans, Infant, Islets of Langerhans, Longitudinal Studies, Middle Aged, Twins, Monozygotic, Autoimmunity, Young Adult
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