Cited by 169Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsTreatment of Major Depression

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Long-term potentiation of exogenous glutamate responses at single dendritic spines

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Bagal, Ashish A., Kao, Joseph P. Y., Tang, Cha-Min, Thompson, Scott M.·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0501956102PMC PMC1242281

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Abstract

Long-term increases in the strength of excitatory transmission at Schaffer collateral-CA1 cell synapses of the hippocampus require the insertion of new α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) into the synapse, but the kinetics of this process are not well established. Using microphotolysis of caged glutamate to activate receptors at single dendritic spines in hippocampal CA1 cells, we report the long-lasting potentiation of AMPAR-mediated currents with only a single pairing of photoreleased glutamate and brief postsynaptic depolarization. This potentiation was N -methyl- d -aspartate receptor (NMDAR)-dependent and was reversed with low-frequency photostimulation in an NMDAR-dependent manner, suggesting that it is mediated by the same mechanism(s) as conventional synaptic long-term potentiation. Potentiation of photolytic responses developed rapidly in a stepwise manner after a brief and variable delay (<60 s) at spines, but could not be induced at extrasynaptic sites on the dendritic shaft. Potentiation was accompanied by a concomitant decrease in postsynaptic, polyamine-dependent paired-pulse facilitation of the photolytic currents, indicating that a change in the subunit composition of the AMPARs underlying the response contributed to the potentiation. These changes are consistent with an increase in the proportion of GluR2-containing AMPARs in the spine head. These results demonstrate that activation of postsynaptic glutamate receptors by glutamate is not only necessary, but sufficient, for the induction of NMDAR-dependent long-term potentiation and reveal additional aspects of its expression.

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Authors: Bagal, A. A., Kao, J. P. Y., Tang, C.-M., & Thompson, S. M.
Affiliations: University of Maryland, Baltimore (US)
ORCID: Kao, Joseph P. Y.
Thompson, Scott M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-09-26
Volume: 102
Issue: 40
Pages: 14434-14439
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0501956102
PMC: PMC1242281
OpenAlex: W2053287773
Cited by: 169
References: 43
Citations by year: 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 10 · 2013: 4 · 2012: 9
FWCI: 9.07
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: long-term potentiation, dendritic spines, AMPA receptors, NMDA receptor, Schaffer collateral-CA1 synapses, hippocampus, GluR2 subunit, paired-pulse facilitation, polyamines, synaptic plasticity, excitatory synaptic transmission
MeSH terms: Animals, Cells, Cultured, Electrophysiology, Hippocampus, Photolysis, Synapses, Receptors, N-Methyl-D-Aspartate, Receptors, Glutamate, Long-Term Potentiation, Glutamic Acid, Dendritic Spines, Rats

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Long-term potentiation of exogenous glutamate responses at single dendritic spines

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