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SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Open accessAbstract
Silent synapses, or excitatory synapses that lack functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. Here, we report that SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Overexpression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. This change is specific for AMPARs because no change is observed in synaptic NMDA receptor expression or total synapse density. In contrast to these results, synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA. In addition, activation of the extracellular signal-regulated kinase, ERK, is significantly decreased in SynGAP-overexpressing neurons, whereas P38 mitogen-activated protein kinase (MAPK) signaling is potentiated. Furthermore, ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. Taken together, these data suggest that SynGAP plays a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission.
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In the citing paper
“Studies using in vitro systems and KO mice have shown that SynGAP expression is inversely correlated to the levels of AMPA receptors, but not NMDA receptors, at the synapse [306].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [306]
In the citing paper
“In addition, disrupting SynGAP expression in dissociated hippocampal neurons can enhance dendritic spine function (Kim et al., 2005; Rumbaugh et al., 2006) or suppress it (Krapivinsky et al., 2004).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
In the citing paper
“depending on the variant expressed, SynGAP can either stimulate (Rumbaugh et al., 2006) or suppress dendritic spine synapse function (McMahon et al., 2012).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
In the citing paper
“This cassette would be expected to cause a truncation of full-length protein, which is known to inactivate SynGAP (Rumbaugh et al., 2006).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
In the citing paper
“Mechanistically, SynGAP shapes developmental synaptic function through its synaptic GAP activity, where it suppresses many biochemical signaling cascades within dendritic spines that promote growth of synapses and insertion of AMPARs (Kim et al., 2005; Krapivinsky et al., 2004; Rumbaugh et al., 2006).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
In the citing paper
“These findings are consistent with the role of SynGAP as an essential repressive factor that contributes to the developmental trajectory of glutamatergic synapse maturation (Kim et al., 2003; Rumbaugh et al., 2006; Vazquez et al., 2004).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
In the citing paper
“However, the role that SynGAP plays in neurons to regulate dendritic spine synapse function has been controversial because some studies report that SynGAP is a repressor of these synapses (Kim et al., 2005; Rumbaugh et al., 2006; Vazquez et al., 2004), while others report that it stimulates them (Krapivinsky et al., 2004; McMahon et al., 2012).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Rumbaugh et al., 2006
Citations
Cites
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science · doi:10.1126/science.277.5324.333 · Cited by 1,543
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
MAPK cascade signalling and synaptic plasticity
Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454
Self-citationRat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation
English, J. D., & Sweatt, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19103 · Cited by 860
Regulation of AMPA receptors during synaptic plasticity
Song, I., & Huganir, R. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02270-1 · Cited by 798
Self-citationRas and Rap control AMPA receptor trafficking during synaptic plasticity
Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00897-8 · Cited by 769
The stress-activated protein kinase pathways
Tibbles, L. A., & Woodgett, J. R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050369 · Cited by 641
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634
Self-citationMolecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory
Adams, J. P., & Sweatt, J. D. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.145401 · Cited by 598
Self-citation
Research works printed but not linked: 1
- A. Bernards Biochim. Biophys. Acta 1603, 47–82 (2003).
Cited by
Sorted by citations
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792
Self-citationArc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779
Self-citationRegulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536
Calmodulin-kinases: modulators of neuronal development and plasticity.
Wayman, G. A., Lee, Y.-S., Tokumitsu, H., Silva, A., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.021 · Cited by 567
The translation of translational control by FMRP: therapeutic targets for FXS
Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491
Ras oncogenes and their downstream targets
Rajalingam, K., Schreck, R., Rapp, U. R., & Albert, Š. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.012 · Cited by 487
Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385
Self-citationGenetic and Epigenetic Networks in Intellectual Disabilities
van Bokhoven, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132512 · Cited by 382
Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.001 · Cited by 349
Self-citationMutations in SYNGAP1 in Autosomal Nonsyndromic Mental Retardation
Hamdan, F. F., Gauthier, J., Spiegelman, D., Noreau, A., Yang, Y., Pellerin, S., Dobrzeniecka, S., Côté, M., Perreau-Linck, E., Carmant, L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805392 · Cited by 336
Kinase cascades and ligand-directed signaling at the kappa opioid receptor
Bruchas, M. R., & Chavkin, C. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1806-y · Cited by 321
Land, B. B., Bruchas, M. R., Schattauer, S., Giardino, W. J., Aita, M., Messinger, D., Hnasko, T. S., Palmiter, R. D., & Chavkin, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910705106 · Cited by 301
Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria
Bruchas, M. R., Land, B. B., Aita, M., Xu, M., Barot, S. K., Li, S., & Chavkin, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3769-07.2007 · Cited by 282
The genetic basis of non-syndromic intellectual disability: a review
Kaufman, L., Ayub, M., & Vincent, J. B. (2010) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9055-2 · Cited by 305
Dendritic Tau in Alzheimer’s Disease
Ittner, A., & Ittner, L. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.003 · Cited by 278
HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory
Sando, R., Gounko, N., Pieraut, S., Liao, L., Yates, J., & Maximov, A. (2012) · Cell · doi:10.1016/j.cell.2012.09.037 · Cited by 274
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271
Self-citationSynaptic Signaling in Learning and Memory
Kennedy, M. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016824 · Cited by 270
Berryer, M. H., Hamdan, F. F., Klitten, L. L., Møller, R. S., Carmant, L., Schwartzentruber, J., Patry, L., Dobrzeniecka, S., Rochefort, D., Neugnot-Cerioli, M., et al. (2013) · Human Mutation · doi:10.1002/humu.22248 · Cited by 266
Regulation of mitogen‐activated protein kinases by glutamate receptors
Wang, J. Q., Fibuch, E. E., & Mao, L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04208.x · Cited by 251
Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation
Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.016 · Cited by 213
Self-citationExonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder
Krupp, D. R., Barnard, R. A., Duffourd, Y., Evans, S. A., Mulqueen, R. M., Bernier, R., Rivière, J.-B., Fombonne, E., & O’Roak, B. J. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.07.016 · Cited by 204
A three-step model for the synaptic recruitment of AMPA receptors
Opazo, P., & Choquet, D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.014 · Cited by 190
De Novo SYNGAP1 Mutations in Nonsyndromic Intellectual Disability and Autism
Hamdan, F. F., Daoud, H., Piton, A., Gauthier, J., Dobrzeniecka, S., Krebs, M.-O., Joober, R., Lacaille, J.-C., Nadeau, A., Milunsky, J. M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.015 · Cited by 187
Vetere, G., Restivo, L., Cole, C. J., Ross, P. J., Ammassari‐Teule, M., Josselyn, S. A., & Frankland, P. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016275108 · Cited by 183
A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.023 · Cited by 180
AMPA-silent synapses in brain development and pathology
Hanse, E., Seth, H., & Riebe, I. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3642 · Cited by 184
Tau exacerbates excitotoxic brain damage in an animal model of stroke
Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00618-0 · Cited by 167
Twenty Years of SynGAP Research: From Synapses to Cognition
Gamache, T. R., Araki, Y., & Huganir, R. L. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0420-19.2020 · Cited by 161
Self-citationRas and Rap Signaling in Synaptic Plasticity and Mental Disorders
Stornetta, R. L., & Zhu, J. (2010) · The Neuroscientist · doi:10.1177/1073858410365562 · Cited by 161
Functions of p38 MAP Kinases in the Central Nervous System
Asih, P. R., Prikas, E., Stefanoska, K., Tan, A. R. P., Ahel, H. I., & Ittner, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570586 · Cited by 163
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Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Shum, C. Y., Lash, L. L., Swanson, G. T., & Penzes, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801581105 · Cited by 155
Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome
Lee, Y., Ehninger, D., Zhou, M., Oh, J.-Y., Kang, M., Kwak, C., Ryu, H.-H., Butz, D. H., Araki, T., Cai, Y., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3863 · Cited by 154
Ozkan, E. D., Creson, T. K., Kramár, E. A., Rojas, C., Seese, R. R., Babyan, A. H., Shi, Y., Lucero, R., Xu, X., Noebels, J. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.015 · Cited by 144
Self-citationSchwarz, J. M., Liang, S.-L., Thompson, S. M., & McCarthy, M. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.008 · Cited by 139
The Postsynaptic Density: There Is More than Meets the Eye
Dosemeci, A., Weinberg, R. J., Reese, T. S., & Tao-Cheng, J.-H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00023 · Cited by 138
Aceti, M., Creson, T. K., Vaissiere, T., Rojas, C., Huang, W.-C., Wang, Y.-X., Petralia, R. S., Page, D. T., Miller, C. A., & Rumbaugh, G. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.001 · Cited by 129
Self-citationSynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin
Carlisle, H. J., Manzerra, P., Marcora, E., & Kennedy, M. B. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4695-08.2008 · Cited by 128
Ras proteins: paradigms for compartmentalised and isoform-specific signalling
Omerović, J., Laude, A., & Prior, I. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7133-8 · Cited by 130
Ye, X., & Carew, T. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.013 · Cited by 121
Guo, X., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., & Rumbaugh, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.223 · Cited by 120
Self-citationSynaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120
Santini, E., & Klann, E. (2014) · Science Signaling · doi:10.1126/scisignal.2005832 · Cited by 118
Jeyabalan, N., & Clement, J. P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00032 · Cited by 130
Kelleher III, R. J., Geigenmüller, U., Hovhannisyan, H., Trautman, E., Pinard, R., Rathmell, B., Carpenter, R., & Margulies, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035003 · Cited by 116
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Inoue, E., Deguchi‐Tawarada, M., Togawa, A., Matsui, C., Arita, K., Katahira-Tayama, S., Sato, T., Yamauchi, E., Oda, Y., & Takai, Y. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200809151 · Cited by 117
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Ksiazek, I., Burkhardt, C., Lin, S., Seddik, R., Maj, M., Bezáková, G., Jucker, M., Arber, S., Caroni, P., Sanes, J. R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1609-07.2007 · Cited by 117
Sun, X., Milovanovic, M., Zhao, Y., & Wolf, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0258-08.2008 · Cited by 111
Michaelson, S. D., Ozkan, E. D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissière, T., Gaffield, M. A., Christie, J. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0268-0 · Cited by 113
Self-citationYoshida, T., Zhang, G., Smith, M. A., Lopez, A. S., Bai, Y., Li, J., Fang, B., Koomen, J. M., Rawal, B., Fisher, K. J., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1559 · Cited by 106
ERK/MAPK signaling and autism spectrum disorders
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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development
Araki, Y., Hong, I., Gamache, T. R., Ju, S., Collado‐Torres, L., Shin, J. H., & Huganir, R. L. (2020) · eLife · doi:10.7554/elife.56273 · Cited by 97
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Fan, J., Cowan, C. M., Zhang, L. Y. J., Hayden, M. R., & Raymond, L. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2491-09.2009 · Cited by 100
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Berryer, M. H., Chattopadhyaya, B., Xing, P., Riebe, I., Bosoi, C., Sanon, N., Antoine-Bertrand, J., Lévesque, M., Avoli, M., Hamdan, F. F., et al. (2016) · Nature Communications · doi:10.1038/ncomms13340 · Cited by 93
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Lv, P., Du, Y., He, C., Peng, L., Zhou, X., Wan, Y., Zeng, M., Zhou, W., Zou, P., Li, C., et al. (2022) · Nature Chemistry · doi:10.1038/s41557-022-00946-9 · Cited by 91
Fan, J., Gladding, C. M., Wang, L., Zhang, L. Y. J., Kaufman, A. M., Milnerwood, A. J., & Raymond, L. A. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.019 · Cited by 94
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Araki, Y., Rajkovich, K. E., Gerber, E. E., Gamache, T. R., Johnson, R. C., Tran, T. H. N., Liu, B., Zhu, Q., Hong, I., Kirkwood, A., et al. (2024) · Science · doi:10.1126/science.adk1291 · Cited by 92
Self-citationA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
Lin, Y., Frei, J. A., Kilander, M. B. C., Shen, W., & Blatt, G. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00263 · Cited by 97
Raldúa, D., & Babin, P. J. (2009) · Environmental Science & Technology · doi:10.1021/es9012454 · Cited by 92
SynGAP isoforms exert opposing effects on synaptic strength
McMahon, A. C., Barnett, M. W., O'Leary, T. S., Stoney, P. N., Collins, M. O., Papadia, S., Choudhary, J. S., Komiyama, N. H., Grant, S. G. N., Hardingham, G. E., et al. (2012) · Nature Communications · doi:10.1038/ncomms1900 · Cited by 91
Regulation of AMPA receptor recruitment at developing synapses
Hall, B. J., & Ghosh, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.010 · Cited by 93
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Kılınç, M., Creson, T. K., Rojas, C., Aceti, M., Ellegood, J., Vaissière, T., Lerch, J. P., & Rumbaugh, G. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.03.008 · Cited by 87
Self-citationKozol, R. A., Cukier, H. N., Zou, B., Mayo, V., Rubeis, S. D., Cai, G., Griswold, A. J., Whitehead, P. L., Haines, J. L., Gilbert, J. R., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv138 · Cited by 95
Funk, A. J., Rumbaugh, G., Harotunian, V., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832d30d9 · Cited by 88
Self-citationConvergence of Hippocampal Pathophysiology in Syngap +/− and Fmr1 −/ y Mice
Barnes, S. A., Wijetunge, L. S., Jackson, A. D., Katsanevaki, D., Osterweil, E. K., Komiyama, N. H., Grant, S. G. N., Bear, M. F., Nägerl, U. V., Kind, P. C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1087-15.2015 · Cited by 84
Wang, C.-C., Held, R. G., & Hall, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083941 · Cited by 90
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Ma, H., Khaled, H. G., Wang, X., Mandelberg, N. J., Cohen, S. M., He, X., & Tsien, R. W. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00742-5 · Cited by 84
McLeod, F., Bossio, A., Marzo, A., Ciani, L., Sibilla, S., Hannan, S. B., Wilson, G. A., Palomer, E., Smart, T. G., Gibb, A. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.119 · Cited by 80
Walkup, W. G., Mastro, T. L., Schenker, L. T., Vielmetter, J., Hu, R., Iancu, A., Reghunathan, M., Bannon, B. D., & Kennedy, M. B. (2016) · eLife · doi:10.7554/elife.16813 · Cited by 78
Dau, A., Gladding, C. M., Sepers, M. D., & Raymond, L. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.013 · Cited by 83
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Zhou, M., Ottenberg, G. K., Sferrazza, G. F., Hubbs, C., Fallahi, M., Rumbaugh, G., Brantley, A. F., & Lasmézas, C. I. (2015) · Brain · doi:10.1093/brain/awv002 · Cited by 77
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Llamosas, N., Arora, V., Vij, R., Kılınç, M., Bijoch, Ł., Rojas, C., Reich, A. M., Sridharan, B., Willems, E., Piper, D. R., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1367-20.2020 · Cited by 86
Self-citationMuhia, M., Yee, B. K., Feldon, J., Markopoulos, F., & Knuesel, I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07079.x · Cited by 71
Luo, J.-H., Qiu, Z.-Q., Zhang, L., & Shu, W.-Q. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.02.021 · Cited by 71
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Liu, Y., Vidensky, S., Ruggiero, A. M., Maier, S., Sitte, H. H., & Rothstein, J. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708096200 · Cited by 68
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Verma, V., Paul, A., Vishwanath, A. A., Vaidya, B., & Clement, J. P. (2019) · Open Biology · doi:10.1098/rsob.180265 · Cited by 68
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Joensuu, M., Lanoue, V., & Hotulainen, P. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.023 · Cited by 65
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An, J., Cai, T., Che, H., Yu, T., Cao, Z., Liu, X., Zhao, F., Jing, J., Shen, X., Liu, M., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.06.002 · Cited by 63
Kalkman, H. O. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.008 · Cited by 62
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Sun, Y., Xu, Y., Cheng, X., Chen, X., Xie, Y., Zhang, L., Wang, L., Hu, J. H., & Gao, Z. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24251 · Cited by 56
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Sullivan, B. J., Ammanuel, S. G., Kipnis, P. A., Araki, Y., Huganir, R. L., & Kadam, S. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.025 · Cited by 59
Self-citationHuang, G., Sun, Z.-L., Li, H., & Feng, D. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.01.007 · Cited by 56
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Metadata
- Authors
- Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Department of Developmental Biology, The Rockefeller University, New York, NY 10021
- Corresponding author
- Huganir, Richard L.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-03-14
- Volume
- 103
- Issue
- 12
- Pages
- 4344-4351
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1450173
- OpenAlex
- W2046170065
- Cited by
- 260
- References
- 40
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 21 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 23 · 2019: 9 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH064856)
- National Institute of Neurological Disorders and Stroke (F32NS043071)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- SynGAP, silent synapses, AMPA receptor trafficking, excitatory synaptic transmission, Ras GTPase-activating protein, ERK signaling, p38 MAPK, synaptic plasticity, miniature excitatory postsynaptic currents, hippocampal neurons, cortical neurons
- MeSH terms
- Animals, Cells, Cultured, Mutation, Synaptic Transmission, Neurons, Synapses, Receptors, AMPA, Mice, Knockout, ras GTPase-Activating Proteins, Mitogen-Activated Protein Kinases, Protein Transport, Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases, Mice, Rats
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