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Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
Open accessAbstract
Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice homozygous for the paucity of lymph node T cell (plt) mutation, naive T cells fail to home to LNs or the lymphoid regions of spleen. Here we demonstrate that expression of SLC is undetectable in plt mice. In addition to the defect in T cell homing, we demonstrate that dendritic cells (DCs) fail to accumulate in spleen and LN T cell zones of plt mice. DC migration to LNs after contact sensitization is also substantially reduced. The physiologic significance of these abnormalities in plt mice is indicated by a markedly increased sensitivity to infection with murine hepatitis virus. The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal. These findings suggest that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.
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Cites
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Cited by
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G., & Förster, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.014 · Cited by 1,086
Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7556 · Cited by 967
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I., Grosveld, G., Gunn, M. D., Jackson, D. G., & Oliver, G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1505 · Cited by 943
Self-citationToll-like receptors and cancer
Rakoff-Nahoum, S., & Medzhitov, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2541 · Cited by 925
Regulation of Dendritic Cell Migration to the Draining Lymph Node
Martín-Fontecha, A., Sebastiani, S., Höpken, U. E., Uguccioni, M., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030448 · Cited by 878
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
Cyster, J. G. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115628 · Cited by 856
Migratory properties of naive, effector, and memory CD8(+) T cells
Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515
Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509
(2003) · PubMed · Cited by 477
Bouchon, A., Hernández-Munain, C., Cella, M., & Colonna, M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1111 · Cited by 460
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., et al. (2001) · Nature · doi:10.1038/35090591 · Cited by 449
Jang, M. H., Sougawa, N., Tanaka, T., Hirata, T., Hiroi, T., Tohya, K., Guo, Z., Umemoto, E., Ebisuno, Y., Yang, B.-G., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.803 · Cited by 430
Chemokines: key players in innate and adaptive immunity
Esche, C., Stellato, C., & Beck, L. A. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23841.x · Cited by 385
Schmid, C. D., Sautkulis, L. N., Danielson, P. E., Cooper, J., Hasel, K. W., Hilbush, B. S., Sutcliffe, J. G., & Carson, M. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01243.x · Cited by 351
Vicari, A. P., & Caux, C. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00033-8 · Cited by 351
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346
Braun, A., Worbs, T., Moschovakis, G. L., Halle, S., Hoffmann, K., Bölter, J., Münk, A., & Förster, R. (2011) · Nature Immunology · doi:10.1038/ni.2085 · Cited by 337
Chemokines in the systemic organization of immunity
Campbell, D. J., Kim, C. H., & Butcher, E. C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00067.x · Cited by 330
A stromal address code defined by fibroblasts
Parsonage, G., Filer, A. D., Haworth, O., Nash, G. B., Rainger, G. E., Salmon, M., & Buckley, C. D. (2005) · Trends in Immunology · doi:10.1016/j.it.2004.11.014 · Cited by 297
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
Ulvmar, M. H., Werth, K., Braun, A., Kelay, P., Hub, E., Eller, K., Chan, L., Lucas, B., Novitzky-Basso, I., Nakamura, K., et al. (2014) · Nature Immunology · doi:10.1038/ni.2889 · Cited by 290
Tal, O., Lim, H. Y., Gurevich, I., Milo, I., Shipony, Z., Ng, L. G., Angeli, V., & Shakhar, G. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102392 · Cited by 269
Expression of CCR7 in multiple sclerosis: implications for CNS immunity
Kivisäkk, P., Mahad, D. J., Callahan, M. K., Sikora, K., Trebst, C., Tucky, B., Wujek, J., Ravid, R., Staugaitis, S. M., Lassmann, H., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20049 · Cited by 267
Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels
Russo, E., Teijeira, A., Vaahtomeri, K., Willrodt, A.-H., Bloch, J. S., Nitschké, M., Santambrogio, L., Kerjaschki, D., Sixt, M., & Halin, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.048 · Cited by 193
Johnson, L. A., & Jackson, D. G. (2010) · International Immunology · doi:10.1093/intimm/dxq435 · Cited by 191
Lymphatic system: An active pathway for immune protection
Liao, S., & von der Weid, P. Y. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.11.012 · Cited by 174
Migration of dendritic cell based cancer vaccines: in vivo veritas?
Adema, G. J., de Vries, I. J. M., Punt, C. J., & Figdor, C. G. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.01.004 · Cited by 134
Leucocyte trafficking via the lymphatic vasculature—mechanisms and consequences
Jackson, D. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00471 · Cited by 120
The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice
Lefebvre, J. S., Maue, A. C., Eaton, S. M., Lanthier, P. A., Tighe, M., & Haynes, L. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00836.x · Cited by 103
Lymphocyte homing to the gut: attraction, adhesion, and commitment
Salmi, M., & Jalkanen, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00285.x · Cited by 103
Cupovic, J., Onder, L., Gil-Cruz, C., Weiler, E., Caviezel-Firner, S., Perez-Shibayama, C., Rülicke, T., Bechmann, I., & Ludewig, B. (2016) · Immunity · doi:10.1016/j.immuni.2015.12.022 · Cited by 98
Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis
Hermida, M. D.-R., de Melo, C. V. B., Lima, I. D. S., Oliveira, G. G. D. S., & dos-Santos, W. L. C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00394 · Cited by 76
Bryce, S. A., Wilson, R. A. M., Tiplady, E. M., Asquith, D. L., Bromley, S. K., Luster, A. D., Graham, G. J., & Nibbs, R. J. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501542 · Cited by 71
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx
Johnson, L. A., Banerji, S., Lagerholm, B. C., & Jackson, D. G. (2021) · Life Science Alliance · doi:10.26508/lsa.202000908 · Cited by 37
Bischof, A. (2000) · doi:10.1002/1521-4141(200003)30:3
Metadata
- Authors
- Gunn, M. D., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L. T., & Nakano, H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-02-01
- Volume
- 189
- Issue
- 3
- Pages
- 451-460
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2150295492
- Cited by
- 1,019
- References
- 1
- FWCI
- 29.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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