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Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes

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Boinagrov, David, Pangratz-Fuehrer, Susanne, Goetz, Georges, Palanker, Daniel·2014·Journal of Neural Engineering

DOI 10.1088/1741-2560/11/2/026008PMC PMC4082997

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Abstract

OBJECTIVE: Intra-retinal placement of stimulating electrodes can provide close and stable proximity to target neurons. We assessed improvement in stimulation thresholds and selectivity of the direct and network-mediated retinal stimulation with intraretinal electrodes, compared to epiretinal and subretinal placements. APPROACH: Stimulation thresholds of the retinal ganglion cells (RGCs) in wild-type rat retina were measured using the patch-clamp technique. Direct and network-mediated responses were discriminated using various synaptic blockers. MAIN RESULTS: Three types of RGC responses were identified: short latency (SL, τ < 5 ms) originating in RGCs, medium latency (ML, 3 < τ < 70 ms) originating in the inner nuclear layer and long latency (LL, τ > 40 ms) originating in photoreceptors. Cathodic epiretinal stimulation exhibited the lowest threshold for direct RGC response and the highest direct selectivity (network/direct thresholds ratio), exceeding a factor of 3 with pulse durations below 0.5 ms. For network-mediated stimulation, the lowest threshold was obtained with anodic pulses in OPL position, and its network selectivity (direct/network thresholds ratio) increased with pulse duration, exceeding a factor of 4 at 10 ms. Latency of all three types of responses decreased with increasing strength of the stimulus. SIGNIFICANCE: These results define the optimal range of pulse durations, pulse polarities and electrode placement for the retinal prostheses aiming at direct or network-mediated stimulation of RGCs.

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“While, many of these studies characterized stimulation efficacy in healthy retina with an intact photoreceptor cell layer, which significantly affects stimulation thresholds (Stett et al., 2000, 2007; Boinagrov et al., 2014; Sim et al., 2014).”
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Authors: Boinagrov, D., Pangratz-Fuehrer, S., Goetz, G., & Palanker, D.
Affiliations: Stanford University (US)
Corresponding author: Boinagrov, David
ORCID: Pangratz-Fuehrer, Susanne
Goetz, Georges
Palanker, Daniel
Venue: Journal of Neural Engineering
Publisher: IOP Publishing
Published: 2014-03-10
Volume: 11
Issue: 2
Pages: 026008
ISSN: 1741-2552 (ISSN-L)
1741-2560
DOI: 10.1088/1741-2560/11/2/026008
PMC: PMC4082997
OpenAlex: W2058723867
Cited by: 146
References: 56
Citations by year: 2026: 5 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 15 · 2018: 15 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 3
FWCI: 6.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: iopscience.iop.org/info/page/text-and-data-mining (tdm)
iopscience.iop.org/page/copyright (vor)
Locations: Journal of Neural Engineering (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Chongqing University
National Institutes of Health
National Eye Institute (R01EY018608)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: retinal ganglion cells, retinal prosthesis, epiretinal stimulation, subretinal stimulation, stimulation selectivity, stimulation threshold, pulse duration, pulse polarity, inner plexiform layer, photoreceptors, rat retina
MeSH terms: Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Male, Microelectrodes, Nerve Net, Retinal Ganglion Cells, Rats, Long-Evans, Rats

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Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes

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