Stimulation strategies for improving the resolution of retinal prostheses
Open accessAbstract
Electrical stimulation using implantable devices with arrays of stimulating electrodes is an emerging therapy for neurological diseases. The performance of these devices depends greatly on their ability to activate populations of neurons with high spatiotemporal resolution. To study electrical stimulation of populations of neurons, retina serves as a useful model because the neural network is arranged in a planar array that is easy to access. Moreover, retinal prostheses are under development to restore vision by replacing the function of damaged light sensitive photoreceptors, which makes retinal research directly relevant for curing blindness. Here we provide a progress review on stimulation strategies developed in recent years to improve the resolution of electrical stimulation in retinal prostheses. We focus on studies performed with explanted retinas, in which electrophysiological techniques are the most advanced. We summarize achievements in improving the spatial and temporal resolution of electrical stimulation of the retina and methods to selectively stimulate neurons with different visual functions. Future directions for retinal prostheses development are also discussed, which could provide insights for other types of neuromodulatory devices in which high-resolution electrical stimulation is required.
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A common approach is to use bipolar stimulation through two close electrodes, as shown in retinal, optic nerve, and thalamic prostheses.
“A common approach is to use bipolar stimulation through two close electrodes, as shown in retinal [36,143,144], optic nerve [75], and thalamic prostheses [81].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [36]
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- Authors
- Tong, W., Meffin, H., Garrett, D. J., & Ibbotson, M. R.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Ibbotson, Michael R.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-03-26
- Volume
- 14
- Pages
- 262-262
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC7135883
- OpenAlex
- W3013276825
- Cited by
- 66
- References
- 122
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 18 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 2 · 2018: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- RMIT Research Repository (RMIT University Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (GNT1118223, GNT1101717)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, electrical stimulation, spatial resolution, temporal resolution, visual function, photoreceptor replacement, blindness, neuromodulation
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