Cited by 638Neuroscience and Neural EngineeringConducting polymers and applicationsAnalog and Mixed-Signal Circuit Design

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Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film

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Ludwig, Kip A, Uram, Jeffrey D, Yang, Junyan, Martin, David C, Kipke, Daryl R·2006·Journal of Neural Engineering

DOI 10.1088/1741-2560/3/1/007

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Abstract

Conductive polymer coatings can be used to modify traditional electrode recording sites with the intent of improving the long-term performance of cortical microelectrodes. Conductive polymers can drastically decrease recording site impedance, which in turn is hypothesized to reduce thermal noise and signal loss through shunt pathways. Moreover, conductive polymers can be seeded with agents aimed at promoting neural growth toward the recording sites or minimizing the inherent immune response. The end goal of these efforts is to generate an ideal long-term interface between the recording electrode and surrounding tissue. The goal of this study was to refine a method to electrochemically deposit surfactant-templated ordered poly(3,4-ethylenedioxythiophene) (PEDOT) films on the recording sites of standard 'Michigan' probes and to evaluate the efficacy of these modified sites in recording chronic neural activity. PEDOT-coated site performance was compared to control sites over a six-week evaluation period in terms of impedance spectroscopy, signal-to-noise ratio, number of viable unit potentials recorded and local field potential recordings. PEDOT sites were found to outperform control sites with respect to signal-to-noise ratio and number of viable unit potentials. The benefit of reduced initial impedance, however, was mitigated by the impedance contribution of typical silicon electrode encapsulation. Coating sites with PEDOT also reduced the amount of low-frequency drift evident in local field potential recordings. These findings indicate that electrode sites electrochemically deposited with PEDOT films are suitable for recording neural activity in vivo for extended periods. This study also provided a unique opportunity to monitor how neural recording characteristics develop over the six weeks following implantation.

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Pattern Recognition with Fuzzy Objective Function Algorithms
Bezdek, J. C. (1981) · doi:10.1007/978-1-4757-0450-1 · Cited by 9,881
A Fuzzy Relative of the ISODATA Process and Its Use in Detecting Compact Well-Separated Clusters
Dunn, J. C. (1973) · Journal of Cybernetics · doi:10.1080/01969727308546046 · Cited by 5,049
Response of brain tissue to chronically implanted neural electrodes
Polikov, V. S., Tresco, P. A., & Reichert, W. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.08.015 · Cited by 1,896
Learning to control a brain–machine interface for reaching and grasping by primates
Carmena, J. M., Lebedev, M. A., Crist, R. E., O'Doherty, J. E., Santucci, D. M., Dimitrov, D. F., Patil, P. G., Henriquez, C. S., & Nicolelis, M. A. L. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000042 · Cited by 1,761
Instant neural control of a movement signal
Serruya, M. D., Hatsopoulos, N. G., Paninski, L., Fellows, M. R., & Donoghue, J. P. (2002) · Nature · doi:10.1038/416141a · Cited by 1,415
A review of methods for spike sorting: the detection and classification of neural action potentials
Lewicki, M. S. (1998) · Network Computation in Neural Systems · doi:10.1088/0954-898x_9_4_001 · Cited by 1,372
Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements
Harris, K. D., Henze, D. A., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.401 · Cited by 1,153
Stimulation of neurite outgrowth using an electrically conducting polymer
Schmidt, C. E., Shastri, V. P., Vacanti, J. P., & Langer, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.8948 · Cited by 1,072
Intracellular Features Predicted by Extracellular Recordings in the Hippocampus In Vivo
Henze, D. A., Borhegyi, Z., Csicsvari, J., Mamiya, A., Harris, K. D., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.390 · Cited by 942
Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays
Biran, R., Martin, D. C., & Tresco, P. A. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.04.020 · Cited by 893
Self-citation

Show all 55 references

Research works printed but not linked: 5

Schmidt E, 1990, Neurophysiol. Tech., 1
Vetter R J, 2004, IEEE Trans. Neural Syst. Rehabil. Eng., 52, 896
10.1088/0954-898X/9/4/001 · DOI
Kuffler S W, 1976, A Cellular Approach to the Function of the Nervous System.
Black J, 1999, Fundamentals of Biocompatibility

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Self-citation
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Electrode modifications to lower electrode impedance and improve neural signal recording sensitivity
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Banakar, M., Hamidi, M., Khurshid, Z., Zafar, M. S., Sapkota, J., Azizian, R., & Rokaya, D. (2022) · Biosensors · doi:10.3390/bios12110927 · Cited by 93
Elastomeric and soft conducting microwires for implantable neural interfaces
Kolarcik, C. L., Luebben, S. D., Sapp, S. A., Hanner, J., Snyder, N. R., Kozai, T. D. Y., Chang, E., Nabity, J., Nabity, S. T., Lagenaur, C. F., et al. (2015) · Soft Matter · doi:10.1039/c5sm00174a · Cited by 90
High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording
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In vivo evaluation of a neural stem cell-seeded prosthesis
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Poole-Warren, L. A., Lovell, N. H., Baek, S., & Green, R. A. (2009) · Expert Review of Medical Devices · doi:10.1586/erd.09.58 · Cited by 71
Long-term recording reliability of liquid crystal polymer µ ECoG arrays
Woods, V., Trumpis, M., Bent, B., Palopoli-Trojani, K., Chiang, C.-H., Wang, C., Yu, C., Insanally, M. N., Froemke, R. C., & Viventi, J. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aae39d · Cited by 63
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Fairfield, J. A. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201701145 · Cited by 70
Bioimpedance modeling to monitor astrocytic response to chronically implanted electrodes
McConnell, G. C., Butera, R. J., & Bellamkonda, R. V. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/5/055005 · Cited by 68
Inferring Neuronal Network Connectivity from Spike Data: A Temporal Data Mining Approach
Patnaik, D., SASTRY, P. S., & Unnikrishnan, K. P. (2008) · Scientific Programming · doi:10.1155/2008/324626 · Cited by 69
Intracranial EEG fluctuates over months after implanting electrodes in human brain
Ung, H., Baldassano, S. N., Bink, H., Krieger, A. Μ., Roberson, S. W., Vitale, F., Wu, C., Freestone, D. R., Nurse, E. S., Leyde, K. W., et al. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa7f40 · Cited by 67
Chronic intracortical neural recordings using microelectrode arrays coated with PEDOT–TFB
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Authors: Ludwig, K. A., Uram, J. D., Yang, J., Martin, D. C., & Kipke, D. R.
Affiliations: University of Michigan (US)
Dow Chemical (United States) (US)
ORCID: Ludwig, Kip A
Yang, Junyan
Martin, David C
Venue: Journal of Neural Engineering
Publisher: IOP Publishing
Published: 2006-03-01
Volume: 3
Issue: 1
Pages: 59-70
ISSN: 1741-2552 (ISSN-L)
1741-2560
DOI: 10.1088/1741-2560/3/1/007
OpenAlex: W2057005089
Cited by: 638
References: 55
Citations by year: 2026: 15 · 2025: 24 · 2024: 24 · 2023: 22 · 2022: 23 · 2021: 37 · 2020: 34 · 2019: 39 · 2018: 52 · 2017: 57 · 2016: 42 · 2015: 51 · 2014: 38 · 2013: 32 · 2012: 24
FWCI: 8.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neural Engineering (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Science Foundation (9986866, 0518079, 0084304)
University of Michigan
National Institutes of Health
National Institute of Neurological Disorders and Stroke (N01 NS 12338)
Division of Materials Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
Keywords: PEDOT, conducting polymer coatings, chronic neural recording, electrodeposition, electrode impedance, signal-to-noise ratio, local field potentials, low-frequency drift
MeSH terms: Action Potentials, Animals, Electrochemistry, Electrodes, Implanted, Equipment Design, Male, Membranes, Artificial, Microelectrodes, Motor Cortex, Neurons, Polymers, Silicon, Time Factors, Rats, Sprague-Dawley, Monitoring, Ambulatory, Bridged Bicyclo Compounds, Heterocyclic, Equipment Failure Analysis, Coated Materials, Biocompatible, Rats

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Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film

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