Obesity at the age of 50 y in men and women exposed to famine prenatally

Obesity in Young Men after Famine Exposure in Utero and Early Infancy

Ravelli, G.-P., Stein, Z. A., & Susser, M. W. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950701 · Cited by 1,647

Glucose tolerance in adults after prenatal exposure to famine

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Global nutrition transition and the pandemic of obesity in developing countries

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Obesity in children and young people: a crisis in public health

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Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043

Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory

Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000611 · Cited by 1,564

Prenatal exposure to the Dutch famine and disease in later life: An overview

Painter, R. C., Roseboom, T. J., & Bleker, O. P. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.04.005 · Cited by 784

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

Painter, R., Osmond, C., Gluckman, P., Hanson, M., Phillips, D., & Roseboom, T. (2008) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.01822.x · Cited by 733

Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45

Roseboom, T. J. (2000) · Heart · doi:10.1136/heart.84.6.595 · Cited by 682

DNA methylation signatures link prenatal famine exposure to growth and metabolism

Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms6592 · Cited by 630

Developmental origins of disease paradigm: A mechanistic and evolutionary perspective

Gluckman, P. D., & Hanson, M. A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000135998.08025.fb · Cited by 607

Boys live dangerously in the womb

Eriksson, J. G., Kajantie, E., Osmond, C., Thornburg, K., & Barker, D. J. P. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.20995 · Cited by 590

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513

Recall of Early Menstrual History and Menarcheal Body Size: After 30 Years, How Well Do Women Remember?

Must, A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.7.672 · Cited by 506

Hungry in the womb: What are the consequences? Lessons from the Dutch famine

Roseboom, T. J., Painter, R. C., van Abeelen, A. F. M., Veenendaal, M. V. E., & de Rooij, S. R. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.06.017 · Cited by 488

The developmental origins of adult disease

Gluckman, P. D., Hanson, M. A., & Pinal, C. (2005) · Maternal & Child Nutrition · doi:10.1111/j.1740-8709.2005.00020.x · Cited by 473

Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies

Gluckman, P. D., Hanson, M. A., Spencer, H. G., & Bateson, P. (2005) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2004.3001 · Cited by 479

Developmental programming of obesity in mammals

Taylor, P. D., & Poston, L. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.032854 · Cited by 473

The Fetal Matrix: Evolution, Development and Disease

Gluckman, P., & Hanson, M. (2004) · doi:10.1017/cbo9781139106955 · Cited by 460

Early onset of coronary artery disease after prenatal exposure to the Dutch famine

Painter, R. C., de Rooij, S. R., Bossuyt, P. M., Simmers, T. A., Osmond, C., Barker, D. J., Bleker, O. P., & Roseboom, T. J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.322 · Cited by 392

Cohort Profile: The Dutch Hunger Winter Families Study

Lumey, L., Stein, A. D., Kahn, H. S., van der Pal-de Bruin, K. M., Blauw, G., Zybert, P. A., & Susser, E. S. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym126 · Cited by 385

Prenatal undernutrition and cognitive function in late adulthood

de Rooij, S. R., Wouters, H., Yonker, J. E., Painter, R. C., & Roseboom, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009459107 · Cited by 364

Plasma lipid profiles in adults after prenatal exposure to the Dutch famine

Roseboom, T. J., van der Meulen, J. H., Osmond, C., Barker, D. J., Ravelli, A. C., & Bleker, O. P. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1101 · Cited by 357

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

Oben, J. A., Mouralidarane, A., Samuelsson, A.-M., Matthews, P. J., Morgan, M. L., Mckee, C., Soeda, J., Fernandez-Twinn, D. S., Martin-Gronert, M. S., Ozanne, S. E., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.042 · Cited by 314

The Role of the Placenta in Fetal Programming—A Review

Godfrey, K. M. (2002) · Placenta · doi:10.1053/plac.2002.0773 · Cited by 305

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Tobi, E. W., Slieker, R. C., Luijk, R., Dekkers, K. F., Stein, A. D., Xu, K. M., Biobank-based Integrative Omics Studies Consortium, Slagboom, P. E., van Zwet, E. W., Lumey, L. H., et al. (2018) · Science Advances · doi:10.1126/sciadv.aao4364 · Cited by 284

Early-life stress, HPA axis adaptation, and mechanisms contributing to later health outcomes

Maniam, J., Antoniadis, C., & Morris, M. J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00073 · Cited by 295

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

Sellayah, D., Bharaj, P., & Sikder, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.010 · Cited by 259

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208

Developmental programming, a pathway to disease

Padmanabhan, V., Cardoso, R. C., & Puttabyatappa, M. (2016) · Endocrinology · doi:10.1210/en.2016-1003 · Cited by 208

The Dutch Famine of 1944–1945: A Pathophysiological Model of Long-Term Consequences of Wasting Disease

Kyle, U. G., & Pichard, C. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232898.74415.42 · Cited by 208

Epigenetic mechanisms in the development of type 2 diabetes

Pinney, S. E., & Simmons, R. A. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.002 · Cited by 205

Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats

Bellinger, L., Sculley, D. V., & Langley-Evans, S. C. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803205 · Cited by 183

Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise

Sharples, A. P., Stewart, C. E., & Seaborne, R. A. (2016) · Aging Cell · doi:10.1111/acel.12486 · Cited by 180

Prenatal cytokine exposure results in obesity and gender-specific programming

Dahlgren, J., Nilsson, C., Jennische, E., Ho, H.-P., Eriksson, E., Niklasson, A., Björntorp, P., Wikland, K. A., & Holmäng, A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e326 · Cited by 172

Early life epigenetic programming and transmission of stress‐induced traits in mammals: How and when can environmental factors influence traits and their transgenerational inheritance?

Gapp, K., von Ziegler, L., Tweedie‐Cullen, R. Y., & Mansuy, I. M. (2014) · BioEssays · doi:10.1002/bies.201300116 · Cited by 136

Life-long echoes–a critical analysis of the developmental origins of adult disease model

Gluckman, P. D., Hanson, M. A., Morton, S. M. B., & Pinal, C. S. (2005) · Neonatology · doi:10.1159/000082311 · Cited by 126

Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression

Ikenasio-Thorpe, B. A., Breier, B. H., Vickers, M. H., & Fraser, M. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07017 · Cited by 106

Cohort Profile: The Dutch Famine Birth Cohort (DFBC)- a Prospective Birth Cohort Study in the Netherlands

Bleker, L. S., de Rooij, S. R., Painter, R. C., Ravelli, A. C., & Roseboom, T. J. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-042078 · Cited by 102

Maternal high-fat diet impacts endothelial function in nonhuman primate offspring

Fan, L., Lindsley, S. R., Comstock, S. M., Takahashi, D. L., Evans, A. E., He, G.-W., Thornburg, K. L., & Grove, K. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.42 · Cited by 98

Fetal origins of the metabolic syndrome

Xita, N., & Tsatsoulis, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05658.x · Cited by 96

Biological embedding of early‐life exposures and disease risk in humans: a role for DNA methylation

Demetriou, C. A., van Veldhoven, K., Relton, C., Stringhini, S., Kyriacou, K., & Vineis, P. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12406 · Cited by 95

Childhood obesity: Prevention and strategies of intervention. A systematic review of school-based interventions in primary schools

Verrotti, A., Penta, L., Zenzeri, L., Agostinelli, S., & De Feo, P. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0153-y · Cited by 96

Changes in Placental Size during Ramadan

Alwasel, S. H., Abotalib, Z., Aljarallah, J. S., Osmond, C., Alkharaz, S. M., Alhazza, I. M., Badr, G., & Barker, D. J. P. (2010) · Placenta · doi:10.1016/j.placenta.2010.04.010 · Cited by 92

Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring

Kereliuk, S., Brawerman, G., & Dolinsky, V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071451 · Cited by 90

Mechanisms IN endocrinology: metabolic syndrome through the female life cycle

Vryonidou, A., Paschou, S. A., Muscogiuri, G., Orio, F., & Goulis, D. G. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0275 · Cited by 88

The effect of California’s paid family leave policy on parent health: a quasi-experimental study.

Lee, B. C., Modrek, S., White, J. S., Batra, A., Collin, D. F., & Hamad, R. (2020) · Social Science & Medicine · doi:10.1016/j.socscimed.2020.112915 · Cited by 73

Fetal Growth Restriction and Postnatal Development

ELEFTHERIADES, M., CREATSAS, G., & NICOLAIDES, K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1365.047 · Cited by 60

Pregnancy and perinatal outcomes according to surgery to conception interval and gestational weight gain in women with previous gastric bypass

Stentebjerg, L. L., Andersen, L. L. T., Renault, K., Støving, R. K., & Jensen, D. M. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1208746 · Cited by 60

Maternal Undernutrition and Fetal Developmental Programming of Obesity: The Glucocorticoid Connection

Correia-Branco, A., Keating, E., & Martel, F. (2015) · Reproductive Sciences · doi:10.1177/1933719114542012 · Cited by 55

Historical cohort studies and the early origins of disease hypothesis: making sense of the evidence: Workshop on ‘Nutritional models of the developmental origins of adult health and disease’

Wells, J. C. K. (2009) · Proceedings of the Nutrition Society · doi:10.1017/s0029665109001086 · Cited by 50

Behavioral epigenetics and the developmental origins of child mental health disorders

Lester, B. M., Marsit, C. J., Conradt, E., Bromer, C., & Padbury, J. F. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000426 · Cited by 48

Gender and asthma

Fuhlbrigge, A. L., Jackson, B., & Wright, R. J. (2002) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00022-x · Cited by 32

Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations

Svoboda, L. K., Ishikawa, T., & Dolinoy, D. C. (2022) · Environmental Epigenetics · doi:10.1093/eep/dvac017 · Cited by 27

Maternal protein intake in pregnancy and offspring metabolic health at age 9–16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls

Maslova, E., Hansen, S., Grunnet, L. G., Strøm, M., Bjerregaard, A. A., Hjort, L., Kampmann, F. B., Madsen, C. M., Baun Thuesen, A., Bech, B. H., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.128637 · Cited by 26

Long-Term Effects of Placental Growth on Overweight and Body Composition

Eriksson, J. G., Gelow, J., Thornburg, K. L., Osmond, C., Laakso, M., Uusitupa, M., Lindi, V., Kajantie, E., & Barker, D. J. P. (2012) · International Journal of Pediatrics · doi:10.1155/2012/324185 · Cited by 14

How epigenetic inheritance fails to explain the Black-White health gap

Charney, E., Darity, W., & Hubbard, L. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.117697 · Cited by 1