Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 270

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Neural Mechanisms of Brain Plasticity with Complex Cognitive Training in Healthy Seniors

Open access
Chapman, S. B., Aslan, S., Spence, J. S., Hart, J. J., Bartz, E. K., Didehbani, N., Keebler, M. W., Gardner, C. M., Strain, J. F., DeFina, L. F., Lu, H.·2015·Cerebral Cortex
DOI 10.1093/cercor/bht234
Open this paper in CoChat — free account

Abstract

Complex mental activity induces improvements in cognition, brain function, and structure in animals and young adults. It is not clear to what extent the aging brain is capable of such plasticity. This study expands previous evidence of generalized cognitive gains after mental training in healthy seniors. Using 3 MRI-based measurements, that is, arterial spin labeling MRI, functional connectivity, and diffusion tensor imaging, we examined brain changes across 3 time points pre, mid, and post training (12 weeks) in a randomized sample (n = 37) who received cognitive training versus a control group. We found significant training-related brain state changes at rest; specifically, 1) increases in global and regional cerebral blood flow (CBF), particularly in the default mode network and the central executive network, 2) greater connectivity in these same networks, and 3) increased white matter integrity in the left uncinate demonstrated by an increase in fractional anisotropy. Improvements in cognition were identified along with significant CBF correlates of the cognitive gains. We propose that cognitive training enhances resting-state neural activity and connectivity, increasing the blood supply to these regions via neurovascular coupling. These convergent results provide preliminary evidence that neural plasticity can be harnessed to mitigate brain losses with cognitive training in seniors.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/cercor/bht234

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 14 references

Research works printed but not linked: 42

  1. Alsop, 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 16, 1236, 10.1097/00004647-199611000-00019 · DOI · Paper page
  2. Anand, 2011, International journal of geriatric psychiatry, 26, 961, 10.1002/gps.2633 · DOI
  3. Aslan, 2010, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 63, 765, 10.1002/mrm.22245 · DOI · Paper page
  4. 2010, PNAS, 107, 4734, 10.1073/pnas.0911855107 · DOI · Paper page
  5. Boyke, 2008, Journal of Neuroscience, 28, 7031, 10.1523/JNEUROSCI.0742-08.2008 · DOI · Paper page
  6. 2011, NeuroImage, 58, 1110, 10.1016/j.neuroimage.2011.06.079 · DOI · Paper page
  7. Bruel-Jungerman, 2007, The Neuroscientist, 13, 492, 10.1177/1073858407302725 · DOI · Paper page
  8. Cappell, 2010, Cortex; a journal devoted to the study of the nervous system and behavior, 46, 462, 10.1016/j.cortex.2009.11.009 · DOI · Paper page
  9. Chapman, 2005, Alzheimer disease and associated disorders, 19, 202, 10.1097/01.wad.0000189050.41064.03 · DOI
  10. Chen, 2006, The Journal of head trauma rehabilitation, 21, 107, 10.1097/00001199-200603000-00004 · DOI
  11. Clark, 2012, Neurobiology of aging, 33, 2733, 10.1016/j.neurobiolaging.2012.01.010 · DOI
  12. Cracchiolo, 2007, Neurobiology of learning and memory, 88, 277, 10.1016/j.nlm.2007.07.007 · DOI
  13. Fox, 2010, 4, 19, 10.3389/fnsys.2010.00019 · DOI · Paper page
  14. 2005, PNAS, 102, 9673, 10.1073/pnas.0504136102 · DOI · Paper page
  15. Hafkemeijer, 2012, Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology, 1822, 431, 10.1016/j.bbadis.2011.07.008 · DOI · Paper page
  16. 2009, PSYCHOL SCI PUBL INTEREST, 9, 1
  17. Kennedy, 2009, Neurobiology of aging, 30, 1657, 10.1016/j.neurobiolaging.2007.12.020 · DOI
  18. Lancaster, 2000, Human brain mapping, 10, 120, 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8 · DOI
  19. 2012, Archives of Neurology, 69, 623, 10.1001/archneurol.2011.2748 · DOI · Paper page
  20. 2002, Radiology, 225, 253, 10.1148/radiol.2251011301 · DOI · Paper page
  21. Liu, 2011, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 65, 120, 10.1002/mrm.22601 · DOI
  22. 2011, Cerebral Cortex, 21, 1426, 10.1093/cercor/bhq224 · DOI · Paper page
  23. 2012, American Journal of Neuroradiology, 33, 1939, 10.3174/ajnr.A3090 · doi:10.3174/ajnr.a3090
  24. 2006, PNAS, 103, 12523, 10.1073/pnas.0605194103 · DOI · Paper page
  25. Mattay, 2006, Neuroscience letters, 392, 32, 10.1016/j.neulet.2005.09.025 · DOI · Paper page
  26. Mori, 1999, The Anatomical Record, 257, 102, 10.1002/(SICI)1097-0185(19990615)257:3<102::AID-AR7>3.0.CO;2-6 · DOI
  27. Mozolic, 2010, 4, 16, 10.3389/neuro.09.016.2010 · DOI
  28. Nichelli, 1995, Neuroreport, 6, 2309, 10.1097/00001756-199511270-00010 · DOI
  29. 2003, PNAS, 100, 13728, 10.1073/pnas.1735487100 · DOI · Paper page
  30. 2002, PNAS, 99, 10237, 10.1073/pnas.172399499 · DOI · Paper page
  31. 2005, Cerebral Cortex, 15, 1676, 10.1093/cercor/bhi044 · DOI · Paper page
  32. Rypma, 2000, Nature neuroscience, 3, 509, 10.1038/74889 · DOI · Paper page
  33. Schlee, 2012, BMC neuroscience [electronic resource], 13, 16, 10.1186/1471-2202-13-16 · DOI
  34. Seghier, 2010, Journal of Neuroscience, 30, 16809, 10.1523/JNEUROSCI.3377-10.2010 · DOI · Paper page
  35. 2007, PNAS, 104, 18760, 10.1073/pnas.0708803104 · DOI · Paper page
  36. Teipel, 2010, Journal of Alzheimer's disease : JAD, 22, 507, 10.3233/JAD-2010-100234 · DOI
  37. Valenzuela, 2007, Brain research. Brain research reviews, 56, 198, 10.1016/j.brainresrev.2007.07.007 · DOI
  38. Vas, 2011, The Journal of head trauma rehabilitation, 26, 224, 10.1097/HTR.0b013e318218dd3d · DOI
  39. Wakana, 2007, NeuroImage, 36, 630, 10.1016/j.neuroimage.2007.02.049 · DOI · Paper page
  40. Wang, 2009, Human brain mapping, 30, 1511, 10.1002/hbm.20623 · DOI · Paper page
  41. Willis, 2009, Restorative neurology and neuroscience, 27, 375, 10.3233/RNN-2009-0527 · DOI
  42. 2007, OGPL Neurology, 69, 1650, 10.1212/01.wnl.0000296941.06685.22 · DOI

Cited by

Metadata

Authors
Chapman, S. B., Aslan, S., Spence, J. S., Hart, J. J., Bartz, E. K., Didehbani, N., Keebler, M. W., Gardner, C. M., Strain, J. F., DeFina, L. F., & Lu, H.
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2013-08-28
Volume
25
Issue
2
Pages
396-405
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bht234
OpenAlex
W2122134216
Cited by
270
References
14
FWCI
8.42
Type
journal article
Language
en
Open access
hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.