Cited by 1,368Physical Activity and HealthAdipokines, Inflammation, and Metabolic DiseasesCoffee research and impacts

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06

Open access

Healy, Genevieve N., Matthews, Charles E., Dunstan, David W., Winkler, Elisabeth A.H., Owen, Neville·2011·European Heart Journal

DOI 10.1093/eurheartj/ehq451PMC PMC3634159

Open this paper in CoChat — free account Open PDF

Abstract

AIMS: Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity. METHODS AND RESULTS: Cross-sectional analyses with 4757 participants (≥ 20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [< 100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends < 0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-%B, and HOMA-%S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends <0.05). There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks. CONCLUSION: These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehq451

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526
Physical Activity in the United States Measured by Accelerometer
TROIANO, R. P., BERRIGAN, D., DODD, K. W., MÂSSE, L. C., TILERT, T., & MCDOWELL, M. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815a51b3 · Cited by 7,638
Physical Activity and Public Health: Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association
(2007) · Circulation · doi:10.1161/circulationaha.107.185649 · Cited by 6,545
Calibration of the Computer Science and Applications, Inc. accelerometer
FREEDSON, P. S., MELANSON, E., & SIRARD, J. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00021 · Cited by 3,825
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,799
National Center for Health Statistics (NCHS)
Feinleib, M. (2005) · Encyclopedia of Biostatistics · doi:10.1002/0470011815.b2a16042 · Cited by 3,134
Total energy intake: implications for epidemiologic analyses.
WILLETT, W., & STAMPFER, M. J. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114366 · Cited by 2,751
RE: “TOTAL ENERGY INTAKE: IMPLICATIONS FOR EPIDEMIOLOGIC ANALYSES”
Palmgren, J., & Kushi, L. H. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115841 · Cited by 2,712
Amount of Time Spent in Sedentary Behaviors in the United States, 2003-2004
Matthews, C. E., Chen, K. Y., Freedson, P. S., Buchowski, M. S., Beech, B. M., Pate, R. R., & Troiano, R. P. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm390 · Cited by 2,631
Self-citation
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546

Show all 28 references

Research works printed but not linked: 1

U.S. Department of Health and Human Services, 2005, U.S. Department of Agriculture. Dietary Guidelines for Americans

Sorted by citations

Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis
Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T., & Biddle, S. J. H. (2012) · Diabetologia · doi:10.1007/s00125-012-2677-z · Cited by 1,789
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1931 · Cited by 1,203
Self-citation
Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents
Ekelund, U. (2012) · JAMA · doi:10.1001/jama.2012.156 · Cited by 1,158
Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach
Chastin, S. F. M., Palarea-Albaladejo, J., Dontje, M. L., & Skelton, D. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139984 · Cited by 1,034
“There is some evidence that the influence of SBmight be independent of time spent in MVPA [6] but this is ignoring the possible confounding effects of sleep and LIPA.”
Sitting time and all-cause mortality risk in 222,497 Australian adults
van der Ploeg, H. P. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2174 · Cited by 884
Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association
Young, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000440 · Cited by 791
Self-citation
Amount of time spent in sedentary behaviors and cause-specific mortality in US adults
Matthews, C. E., George, S. M., Moore, S. C., Bowles, H. R., Blair, A., Park, Y., Troiano, R. P., Hollenbeck, A., & Schatzkin, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.019620 · Cited by 655
Self-citation
Measurement of Adults' Sedentary Time in Population-Based Studies
Healy, G. N., Clark, B. K., Winkler, E. A. H., Gardiner, P. A., Brown, W. J., & Matthews, C. E. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.05.005 · Cited by 628
Self-citation
Too much sitting – A health hazard
Dunstan, D. W., Howard, B., Healy, G. N., & Owen, N. G. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.05.020 · Cited by 632
Self-citation
Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults
Diaz, K. M., Howard, V. J., Hutto, B., Colabianchi, N., Vena, J. E., Safford, M. M., Blair, S. N., & Hooker, S. P. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0212 · Cited by 570
Sedentary behaviour and cardiovascular disease: a review of prospective studies
Ford, E. S., & Caspersen, C. J. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys078 · Cited by 530
The contribution of office work to sedentary behaviour associated risk
Parry, S. P., & Straker, L. M. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-296 · Cited by 571
Considerations when using the activPAL monitor in field-based research with adult populations
Edwardson, C. L., Winkler, E. A. H., Bodicoat, D. H., Yates, T., Davies, M. J., Dunstan, D. W., & Healy, G. N. (2017) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.02.002 · Cited by 502
Self-citation
Sedentary behaviour and the risk of depression: a meta-analysis
Zhai, L., Zhang, Y., & Zhang, D. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093613 · Cited by 500
Prolonged sedentary time and physical activity in workplace and non-work contexts: a cross-sectional study of office, customer service and call centre employees
Thorp, A. A., Healy, G. N., WINKLER, E. A. H., Clark, B., Gardiner, P. A., Owen, N. G., & Dunstan, D. W. (2012) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-9-128 · Cited by 512
Self-citation
The sedentary office: an expert statement on the growing case for change towards better health and productivity
Buckley, J., Hedge, A., Yates, T. E., Copeland, R. J., Loosemore, M. P., Hamer, M., Bradley, G., & Dunstan, D. W. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-094618 · Cited by 465
Self-citation
Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial
Peddie, M. C., Bone, J. L., Rehrer, N. J., Skeaff, C. M., Gray, A. R., & Perry, T. L. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051763 · Cited by 431
Reallocating time to sleep, sedentary behaviors, or active behaviors: associations with cardiovascular disease risk biomarkers, NHANES 2005–2006
Buman, M. P., Winkler, E. A. H., Kurka, J. M., Hekler, E. B., Baldwin, C. M., Owen, N., Ainsworth, B. E., Healy, G. N., & Gardiner, P. A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt292 · Cited by 427
Self-citation
Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
Dempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2336 · Cited by 405
Self-citation
Routine assessment and promotion of physical activity in healthcare settings: A scientific statement from the American Heart Association
Lobelo, F., Rohm Young, D., Sallis, R., Garber, M. D., Billinger, S. A., Duperly, J., Hutber, A., Pate, R. R., Thomas, R. J., Widlansky, M. E., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000559 · Cited by 402
Relationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease
Chomistek, A. K., Manson, J. E., Stefanick, M. L., Lu, B., Sands-Lincoln, M., Going, S. B., Garcia, L., Allison, M. A., Sims, S. T., LaMonte, M. J., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.031 · Cited by 389
“In accelerometer studies, having a higher number of breaks in sedentary time was inversely associated with waist circumference, BMI, triglycerides, 2-h plasma glucose, and C-reactive protein, independent of total time spent sitting and physical activity (22,23).”
Sit–Stand Workstations
Alkhajah, T. A., Reeves, M. M., Eakin, E., WINKLER, E. A. H., Owen, N. G., & Healy, G. N. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.05.027 · Cited by 381
Self-citation
A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta‐analysis of controlled trials
Prince, S. A., Saunders, T. J., Gresty, K., & Reid, R. D. (2014) · Obesity Reviews · doi:10.1111/obr.12215 · Cited by 382
Physiology of sedentary behavior
Pinto, A. J., Bergouignan, A., Dempsey, P. C., Roschel, H., Owen, N. G., Gualano, B., & Dunstan, D. W. (2023) · Physiological Reviews · doi:10.1152/physrev.00022.2022 · Cited by 442
Self-citation
Meta‐analysis of the relationship between breaks in sedentary behavior and cardiometabolic health
Chastin, S. F. M., Egerton, T., Leask, C., & Stamatakis, E. (2015) · Obesity · doi:10.1002/oby.21180 · Cited by 363
Television Viewing and Time Spent Sedentary in Relation to Cancer Risk: A Meta-Analysis
Schmid, D., & Leitzmann, M. F. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju098 · Cited by 379
Reducing sitting time in office workers: Short-term efficacy of a multicomponent intervention
Healy, G. N., Eakin, E., LaMontagne, A. D., Owen, N. G., WINKLER, E. A. H., Wiesner, G., Gunning, L., Neuhaus, M., Lawler, S., Fjeldsoe, B. S., et al. (2013) · Preventive Medicine · doi:10.1016/j.ypmed.2013.04.004 · Cited by 340
Self-citation
Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health
Henson, J., Yates, T., Biddle, S. J. H., Edwardson, C. L., Khunti, K., Wilmot, E. G., Gray, L. J., Gorely, T., Nimmo, M. A., & Davies, M. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2845-9 · Cited by 337
Sit less and move more for cardiovascular health: emerging insights and opportunities
Dunstan, D. W., Dogra, S., Carter, S. E., & Owen, N. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00547-y · Cited by 333
Self-citation
Reducing occupational sedentary time: a systematic review and meta‐analysis of evidence on activity‐permissive workstations
Neuhaus, M., Eakin, E., Straker, L. M., Owen, N. G., Dunstan, D. W., Reid, N., & Healy, G. N. (2014) · Obesity Reviews · doi:10.1111/obr.12201 · Cited by 350
Self-citation
Sedentary Behaviour as an Emerging Risk Factor for Cardiometabolic Diseases in Children and Youth
Saunders, T. J., Chaput, J., & Tremblay, M. S. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.08.266 · Cited by 331
Effects of interrupting prolonged sitting with physical activity breaks on blood glucose, insulin and triacylglycerol measures: A systematic review and meta-analysis
Loh, R., Stamatakis, E., Folkerts, D., Allgrove, J. E., & Moir, H. J. (2020) · Sports Medicine · doi:10.1007/s40279-019-01183-w · Cited by 326
Wearable activity trackers, accuracy, adoption, acceptance and health impact: A systematic literature review
Shin, G., Jarrahi, M. H., Fei, Y., Karami, A., Gafinowitz, N., Byun, A., & Lu, X. (2019) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2019.103153 · Cited by 326
A Catalog of Rules, Variables, and Definitions Applied to Accelerometer Data in the National Health and Nutrition Examination Survey, 2003–2006
Tudor-Locke, C. E., Camhi, S. M., & Troiano, R. P. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110332 · Cited by 319
Daily physical activity assessment with accelerometers: new insights and validation studies
Plasqui, G., Bonomi, A. G., & Westerterp, K. R. (2013) · Obesity Reviews · doi:10.1111/obr.12021 · Cited by 345
The Effects of Breaking up Prolonged Sitting Time
Benatti, F. B., & Ried‐Larsen, M. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000654 · Cited by 312
Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers
Healy, G. N., WINKLER, E. A. H., Owen, N. G., Anuradha, S., & Dunstan, D. W. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv308 · Cited by 306
Self-citation
Association Between Questionnaire- and Accelerometer-Assessed Physical Activity: The Role of Sociodemographic Factors
Sabia, S., van Hees, V. T., Shipley, M. J., Trenell, M. I., Hagger-Johnson, G., Elbaz, A., Kivimaki, M., & Singh-Manoux, A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt330 · Cited by 304
Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis
Cliff, D. P., Hesketh, K. D., Vella, S. A., Hinkley, T., Tsiros, M. D., Ridgers, N. D., Carver, A., Veitch, J., Parrish, A., Hardy, L. L., et al. (2016) · Obesity Reviews · doi:10.1111/obr.12371 · Cited by 327
The effect of physical activity on mediators of inflammation
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12156 · Cited by 311
Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study
van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., van der Velde, J. H. P. M., Willems, P. J. B., Savelberg, H. H. C. M., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., et al. (2016) · Diabetologia · doi:10.1007/s00125-015-3861-8 · Cited by 299
A Cluster Randomized Controlled Trial to Reduce Office Workers’ Sitting Time
Healy, G. N., Eakin, E., Owen, N. G., LaMontagne, A. D., Moodie, M., WINKLER, E. A. H., Fjeldsoe, B. S., Wiesner, G., Willenberg, L., & Dunstan, D. W. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000972 · Cited by 298
Self-citation
Sedentary Behavior, Physical Activity, and Markers of Health in Older Adults
GENNUSO, K. P., GANGNON, R. E., MATTHEWS, C. E., THRAEN-BOROWSKI, K. M., & COLBERT, L. H. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318288a1e5 · Cited by 292
Self-citation
Associations between sedentary behaviour and body composition, muscle function and sarcopenia in community-dwelling older adults
Gianoudis, J., Bailey, C. A., & Daly, R. M. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2895-y · Cited by 312
Physical Activity and Sedentary Behaviors in People With Stroke Living in the Community: A Systematic Review
English, C., Manns, P. J., Tucak, C., & Bernhardt, J. (2014) · Physical Therapy · doi:10.2522/ptj.20130175 · Cited by 278
Is the time right for quantitative public health guidelines on sitting? A narrative review of sedentary behaviour research paradigms and findings
Stamatakis, E., Ekelund, U., Ding, D., Hamer, M., Bauman, A. E., & Lee, I.-M. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099131 · Cited by 284
Validity of Two Wearable Monitors to Estimate Breaks from Sedentary Time
Lyden, K. A., Keadle, S. K., STAUDENMAYER, J. W., & Freedson, P. S. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318260c477 · Cited by 300
Objectively measured physical activity and sedentary time during childhood, adolescence and young adulthood: a cohort study
Ortega, F. B., Konstabel, K., Pasquali, E., Ruiz, J. R., Hurtig-Wennlöf, A., Mäestu, J., Löf, M., Harro, J., Bellocco, R., Labayen, I., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060871 · Cited by 281
Definition, Measurement, and Health Risks Associated with Sedentary Behavior
Gibbs, B. B., Hergenroeder, A. L., Katzmarzyk, P. T., Lee, I.-M. M., & Jakicic, J. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000517 · Cited by 275
Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms
Carter, S. E., Hartman, Y., Holder, S. M., Thijssen, D. H. J., & Hopkins, N. D. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000106 · Cited by 286
Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study
Henson, J., Davies, M. J., Bodicoat, D. H., Edwardson, C. L., Gill, J. M. R., Stensel, D. J., Tolfrey, K., Dunstan, D. W., Khunti, K., & Yates, T. (2016) · Diabetes Care · doi:10.2337/dc15-1240 · Cited by 270
Self-citation
Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study
McConnell, M. V., Shcherbina, A., Pavlovic, A., Homburger, J. R., Goldfeder, R. L., Waggot, D., Cho, M. K., Rosenberger, M. E., Haskell, W. L., Myers, J., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2016.4395 · Cited by 239
Workplace Sitting Breaks Questionnaire (SITBRQ): an assessment of concurrent validity and test-retest reliability
Pedišić, Ž., Bennie, J. A., Timperio, A. F., Crawford, D. A., Dunstan, D. W., Bauman, A. E., & Salmon, J. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1249 · Cited by 254
Self-citation
Feasibility of Reducing Older Adults' Sedentary Time
Gardiner, P. A., Eakin, E., Healy, G. N., & Owen, N. G. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.03.020 · Cited by 265
Self-citation
Screen Time, Other Sedentary Behaviours, and Obesity Risk in Adults: A Review of Reviews
Biddle, S., García, E. B., Pedišić, Ž., Bennie, J. A., Vergeer, I., & Wiesner, G. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0256-9 · Cited by 268
Sedentariness and Health: Is Sedentary Behavior More Than Just Physical Inactivity?
Panahi, S., & Tremblay, A. (2018) · Frontiers in Public Health · doi:10.3389/fpubh.2018.00258 · Cited by 273
Estimating Activity and Sedentary Behavior from an Accelerometer on the Hip or Wrist
Rosenberger, M. E., Haskell, W. L., Albinali, F., Mota, S., Nawyn, J., & Intille, S. S. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827f0d9c · Cited by 258
Associations of objectively-assessed physical activity and sedentary time with depression: NHANES (2005–2006)
Vallance, J. K., Winkler, E. A. H., Gardiner, P. A., Healy, G. N., Lynch, B. M., & Owen, N. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.07.013 · Cited by 238
Self-citation
The activPALTM Accurately Classifies Activity Intensity Categories in Healthy Adults
Lyden, K. A., Keadle, S. K., STAUDENMAYER, J. W., & Freedson, P. S. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001177 · Cited by 244
Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review
Brocklebank, L. A., Falconer, C., Page, A. S., Perry, R. A., & Cooper, A. R. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.013 · Cited by 245
Sitting and Activity Time in People With Stroke
English, C., Healy, G. N., Coates, A. M., Lewis, L. K., Olds, T., & Bernhardt, J. A. (2015) · Physical Therapy · doi:10.2522/ptj.20140522 · Cited by 226
Self-citation
Sitting patterns at work: objective measurement of adherence to current recommendations
Ryan, C. G., Dall, P., Granat, M. H., & Grant, P. (2011) · Ergonomics · doi:10.1080/00140139.2011.570458 · Cited by 247
Screen Time and Health Indicators Among Children and Youth: Current Evidence, Limitations and Future Directions
Saunders, T. J., & Vallance, J. K. (2016) · Applied Health Economics and Health Policy · doi:10.1007/s40258-016-0289-3 · Cited by 252
Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population
Henson, J. J., Yates, T. E., Edwardson, C. L., Khunti, K. K., Talbot, D. C. S., Gray, L. J., Leigh, T. M., Carter, P., & Davies, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078350 · Cited by 219
Sitting Time and Risk of Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis
Bailey, D. P., Hewson, D. J., Champion, R. B., & Sayegh, S. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.04.015 · Cited by 219
Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis
Katzmarzyk, P. T., & Lee, I.-M. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-000828 · Cited by 218
Workplace Sitting and Height-Adjustable Workstations
Neuhaus, M., Healy, G. N., Dunstan, D. W., Owen, N. G., & Eakin, E. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.09.009 · Cited by 216
Self-citation
Alternating Bouts of Sitting and Standing Attenuate Postprandial Glucose Responses
Thorp, A. A., Kingwell, B. A., Sethi, P., Hammond, L. J., Owen, N. G., & Dunstan, D. W. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000337 · Cited by 215
Self-citation
Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts
Hughson, R. L., Robertson, A. D., Arbeille, P., Shoemaker, J. K., Rush, J. W. E., Fraser, K. S., & Greaves, D. K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00802.2015 · Cited by 219
Sedentary Behavior and Public Health: Integrating the Evidence and Identifying Potential Solutions
Owen, N. G., Healy, G. N., Dempsey, P. C., Salmon, J., Timperio, A. F., Clark, B., Goode, A. D., Koorts, H., Ridgers, N. D., Hadgraft, N. T., et al. (2020) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094201 · Cited by 218
Self-citation
Point-of-Choice Prompts to Reduce Sitting Time at Work
Evans, R. E., Fawole, H. O., Sheriff, S. A., Dall, P., Grant, P., & Ryan, C. G. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.05.010 · Cited by 219
B-MOBILE - A Smartphone-Based Intervention to Reduce Sedentary Time in Overweight/Obese Individuals: A Within-Subjects Experimental Trial
Bond, D. S., Thomas, J. G., Raynor, H. A., Moon, J., Sieling, J., Trautvetter, J., Leblond, T. L., & Wing, R. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100821 · Cited by 210
Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes
Cooper, A. R., Sebire, S., Montgomery, A. A., Peters, T. J., Sharp, D. J., Jackson, N., Fitzsimons, K., Dayan, C. M., & Andrews, R. C. (2012) · Diabetologia · doi:10.1007/s00125-011-2408-x · Cited by 195
Agreement between activPAL and ActiGraph for assessing children's sedentary time
Ridgers, N. D., Salmon, J., Ridley, K., O'Connell, E., Arundell, L., & Timperio, A. F. (2012) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-9-15 · Cited by 203
Sedentary behavior: Understanding and influencing adults' prolonged sitting time
Owen, N. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.08.024 · Cited by 187
Self-citation
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Wheeler, M. J., Dempsey, P. C., Grace, M. S., Ellis, K. A., Gardiner, P. A., GREEN, D. J., & Dunstan, D. W. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.04.001 · Cited by 200
Self-citation
Sedentary behavior as a mediator of type 2 diabetes
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2014) · Medicine and Sport Science · doi:10.1159/000357332 · Cited by 185
Associations of Sedentary Behavior, Sedentary Bouts and Breaks in Sedentary Time with Cardiometabolic Risk in Children with a Family History of Obesity
Saunders, T. J., Tremblay, M. S., Mathieu, M.-E., Henderson, M., O’Loughlin, J. L., Tremblay, A., & Chaput, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079143 · Cited by 183
Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta-analyses
Hadgraft, N. T., WINKLER, E. A. H., Climie, R. E., Grace, M. S., Romero, L., Owen, N. G., Dunstan, D. W., Healy, G. N., & Dempsey, P. C. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101154 · Cited by 191
Self-citation
Measuring Older Adults' Sedentary Time
Gardiner, P. A., Clark, B., Healy, G. N., Eakin, E., WINKLER, E. A. H., & Owen, N. G. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821b94f7 · Cited by 176
Self-citation
Accelerometer-based Physical Activity
Bassett, D. R., Troiano, R. P., McClain, J. J., & Wolff, D. L. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000468 · Cited by 186
Managing Sedentary Behavior to Reduce the Risk of Diabetes and Cardiovascular Disease
Dempsey, P. C., Owen, N. G., Biddle, S., & Dunstan, D. W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0522-0 · Cited by 189
Self-citation
Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes
Dempsey, P. C., Sacre, J. W., Larsen, R. N., Straznicky, N. E., Sethi, P., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001101 · Cited by 173
Self-citation
Sedentary Behavior and Physical Function: Objective Evidence From the Osteoarthritis Initiative
Lee, J. J., Chang, R. W., Ehrlich‐Jones, L., Kwoh, C. K., Nevitt, M. C., Semanik, P. A., Sharma, L., Sohn, M., Song, J., & Dunlop, D. D. (2014) · Arthritis Care & Research · doi:10.1002/acr.22432 · Cited by 186
Patterns of sedentary time and cardiometabolic risk among Canadian adults
Carson, V., Wong, S. L., Winkler, E., Healy, G. N., Colley, R. C., & Tremblay, M. S. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.04.005 · Cited by 172
Self-citation
Weekday and weekend patterns of objectively measured sitting, standing, and stepping in a sample of office-based workers: the active buildings study
Smith, L., Hamer, M., Ucci, M., Marmot, A., Gardner, B., Sawyer, A. D. M., Wardle, J., & Fisher, A. (2015) · BMC Public Health · doi:10.1186/s12889-014-1338-1 · Cited by 185
Patterns of Sedentary Behavior in US Middle-Age and Older Adults: The REGARDS Study
DIAZ, K. M., HOWARD, V. J., HUTTO, B., COLABIANCHI, N., VENA, J. E., BLAIR, S. N., & HOOKER, S. P. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000792 · Cited by 170
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
Bellettiere, J., Winkler, E. A. H., Chastin, S. F. M., Kerr, J., Owen, N., Dunstan, D. W., & Healy, G. N. (2017) · PLOS ONE · doi:10.1371/journal.pone.0180119 · Cited by 169
Self-citation
Prolonged sitting: is it a distinct coronary heart disease risk factor?
Dunstan, D. W., Thorp, A. A., & Healy, G. N. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283496605 · Cited by 166
Self-citation
Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?
Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164
Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults
Gilchrist, S. C., Howard, V. J., Akinyemiju, T., Judd, S. E., Cushman, M., Hooker, S. P., & Diaz, K. M. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.2045 · Cited by 170
Participatory Workplace Interventions Can Reduce Sedentary Time for Office Workers—A Randomised Controlled Trial
Parry, S. P., Straker, L. M., Gilson, N. D., & Smith, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078957 · Cited by 184
Reducing office workers’ sitting time: rationale and study design for the Stand Up Victoria cluster randomized trial
Dunstan, D. W., Wiesner, G., Eakin, E., Neuhaus, M., Owen, N. G., LaMontagne, A. D., Moodie, M., WINKLER, E. A. H., Fjeldsoe, B. S., Lawler, S., et al. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1057 · Cited by 166
Self-citation
Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management
Dempsey, P. C., Owen, N. G., Yates, T. E., Kingwell, B. A., & Dunstan, D. W. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0797-4 · Cited by 165
Self-citation
A review of the assessment and prevalence of sedentarism in older adults, its physiology/health impact and non-exercise mobility counter-measures
Wullems, J. A., Verschueren, S., Degens, H., Morse, C. I., & Onambélé-Pearson, G. L. (2016) · Biogerontology · doi:10.1007/s10522-016-9640-1 · Cited by 177
The Ubiquity of the Screen: An Overview of the Risks and Benefits of Screen Time in Our Modern World
LeBlanc, A. G., Gunnell, K. E., Prince, S. A., Saunders, T. J., Barnes, J. D., & Chaput, J. (2017) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000039 · Cited by 178
The independent associations of sedentary behaviour and physical activity on cardiorespiratory fitness
Santos, R., Mota, J. A. P. S., Okely, A. D., Pratt, M., Moreira, C. M. M., Coelho-e-Silva, M. J., Vale, S. M. C. G., & Sardinha, L. B. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091610 · Cited by 174
Associations of Objectively Assessed Physical Activity and Sedentary Time with All-Cause Mortality in US Adults: The NHANES Study
Schmid, D., Ricci, C., & Leitzmann, M. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119591 · Cited by 168
Increasing physical activity in stroke survivors using STARFISH, an interactive mobile phone application: a pilot study
Paul, L., Wyke, S., Brewster, S. A., Sattar, N. A., Gill, J. M. R., Alexander, G., Rafferty, D., McFadyen, A. K., Ramsay, A., & Dybus, A. (2016) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2015.1122266 · Cited by 165
The SOS-framework (Systems of Sedentary behaviours): an international transdisciplinary consensus framework for the study of determinants, research priorities and policy on sedentary behaviour across the life course: a DEDIPAC-study
CHASTIN, S. F. M., Craemer, M. D., Lien, N., Bernaards, C. M., Buck, C., Oppert, J., Nazare, J., Lakerveld, J., O’Donoghue, G., Holdsworth, M., et al. (2016) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-016-0409-3 · Cited by 166
Self-citation

Authors: Healy, G. N., Matthews, C. E., Dunstan, D. W., Winkler, E. A. H., & Owen, N.
Affiliations: Baker Heart and Diabetes Institute (AU)
National Cancer Institute (US)
The University of Queensland (AU)
Corresponding author: Healy, Genevieve N.
ORCID: Healy, Genevieve N.
Matthews, Charles E.
Dunstan, David W.
Winkler, Elisabeth A.H.
Owen, Neville
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2011-01-11
Volume: 32
Issue: 5
Pages: 590-597
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehq451
PMC: PMC3634159
OpenAlex: W2150722389
Cited by: 1,368
References: 28
Citations by year: 2026: 21 · 2025: 31 · 2024: 49 · 2023: 57 · 2022: 80 · 2021: 94 · 2020: 106 · 2019: 102 · 2018: 104 · 2017: 125 · 2016: 112 · 2015: 146 · 2014: 135 · 2013: 102 · 2012: 71
FWCI: 73.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Heart Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
eSpace (Curtin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Funders: National Institutes of Health (Z99 CA999999)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: sedentary behavior, sedentary breaks, cardiometabolic risk, inflammatory markers, C-reactive protein, waist circumference, HDL cholesterol, triglycerides, insulin, HOMA-IR, HOMA-β, accelerometer-measured sedentary time, sex differences, racial and ethnic differences, cardiovascular risk, NHANES
MeSH terms: Acceleration, Adult, Aged, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Nutrition Surveys, Smoking, United States, Biomarkers, Age Distribution, Sex Distribution, Waist Circumference, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks