Cited by 3,658Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

The DOI matches its Crossref record; 127 of the 135 references it cites were found in a registry or an index.

Dietary Intake and Bioavailability of Polyphenols

Open access

Scalbert, Augustin, Williamson, Gary·2000·The Journal of Nutrition

DOI 10.1093/jn/130.8.2073s

Open this paper in CoChat — free account

Abstract

The main dietary sources of polyphenols are reviewed, and the daily intake is calculated for a given diet containing some common fruits, vegetables and beverages. Phenolic acids account for about one third of the total intake and flavonoids account for the remaining two thirds. The most abundant flavonoids in the diet are flavanols (catechins plus proanthocyanidins), anthocyanins and their oxidation products. The main polyphenol dietary sources are fruit and beverages (fruit juice, wine, tea, coffee, chocolate and beer) and, to a lesser extent vegetables, dry legumes and cereals. The total intake is approximately 1 g/d. Large uncertainties remain due to the lack of comprehensive data on the content of some of the main polyphenol classes in food. Bioavailability studies in humans are discussed. The maximum concentration in plasma rarely exceeds 1 microM after the consumption of 10-100 mg of a single phenolic compound. However, the total plasma phenol concentration is probably higher due to the presence of metabolites formed in the body's tissues or by the colonic microflora. These metabolites are still largely unknown and not accounted for. Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides. A better understanding of these factors is essential to explain the large variations in bioavailability observed among polyphenols and among individuals.

Integrity signals

Registry

Crossref · 10.1093/jn/130.8.2073s

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
Singleton, V. L., & Rossi, J. A. (1965) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1965.16.3.144 · Cited by 24,852
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,700
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,492
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Fruit and vegetables, and cardiovascular disease: A review
Ness, A. R., & Powles, J. W. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.1.1 · Cited by 1,368
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216

Show all 135 references

Research works printed but not linked: 9

Boukharta, M., Jalbert, G. & Castonguay, A. (1992) Efficacy of ellagitannins and ellagic acid as cancer chemopreventive agents. XVIth International Conference of the Groupe Polyphénols, Lisbon, Portugal, pp. 245–249.
Clifford, M. N. (1996) Anthocyanins in foods. Symposium on Polyphenols and Anthocyanins as Food Colourants and Antioxidants, Brussels, Belgium, pp. 1–19, EU.
Hara, 1995, Special issue on tea, Food Rev. Int, 11, 371
Henn, 1998, Gesamtphenolgehalt und antioxidative Kapazitat handelsublicher Getranke, Ernahr.-Umsch, 45, 308
Jacobson, 1983, A preliminary investigation of the metabolism of dietary phenolics in humans, Nutr. Rep. Int, 28, 1409
Leupold, 1981, Zur analytick phenolischer Verbindungen im Bier, Brauwissenschaft, 34, 205
Macheix, J.-J., Fleuriet, A. & Billot, J. (1990) Fruit Phenolics. CRC Press, Boca Raton, FL.
Plumb, 1999, Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora, J. Sci. Food Agric, 79, 390, 10.1002/(SICI)1097-0010(19990301)79:3<390::AID-JSFA258>3.0.CO;2-0 · DOI
Santos-Buelga, C. & Scalbert, A. (2000) Proanthocyanidins and tannin-like compounds: nature, occurrence, dietary intake and effects on nutrition and health. J. Food Sci. Agric. (in press). · DOI

Sorted by citations

Items 401–500 of 1,011

Oolong tea: A critical review of processing methods, chemical composition, health effects, and risk
Ng, K. S., Cao, Z.-J., Chen, H., Zhao, Z., Zhu, L., & Yi, T. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1347556 · Cited by 179
Nutrition, Well-Being and Health
(2012) · doi:10.5772/1864 · Cited by 178
Seasonal and cultivar variations in antioxidant and sensory quality of pomegranate (Punica granatum L.) fruit
Borochov‐Neori, H., Judeinstein, S., Tripler, E., Harari, M., Greenberg, A., Shomer, I., & Holland, D. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.10.011 · Cited by 176
Phenolic acid content and radical scavenging activity of extracts from medlar (Mespilus germanica L.) fruit at different stages of ripening
Grúz, J., Ayaz, F. A., Torun, H., & Strnad, M. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.06.030 · Cited by 176
Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts
Ekpenyong, C. E., Akpan, E. E., & Azah, N. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30023-6 · Cited by 183
“Phenolics, flavonoids, and glycosides: While most of the polyphenols are known to be readily absorbed ([37-38]), these compounds tend to undergo modifications into other forms in the biological systems ([22]).”
Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes
Androutsopoulos, V. P., Papakyriakou, A., Vourloumis, D., Tsatsakis, A. M., & Spandidos, D. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.009 · Cited by 175
Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)
Salucci, M., Stivala, L. A., Maiani, G., Bugianesi, R., & Vannini, V. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600295 · Cited by 175
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
Mennen, L. I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., & Scalbert, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061808 · Cited by 174
Self-citation
Modulation of signalling nuclear factor-κB activation pathway by polyphenols in human intestinal Caco-2 cells
Romier, B., Walle, J. V. D., During, A., Larondelle, Y., & Schneider, Y. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508966666 · Cited by 174
The role of polyphenols in poultry nutrition
Abdel‐Moneim, A. E., Shehata, A. M., Alzahrani, S. O., Shafi, M. E., Mesalam, N. M., Taha, A. E.-S., Swelum, A. A., Arif, M. A., Fayyaz, M., & El-Hack, M. E. A. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13455 · Cited by 183
Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells
Kang, K. A., Lee, K. H., Chae, S., Zhang, R., Jung, M. S., Lee, Y., Kim, S. Y., Kim, H. S., Joo, H. G., Park, J. W., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.008 · Cited by 173
Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice
Woo, M., Jeon, S.-M., Shin, Y. C., Lee, M., Kang, M. A., & Choi, M. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900079 · Cited by 173
Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease
Winter, A. N., & Bickford, P. C. (2019) · Antioxidants · doi:10.3390/antiox8090333 · Cited by 185
“They are appealing as therapeutic agents for many reasons, one of the most notable being that they are among the most commonly consumed flavonoids in a normal diet and, for this reason, they are generally recognized as safe [7].”
Background
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems
Chen, Z., Farag, M. A., Zhong, Z., Zhang, C., Yang, Y. P., Wang, S., & Wang, Y. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113870 · Cited by 176
Antiatherogenic properties of flavonoids: Implications for cardiovascular health
Mulvihill, E. E., & Huff, M. W. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)71056-4 · Cited by 172
A Perception on Health Benefits of Coffee
George, S. E., Ramalakshmi, K., & Rao, L. J. M. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701522445 · Cited by 172
Evaluation of nutritional and antioxidant properties of the tropical fruits banana, litchi, mango, papaya, passion fruit and pineapple cultivated in Réunion French Island
Septembre‐Malaterre, A., Stanislas, G., Quessary, E. D., & Gonthier, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.147 · Cited by 172
The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms
Dayem, A. A., Choi, H. J., Yang, G., Kim, K., Saha, S. K., & Cho, S. (2016) · Nutrients · doi:10.3390/nu8090581 · Cited by 182
“Average daily consumption of polyphenols is estimated to be around one gram [55].”
Background
Intestinal Absorption of p-Coumaric and Gallic Acids in Rats after Oral Administration
Konishi, Y., Hitomi, Y., & Yoshioka, E. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035366k · Cited by 171
The impact of oolong and black tea polyphenols on human health
Zhang, H., Qi, R., & Mine, Y. (2019) · Food Bioscience · doi:10.1016/j.fbio.2019.03.009 · Cited by 171
Toxicology and safety of anti-oxidant of bamboo leaves. Part 1: Acute and subchronic toxicity studies on anti-oxidant of bamboo leaves
Lu, B., Wu, X., Tie, X., Zhang, Y., & Zhang, Y. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.01.019 · Cited by 170
Minerals, Phenolic Compounds, and Antioxidant Capacity of Citrus Peel Extract by Hot Water
Xu, G., Chen, J., Liu, D. H., Zhang, Y., Jiang, P., & Xiwen, Y. E. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00546.x · Cited by 170
Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease
Marnewick, J. L., Rautenbach, F., Venter, I., Neethling, H., Blackhurst, D., Wolmarans, P., & Macharia, M. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.061 · Cited by 170
“The 4-week period is sufficient to prevent a carry over effect for flavonoids, as most flavonoids have been shown to have short elimination half-lives (Scalbert and Williamson, 2000; Scalbert et al., 2002).”
Background
Citrus flavonoids as potential therapeutic agents: A review
Alam, F., Mohammadin, K., Shafique, Z., Amjad, S. T., & Asad, M. H. H. B. (2021) · Phytotherapy Research · doi:10.1002/ptr.7261 · Cited by 169
Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer
Russo, G. L., Russo, M., Spagnuolo, C., Tedesco, I., Bilotto, S., Iannitti, R., & Palumbo, R. (2013) · Cancer treatment and research · doi:10.1007/978-3-642-38007-5_11 · Cited by 174
A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica
Saleem, S., Muhammad, G., Hussain, M. A., & Bukhari, S. N. A. (2018) · Phytotherapy Research · doi:10.1002/ptr.6076 · Cited by 187
“Various secondary metabolites (flavonoids, nimbolide, azadirachtin, etc.) are responsible for antimicrobial and antioxidative potential of this medicinal tree (Manach, Scalbert, Morand, Rémésy, & Jiménez, 2004; Scalbert & Williamson, 2000).”
Background
Zinc Oxide Nanoparticles Boosts Phenolic Compounds and Antioxidant Activity of Capsicum annuum L. during Germination
García-López, J. I., Zavala‐García, F., Olivares‐Sáenz, E., Lira-Saldívar, R. H., Barriga‐Castro, E. D., Ruíz-Torres, N. A., Ramos-Cortez, E., Vázquez-Alvarado, R. E., & Niño‐Medina, G. (2018) · Agronomy · doi:10.3390/agronomy8100215 · Cited by 168
“Several thousands of phenolic compounds have been identified in plants and although is almost impossible to know the nature of all the phenolics present in a single sample, it is desirable to know the main classes of phenolic compounds present in it [51].”
Background
Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress
Schwedhelm, E., Maas, R., Troost, R., & ger, R. H. B. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00003 · Cited by 172
Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity
Vauzour, D., Corona, G., & Spencer, J. P. E. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.016 · Cited by 166
Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ
Bandele, O. J., & Osheroff, N. (2007) · Biochemistry · doi:10.1021/bi7000664 · Cited by 167
The effects of grape and red wine polyphenols on gut microbiota – A systematic review
Nash, V., Ranadheera, C. S., Georgousopoulou, E. N., Mellor, D. D., Panagiotakos, D. B., McKune, A. J., Kellett, J., & Naumovski, N. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.019 · Cited by 171
Polyphenols: From Classification to Therapeutic Potential and Bioavailability
Ciupei, D., Colișar, A., LEOPOLD, L. F., Stănilă, A., & Diaconeasa, Z. M. (2024) · Foods · doi:10.3390/foods13244131 · Cited by 201
“States to land approximately at 1 g/d [81], this value remaining the most used reference intakes for anthocyanins Flavonol intake in the U.S., Denmark, and Holland is about 20–25 mg/d, while in Italy, it was estimated a mean, with 15 mg/d higher. have not been established in most countries.”
Phytochemical Profile of Main Antioxidants in Different Fractions of Purple and Blue Wheat, and Black Barley
Siebenhandl‐Ehn, S., Grausgruber, H., Pellegrini, N., Rio, D. D., Fogliano, V., Pernice, R., & Berghofer, E. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072021j · Cited by 167
Inhibitory Effect of Phenolic Acids on the Proliferation of 3T3-L1 Preadipocytes in Relation to Their Antioxidant Activity
Hsu, C., Huang, S.-L., & Yen, G. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0609882 · Cited by 166
Autism: Transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents
Román, G. C. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.023 · Cited by 171
Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3
Donovan, J. L., Lee, A., Rios, L., Rios, L. Y., Morand, C., Scalbert, A., & Rémésy, C. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn2001517 · Cited by 197
Self-citation
Luteolin and Chrysin Differentially Inhibit Cyclooxygenase-2 Expression and Scavenge Reactive Oxygen Species but Similarly Inhibit Prostaglandin-E2 Formation in RAW 264.7 Cells
Harris, G. K., Qian, Y. R., Leonard, S. S., Sbarra, D. C., & Shi, X. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1517 · Cited by 168
The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics
van Dorsten, F. A., Grün, C. H., van Velzen, E. J. J., Jacobs, D. M., Draijer, R., & van Duynhoven, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900212 · Cited by 169
Apples and Cardiovascular Health—Is the Gut Microbiota a Core Consideration?
Koutsos, A., Tuohy, K., & Lovegrove, J. (2015) · Nutrients · doi:10.3390/nu7063959 · Cited by 6
“However, a significant proportion of chlorogenic acid (5-caffeoylquinic acid), may reach the colon where it can be further metabolized by the gut microbiota [59,60,67,68].”
Influential
Review: Health Effects of Cocoa Flavonoids
Lamuela-Raventós, R. M., Romero‐Pérez, A. I., Andrés‐Lacueva, C., & Tornero, A. C. F. (2005) · Food Science and Technology International · doi:10.1177/1082013205054498 · Cited by 166
Polyphenol levels in human urine after intake of six different polyphenol-rich beverages
Ito, H., Gonthier, M., Manach, C., Morand, C., Mennen, L. I., Rémésy, C., & Scalbert, A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051522 · Cited by 165
Self-citation
Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants
Pinto, T., Aires, A., Cosme, F., Bacelar, E. L. V. A., Morais, M. C., Oliveira, I. V., Ferreira-Cardoso, J. V., Anjos, R., Vilela, A., & Gonçalves, B. C. (2021) · Foods · doi:10.3390/foods10010106 · Cited by 172
Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo
Terao, J., Murota, K., & Kawai, Y. (2010) · Food & Function · doi:10.1039/c0fo00106f · Cited by 164
Phenolic compounds in agri-food by-products, their bioavailability and health effects
Shahidi, F., Vamadevan, V., Oh, W. Y., & Peng, H. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5178 · Cited by 175
Effects of micronization on dietary fiber composition, physicochemical properties, phenolic compounds, and antioxidant capacity of grape pomace and its dietary fiber concentrate
Bender, A. B. B., Speroni, C. S., Moro, K. I. B., Morisso, F. D. P., dos Santos, D. R., da Silva, L. P., & Penna, N. G. (2019) · LWT · doi:10.1016/j.lwt.2019.108652 · Cited by 164
Autophagy, polyphenols and healthy ageing
Pallauf, K., & Rimbach, G. H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.008 · Cited by 167
Cytotoxicity and Antiproliferative Activities of Several Phenolic Compounds Against Three Melanocytes Cell Lines: Relationship Between Structure and Activity
Yanez, J., Vicente, V., Alcaraz, M., Castillo, J., Benavente-García, O., Canteras, M., & Teruel, J. (2004) · Nutrition and Cancer · doi:10.1207/s15327914nc4902_11 · Cited by 165
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
Spencer, J. P. E. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110000054 · Cited by 163
Sample handling strategies for the determination of biophenols in food and plants
Tura, D., & Robards, K. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)00879-8 · Cited by 163
The toxicology and safety of apple polyphenol extract
Shoji, T., Akazome, Y., Kanda, T., & Ikeda, M. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.02.008 · Cited by 163
Polyphenols Are Intensively Metabolized in the Human Gastrointestinal Tract after Apple Juice Consumption
Kahle, K., Hümmer, W., Kempf, M. A., Scheppach, W. M., Erk, T., & Richling, E. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071942r · Cited by 162
Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation
Ding, Y., Zhang, B., Zhou, K., Chen, M., Wang, M., Jia, Y., Song, Y., Li, Y., & Wen, A. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.045 · Cited by 164
The Key Importance of Soy Isoflavone Bioavailability to Understanding Health Benefits
Larkin, T., Price, W. E., & Astheimer, L. B. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701542716 · Cited by 161
Influence of apple polyphenols on inflammatory gene expression
Jung, M., Triebel, S., Anke, T., Richling, E., & Erkel, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800575 · Cited by 161
Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
Brand, W., Schutte, M. E., Williamson, G., van Zanden, J. J., Cnubben, N. H. P., Groten, J. P., van BLADEREN, P. J., & Rietjens, I. M. C. M. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.081 · Cited by 161
Self-citation
Effects of Coffee Consumption on Oxidative Susceptibility of Low-Density Lipoproteins and Serum Lipid Levels in Humans
Yukawa, G. S., Mune, M., Otani, H., Tone, Y., Liang, X.-M., Iwahashi, H., & Sakamoto, W. (2004) · Biochemistry (Moscow) · doi:10.1023/b:biry.0000016354.05438.0f · Cited by 161
Cruciferous Vegetables and Their Bioactive Metabolites: from Prevention to Novel Therapies of Colorectal Cancer
Ağagündüz, D., Şahin, T. Ö., Yılmaz, B., Ekenci, K. D., Özer, Ş. D., & Capasso, R. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1534083 · Cited by 161
“Phenolics are first hydrolysed to their free aglycones, then conjugated by methylation, sulfation, glucuronidation, or a combination thereof [120].”
Background
Bioavailability of Flavan-3-ols and Procyanidins: Gastrointestinal Tract Influences and Their Relevance to Bioactive Forms In Vivo
Spencer, J. P. E., Schroeter, H., Rechner, A. R., & Rice-Evans, C. A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203558 · Cited by 161
Risk of Cardiovascular Disease–Related and All-Cause Death According to Serum Concentrations of Enterolactone
Vanharanta, M., Voutilainen, S., Rissanen, T. H., Adlercreutz, H., & Salonen, J. T. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1099 · Cited by 161
Urinary metabolites as biomarkers of polyphenol intake in humans—a systematic review
Pérez-Jiménez, J., Hubert, J., Hooper, L., Cassidy, A., Manach, C., Williamson, G., & Scalbert, A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29924 · Cited by 159
“More than 1 g of polyphenols per day is commonly ingested with the diet (1, 2).”
Fucaceae: A Source of Bioactive Phlorotannins
Catarino, M. D., Silva, A. M. S., & Cardoso, S. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061327 · Cited by 166
Comparison of the Neuroprotective and Anti‐Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4‐Hydroxybenzoic Acid
Winter, A. N., Brenner, M. C., Punessen, N., Snodgrass, M., Byars, C., Arora, Y., & Linseman, D. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6297080 · Cited by 160
“In particular, anthocyanins, a unique class of flavonoid compounds, show significant potential as a treatment for neurodegenerative disease for these reasons in addition to the observation that they are among the most commonly consumed polyphenolic species around the world [8].”
Background
Black chokeberry (Aronia melanocarpa) polyphenols reveal different antioxidant, antimicrobial and neutrophil-modulating activities
Denev, P. N., Čı́ž, M., Kratchanova, M. G., & Blazheva, D. E. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.108 · Cited by 164
Functional foods as potential therapeutic options for metabolic syndrome
Brown, L., Poudyal, H., & Panchal, S. K. (2015) · Obesity Reviews · doi:10.1111/obr.12313 · Cited by 163
“2), found in onions, apples and tea in high concentrations (90,91), have shown positive responses in animal models of human diseases such as hypertension, hyperlipi-”
Background
Dietary flavonoid intake and lung cancer—A population‐based case‐control study
Cui, Y., Morgenstern, H., Greenland, S., Tashkin, D. P., Mao, J. T., Cai, L., Cozen, W., Mack, T. M., Lu, Q., & Zhang, Z. (2008) · Cancer · doi:10.1002/cncr.23398 · Cited by 158
Studies on apple and blueberry fruit constituents: do the polyphenols reach the colon after ingestion?
Kahle, K., Kraus, M., Scheppach, W., Ackermann, M., Ridder, F., & Richling, E. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500211 · Cited by 150
Wine Polyphenols: Potential Agents in Neuroprotection
Basli, A., Soulet, S., Chaher, N., Mérillon, J., Chibane, M., Monti, J., & Richard, T. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/805762 · Cited by 162
“Some of them who are not absorbed pass to the large intestine and undergo colonic biotransformation by the enzymes of the colonic microflora [118].”
Background
Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment
Afrin, S., Giampieri, F., Gasparrini, M., Forbes-Hernández, T. Y., Varela‐López, A., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2016) · Molecules · doi:10.3390/molecules21020169 · Cited by 162
Modulatory effects of plant phenols on human multidrug‐resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)
Wu, C., Calcagno, A. M., Hladky, S. B., Ambudkar, S. V., & Barrand, M. A. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04888.x · Cited by 160
Hawthorn: Potential Roles in Cardiovascular Disease
Chang, W., Dao, J., & Shao, Z. (2005) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x05002606 · Cited by 159
Natural polyphenol disposition via coupled metabolic pathways
Liu, Z., & Hu, M. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.3.389 · Cited by 158
Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Panchal, S. K., Ward, L. C., & Brown, L. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0358-9 · Cited by 158
A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males
Phillips, T., Childs, A. C., Dreon, D. M., Phinney, S. D., & Leeuwenburgh, C. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000099112.32342.10 · Cited by 157
Consumption of green tea favorably affects oxidative stress markers in weight-trained men
Panza, V. P., Wazlawik, E., Schütz, G. R., Comin, L., Hecht, K. C., & da Silva, E. L. (2008) · Nutrition · doi:10.1016/j.nut.2008.01.009 · Cited by 158
Effect of Maturity on Phenolics (Phenolic Acids and Flavonoids) Profile of Strawberry Cultivars and Mulberry Species from Pakistan
Mahmood, T., Anwar, F., Abbas, M., & Saari, N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13044591 · Cited by 158
“Among the phytochemicals in fruit, phenolic acids and flavonols are regarded as major functional food components and are thought to contribute to the health effects of fruit-derived products due to the prevention of various diseases associated with oxidative stress, such as cancers, cardiovascular diseases and inflamm…”
Background
Molecular and Biochemical Analysis of Two cDNA Clones Encoding Dihydroflavonol-4-Reductase fromMedicago truncatula
Xie, D., Jackson, L. A., Cooper, J. D., Ferreira, D., & Paiva, N. L. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.030221 · Cited by 157
Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications
Magrone, T., Russo, M. A., & Jirillo, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00677 · Cited by 164
“Of note, a part of unabsorbed flavanols is excreted into the feces (33, 38, 39).”
Inhibition of Protein Glycation by Extracts of Culinary Herbs and Spices
Dearlove, R. P., Greenspan, P., Hartle, D. K., Swanson, R. B., & Hargrove, J. L. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.536 · Cited by 157
Phenolic composition and antioxidant properties of some traditionally used medicinal plants affected by the extraction time and hydrolysis
Komes, D., Belščak‐Cvitanović, A., Horžić, D., Rusak, G., Likić, S., & Berendika, M. (2010) · Phytochemical Analysis · doi:10.1002/pca.1264 · Cited by 156
“Glycosylation influences their chemical, physical and biological properties, including their absorption and bioavailability in human organism (Scalbert and Williamson, 2000).”
Background
Acute Effects of Chlorogenic Acid on Nitric Oxide Status, Endothelial Function, and Blood Pressure in Healthy Volunteers: A Randomized Trial
Mubarak, A., Bondonno, C. P., Liu, A. H., Considine, M. J., Rich, L., Mas, E., Croft, K. D., & Hodgson, J. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303440j · Cited by 157
Mediterranean non-cultivated vegetables as dietary sources of compounds with antioxidant and biological activity
Morales, P., Ferreira, I. C. F. R., Carvalho, A. M., Sánchez‐Mata, M. D. C., Cámara, M., Fernández‐Ruiz, V., Pardo‐de‐Santayana, M., & Tardío, J. (2013) · LWT · doi:10.1016/j.lwt.2013.08.017 · Cited by 165
Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?
Goszcz, K., Duthie, G. G., Stewart, D., Leslie, S. J., & Megson, I. L. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13708 · Cited by 160
“Unabsorbed polyphenols are excreted from the body in faeces (Scalbert and Williamson, 2000).”
Background
Changes in bioactive compounds and antioxidant activity of plant-based foods by gastrointestinal digestion: a review
Ketnawa, S., Reginio, F. C., Thuengtung, S., & Ogawa, Y. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1878100 · Cited by 156
Purple passion fruit (Passiflora edulis f. edulis): A comprehensive review on the nutritional value, phytochemical profile and associated health effects
Fonseca, A. M. A., Geraldi, M. V., Maróstica, M. R., Silvestre, A. J. D., & Rocha, S. M. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111665 · Cited by 176
Epigallocatechin-3-gallate, a Green Tea–Derived Polyphenol, Inhibits IL-1β-Dependent Proinflammatory Signal Transduction in Cultured Respiratory Epithelial Cells
Wheeler, D. S., Catravas, J. D., Odoms, K., Denenberg, A. G., Malhotra, V., & Wong, H. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1039 · Cited by 156
Quercetin Glucuronides but Not Glucosides Are Present in Human Plasma after Consumption of Quercetin-3-Glucoside or Quercetin-4′-Glucoside
Sesink, A. L. A., O’Leary, K. A., & Hollman, P. C. H. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.1938 · Cited by 156
Yeast-cell-based microencapsulation of chlorogenic acid as a water-soluble antioxidant
Shi, G., Rao, L., Yu, H., Xiang, H., Pen, G., Long, S., & Chen, Y. (2006) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2006.06.038 · Cited by 155
Quercetin and its derivatives: chemical structure and bioactivity - a review
Materska, M. (2008) · Polish Journal of Food and Nutrition Sciences · Cited by 154
Inhibition of human cytochromes P450 by components of Ginkgo biloba
Moltke, L. L., Weemhoff, J. L., Bedіr, E., Khan, I. A., Harmatz, J. S., Goldman, P., & Greenblatt, D. J. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044021 · Cited by 155
Genotoxicity of phytoestrogens
Stopper, H., Schmitt, E., & Kobras, K. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.029 · Cited by 155
The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety
Dias, G. P., Cavegn, N., Nix, A., do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S. A., Nardi, A. E., Gardino, P. F., & Thuret, S. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/541971 · Cited by 153
“Dietary polyphenols are thought to be the most abundant antioxidants in foods and beverages [63], with particular potential to inhibit neuroinflammation (reviewed in [64]).”
Background
In vitro Cytotoxicity of Epigallocatechin Gallate and Tea Extracts to Cancerous and Normal Cells from the Human Oral Cavity
Weisburg, J. H., Weissman, D. B., Sedaghat, T., & Babich, H. (2004) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2004.pto_950407.x · Cited by 153
A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk
Santhakumar, A. B., Bulmer, A. C., & Singh, I. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12177 · Cited by 159
Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects
Corona, G., Deiana, M., Incani, A., Vauzour, D., Dessì, M., & Spencer, J. P. E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.049 · Cited by 153
Spices in the management of diabetes mellitus
Bi, X., Lim, J. C. L., & Henry, C. J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.08.111 · Cited by 153
Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers
Patra, A., Satpathy, S., Shenoy, A. K., Bush, J. E., Kazi, M., & Hussain, M. D. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s153094 · Cited by 153
“Introduction Quercetin (3,5,7,3′,4′-pentahydroxyflavone, QCT) (Figure 1) is a polyphenolic compound that is present in many plants, fruits, and vegetables.(1) It belongs to the flavonoid category, which is a class of polyphenolic compounds containing a basic skeleton of diphenylpropane and a common flavone moiety cont…”
Food Content, Processing, Absorption and Metabolism of Onion Flavonoids
Németh, K., & Piskuła, M. (2007) · Critical reviews in food science and nutrition · doi:10.1080/10408390600846291 · Cited by 145
Polyphenol Supplementation as a Complementary Medicinal Approach to Treating Inflammatory Bowel Disease
Biasi, F., Astegiano, M., Maina, M., Leonarduzzi, G., & Poli, G. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797535263 · Cited by 154
“Consequently, the only significant site for chlorogenic acid metabolism is the colon, where it becomes metabolized by commensal bacteria [69].”
BackgroundInfluential
Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers – a review
Mukhopadhyay, P., & Prajapati, A. (2015) · RSC Advances · doi:10.1039/c5ra18896b · Cited by 152
The role of natural polyphenols in cell signaling and cytoprotection against cancer development
Lewandowska, H., Kalinowska, M., Lewandowski, W., Stępkowski, T. M., & Brzóska, K. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.006 · Cited by 157
“The average consumption of polyphenols in the diet is 1 g/day [3,4].”
Background

Authors: Scalbert, A., & Williamson, G.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Norwich Research Park (GB)
ORCID: Scalbert, Augustin
Williamson, Gary
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2000-08
Volume: 130
Issue: 8
Pages: 2073S-2085S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/130.8.2073s
OpenAlex: W2105234557
Cited by: 3,658
References: 135
Citations by year: 2026: 68 · 2025: 83 · 2024: 116 · 2023: 109 · 2022: 121 · 2021: 179 · 2020: 156 · 2019: 172 · 2018: 172 · 2017: 171 · 2016: 168 · 2015: 180 · 2014: 208 · 2013: 225 · 2012: 230
FWCI: 8.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8221 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: dietary polyphenols, polyphenol bioavailability, dietary intake, phenolic acids, flavonoids, flavan-3-ols, catechins, proanthocyanidins, anthocyanins, flavonoid glycosides, polyphenol metabolism, colonic microbiota, beverages, fruits and vegetables
MeSH terms: Animals, Biological Availability, Diet, Flavonoids, Food Analysis, Humans, Intestinal Absorption, Phenols, Polymers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary Intake and Bioavailability of Polyphenols

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks