Cited by 3,658Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

The DOI matches its Crossref record; 127 of the 135 references it cites were found in a registry or an index.

Dietary Intake and Bioavailability of Polyphenols

Open access

Scalbert, Augustin, Williamson, Gary·2000·The Journal of Nutrition

DOI 10.1093/jn/130.8.2073s

Open this paper in CoChat — free account

Abstract

The main dietary sources of polyphenols are reviewed, and the daily intake is calculated for a given diet containing some common fruits, vegetables and beverages. Phenolic acids account for about one third of the total intake and flavonoids account for the remaining two thirds. The most abundant flavonoids in the diet are flavanols (catechins plus proanthocyanidins), anthocyanins and their oxidation products. The main polyphenol dietary sources are fruit and beverages (fruit juice, wine, tea, coffee, chocolate and beer) and, to a lesser extent vegetables, dry legumes and cereals. The total intake is approximately 1 g/d. Large uncertainties remain due to the lack of comprehensive data on the content of some of the main polyphenol classes in food. Bioavailability studies in humans are discussed. The maximum concentration in plasma rarely exceeds 1 microM after the consumption of 10-100 mg of a single phenolic compound. However, the total plasma phenol concentration is probably higher due to the presence of metabolites formed in the body's tissues or by the colonic microflora. These metabolites are still largely unknown and not accounted for. Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides. A better understanding of these factors is essential to explain the large variations in bioavailability observed among polyphenols and among individuals.

Integrity signals

Registry

Crossref · 10.1093/jn/130.8.2073s

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
Singleton, V. L., & Rossi, J. A. (1965) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1965.16.3.144 · Cited by 24,852
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,700
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,492
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Fruit and vegetables, and cardiovascular disease: A review
Ness, A. R., & Powles, J. W. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.1.1 · Cited by 1,368
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216

Show all 135 references

Research works printed but not linked: 9

Boukharta, M., Jalbert, G. & Castonguay, A. (1992) Efficacy of ellagitannins and ellagic acid as cancer chemopreventive agents. XVIth International Conference of the Groupe Polyphénols, Lisbon, Portugal, pp. 245–249.
Clifford, M. N. (1996) Anthocyanins in foods. Symposium on Polyphenols and Anthocyanins as Food Colourants and Antioxidants, Brussels, Belgium, pp. 1–19, EU.
Hara, 1995, Special issue on tea, Food Rev. Int, 11, 371
Henn, 1998, Gesamtphenolgehalt und antioxidative Kapazitat handelsublicher Getranke, Ernahr.-Umsch, 45, 308
Jacobson, 1983, A preliminary investigation of the metabolism of dietary phenolics in humans, Nutr. Rep. Int, 28, 1409
Leupold, 1981, Zur analytick phenolischer Verbindungen im Bier, Brauwissenschaft, 34, 205
Macheix, J.-J., Fleuriet, A. & Billot, J. (1990) Fruit Phenolics. CRC Press, Boca Raton, FL.
Plumb, 1999, Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora, J. Sci. Food Agric, 79, 390, 10.1002/(SICI)1097-0010(19990301)79:3<390::AID-JSFA258>3.0.CO;2-0 · DOI
Santos-Buelga, C. & Scalbert, A. (2000) Proanthocyanidins and tannin-like compounds: nature, occurrence, dietary intake and effects on nutrition and health. J. Food Sci. Agric. (in press). · DOI

Sorted by citations

Items 101–200 of 1,011

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 467
“Phenolics are found in most of the 350 plant-derived foods regularly consumed by humans [3] and different epidemiological studies as well as clinical trials have correlated phenolic compounds with the prevention of chronic degenerative diseases [4].”
Background
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
Kwon, O., Eck, P., Chen, S., Corpe, C. P., Lee, J., Kruhlak, M. J., & Levine, M. N. (2006) · The FASEB Journal · doi:10.1096/fj.06-6620com · Cited by 450
Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
Costabile, A., Klinder, A., Fava, F., Napolitano, A., Fogliano, V., Leonard, C., Gibson, G. R., & Tuohy, K. M. (2008) · British Journal of Nutrition · doi:10.1017/s0007114507793923 · Cited by 444
Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L.
Bennett, R. N., Mellon, F. A., Foidl, N., Pratt, J. H., DuPont, M. S., Perkins, L., & Kroon, P. A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0211480 · Cited by 445
A Review of the Effects and Mechanisms of Polyphenolics in Cancer
Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591000541 · Cited by 446
Nutrition, physical activity, and cardiovascular disease: An update
IGNARRO, L., Balestrieri, M. L., & Claudio Napoli, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.030 · Cited by 454
DEGRADATION OF GINSENOSIDES IN HUMANS AFTER ORAL ADMINISTRATION
Tawab, M. A., Bahr, U., Karas, M., Wurglics, M., & Schubert‐Zsilavecz, M. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.8.1065 · Cited by 440
Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms
Singh, M., Arseneault, M., Sanderson, J. T., Murthy, V., & Ramassamy, C. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0735073 · Cited by 450
The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans
Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435
Dietary Intake and Major Food Sources of Polyphenols in Finnish Adults3
Ovaskainen, M., Törrönen, R., Koponen, J. M., Sinkko, H., Hellström, J., Reinivuo, H., & Mattila, P. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.562 · Cited by 437
Major Mango Polyphenols and Their Potential Significance to Human Health
Masibo, M., & Qian, H. (2008) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2008.00047.x · Cited by 425
Lifestyle risk factors for oral cancer
Petti, S. (2008) · Oral Oncology · doi:10.1016/j.oraloncology.2008.05.018 · Cited by 438
Microbial metabolism of dietary phenolic compounds in the colon
Aura, A. (2008) · Phytochemistry Reviews · doi:10.1007/s11101-008-9095-3 · Cited by 417
Bioavailability of Phenolic Compounds
Karakaya, S. (2004) · Critical reviews in food science and nutrition · doi:10.1080/10408690490886683 · Cited by 384
Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
Su, H., Hung, L., & Chen, J.-K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2005 · Cited by 410
Polyphenols, oral health and disease: A review
Petti, S., & Scully, C. M. (2009) · Journal of Dentistry · doi:10.1016/j.jdent.2009.02.003 · Cited by 411
Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter
Myhrstad, M. C. W., Carlsen, H., Nordström, O., Blomhoff, R., & Moskaug, J. Ø. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00812-7 · Cited by 408
DNA topoisomerase II, genotoxicity, and cancer
McClendon, A. K., & Osheroff, N. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.06.009 · Cited by 407
The Biological Relevance of Direct Antioxidant Effects of Polyphenols for Cardiovascular Health in Humans Is Not Established1–4
Hollman, P. C. H., Cassidy, A., Comte, B., Heinonen, M., Richelle, M., Richling, E., Serafini, M., Scalbert, A., Sies, H., & Vidry, S. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.131490 · Cited by 406
Self-citation
Flavonoids: Prospective Drug Candidates
Cazarolli, L. H., Zanatta, L. C. B., Alberton, E., Figueiredo, M. S. R. B., Folador, P., Damazio, R. G., Pizzolatti, M. G., & Silva, F. R. B. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708786369564 · Cited by 405
Phenolic compounds: their journey after intake
Rodríguez, G. R. V., Palafox-Carlos, H., Wall‐Medrano, A., Ayala-Zavala, J. F., Chen, C.-Y. O., Robles‐Sánchez, M., Astiazarán‐García, H., Alvarez-Parrilla, E., & González-Aguilar, G. A. (2013) · Food & Function · doi:10.1039/c3fo60361j · Cited by 421
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396
“, glucuronides, O-mehtylethers, and/or sulphates) through the respective action of UDP-glucuronosyltransferase (UGT), catechol-Omethyltransferase (COMT), and sulphotransferases would be the circulating forms in the human body [36, 37].”
Background
Possible effects of dietary polyphenols on sugar absorption and digestion
Williamson, G. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200511 · Cited by 389
Self-citation
RETRACTED: Updated Knowledge about Polyphenols: Functions, Bioavailability, Metabolism, and Health
Landete, J. M. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.513779 · Cited by 405
“More than 4000 chemically-unique flavonoids have been identified in plants, particularly fruits, vegetables, nuts, seeds, and flowers, as well as in several beverages, delivering a complex mixture of polyphenols and phenolic acids to our gastrointestinal tract (Scalbert and Williamson, 2000).”
Background
Retracted
Anthocyanins—More Than Nature′s Colours
Konczak, I., & Zhang, W. Y. (2004) · BioMed Research International · doi:10.1155/s1110724304407013 · Cited by 400
Functionality of Food Components and Emerging Technologies
Galanakis, C. M. (2021) · Foods · doi:10.3390/foods10010128 · Cited by 415
Absorption of Phenolic Acids in Humans after Coffee Consumption
Nardini, M., Cirillo, E., Natella, F., & Scaccini, C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0257547 · Cited by 386
Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties
Yoon, J., & Baek, S. J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.5.585 · Cited by 390
Molecular mechanism of α-tocopherol action
Azzi, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.013 · Cited by 387
Transport of Proanthocyanidin Dimer, Trimer, and Polymer Across Monolayers of Human Intestinal Epithelial Caco-2 Cells
Déprez, S., Mila, I., Huneau, J., Tomé, D., & Scalbert, A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203503 · Cited by 379
Self-citation
Evidence for health benefits of plant phenols: local or systemic effects?
Hollman, P. C. H. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.900 · Cited by 377
Berry Fruits for Cancer Prevention: Current Status and Future Prospects
Seeram, N. P. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072504n · Cited by 376
Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management
Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J. (2017) · Nutrients · doi:10.3390/nu9121310 · Cited by 376
“Phenolics are generally thought to be poorly absorbed with plasma concentrations rarely exceeding 1 μM following ingestion of a single phenolic compound [59].”
Background
Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora
Keppler, K., & Humpf, H. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.05.003 · Cited by 376
Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function
Murphy, K. J., Chronopoulos, A., Singh, I., Francis, M., Moriarty, H., Pike, M. J., Turner, A., Mann, N. J., & Sinclair, A. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.6.1466 · Cited by 375
Food processing strategies to enhance phenolic compounds bioaccessibility and bioavailability in plant-based foods
Ribas, A. I., Martín‐Belloso, O., Soliva‐Fortuny, R., & Elez‐Martínez, P. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1331200 · Cited by 374
“Actually, phenolic compounds are the largest group of dietary antioxidants in humans (Scalbert and Williamson, 2000).”
Background
Quantitative Kinetic Analysis of Hydrogen Transfer Reactions from Dietary Polyphenols to the DPPH Radical
Goupy, P. M., Dufour, C., Loonis, M., & Dangles, O. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025938l · Cited by 372
Bioavailability of anthocyanins and derivatives
Fernandes, I., Faria, A., Calhau, C., de Freitas, V. A. P., & Mateus, N. F. D. C. B. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.05.010 · Cited by 373
Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo?
Fardet, A., Rock, E., & Rémésy, C. (2008) · Journal of Cereal Science · doi:10.1016/j.jcs.2008.01.002 · Cited by 366
Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects
Castilla, P., Echarri, R., Dávalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gómez‐Coronado, D., Ortuño, J. Á., & Lasunción, M. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.252 · Cited by 373
Cardioprotective Effects of Dietary Polyphenols
Zern, T. L., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2291 · Cited by 367
Antioxidant activity and antimicrobial effect of berry phenolics – a Finnish perspective
Heinonen, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700006 · Cited by 367
Antioxidant Activity of Phenolic Compounds: FromIn VitroResults toIn VivoEvidence
Fernández‐Pachón, M., Villaño, D., Troncoso, A. M., & García-Parrilla, M. C. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701761845 · Cited by 374
Grape Seed-Derived Procyanidins Have an Antihyperglycemic Effect in Streptozotocin-Induced Diabetic Rats and Insulinomimetic Activity in Insulin-Sensitive Cell Lines
Pinent, M., Blay, M., Bladé, C., Salvadó, M. J., Arola, L., & Ardèvol, A. (2004) · Endocrinology · doi:10.1210/en.2004-0764 · Cited by 363
Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31–June 1, 2005, Washington, DC1, , ,
Erdman, J. W., Balentine, D. A., Arab, L., Beecher, G. R., Dwyer, J. T., Folts, J. D., Harnly, J. M., Hollman, P. C. H., Keen, C. L., Mazza, G., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.718s · Cited by 363
Self-citation
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
“…et al. 2010; Perron and Brumaghim 2009; Perron et al. 2008; Petti and Scully 2009; Pietta 2000; Rice-Evans and Packer 2003; Scalbert et al. 2005; Scalbert and Williamson 2000; Seifried et al. 2007; Slemmer et al. 2008; Spencer et al. 2008; Yadav and Bhatnagar 2007a, b, 2010), including…”
Background
Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease
Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., Humala, N., Teplow, D. B., & Pasinetti, G. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-08.2008 · Cited by 360
Mediterranean diet and nonalcoholic fatty liver disease
Anania, C., Perla, F. M., Olivero, F., Pacifico, L., & Chiesa, C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i19.2083 · Cited by 353
Cocoa and chocolate flavonoids: Implications for cardiovascular health
Steinberg, F. M., Bearden, M. M., & Keen, C. L. (2003) · Journal of the American Dietetic Association · doi:10.1053/jada.2003.50028 · Cited by 349
Health functionality of apigenin: A review
Ali, F. R., Rahul, R., Naz, F., Jyoti, S., & Siddique, Y. H. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1207188 · Cited by 344
“A generalized model of apigenin absorption and distribution in humans and other mammalian models.([82]) 1202 F.”
Background
Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines
Araújo, J. R., Gonçalves, P., & Martel, F. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.01.006 · Cited by 340
“The most important dietary sources of polyphenols are fruits, vegetables, seeds, and beverages such as fruit juice, green tea, coffee, cocoa drinks, red wine, and beer [13].”
Background
Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
Imran, M., Rauf, A., Shah, Z. A., Saeed, F., Imran, A., Arshad, M. U., Ahmad, B., Bawazeer, S., Atif, M., Peters, D. G., et al. (2018) · Phytotherapy Research · doi:10.1002/ptr.6227 · Cited by 341
Systematic Analysis of the Content of 502 Polyphenols in 452 Foods and Beverages: An Application of the Phenol-Explorer Database
Pérez‐Jiménez, J., Neveu, V., Vos, F., & Scalbert, A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100128b · Cited by 340
Self-citation
Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges
Elmowafy, M., Shalaby, K., Elkomy, M. H., Alsaidan, O. A., Gomaa, H. A. M., Abdelgawad, M. A., & Mostafa, E. M. (2023) · Polymers · doi:10.3390/polym15051123 · Cited by 373
“For example, nearly 10% of orally administered polyphenols, or their metabolites, are detected in urine and plasma [110].”
Background
Risks and safety of polyphenol consumption
Mennen, L. I., Walker, R., Bennetau-Pelissero, C., & Scalbert, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.326s · Cited by 340
Self-citation
Comparison of the Antioxidant Activity of Commonly Consumed Polyphenolic Beverages (Coffee, Cocoa, and Tea) Prepared per Cup Serving
Richelle, M., Tavazzi, I., & Offord, E. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0101410 · Cited by 337
Ins and outs of dietary phytochemicals in cancer chemoprevention
Russo, G. L. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.02.014 · Cited by 338
Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases
Zordoky, B. N. M., Robertson, I. M., & Dyck, J. R. B. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.016 · Cited by 348
“Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenolic compound belonging to the stilbenes group [3].”
Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
Rios, L. Y., Gonthier, M., Rémésy, C., Mila, I., Lapierre, C., Lazarus, S. A., Williamson, G., & Scalbert, A. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.912 · Cited by 331
Self-citation
In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment
Fantini, M. C., Benvenuto, M., Masuelli, L., Frajese, G. V., Tresoldi, I., Modesti, A., & Bei, R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16059236 · Cited by 330
“Polyphenols occur in various chemical structures that influence their intestinal absorption and the kinds of metabolites circulating in plasma [102].”
BackgroundInfluential
Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption
Sugiyama, H., Akazome, Y., Shoji, T., Yamaguchi, A., Yasue, M., Kanda, T., & Ohtake, Y. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070569k · Cited by 329
Phenol‐Based Antioxidants and the In Vitro Methods Used for Their Assessment
Craft, B. D., Kerrihard, A. L., Amarowicz, R., & Pegg, R. B. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2011.00173.x · Cited by 329
“The human digestive tract can degrade or alter the chemical form of antioxidant compounds as they pass through the stomach, preventing them from being absorbed in the lower intestines, and, therefore, rendering them ineffective at preventing oxidation in the body (Scalbert and Williamson 2000).”
Background
Dietary polyphenol impact on gut health and microbiota
Wan, M. L. Y., Co, V. A., & El-Nezami, H. S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1744512 · Cited by 340
Green tea (Camellia sinensis) for the prevention of cancer
Filippini, T., Malavolti, M., Borrelli, F., Izzo, A. A., Fairweather‐Tait, S. J., Horneber, M., & Vinceti, M. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005004.pub3 · Cited by 338
Flavor formation based on lipid in meat and meat products: A review
Ying-hua, F., Cao, S., Li, Y., & Li, Z. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14439 · Cited by 324
Effect of thermal and high pressure processing on antioxidant activity and instrumental colour of tomato and carrot purées
Patras, A., Brunton, N. P., Pieve, S. D., Butler, F., & Downey, G. (2008) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2008.09.008 · Cited by 323
Cherry Antioxidants: From Farm to Table
Ferretti, G., Bacchetti, T., Belleggia, A., & Neri, D. (2010) · Molecules · doi:10.3390/molecules15106993 · Cited by 326
“It has been demonstrated that bioavailability varies widely among polyphenols and, for some of compounds, among dietary sources, depending on the forms they contain [30,31].”
Background
Cocoa procyanidins are stable during gastric transit in humans,,
Rios, L. Y., Bennett, R. N., Lazarus, S. A., Rémésy, C., Scalbert, A., & Williamson, G. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1106 · Cited by 327
Self-citation
Neuroprotective Effects of Citrus Flavonoids
Hwang, S.-L., Shih, P., & Yen, G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204452y · Cited by 326
Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease
Orr, M., Gonzales, M., Garbarino, V., Kautz, T., Palavicini, J., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J., Zare, H., Xu, P., et al. (2023) · doi:10.21203/rs.3.rs-2809973/v1 · Cited by 319
Phenolic Compounds: Functional Properties, Impact of Processing and Bioavailability
Minatel, I. O., Borges, C. V., Ferreira, M. I., Gómez, H. A. G., Chen, C.-Y. O., & Lima, G. P. P. (2017) · InTech eBooks · doi:10.5772/66368 · Cited by 318
“The total intake of polyphenols, in the studies grouped for this review, ranged from 6.4 to 1000 mg/day [ 112 ].”
BackgroundInfluential
Antimicrobial Activity of Tunisian Quince (Cydonia oblonga Miller) Pulp and Peel Polyphenolic Extracts
Fattouch, S., Caboni, P., Coroneo, V., Tuberoso, C. I. G., Angioni, A., Dessì, S., Marzouki, M. N., & Cabras, P. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062614e · Cited by 317
Flavonol and Flavone Intakes in US Health Professionals
SAMPSON, L., Rimm, E. B., Hollman, P. C. H., de Vries, J. H. M., & Katan, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90314-7 · Cited by 315
Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b
Wang, D., Xia, M., Xiao, Y., Li, D., Wang, L., Xu, Y., Jin, T., & Ling, W. (2012) · Circulation Research · doi:10.1161/circresaha.112.266502 · Cited by 319
Processing Strawberries to Different Products Alters Contents of Vitamin C, Total Phenolics, Total Anthocyanins, and Antioxidant Capacity
Klopotek, Y., Otto, K., & Böhm, V. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf047947v · Cited by 314
Daily Polyphenol Intake in France from Fruit and Vegetables
Brat, P., Georgé, S., Bellamy, A., Chaffaut, L. D., Scalbert, A., Mennen, L. I., Arnault, N., & Amiot, M. J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.9.2368 · Cited by 317
Self-citation
Stability and biological activity of wild blueberry (Vaccinium angustifolium) polyphenols during simulated in vitro gastrointestinal digestion
Correa-Betanzo, J., Allen‐Vercoe, E., McDonald, J. A. K., Schroeter, K., Corredig, M., & Paliyath, G. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.05.135 · Cited by 311
“Thus, phenolic compounds that enter the colon consist largely of unabsorbed glycosides, and conjugates that have been cycled through ileal and hepatic metabolism (Scalbert & Williamson, 2000).”
Background
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial
Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02543-w · Cited by 334
“Q is found in many fruits and vegetables 34,35 .”
Phenolic Compounds and Plant Phenolic Extracts as Natural Antioxidants in Prevention of Lipid Oxidation in Seafood: A Detailed Review
Maqsood, S., Benjakul, S., Abushelaibi, A. A., & Alam, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12106 · Cited by 310
Modulation of endogenous antioxidant system by wine polyphenols in human disease
Rodrigo, R., Miranda, A. L., & Vergara, L. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.11.034 · Cited by 318
Quercetin Derivatives Are Deconjugated and Converted to Hydroxyphenylacetic Acids but Not Methylated by Human Fecal Flora in Vitro
Aura, A., O’Leary, K. A., Williamson, G., Ojala, M., Bailey, M., Puupponen‐Pimiä, R., Nuutila, A. M., Oksman‐Caldentey, K., & Poutanen, K. S. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0108056 · Cited by 306
Self-citation
Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease
Choi, D., Lee, Y., Hong, J. T., & Lee, H. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.014 · Cited by 311
“Chemical, physical and biological properties of the compounds are significantly affected by glycosylation [114].”
Background
Effect of Grape Pomace Concentrate and Vitamin E on Digestibility of Polyphenols and Antioxidant Activity in Chickens
Brenes, A., Viveros, A., Goñi, I., Centeno, C., Sáyago-Ayerdy, S. G., Arija, I., & Saura-Calixto, F. D. (2008) · Poultry Science · doi:10.3382/ps.2007-00297 · Cited by 304
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-07.2007 · Cited by 303
Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds
Cerdá, B., Periago, P., Espín, J. C., & Tomás-Barberán, F. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050384i · Cited by 301
Designing a broad-spectrum integrative approach for cancer prevention and treatment
Block, K. I., Gyllenhaal, C., Lowe, L. J., Amedei, A., Amin, A. R. M. R., Amin, A., Aquilano, K., Arbiser, J. L., Arreola, A., Arzumanyan, A. L., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.09.007 · Cited by 308
Antioxidant-rich natural fruit and vegetable products and human health
Jideani, A. I. O., Silungwe, H., Takalani, T., OMOLOLA, A. O., Udeh, H. O., & Anyasi, T. A. (2021) · International Journal of Food Properties · doi:10.1080/10942912.2020.1866597 · Cited by 321
The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats
Tsang, C., Auger, C., Mullen, W., Bornet, A., Rouanet, J., Crozier, A., & Teissèdre, P. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051480 · Cited by 298
Natural Antioxidants: Fascinating or Mythical Biomolecules?
Ndhlala, A. R., Moyo, M., & Staden, J. V. (2010) · Molecules · doi:10.3390/molecules15106905 · Cited by 297
“The most abundant phenolic compounds in foods are caffeic and ferulic acids (in Figures 1 and 2) [29].”
BackgroundMethodInfluential
Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
Ishisaka, A., Ichikawa, S., Sakakibara, H., Piskula, M. K., Nakamura, T., Kato, Y., Ito, M., Miyamoto, K.-I., Tsuji, A., Kawai, Y., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.017 · Cited by 293
Dietary fiber and phenolic compounds as functional ingredients: interaction and possible effect after ingestion
Quirós-Sauceda, A. E., Palafox-Carlos, H., Sáyago‐Ayerdi, S. G., Ayala-Zavala, J. F., Bello‐Pérez, L. A., Álvarez-Parrilla, E., la Rosa, L. A. D., González-Córdova, A. F., & González-Aguilar, G. A. (2014) · Food & Function · doi:10.1039/c4fo00073k · Cited by 293
Changes of flavonoids, vitamin C and antioxidant capacity in minimally processed citrus segments and juices during storage
CARO, A. D., Piga, A., Vacca, V., & Agabbio, M. (2003) · Food Chemistry · doi:10.1016/s0308-8146(03)00180-8 · Cited by 289
Plant polyphenols: are they the new magic bullet?
Duthie, G. G., Gardner, P. T., & Kyle, J. A. M. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003275 · Cited by 289
Effect of primary processing of cereals and legumes on its nutritional quality: A comprehensive review
Oghbaei, M., & Prakash, J. (2016) · Cogent Food & Agriculture · doi:10.1080/23311932.2015.1136015 · Cited by 297
“The consumption of cereal products contributes to the phenolic acid intake only when whole grains are used for their manufacture (Scalbert & Williamson, 2000).”
Background
Cancer Chemopreventive Potential of Apples, Apple Juice, and Apple Components
Gerhäuser, C. (2008) · Planta Medica · doi:10.1055/s-0028-1088300 · Cited by 286
Antioxidant in Mango (Mangifera indica L.) Pulp
Ribeiro, S. M. R., Queiroz, J. H., de Queiroz, M. E. L. R., Campos, F. M., & Sant’Ana, H. M. P. (2007) · Plant Foods for Human Nutrition · doi:10.1007/s11130-006-0035-3 · Cited by 288
Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties
Speisky, H., Shahidi, F., de Camargo, A. C., & Fuentes, J. (2022) · Antioxidants · doi:10.3390/antiox11010133 · Cited by 322
Bioavailability and metabolism
Stahl, W. (2002) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00016-x · Cited by 292
Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds
Sharifi‐Rad, J., Rodrigues, C. F., Sharopov, F. S., Docea, A. O., Karaça, A. C., Sharifi‐Rad, M., Kahveci, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 303
“In the colon, polyphenols are initially digested into smaller phenolic structures by the gut microflora [17,18].”
Background
Mechanistic insights and perspectives involved in neuroprotective action of quercetin
Grewal, A. K., Singh, T. G., Sharma, D., Sharma, V., Singh, M., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111729 · Cited by 295

Authors: Scalbert, A., & Williamson, G.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Norwich Research Park (GB)
ORCID: Scalbert, Augustin
Williamson, Gary
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2000-08
Volume: 130
Issue: 8
Pages: 2073S-2085S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/130.8.2073s
OpenAlex: W2105234557
Cited by: 3,658
References: 135
Citations by year: 2026: 68 · 2025: 83 · 2024: 116 · 2023: 109 · 2022: 121 · 2021: 179 · 2020: 156 · 2019: 172 · 2018: 172 · 2017: 171 · 2016: 168 · 2015: 180 · 2014: 208 · 2013: 225 · 2012: 230
FWCI: 8.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8221 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: dietary polyphenols, polyphenol bioavailability, dietary intake, phenolic acids, flavonoids, flavan-3-ols, catechins, proanthocyanidins, anthocyanins, flavonoid glycosides, polyphenol metabolism, colonic microbiota, beverages, fruits and vegetables
MeSH terms: Animals, Biological Availability, Diet, Flavonoids, Food Analysis, Humans, Intestinal Absorption, Phenols, Polymers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary Intake and Bioavailability of Polyphenols

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks