The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Suppression of Humoral Immunity in Mice following Exposure to Perfluorooctane Sulfonate
Abstract
Adult male and female B6C3F1 mice were exposed to perfluorooctane sulfonate (PFOS) daily via gavage for 28 days (0, 0.005, 0.05, 0.1, 0.5, 1, or 5 mg/kg total administered dose [TAD]). Following exposure, various immune parameters were assessed and serum PFOS concentrations were determined. Lymphocyte proliferation was not altered in either gender. Natural killer cell activity was increased compared with control at 0.5, 1, and 5 mg/kg TAD in male mice but was not altered in female mice. At these treatment levels, splenic T-cell immunophenotypes were minimally altered in females, but all T-cell subpopulations were significantly modulated in males beginning at 0.1 mg/kg TAD. The sheep red blood cell (SRBC) plaque-forming cell (PFC) response was suppressed in male mice beginning at 0.05 mg/kg TAD and in females at 0.5 mg/kg TAD. Serum trinitrophenyl (TNP)-specific IgM titers were also decreased by PFOS after TNP-LPS (TNP conjugated to lipopolysacharide) challenge suggesting that the humoral immune effects may be attributed to the B-cell rather than T-cell because both T-dependent (SRBC) and T-independent (TI) (TNP-LPS) antigens result in suppressed IgM production. Based on the PFC response, the low observed effect level (LOEL) for males was 0.05 mg/kg TAD (ED(50) = 0.021 mg/kg TAD) and for females was 0.5 mg/kg TAD (ED(50) = 0.59 mg/kg TAD). Measured PFOS serum concentrations at these dose levels were 91.5 +/- 22.2 ng/g and 666 +/- 108 ng/g (mean +/- SD), respectively. The male LOEL serum level was approximately 14-fold lower than reported mean blood levels from occupationally exposed humans and fell in the upper range of concentrations reported for the general population. Overall, this study provides a profile of PFOS immunotoxicity showing effects at levels reported in humans and identifies the B-cells as a potential target.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · cited 1×
“In studies with Cynomolgus monkeys exposed to PFOS, females did not exhibit a decrease in circulating plasma estradiol levels, yet males did without a corresponding increase in testosterone levels (Seacat et al. , 2002).”
Background
Cited by
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989
Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
Grandjean, P., Andersen, E. W., Budtz-Jørgensen, E., Nielsen, F., Mølbak, K., Weihe, P., & Heilmann, C. (2012) · JAMA · doi:10.1001/jama.2011.2034 · Cited by 809
Immunotoxicity of Perfluorinated Compounds: Recent Developments
DeWitt, J. C., Peden-Adams, M. M., Keller, J. M., & Germolec, D. R. (2012) · Toxicologic Pathology · doi:10.1177/0192623311428473 · Cited by 457
Self-citationToxicology of perfluorinated compounds
Stahl, T., Mattern, D., & Brunn, H. (2011) · Environmental Sciences Europe · doi:10.1186/2190-4715-23-38 · Cited by 432
Granum, B., Haug, L. S., Namork, E., Stølevik, S. B., Thomsen, C., Aaberge, I. S., van Loveren, H., Løvik, M., & Nygaard, U. C. (2013) · Journal of Immunotoxicology · doi:10.3109/1547691x.2012.755580 · Cited by 339
Consideration of pathways for immunotoxicity of per-and polyfluoroalkyl substances (PFAS)
Ehrlich, V., Bil, W., Vandebriel, R., Granum, B., Luijten, M., Lindeman, B., Grandjean, P., Kaiser, A.-M., Hauzenberger, I., Hartmann, C., et al. (2023) · Environmental Health · doi:10.1186/s12940-022-00958-5 · Cited by 318
PFAS health effects database: protocol for a systematic evidence map
Pelch, K. E., Reade, A., Wolffe, T. A. M., & Kwiatkowski, C. F. (2019) · Environment International · doi:10.1016/j.envint.2019.05.045 · Cited by 300
Per- and polyfluorinated substances (PFASs): Environmental challenges
Krafft, M. P., & Riess, J. G. (2015) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2015.07.004 · Cited by 294
Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M. T., Tanguay, R. L., & Dong, Q. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.02.003 · Cited by 283
DeWitt, J. C., Blossom, S. J., & Schaider, L. A. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0097-y · Cited by 241
Analysis of perfluoroalkyl substances in waters from Germany and Spain
Llorca, M., Farré, M., Picó, Y., Müller, J., Knepper, T. P., & Barceló, D. (2012) · Science of The Total Environment · doi:10.1016/j.scitotenv.2012.05.011 · Cited by 170
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166
Guillette, T. C., McCord, J., Guillette, M., Polera, M. E., Rachels, K. T., Morgeson, C., Kotlarz, N., Knappe, D. R. U., Reading, B. J., Strynar, M., et al. (2020) · Environment International · doi:10.1016/j.envint.2019.105358 · Cited by 164
Long, M., Ghisari, M., & Bonefeld-Jørgensen, E. C. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1628-7 · Cited by 144
Binding of PFOS to Serum Albumin and DNA: Insight into the Molecular Toxicity of Perfluorochemicals
Zhang, X., Chen, L., Fei, X.-C., Ma, Y.-S., & Gao, H.-W. (2009) · BMC Molecular Biology · doi:10.1186/1471-2199-10-16 · Cited by 119
Biodegradation of Fluorinated Alkyl Substances
Frömel, T., & Knepper, T. P. (2010) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4419-6880-7_3 · Cited by 119
Peden-Adams, M. M., Stuckey, J. E., Gaworecki, K. M., Berger-Ritchie, J., Bryant, K., Jodice, P. G., Scott, T. R., Ferrario, J. B., Guan, B., Vigo, C., et al. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.10.009 · Cited by 84
Self-citationChen, J., Das, S. R., La Du, J., Corvi, M. M., Bai, C., Chen, Y., Liu, X., Zhu, G., Tanguay, R. L., Dong, Q., et al. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2031 · Cited by 70
Karoyo, A., & Wilson, L. (2015) · Nanomaterials · doi:10.3390/nano5020981 · Cited by 68
Bil, W., Ehrlich, V., Chen, G., Vandebriel, R., Zeilmaker, M., Luijten, M., Uhl, M., Marx-Stoelting, P., Halldorsson, T. I., & Bokkers, B. (2023) · Environment International · doi:10.1016/j.envint.2022.107727 · Cited by 51
Subchronic Effects of Perfluorooctanesulfonate Exposure on Inflammation in Adult Male C57BL/6 Mice
Dong, G., Zhang, Y., Zheng, L., Liang, Z., Jin, Y., & He, Q. (2012) · Environmental Toxicology · doi:10.1002/tox.20642 · Cited by 49
Lilienthal, H., Dieter, H. H., Hölzer, J., & Wilhelm, M. (2017) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2017.03.001 · Cited by 39
Houck, K. (2022) · ALTEX · doi:10.14573/altex.2203041 · Cited by 20
“For instance, PPARa and PPARg are known molecular targets for PFAS, and among numerous bioactivities associated with these receptors in the literature are effects on the immune system, primarily categorized as anti-inflammatory and suggested as a mechanism for PFAS immunosuppression (Christofides et al., 2021; Peden-A…”
Metadata
- Authors
- Peden-Adams, M. M., Keller, J. M., EuDaly, J. G., Berger, J., Gilkeson, G. S., & Keil, D. E.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-20
- Volume
- 104
- Issue
- 1
- Pages
- 144-154
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2134883557
- Cited by
- 277
- References
- 6
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
