Cited by 308

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Apolipoprotein E: from atherosclerosis to Alzheimerʼs disease and beyond

Mahley, Robert W., Huang, Yadong·1999·Current Opinion in Lipidology

DOI 10.1097/00041433-199906000-00003

Open this paper in CoChat — free account

Abstract

Apolipoprotein E is a key regulator of plasma lipid levels. Our appreciation of its role continues to expand as additional aspects of its function are discovered. Apolipoprotein E affects the levels of all lipoproteins, either directly or indirectly by modulating their receptor-mediated clearance or lipolytic processing and the production of hepatic very low density lipoproteins. Furthermore, it plays a critical role in neurobiology. The apolipoprotein E4 allele is the major susceptibility gene related to the occurrence and early age of onset of Alzheimer's disease. It is probable that one of the major functions of apolipoprotein E in the central nervous system is to mediate neuronal repair, remodeling, and protection, with apolipoprotein E4 being less effective than the E3 and E2 alleles. The isoform-specific effects of apolipoprotein E are currently being unraveled through detailed structure and function studies of this protein.

Integrity signals

Registry

Crossref · 10.1097/00041433-199906000-00003

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Self-citation
Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E
Wilson, C., Wardell, M. R., Weisgraber, K. H., Mahley, R. W., & Agard, D. A. (1991) · Science · doi:10.1126/science.2063194 · Cited by 678
Self-citation
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Isoform-specific binding of apolipoprotein E to beta-amyloid.
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540
Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins
Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433
Self-citation
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404
Self-citation

Show all 16 references

Research works printed but not linked: 76

Mahley, 1988, Science, 240, 622, 10.1126/science.3283935 · DOI · Paper page
Mahley, 1999, J Lipid Res, 40, 1, 10.1016/S0022-2275(20)33334-4 · DOI · Paper page
Weisgraber, 1996, FASEB J, 10, 1485, 10.1096/fasebj.10.13.8940294 · DOI
Shore, 1973, Biochemistry, 12, 502, 10.1021/bi00727a022 · DOI · Paper page
Mahley, 1983, Arch Pathol Lab Med, 107, 393
Bersot, 1976, J Biol Chem, 251, 2395, 10.1016/S0021-9258(17)33600-1 · DOI · Paper page
Utermann, 1975, FEBS Lett, 56, 352, 10.1016/0014-5793(75)81125-2 · DOI · Paper page
Mahley, 1995, Curr Opin Lipidol, 6, 86, 10.1097/00041433-199504000-00005 · DOI
Roses, 1996, Annu Rev Med, 47, 387, 10.1146/annurev.med.47.1.387 · DOI · Paper page
Utermann, 1977, Nature, 269, 604, 10.1038/269604a0 · DOI · Paper page
Havel, 1973, Proc Natl Acad Sci U S A, 70, 2015, 10.1073/pnas.70.7.2015 · DOI · Paper page
Schneider, 1981, J Clin Invest, 68, 1075, 10.1172/JCI110330 · DOI · Paper page
Weisgraber, 1982, J Biol Chem, 257, 2518, 10.1016/S0021-9258(18)34954-8 · DOI · Paper page
Brown, 1981, Science, 212, 628, 10.1126/science.6261329 · DOI · Paper page
Sherrill, 1980, J Biol Chem, 255, 1804, 10.1016/S0021-9258(19)85951-3 · DOI
Windler, 1980, J Biol Chem, 255, 5475, 10.1016/S0021-9258(19)70811-4 · DOI
Herz, 1988, EMBO J, 7, 4119, 10.1002/j.1460-2075.1988.tb03306.x · DOI
Herz, 1994, Ann NY Acad Sci, 737, 14, 10.1111/j.1749-6632.1994.tb44298.x · DOI
Brown, 1991, Curr Opin Lipidol, 2, 65, 10.1097/00041433-199104000-00002 · DOI
Herz, 1995, Curr Opin Lipidol, 6, 97, 10.1097/00041433-199504000-00007 · DOI · Paper page
Kowal, 1989, Proc Natl Acad Sci U S A, 86, 5810, 10.1073/pnas.86.15.5810 · DOI
Ji, 1993, J Biol Chem, 268, 10160, 10.1016/S0021-9258(18)82186-X · DOI · Paper page
Ji, 1995, J Lipid Res, 36, 583, 10.1016/S0022-2275(20)39892-8 · DOI
Mahley, 1979, Biochim Biophys Acta, 575, 81, 10.1016/0005-2760(79)90133-4 · DOI
Ji, 1994, J Biol Chem, 269, 2764, 10.1016/S0021-9258(17)42009-6 · DOI
Beisiegel, 1991, Proc Natl Acad Sci U S A, 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
Chappell, 1993, J Biol Chem, 268, 14168, 10.1016/S0021-9258(19)85223-7 · DOI
Ji, 1994, J Biol Chem, 269, 13429, 10.1016/S0021-9258(17)36850-3 · DOI
Ji, 1997, J Biol Chem, 272, 31285, 10.1074/jbc.272.50.31285 · DOI · Paper page
Willnow, 1994, Science, 264, 1471, 10.1126/science.7515194 · DOI
Hussain, 1991, J Biol Chem, 266, 13936, 10.1016/S0021-9258(18)92792-4 · DOI
Wetterau, 1988, J Biol Chem, 263, 6240, 10.1016/S0021-9258(18)68778-2 · DOI · Paper page
Dong, 1994, J Biol Chem, 269, 22358, 10.1016/S0021-9258(17)31797-0 · DOI · Paper page
Dong, 1996, J Biol Chem, 271, 19053, 10.1074/jbc.271.32.19053 · DOI · Paper page
Inneraity, 1984, J Biol Chem, 259, 7261, 10.1016/S0021-9258(17)39866-6 · DOI · Paper page
Bradley, 1984, J Biol Chem, 259, 14728, 10.1016/S0021-9258(17)42663-9 · DOI
Weisgraber, 1986, J Biol Chem, 261, 2068, 10.1016/S0021-9258(17)35898-2 · DOI · Paper page
Wilson, 1994, Structure, 2, 713, 10.1016/S0969-2126(00)00072-1 · DOI · Paper page
Lalazar, 1988, J Biol Chem, 263, 3542, 10.1016/S0021-9258(18)68957-4 · DOI · Paper page
Salah, 1997, J Lipid Res, 38, 904, 10.1016/S0022-2275(20)37215-1 · DOI
Cohn, 1996, Arterioscler Thromb Vasc Biol, 16, 149, 10.1161/01.ATV.16.1.149 · DOI
1998, J Biol Chem, 273, 26388, 10.1074/jbc.273.41.26388 · DOI · Paper page
Chait, 1978, Metabolism, 27, 1055, 10.1016/0026-0495(78)90151-8 · DOI
Ehnholm, 1984, Proc Natl Acad Sci U S A, 81, 5566, 10.1073/pnas.81.17.5566 · DOI
1998, J Biol Chem, 273, 17483, 10.1074/jbc.273.28.17483 · DOI
Rensen, 1996, J Biol Chem, 271, 14791, 10.1074/jbc.271.25.14791 · DOI · Paper page
Jong, 1997, Biochem J, 328, 745, 10.1042/bj3280745 · DOI · Paper page
Huang, 1997, Arterioscler Thromb Vasc Biol, 17, 2817, 10.1161/01.ATV.17.11.2817 · DOI
Huang, 1996, J Biol Chem, 271, 29146, 10.1074/jbc.271.46.29146 · DOI
Woollett, 1995, Proc Natl Acad Sci U S A, 92, 12500, 10.1073/pnas.92.26.12500 · DOI
Fan, 1998, J Clin Invest, 101, 2151, 10.1172/JCI1599 · DOI
Kuipers, 1997, J Clin Invest, 100, 2915, 10.1172/JCI119841 · DOI
Weisgraber, 1994, Curr Opin Struct Biol, 4, 507, 10.1016/S0959-440X(94)90212-7 · DOI
Elshourbagy, 1985, Proc Natl Acad Sci U S A, 82, 203, 10.1073/pnas.82.1.203 · DOI · Paper page
Pitas, 1987, J Biol Chem, 262, 14352, 10.1016/S0021-9258(18)47945-8 · DOI · Paper page
Ignatius, 1986, Proc Natl Acad Sci U S A, 83, 1125, 10.1073/pnas.83.4.1125 · DOI
Boyles, 1989, J Clin Invest, 83, 1015, 10.1172/JCI113943 · DOI · Paper page
Nathan, 1994, Science, 264, 850, 10.1126/science.8171342 · DOI · Paper page
Nathan, 1995, J Biol Chem, 270, 19791, 10.1074/jbc.270.34.19791 · DOI · Paper page
Bellosta, 1995, J Biol Chem, 270, 27063, 10.1074/jbc.270.45.27063 · DOI · Paper page
Rebeck, 1993, Neuron, 11, 575, 10.1016/0896-6273(93)90070-8 · DOI · Paper page
Corder, 1993, Science, 261, 921, 10.1126/science.8346443 · DOI · Paper page
Lippa, 1997, Neurology, 48, 515, 10.1212/WNL.48.2.515 · DOI
Slooter, 1997, J Am Med Assoc, 277, 818, 10.1001/jama.1997.03540340052032 · DOI
Nicoll, 1996, Ann NY Acad Sci, 777, 271, 10.1111/j.1749-6632.1996.tb34431.x · DOI
Holtzman, 1995, Proc Natl Acad Sci U S A, 92, 9480, 10.1073/pnas.92.21.9480 · DOI · Paper page
Strittmatter, 1994, Proc Natl Acad Sci U S A, 91, 11183, 10.1073/pnas.91.23.11183 · DOI · Paper page
Han, 1994, J Neuropathol Exp Neurol, 53, 535, 10.1097/00005072-199409000-00013 · DOI · Paper page
Namba, 1991, Brain Res, 541, 163, 10.1016/0006-8993(91)91092-F · DOI · Paper page
Strittmatter, 1993, Proc Natl Acad Sci U S A, 90, 8098, 10.1073/pnas.90.17.8098 · DOI · Paper page
Wisniewski, 1994, Am J Pathol, 145, 1030
Kounnas, 1995, Cell, 82, 331, 10.1016/0092-8674(95)90320-8 · DOI · Paper page
LaDu, 1997, J Neurosci Res, 49, 9, 10.1002/(SICI)1097-4547(19970701)49:1<9::AID-JNR2>3.0.CO;2-H · DOI
Masliah, 1995, Exp Neurol, 136, 107, 10.1006/exnr.1995.1088 · DOI
Sheng, 1998, J Cereb Blood Flow Metab, 18, 361, 10.1097/00004647-199804000-00003 · DOI
Poirier, 1993, Lancet, 342, 697, 10.1016/0140-6736(93)91705-Q · DOI · Paper page

Sorted by citations

Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Self-citation
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235
Untitled work
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284
A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912
Self-citation
Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer’s diseases
Huang, Y., & Mahley, R. W. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.025 · Cited by 829
Self-citation
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580
Self-citation
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes
Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447
Self-citation
Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice
Brecht, W. J., Harris, F. M., Chang, S., Tesseur, I., Yu, G.-Q., Xu, Q., Dee Fish, J., Wyss-Coray, T., Buttini, M., Mucke, L., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4315-03.2004 · Cited by 403
Self-citation
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
Harris, F. M., Brecht, W. J., Xu, Q., Tesseur, I., Kekonius, L., Wyss-Coray, T., Fish, J. D., Masliah, E., Hopkins, P. C., Scearce-Levie, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434398100 · Cited by 342
Self-citation
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
Chang, S., Ma, T. R., Miranda, R. D., Balestra, M. E., Mahley, R. W., & Huang, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508254102 · Cited by 319
Self-citation
Characterization of four lipoprotein classes in human cerebrospinal fluid
Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., & Mahley, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508693102 · Cited by 275
Self-citation
Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease
Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242
Self-citation
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation
Buttini, M., Yu, G.-Q., Shockley, K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, F. M., & Mucke, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10539.2002 · Cited by 183
“ApoE is a 34 kDa lipid carrier protein that participates in the maintenance and repair of neurons (Mahley and Huang, 1999).”
Background
Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
Huang, Y. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.004 · Cited by 170
Self-citation
Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase
Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408127200 · Cited by 151
Self-citation
Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins
Mendivil, C. O., Zheng, C., Furtado, J., Lel, J., & Sacks, F. M. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.197830 · Cited by 145
Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
Nakamura, T., Watanabe, A., Fujino, T., Hosono, T., & Michikawa, M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-35 · Cited by 124
Plasma kinetics of apoC-III and apoE in normolipidemic and hypertriglyceridemic subjects.
Batal, R., Tremblay, M., Barrett, P. H. R., Jacques, H., Fredenrich, A., Mamer, O., Davignon, J., & Cohn, J. S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32379-8 · Cited by 113
New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E
Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113
Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner
Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
An apolipoprotein E variant may protect against age‐related macular degeneration through cytokine regulation
Bojanowski, C. M., Shen, D., Chew, E. Y., Ning, B., Csaky, K. G., Green, W. R., Chan, C., & Tuo, J. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20233 · Cited by 62
Contributions of the Carboxyl-Terminal Helical Segment to the Self-Association and Lipoprotein Preferences of Human Apolipoprotein E3 and E4 Isoforms
Sakamoto, T., Tanaka, M., Vedhachalam, C., Nickel, M., Nguyen, D., Dhanasekaran, P., Phillips, M. C., Lund-Katz, S., & Saito, H. (2008) · Biochemistry · doi:10.1021/bi701923h · Cited by 54
Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE
Lund-Katz, S., Wehrli, S., Zaiou, M., Newhouse, Y., Weisgraber, K. H., & Phillips, M. C. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31612-6 · Cited by 40
Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia
Renee Ruhaak, L., van der Laarse, A., & Cobbaert, C. M. (2019) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563219827620 · Cited by 38
The presence of apoE4, not the absence of apoE3, contributes to AD pathology
Teter, B., Raber, J., Nathan, B., & Crutcher, K. A. (2002) · Journal of Alzheimer's Disease · doi:10.3233/jad-2002-4305 · Cited by 37

Authors: Mahley, R. W., & Huang, Y.
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-06
Volume: 10
Issue: 3
Pages: 207-218
ISSN: 0957-9672
DOI: 10.1097/00041433-199906000-00003
Cited by: 308
References: 16
Language: en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Apolipoprotein E: from atherosclerosis to Alzheimerʼs disease and beyond

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks