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PreprintCited by 27Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Perineuronal nets affect memory and learning after synapse withdrawal

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Ruzicka, Jiri, Dalecka, Marketa, Safrankova, Kristyna, Peretti, Diego, Mallucci, Giovanna, Jendelova, Pavla, Kwok, Jessica CF, Fawcett, James W·2021·Translational Psychiatry
DOI 10.1101/2021.04.13.439599PMC PMC9666654
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Abstract

Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs which contain synapses can act as a memory store, which remains stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring positional memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of naïve animals and not worsened by PNN attenuation. After HLS, animals lacking PNNs showed faster relearning. Absence of PNNs affected the restoration of inhibitory and excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage.

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  • In the perirhinal cortex and hippocampus, ChABC digestion increases inhibitory inputs to PV interneurons.

    “In the perirhinal cortex and hippocampus, ChABC digestion increases inhibitory inputs to PV interneurons [43–45]”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [44]

  • Digestion of hippocampal PNNs with ChABC promotes re-learning of a once-trained Morris water maze task.

    “In contrast, digestion of hippocampal PNNs with ChABC promotes re-learning of a once-trained Morris water maze task (Ruzicka et al., 2021, unpublished results).”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as Ruzicka et al., 2021, unpublished results

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Metadata

Authors
Ruzicka, J., Dalecka, M., Safrankova, K., Peretti, D., Mallucci, G., Jendelova, P., Kwok, J. C., & Fawcett, J. W.
Affiliations
  • Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
  • University of Cambridge (GB)
  • University of Leeds (GB)
ORCID
Venue
Translational Psychiatry
Publisher
openRxiv
Published
2021-04-14
Volume
12
Issue
1
Pages
480-480
ISSN
2158-3188 (ISSN-L)
DOI
10.1101/2021.04.13.439599
PMC
PMC9666654
OpenAlex
W4309438518
Cited by
27
References
1
Citations by year
2026: 5 · 2025: 8 · 2024: 10 · 2023: 2 · 2022: 2
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Psychiatry (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo
  • Apollo (cc-by)
Funders
  • Epilepsy Research UK
  • Ministerstvo Školství, Mládeže a Tělovýchovy (LM2018129, Large RI Project LM2018129 Czech-BioImaging, LM2018129Czech-BioImaging, CZ.02., CZ.02.1.01/0.0./0.0/15_003/0000419, CZ.02.1.01/0.0/0.0/18_046/0016045, CZ.02.1.01/0.0/0.0/15_003, CZ.02.1.01, CZ.02.1.01/0.0, NEURORECON CZ.02.1.01/0.0/0.0/15_003/0000419)
  • Medical Research Council (WFL-UK-008-15, CZ.02.1.01/0.0/0.0/15_003/0000419, MR/R004463/1, 19-10365S, MR/V002694, MR/V002694/1)
  • European Regional Development Fund (02.1.01/0.0/0.0, CZ.02, CZ.02.1.01, CZ.02.1.01/0.0, LM2018129, CZ.02.1.01/0.0/0.0/18_046/0016045, CZ.02.1.01/0.0/0.0, /0.0/15_003/0000419)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
perineuronal nets, hippocampus, place memory, memory extinction, anoxia, chondroitinase ABC, aggrecan, excitatory synapses, memory storage, learning
MeSH terms
Animals, Extracellular Matrix, Learning, Neurons, Synapses, Extracellular Matrix Proteins

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