TCF/LEFs and Wnt Signaling in the Nucleus

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Vitamin D

Norman, A. W. (1979) · Cited by 3,769

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,169

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905

The complex language of chromatin regulation during transcription

Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,581

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,202

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139

The genome of the blood fluke Schistosoma mansoni

Berriman, M., Haas, B. J., LoVerde, P. T., Wilson, R. A., Dillon, G. P., Cerqueira, G. C., Mashiyama, S. T., Al-Lazikani, B., Andrade, L. F., Ashton, P. D., et al. (2009) · Nature · doi:10.1038/nature08160 · Cited by 1,058

The Amphimedon queenslandica genome and the evolution of animal complexity

Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049

Diversity and Complexity in DNA Recognition by Transcription Factors

Badis, G., Berger, M. F., Philippakis, A. A., Talukder, S., Gehrke, A. R., Jaeger, S. A., Chan, E. T., Metzler, G., Vedenko, A., Chen, X., et al. (2009) · Science · doi:10.1126/science.1162327 · Cited by 990

The many ways of Wnt in cancer

Polakis, P. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.007 · Cited by 866

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G., & Kemler, R. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00597-7 · Cited by 856

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Lyssenko, V., Lupi, R., Marchetti, P., Del Guerra, S., Orho-Melander, M., Almgren, P., Sjögren, M., Ling, C., Eriksson, K.-F., Lethagen, Υ.-L., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30706 · Cited by 829

Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling

Pálmer, H. G., González-Sancho, J. M., Espada, J., Berciano, M. T., Puig, I., Baulida, J., Quintanilla, M., Cano, A., de Herreros, A. G., Lafarga, M., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102028 · Cited by 802

Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

Essers, M. A. G., de Vries-Smits, L. M. M., Barker, N., Polderman, P. E., Burgering, B. M. T., & Korswagen, H. C. (2005) · Science · doi:10.1126/science.1109083 · Cited by 745

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature · doi:10.1038/26982 · Cited by 730

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destrée, O., & Clevers, H. (1998) · Nature · doi:10.1038/26989 · Cited by 674

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660

CREBBP mutations in relapsed acute lymphoblastic leukaemia

Mullighan, C. G., Zhang, J., Kasper, L. H., Lerach, S., Payne-Turner, D., Phillips, L. A., Heatley, S. L., Holmfeldt, L., Collins-Underwood, J. R., Ma, J., et al. (2011) · Nature · doi:10.1038/nature09727 · Cited by 637

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

Travis, A., Amsterdam, A., Belanger, C., & Grosschedl, R. (1991) · Genes & Development · doi:10.1101/gad.5.5.880 · Cited by 614

Wnt signaling: is the party in the nucleus?

Willert, K., & Jones, K. A. (2006) · Genes & Development · doi:10.1101/gad.1424006 · Cited by 589

β-Catenin hits chromatin: regulation of Wnt target gene activation

Mosimann, C., Hausmann, G., & Basler, K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2654 · Cited by 575

Structural basis for DNA bending by the architectural transcription factor LEF-1

Love, J. J., Li, X., Case, D. A., Giese, K., Grosschedl, R., & Wright, P. E. (1995) · Nature · doi:10.1038/376791a0 · Cited by 573

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Kramps, T., Peter, O., Brunner, E., Nellen, D., Froesch, B., Chatterjee, S., Murone, M., Züllig, S., & Basler, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00679-7 · Cited by 561

β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

Daniels, D. L., & Weis, W. I. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb912 · Cited by 551

Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting β-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription

Almeida, M., Han, L., Martin-Millan, M., O'Brien, C. A., & Manolagas, S. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702811200 · Cited by 548

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

Giese, K., Kingsley, C., Kirshner, J. R., & Grosschedl, R. (1995) · Genes & Development · doi:10.1101/gad.9.8.995 · Cited by 541

The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling

Ishitani, T., Kishida, S., Hyodo-Miura, J., Ueno, N., Yasuda, J., Waterman, M., Shibuya, H., Moon, R. T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.131-139.2003 · Cited by 541

Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development

Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., Ohgi, K. A., Lin, C., Gleiberman, A., Wang, J., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01084-x · Cited by 539

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

van de Wetering, M., Oosterwegel, M., Dooijes, D., & Clevers, H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07928.x · Cited by 538

Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia

Kaidi, A., Williams, A. C., & Paraskeva, C. (2007) · Nature Cell Biology · doi:10.1038/ncb1534 · Cited by 517

Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm

Thorpe, C. J., Schlesinger, A., Carter, J. C., & Bowerman, B. (1997) · Cell · doi:10.1016/s0092-8674(00)80530-9 · Cited by 514

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells

Cole, M. F., Johnstone, S. E., Newman, J. J., Kagey, M. H., & Young, R. A. (2008) · Genes & Development · doi:10.1101/gad.1642408 · Cited by 514

Signals and Combinatorial Functions of Histone Modifications

Suganuma, T., & Workman, J. L. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061809-175347 · Cited by 499

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

Steger, D. J., Lefterova, M. I., Ying, L., Stonestrom, A. J., Schupp, M., Zhuo, D., Vakoc, A. L., Kim, J.-E., Chen, J., Lazar, M. A., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02076-07 · Cited by 497

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493

Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice

Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

Hovanes, K., Li, T. W. H., Munguia, J. E., Truong, T., Milovanovic, T., Lawrence Marsh, J., Holcombe, R. F., & Waterman, M. L. (2001) · Nature Genetics · doi:10.1038/ng0501-53 · Cited by 458

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T., & Clevers, H. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456

O2 regulates stem cells through Wnt/β-catenin signalling

Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 454

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

Reya, T., O'Riordan, M., Okamura, R., Devaney, E., Willert, K., Nusse, R., & Grosschedl, R. (2000) · Immunity · doi:10.1016/s1074-7613(00)00004-2 · Cited by 450

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

Chen, G., Fernandez, J., Mische, S., & Courey, A. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2218 · Cited by 446

Diversity of LEF/TCF action in development and disease

Arce, L., Yokoyama, N. N., & Waterman, M. L. (2006) · Oncogene · doi:10.1038/sj.onc.1210056 · Cited by 438

Crystal Structure of a β-Catenin/Tcf Complex

Graham, T. A., Weaver, C., Mao, F., Kimelman, D., & Xu, W. (2000) · Cell · doi:10.1016/s0092-8674(00)00192-6 · Cited by 405

Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

Kim, C.-H., Oda, T., Itoh, M., Jiang, D., Artinger, K. B., Chandrasekharappa, S. C., Driever, W., & Chitnis, A. B. (2000) · Nature · doi:10.1038/35038097 · Cited by 396

The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes

Sierra, J., Yoshida, T., Joazeiro, C. A., & Jones, K. A. (2006) · Genes & Development · doi:10.1101/gad.1385806 · Cited by 385

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

Cauchi, S., El Achhab, Y., Choquet, H., Dina, C., Krempler, F., Weitgasser, R., Nejjari, C., Patsch, W., Chikri, M., Meyre, D., et al. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0203-4 · Cited by 379

Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?

Mulholland, D. J., Dedhar, S., Coetzee, G. A., & Nelson, C. C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0034 · Cited by 377

Beta-catenin mutations in human prostate cancer.

Voeller, H. J., Truica, C., & Gelmann, E. P. (1998) · PubMed · Cited by 371

Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin

Hsu, S.-C., Galceran, J., & Grosschedl, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4807 · Cited by 363

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.7.1410 · Cited by 361

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

Waterman, M. L., Fischer, W. H., & Jones, K. A. (1991) · Genes & Development · doi:10.1101/gad.5.4.656 · Cited by 359

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

Haegebarth, A., & Clevers, H. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080758 · Cited by 353

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.

Truica, C. I., Byers, S. W., & Gelmann, E. P. (2000) · PubMed · Cited by 350

Linking β-Catenin to Androgen-signaling Pathway

Yang, F., Li, X., Sharma, M., Sasaki, C. Y., Longo, D. L., Lim, B., & Sun, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111962200 · Cited by 342

Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

Korinek, V., Barker, N., Willert, K., Molenaar, M., Roose, J., Wagenaar, G., Markman, M., Lamers, W., Destree, O., & Clevers, H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1248 · Cited by 325

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Mohan, M., Herz, H.-M., Takahashi, Y.-H., Lin, C., Lai, K. C., Zhang, Y., Washburn, M. P., Florens, L., & Shilatifard, A. (2010) · Genes & Development · doi:10.1101/gad.1898410 · Cited by 313

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Bass, A. J., Lawrence, M. S., Brace, L. E., Ramos, A. H., Drier, Y., Cibulskis, K., Sougnez, C., Voet, D., Saksena, G., Sivachenko, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.936 · Cited by 309

The Emerging Genetic Architecture of Type 2 Diabetes

Doria, A., Patti, M.-E., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.006 · Cited by 305

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

Yi, F., Pereira, L., Hoffman, J. A., Shy, B. R., Yuen, C. M., Liu, D. R., & Merrill, B. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2283 · Cited by 303

Wnt Signaling from Development to Disease: Insights from Model Systems

Cadigan, K. M., & Peifer, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002881 · Cited by 302

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

Goentoro, L., & Kirschner, M. W. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.017 · Cited by 300

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.

Orsulic, S., & Peifer, M. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.5.1283 · Cited by 294

POP-1 and Anterior–Posterior Fate Decisions in C. elegans Embryos

Lin, R., Hill, R. J., & Priess, J. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80917-4 · Cited by 282

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1 −/− mice

Kratochwil, K., Galceran, J., Tontsch, S., Roth, W., & Grosschedl, R. (2002) · Genes & Development · doi:10.1101/gad.1035602 · Cited by 270

Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination

Olson, L. E., Tollkuhn, J., Scafoglio, C., Krones, A., Zhang, J., Ohgi, K. A., Wu, W., Taketo, M. M., Kemler, R., Grosschedl, R., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.046 · Cited by 270

Interactions between SOX factors and Wnt/β‐catenin signaling in development and disease

Kormish, J. D., Sinner, D., & Zorn, A. M. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22046 · Cited by 266

DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1.

Giese, K., Amsterdam, A., & Grosschedl, R. (1991) · Genes & Development · doi:10.1101/gad.5.12b.2567 · Cited by 265

Upregulation of c- MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells

Wright, J. B., Brown, S. J., & Cole, M. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01384-09 · Cited by 258

Maintaining embryonic stem cell pluripotency with Wnt signaling

Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257

The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators

Teo, J.-L., & Kahn, M. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.09.012 · Cited by 248

XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development

Brannon, M., Brown, J. D., Bates, R., Kimelman, D., & Moon, R. T. (1999) · Development · doi:10.1242/dev.126.14.3159 · Cited by 247

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis

Oosterwegel, M., van de Wetering, M., Timmerman, J., Kruisbeek, A., Destree, O., Meijlink, F., & Clevers, H. (1993) · Development · doi:10.1242/dev.118.2.439 · Cited by 247

Androgen receptors in prostate cancer.

Culig, Z., Klocker, H., Bartsch, G., & Hobisch, A. (2002) · Endocrine-related cancer · doi:10.1677/erc.0.0090155 · Cited by 247

Tcf3: a transcriptional regulator of axis induction in the early embryo

Merrill, B. J., Pasolli, H. A., Polak, L., Rendl, M., García-García, M. J., Anderson, K. V., & Fuchs, E. (2004) · Development · doi:10.1242/dev.00935 · Cited by 242

The Molecular Basis of Vitamin D Receptor and β-Catenin Crossregulation

Shah, S., Islam, M. N., Dakshanamurthy, S., Rizvi, I., Rao, M., Herrell, R., Zinser, G., Valrance, M., Aranda, A., Moras, D., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.037 · Cited by 238

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

Hatzis, P., van der Flier, L. G., van Driel, M. A., Guryev, V., Nielsen, F., Denissov, S., Nijman, I. J., Koster, J., Santo, E. E., Welboren, W., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02175-07 · Cited by 228

Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

van de Wetering, M., & Clevers, H. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05374.x · Cited by 217

β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator

Billin, A. N., Thirlwell, H., & Ayer, D. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6882-6890.2000 · Cited by 216

The kinase TNIK is an essential activator of Wnt target genes

Mahmoudi, T., Li, V. S. W., Ng, S. S., Taouatas, N., Vries, R. G. J., Mohammed, S., Heck, A. J., & Clevers, H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.285 · Cited by 209

Structure of a human Tcf4-beta-catenin complex.

Poy, F., Lepourcelet, M., Shivdasani, R. A., & Eck, M. J. (2001) · Nature Structural Biology · doi:10.1038/nsb720 · Cited by 205

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

Nguyen, H., Merrill, B. J., Polak, L., Nikolova, M., Rendl, M., Shaver, T. M., Pasolli, H. A., & Fuchs, E. (2009) · Nature Genetics · doi:10.1038/ng.431 · Cited by 201

Extensive Alternative Splicing and Dual Promoter Usage Generate Tcf-1 Protein Isoforms with Differential Transcription Control Properties

De Wetering, M. V., Castrop, J., Korinek, V., & Clevers, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.745 · Cited by 191

Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

Li, Z., Nie, F., Wang, S., & Li, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009353108 · Cited by 184

A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Tang, W., Dodge, M., Gundapaneni, D., Michnoff, C., Roth, M., & Lum, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804709105 · Cited by 178

Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex

Fiedler, M., Sánchez-Barrena, M. J., Nekrasov, M., Mieszczanek, J., Rybin, V., Müller, J., Evans, P., & Bienz, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.011 · Cited by 174

The Androgen Receptor Can Promote β-Catenin Nuclear Translocation Independently of Adenomatous Polyposis Coli

Mulholland, D. J., Cheng, H., Reid, K., Rennie, P. S., & Nelson, C. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200135200 · Cited by 172

The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.

Duval, A., Rolland, S., Tubacher, E., Bui, H., Thomas, G. D., & Hamelin, R. (2000) · PubMed · Cited by 171

β-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription

Song, L.-N., Herrell, R., Byers, S., Shah, S., Wilson, E. M., & Gelmann, E. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1674-1687.2003 · Cited by 169

Detection and analysis of ?-catenin mutations in prostate cancer

Chesire, D. R., Ewing, C. M., Sauvageot, J., Bova, G. S., & Isaacs, W. B. (2000) · The Prostate · doi:10.1002/1097-0045(20001201)45:4<323::aid-pros7>3.0.co;2-w · Cited by 168

Liganded Androgen Receptor Interaction with β-Catenin

Pawlowski, J. E., Ertel, J. R., Allen, M. P., Xu, M., Butler, C., Wilson, E. M., & Wierman, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200545200 · Cited by 166

β-Catenin Primes Organizer Gene Expression by Recruiting a Histone H3 Arginine 8 Methyltransferase, Prmt2

Blythe, S. A., Cha, S.-W., Tadjuidje, E., Heasman, J., & Klein, P. S. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.007 · Cited by 165

Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W., & Sokol, S. Y. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.005 · Cited by 164

C‐terminal‐binding protein directly activates and represses Wnt transcriptional targets in Drosophila

Fang, M., Li, J., Blauwkamp, T., Bhambhani, C., Campbell, N., & Cadigan, K. M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601153 · Cited by 164

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

Bottomly, D., Kyler, S. L., McWeeney, S. K., & Yochum, G. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq363 · Cited by 163

The APC Tumor Suppressor Binds to C-Terminal Binding Protein to Divert Nuclear β-Catenin from TCF

Hamada, F., & Bienz, M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.022 · Cited by 159

Crosstalk between the Androgen Receptor and β-Catenin in Castrate-Resistant Prostate Cancer

Wang, G., Wang, J., & Sadar, M. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1718 · Cited by 155

Ligand-dependent inhibition of β-catenin/TCF signaling by androgen receptor

Chesire, D. R., & Isaacs, W. B. (2002) · Oncogene · doi:10.1038/sj.onc.1206049 · Cited by 151

How do they do Wnt they do?: regulation of transcription by the Wnt/β‐catenin pathway

Archbold, H. C., Yang, Y., Chen, L., & Cadigan, K. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02293.x · Cited by 149

A β-Catenin Identified by Functional Rather Than Sequence Criteria and Its Role in Wnt/MAPK Signaling

Kidd, A. R., Miskowski, J. A., Siegfried, K. R., Sawa, H., & Kimble, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.03.029 · Cited by 149

Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

Niu, Y., Chang, T.-M., Yeh, S., Ma, W., Wang, Y. Z., & Chang, C. (2010) · Oncogene · doi:10.1038/onc.2010.121 · Cited by 148

The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

Pálmer, H. G., Anjos‐Afonso, F., Carmeliet, G., Takeda, H., & Watt, F. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001483 · Cited by 146

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

Weise, A., Bruser, K., Elfert, S., Wallmen, B., Wittel, Y., Wöhrle, S., & Hecht, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1197 · Cited by 144

Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

Carrera, I., Janody, F., Leeds, N. B., Duveau, F., & Treisman, J. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709749105 · Cited by 139

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolismPreprint

Savic, D., Ye, H., Aneas, I., Park, S. Y., Bell, G. I., & Nóbrega, M. A. (2011) · Genome Research · doi:10.1101/gr.123745.111 · Cited by 139

Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans

Lo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R. (2004) · Cell · doi:10.1016/s0092-8674(04)00203-x · Cited by 138

Wnt3a Growth Factor Induces Androgen Receptor-Mediated Transcription and Enhances Cell Growth in Human Prostate Cancer Cells

Verras, M., Brown, J. D., Li, X., Nusse, R., & Sun, Z. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2370 · Cited by 137

A Unique DNA Binding Domain Converts T-Cell Factors into Strong Wnt Effectors

Atcha, F. A., Syed, A., Wu, B., Hoverter, N. P., Yokoyama, N. N., Ting, J.-H. T., Munguia, J. E., Mangalam, H. J., Marsh, J., & Waterman, M. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02132-06 · Cited by 132

Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth

Shitashige, M., Satow, R., Jigami, T., Aoki, K., Honda, K., Shibata, T., Ono, M., Hirohashi, S., & Yamada, T. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0306 · Cited by 132

Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation

Bierie, B., Nozawa, M., Renou, J., Shillingford, J. M., Morgan, F., Oka, T., Taketo, M. M., Cardiff, R. D., Miyoshi, K., Wagner, K., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206426 · Cited by 132

HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells

Valenta, T., Lukas, J., & Kořínek, V. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg346 · Cited by 131

Sequence-specific HMG box factors recognize 10-12 base pair minor groove motifs

van Beest, M., Dooijes, D., van de Wetering, M. D., Kjærulff, S., Bonvin, A. M. J. J., Nielsen, O., & Clevers, H. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004102200 · Cited by 130

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

Gu, B., Sun, P., Yuan, Y., Moraes, R., Li, A., Teng, A., Agrawal, A., Rhéaume, C., Bilanchone, V., Veltmaat, J. M., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810133 · Cited by 130

The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens

Schweizer, L., Rizzo, C. A., Spires, T. E., Platero, J. S., Wu, Q., Lin, T.-A., Gottardis, M. M., & Attar, R. M. (2008) · BMC Cell Biology · doi:10.1186/1471-2121-9-4 · Cited by 129

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

Angus-Hill, M. L., Elbert, K. M., Hidalgo, J., & Capecchi, M. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102300108 · Cited by 127

Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos

Gregorieff, A., Grosschedl, R., & Clevers, H. C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600191 · Cited by 123

Quantitative Profiling of In Vivo-assembled RNA-Protein Complexes Using a Novel Integrated Proteomic Approach

Tsai, B. P., Wang, X., Huang, L., & Waterman, M. L. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.007385 · Cited by 123

A New Look at TCF and β-Catenin through the Lens of a Divergent C. elegans Wnt Pathway

Phillips, B. T., & Kimble, J. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.002 · Cited by 119

Role of WNT pathway in the determination of human mesenchymal stem cells into preadipocytes

Laudes, M. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0169 · Cited by 118

C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity

Herman, M. A. (2001) · Development · doi:10.1242/dev.128.4.581 · Cited by 118

Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data

Blahnik, K. R., Dou, L., O’Geen, H., McPhillips, T., Xu, X., Cao, A. R., Iyengar, S., Nicolet, C. M., Ludäscher, B., Korf, I. F., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1012 · Cited by 117

C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels

Shetty, P. V., Lo, M., Robertson, S. M., & Lin, R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.008 · Cited by 117

The role of vitamin D receptor mutations in the development of alopecia

Malloy, P. J., & Feldman, D. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.045 · Cited by 112

Knockdown of β-Catenin Through shRNA Cause a Reversal of EMT and Metastatic Phenotypes Induced by HIF-1α

Zhao, J., Luo, Y., Jiang, Y., He, D., & Wu, C. (2011) · Cancer Investigation · doi:10.3109/07357907.2010.512595 · Cited by 111

Activation of β‐Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration

Yu, X., Wang, Y., Jiang, M., Bierie, B., Roy‐Burman, P., Shen, M. M., Taketo, M. M., Wills, M. L., & Matusik, R. J. (2008) · The Prostate · doi:10.1002/pros.20877 · Cited by 110

TCFs and Wnt/β-catenin Signaling

Cadigan, K. M. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-386499-4.00001-x · Cited by 108

A POP‐1 repressor complex restricts inappropriate cell type‐specific gene transcription during Caenorhabditis elegans embryogenesis

Calvo, D., Victor, M., Gay, F., Sui, G., Luke, M. P.-S., Dufourcq, P., Wen, G., Maduro, M., Rothman, J. H., & Shi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7197 · Cited by 107

Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer

Li, T. W. H., Ting, J.-H. T., Yokoyama, N. N., Bernstein, A., van de Wetering, M., & Waterman, M. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00105-06 · Cited by 107

Repression of organizer genes in dorsal and ventralXenopuscells mediated by maternal XTcf3

Houston, D. W., Kofron, M. J., Resnik, E., Langland, R., Destrée, O., Wylie, C. C., & Heasman, J. (2002) · Development · doi:10.1242/dev.129.17.4015 · Cited by 107

A Coactivator Role of CARM1 in the Dysregulation of β-Catenin Activity in Colorectal Cancer Cell Growth and Gene Expression

Ou, C. Y., LaBonte, M. J., Manegold, P. C., So, A. Y., Ianculescu, I., Gerke, D. S., Yamamoto, K. R., Ladner, R. D., Kahn, M., Kim, J. H., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0223 · Cited by 106

Dynamics of a Developmental Switch: Recursive Intracellular and Intranuclear Redistribution of Caenorhabditis elegans POP-1 Parallels Wnt-Inhibited Transcriptional Repression

Maduro, M., Lin, R., & Rothman, J. H. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0721 · Cited by 106

Distinct roles forXenopusTcf/Lef genes in mediating specific responses to Wnt/β-catenin signalling in mesoderm development

Liu, F., van den Broek, O., Destrée, O., & Hoppler, S. (2005) · Development · doi:10.1242/dev.02152 · Cited by 105

Molecular Integration of Inductive and Mesoderm-Intrinsic Inputs Governs even-skipped Enhancer Activity in a Subset of Pericardial and Dorsal Muscle Progenitors

Knirr, S., & Frasch, M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0397 · Cited by 105

Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2

Hikasa, H., & Sokol, S. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.185280 · Cited by 105

Tissue-specific alternative splicing of TCF7L2

Prokunina‐Olsson, L., Welch, C., Hansson, O., Adhikari, N., Scott, L. J., Usher, N., Tong, M., Sprau, A. G., Swift, A. J., Bonnycastle, L. L., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp321 · Cited by 105

The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing

Hovanes, K., Li, T. W. H., & Waterman, M. L. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1994 · Cited by 101

Sequence-specific High Mobility Group Box Factors Recognize 10–12-Base Pair Minor Groove Motifs

van Beest, M., Dooijes, D., van de Wetering, M., Kjærulff, S., Bonvin, A. M. J. J., Nielsen, O., & Clevers, H. C. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61506-1 · Cited by 101

A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers

Yochum, G. S., Sherrick, C. M., MacPartlin, M., & Goodman, R. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912294107 · Cited by 98

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Norton, L., Fourcaudot, M. J., Abdul-Ghani, M. A., Winnier, D. A., Mehta, F. F., Jenkinson, C. P., & DeFronzo, R. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2289-z · Cited by 94

β-Catenin Interacts with MyoD and Regulates Its Transcription Activity

Kim, C., Neiswender, H., Baik, E. J., Xiong, W., & Mei, L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01682-07 · Cited by 93

Dissecting nuclear Wingless signalling: Recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins

Städeli, R., & Basler, K. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.07.004 · Cited by 91

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

Arce, L., Pate, K. T., & Waterman, M. L. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-159 · Cited by 91

Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion

Chen, J., Luo, Q., Yuan, Y., Huang, X., Cai, W., Li, C., Wei, T.-Z., Zhang, L., Yang, M., Liu, Q., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00465-10 · Cited by 91

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

Mahmoudi, T., Boj, S. F., Hatzis, P., Li, V. S. W., Taouatas, N., Vries, R. G. J., Teunissen, H., Begthel, H., Korving, J., Mohammed, S., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000539 · Cited by 90

Wnt Signaling and CEH-22/tinman/Nkx2.5 Specify a Stem Cell Niche in C. elegans

Lam, N., Chesney, M. A., & Kimble, J. E. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.015 · Cited by 89

Wingless Signaling Induces Widespread Chromatin Remodeling of Target Loci

Parker, D. S., Ni, Y., Chang, J. L., Li, J., & Cadigan, K. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01230-07 · Cited by 79

Cross-regulation of signaling pathways: An example of nuclear hormone receptors and the canonical Wnt pathway

Beildeck, M. E., Gelmann, E. P., & Stephen, W. B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.001 · Cited by 77

Recruitment of β-Catenin by Wild-Type or Mutant Androgen Receptors Correlates with Ligand-Stimulated Growth of Prostate Cancer Cells

Masiello, D., Chen, S., Xu, Y., Verhoeven, M. C., Choi, E., Hollenberg, A. N., & Balk, S. P. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0436 · Cited by 76

Activation of β-Catenin Signaling in Prostate Cancer by Peptidyl-Prolyl Isomerase Pin1-Mediated Abrogation of the Androgen Receptor-β-Catenin Interaction

Chen, S., Wulf, G. M., Zhou, X. Z., Rubin, M. A., Lu, K. P., & Balk, S. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.929-939.2006 · Cited by 74

T-Cell Factor 4N (TCF-4N), a Novel Isoform of Mouse TCF-4, Synergizes with β-Catenin To Coactivate C/EBPα and Steroidogenic Factor 1 Transcription Factors

Kennell, J. A., O’Leary, E. E., Gummow, B. M., Hammer, G. D., & MacDougald, O. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5366-5375.2003 · Cited by 73

The oligomeric state of CtBP determines its role as a transcriptional co‐activator and co‐repressor of Wingless targets

Bhambhani, C., Chang, J. L., Akey, D. L., & Cadigan, K. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.100 · Cited by 72

Cleavage of β-Catenin by Calpain in Prostate and Mammary Tumor Cells

Rios‐Doria, J., Kuefer, R., Ethier, S. P., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1048 · Cited by 72

TCF7L2 splice variants have distinct effects on β-cell turnover and function

Bacquer, O. L., Shu, L., Marchand, M., NEVE, B. P., Paroni, F., Kerr-Conte, J., Pattou, F. N., Froguel, P., & Maedler, K. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr072 · Cited by 71

Differential Importin-α Recognition and Nuclear Transport by Nuclear Localization Signals within the High-Mobility-Group DNA Binding Domains of Lymphoid Enhancer Factor 1 and T-Cell Factor 1

Prieve, M. G., Guttridge, K. L., Munguia, J. E., & Waterman, M. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4819 · Cited by 71

Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF

Chang, M. V., Chang, J. L., Gangopadhyay, A., Shearer, A. M., & Cadigan, K. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.10.047 · Cited by 68

Pygopus and the Wnt signaling pathway: A diverse set of connections

Jessen, S., Gu, B., & Dai, X. (2008) · BioEssays · doi:10.1002/bies.20757 · Cited by 67

Functional Diversity of Xenopus Lymphoid Enhancer Factor/T-cell Factor Transcription Factors Relies on Combinations of Activating and Repressing Elements

Gradl, D., König, A. O., & Wedlich, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107055200 · Cited by 62

Identification of Two Regulatory Elements within the High Mobility Group Box Transcription Factor XTCF-4

Pukrop, T., Gradl, D., Henningfeld, K. A., Knöchel, W., Wedlich, D., & Kühl, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007533200 · Cited by 61

Differential Control of Wnt Target Genes Involves Epigenetic Mechanisms and Selective Promoter Occupancy by T-Cell Factors

Wöhrle, S., Wallmen, B., & Hecht, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00555-07 · Cited by 60

Translating the histone code into leukemia

Linggi, B. E., Brandt, S. J., Sun, Z., & Hiebert, S. W. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20604 · Cited by 60

Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops

Yochum, G. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018966 · Cited by 55

decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm

Yang, X. S., van Beest, M., Clevers, H. C., Jones, T. L., Hursh, D. A., & Mortin, M. A. (2000) · Development · doi:10.1242/dev.127.17.3695 · Cited by 55

T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications

Lluı́s, F., Ombrato, L., Pedone, E., Pepe, S., Merrill, B. J., & Cosma, M. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017402108 · Cited by 54

The C. elegans SYS-1 Protein Is a Bona Fide β-Catenin

Liu, J., Phillips, B. T., Amaya, M. F., Kimble, J. E., & Xu, W. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.015 · Cited by 54

A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer

Najdi, R., Syed, A. O., Arce, L., Theisen, H., Ting, J.-H., Atcha, F. A., Nguyen, A. V., Martinez, M. E., Holcombe, R. F., Edwards, R. A., et al. (2009) · Oncogene · doi:10.1038/onc.2009.271 · Cited by 53

Effects of WNT/β-catenin pathway activation on signaling through T-cell factor and androgen receptor in prostate cancer cell lines

Cronauer, M. V., Schulz, W. A., Ackermann, R., & Burchardt, M. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.4.1033 · Cited by 53

Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes

Standley, H. J., Destrée, O., Kofron, M. J., Wylie, C., & Heasman, J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.012 · Cited by 52

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Näthke, I. S., & Rocha, S. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0312 · Cited by 52

Interaction of β-Catenin and TIF2/GRIP1 in Transcriptional Activation by the Androgen Receptor

Song, L., & Gelmann, E. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503850200 · Cited by 52

A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer

Yokoyama, N. N., Pate, K. T., Sprowl-Tanio, S., & Waterman, M. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq492 · Cited by 51

HIC-5 Is a Novel Repressor of Lymphoid Enhancer Factor/T-cell Factor-driven Transcription

Ghogomu, S. M., van Venrooy, S., Ritthaler, M., Wedlich, D., & Gradl, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505869200 · Cited by 49

Myeloid Translocation Gene Family Members Associate with T-Cell Factors (TCFs) and Influence TCF-Dependent Transcription

Moore, A. C., Amann, J. M., Williams, C. S., Tahinci, E., Farmer, T. E., Martinez, J. A., Yang, G., Luce, K. S., Lee, E. N., & Hiebert, S. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01242-07 · Cited by 48

High-throughput assay for determining specificity and affinity of protein-DNA binding interactions

Hallikas, O. K., & Taipale, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.33 · Cited by 48

Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes

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Lyu, J., Jho, E., & Lu, W. (2011) · Cell Research · doi:10.1038/cr.2011.47 · Cited by 45

Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation

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Liu, Y. I., Chang, M. V., Li, H. E., Barolo, S., Chang, J. L., Blauwkamp, T. A., & Cadigan, K. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.011 · Cited by 44

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Tsedensodnom, O., Koga, H., Rosenberg, S. A., Nambotin, S. B., Carroll, J. J., Wands, J. R., & Kim, M. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.01.015 · Cited by 42

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An internal ribosome entry site mediates translation of lymphoid enhancer factor-1

Jiménez, J., Jang, G. Μ., Semler, B. L., & Waterman, M. L. (2005) · RNA · doi:10.1261/rna.7226105 · Cited by 38

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Yang, X., Huang, S., Lo, M., Mizumoto, K., Sawa, H., Xu, W., Robertson, S. M., & Lin, R. (2011) · Development · doi:10.1242/dev.069054 · Cited by 27

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