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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

Ronco, Lucienne V., Karpova, Alla Y., Vidal, Marc, Howley, Peter M.·1998·Genes & Development
DOI 10.1101/gad.12.13.2061
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Abstract

Interferon regulatory factor-3 (IRF-3) was found to specifically interact with HPV16 E6 in a yeast two-hybrid screen. IRF-3 is activated by the presence of double-stranded RNA or by virus infection to form a stable complex with other transcriptional regulators that bind to the regulatory elements of the IFNβ promoter. We show that IRF-3 is a potent transcriptional activator and demonstrate that HPV16 E6 can inhibit its transactivation function. The expression of HPV16 E6 in primary human keratinocytes inhibits the induction of IFNβ mRNA following Sendai virus infection. The binding of HPV16 E6 to IRF-3 does not result in its ubiquitination or degradation. We propose that the interaction of E6 with IRF-3 and the inhibition of IRF-3’s transcriptional activity may provide the virus a means to circumvent the normal antiviral response of an HPV16-infected cell.

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Cited by

Metadata

Authors
Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1998-07-01
Volume
12
Issue
13
Pages
2061-2072
ISSN
  • 0890-9369
  • 1549-5477
DOI
10.1101/gad.12.13.2061
Cited by
544
References
6
Language
en

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