REFMAC 5 for the refinement of macromolecular crystal structures

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cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

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The structure of the dynactin complex and its interaction with dynein

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

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Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

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High thermodynamic stability of parametrically designed helical bundles

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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

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Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

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Molecular mechanism of APC/C activation by mitotic phosphorylation

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Structure and insights into the function of a Ca2+-activated Cl− channel

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The structure and substrate specificity of human Cdk12/Cyclin K

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Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

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Protein sequence design with a learned potential

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Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

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Structure of a CLC chloride ion channel by cryo-electron microscopy

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Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications

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Separating the effects of nucleotide and EB binding on microtubule structure

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Assessment of three‐dimensional RNA structure prediction in CASP15

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Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

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Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring

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Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

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Structure–Function Insights into Direct Lipid Transfer between Membranes by Mmm1–Mdm12 of ERMES

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Architecture of human Rag GTPase heterodimers and their complex with mTORC1

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

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Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

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Deconstruction of the Ras switching cycle through saturation mutagenesis

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Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK

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Indications of radiation damage in ferredoxin microcrystals using high-intensity X-FEL beams

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Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

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Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

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Structural basis for kinesin-1:cargo recognition

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Crystal structures of a double-barrelled fluoride ion channel

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Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator

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Structural insights into SUN-KASH complexes across the nuclear envelope

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Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease

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Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

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Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway

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Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex

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Cyclic di‐AMP targets the cystathionine beta‐synthase domain of the osmolyte transporter OpuC

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DSSP 4: FAIR annotation of protein secondary structure

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Crystal structure of the human oxytocin receptor

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Implications of AlphaFold 2 for crystallographic phasing by molecular replacement

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Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ)

Degtjarik, O., Golovenko, D., Diskin-Posner, Y., Abrahmsén, L., Rozenberg, H., & Shakked, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-27142-6 · Cited by 78

Computational design of epitope-specific functional antibodies

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Posttranslational modification of microtubules by the MATCAP detyrosinase

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Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

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Structural basis for the assembly of the Ragulator-Rag GTPase complex

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Molecular pharmacodynamics of emixustat in protection against retinal degeneration

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CMM—An enhanced platform for interactive validation of metal binding sites

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Watching proteins function with time-resolved x-ray crystallography

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Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis

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Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

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Structural basis for amyloidogenic peptide recognition by sorLA

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Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney

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