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Cited by 274

The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.

Biological interplay between proteoglycans and their innate immune receptors in inflammation

Open access
Frey, Helena, Schroeder, Nina, Manon‐Jensen, Tina, Iozzo, Renato V., Schaefer, Liliana·2013·The FEBS Journal
DOI 10.1111/febs.12145
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Abstract

An emerging body of evidence indicates that secreted proteoglycans act as signaling molecules, in addition to their canonical function in maintaining and regulating the architecture of various extracellular matrices. Proteoglycans interact with a number of receptors that regulate growth, motility and immune response. In part, as a consequence of their complex structure, proteoglycans can induce crosstalk among various families of receptors and can also interact with natural receptor ligands, often blocking and sequestering their bioactivity. In their soluble form, originating from either partial proteolytic processing or through de novo synthesis by activated cells, some proteoglycans can become potent danger signals, denoting tissue stress and injury. Recently, it has been shown that proteoglycans, especially those belonging to the small leucine‐rich and hyaluronan‐binding gene families as well as the glycosaminoglycan hyaluronan, act as endogenous ligands of the toll‐like receptors, a group of central receptors regulating innate immunity. Furthermore, proteoglycans can activate intracellular inflammasomes and trigger sterile inflammation. In this review, we critically assess the signaling events induced by the proteoglycans biglycan, decorin, lumican and versican as well as hyaluronan during inflammation. We discuss the intriguing emerging notion that, in spite of structural diversity of biglycan, decorin, versican and hyaluronan, all of them signal through the same toll‐like receptors, albeit triggering differential responses and biological outcomes. Finally, we review the modes of action of these endogenous ligands of toll‐like receptors and their ability to specifically modify the final signaling events and the inflammatory response.

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Metadata

Authors
Frey, H., Schroeder, N., Manon‐Jensen, T., Iozzo, R. V., & Schaefer, L.
Venue
The FEBS Journal
Publisher
Wiley
Published
2013-02-21
Volume
280
Issue
10
Pages
2165-2179
ISSN
  • 1742-464X (ISSN-L)
  • 1742-4658
DOI
10.1111/febs.12145
OpenAlex
W2026550755
Cited by
274
References
150
FWCI
14.77
Type
journal article
Language
en
Open access
green

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