The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Regulation of miRNA expression during neural cell specification
Abstract
MicroRNA (miRNA) are a newly recognized class of small, noncoding RNA molecules that participate in the developmental control of gene expression. We have studied the regulation of a set of highly expressed neural miRNA during mouse brain development. Temporal control is a characteristic of miRNA regulation in C. elegans and Drosophila, and is also prominent in the embryonic brain. We observed significant differences in the onset and magnitude of induction for individual miRNAs. Comparing expression in cultures of embryonic neurons and astrocytes we found marked lineage specificity for each of the miRNA in our study. Two of the most highly expressed miRNA in adult brain were preferentially expressed in neurons (mir-124, mir-128). In contrast, mir-23, a miRNA previously implicated in neural specification, was restricted to astrocytes. mir-26 and mir-29 were more strongly expressed in astrocytes than neurons, others were more evenly distributed (mir-9, mir-125). Lineage specificity was further explored using reporter constructs for two miRNA of particular interest (mir-125 and mir-128). miRNA-mediated suppression of both reporters was observed after transfection of the reporters into neurons but not astrocytes. miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development.
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In the citing paper
“The decrease in miR-23 levels can lead to the accumulation of Hes1 during retinal acid-induced neural differentiation in NT2 cells, which in turn affects neural differentiation.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“miR-23 has the ability to affect neural differentiation.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“Hes1 is also directly targeted by miR-124, and the knockdown of miR-124 levels mediated by locked nucleic acids is similar to the effect of miR-23 inhibition.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“It indicates that the regulation of neural development by miR-23 is probably achieved through the combined action of other miRNAs.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“A basic helix-loop-helix transcriptional repressor, named Hes1, is an authentic target of miR-23.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“miR-23 is specifically expressed in astrocytes of the adult brain and is one of the miRNAs that are highly expressed in neurons during brain development.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“The expression level of Hes1 increases, ultimately hindering neuronal differentiation of P19 cells induced by the retinoic acid [[129], [130], [131]].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [129]
In the citing paper
“Notably, three miRNAs (miR-23, miR-26 and miR-29) that are found in oligodendrocyte lineage cells were previously described as enriched in astrocytes (Smirnova et al., 2005).”
From Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes (2008) · cites this paper as Smirnova et al., 2005
In the citing paper
“miR-124 is known to be expressed in the CNS by neuronal cells23,39–41.”
From MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2011) · cites this paper as [23]
In the citing paper
“Such expression in neurons of the adult brain is shared with mouse miR-124 [30].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [30]
In the citing paper
“This profile is one of the best conserved miRNA patterns, as a similar restriction to mature neurons is seen for mouse and fly miR-124 [12,30].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [30]
In the citing paper
“miR-23 is involved in neuronal specification, and miR-146a implicated in the prevention of neuroligin 1-dependent synaptogenesis, and both were enriched in astrocytes compared to neurons [54, 67].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [67]
In the citing paper
“being prominently observed in differentiating neuronal cells29,31”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [31]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., Shimizu, M., Rattan, S., Bullrich, F., Negrini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307323101 · Cited by 4,096
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
MicroRNA targets in Drosophila
Enright, A. J., John, B., Gaul, U., Tuschl, T., Sander, C., & Marks, D. S. (2003) · Genome Biology · doi:10.1186/gb-2003-5-1-r1 · Cited by 3,597
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Items 101–200 of 715
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Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158
Engineered lentiviral vector targeting astrocytes In vivo
Colin, A., Faideau, M., Dufour, N., Auregan, G., Hassig, R., Andrieu, T., Brouillet, E., Hantraye, P., Bonvento, G., & Déglon, N. (2009) · Glia · doi:10.1002/glia.20795 · Cited by 158
Chen, H. M., DeLong, C. J., Bame, M., Rajapakse, I., Herron, T. J., McInnis, M. G., & O’Shea, K. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.12 · Cited by 156
Impact of microRNAs on ischemic stroke: From pre- to post-disease
Li, G., Morris-Blanco, K. C., Lopez, M. S., Yang, T., Zhao, H., Vemuganti, R., & Luo, Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.002 · Cited by 159
The Elegance of the MicroRNAs: A Neuronal Perspective
Kosik, K. S., & Krichevsky, A. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.019 · Cited by 158
Non‐coding RNAs in the nervous system
Mehler, M. F., & Mattick, J. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113191 · Cited by 157
Nie, K., Gomez, M. F., Landgraf, P., García, J. F., Liu, Y., Tan, L. H. C., Chadburn, A., Tuschl, T., Knowles, D. M., & Tam, W. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080009 · Cited by 155
Developmental neurotoxicity – Challenges in the 21st Century and In Vitro Opportunities
Smirnova, L. (2014) · ALTEX · doi:10.14573/altex.1403271 · Cited by 166
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Buckley, N. J., Johnson, R., Zuccato, C., Bithell, A., & Cattaneo, E. F. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.02.003 · Cited by 158
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Xia, H.-F., He, T.-Z., Liu, C., Cui, Y., Song, P., Jin, X., & Ma, X. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000218181 · Cited by 152
Notaras, M., Lodhi, A., Dündar, F., Collier, P., Sayles, N. M., Tilgner, H., Greening, D., & Colak, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01316-6 · Cited by 150
MicroRNAs as biomarkers for CNS cancer and other disorders
Smaele, E. D., Ferretti, E., & Gulino, A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.103 · Cited by 154
Stage-Specific Modulation of Cortical Neuronal Development by Mmu-miR-134
Gaughwin, P. M., Cieśla, M., Yang, H. H., Lim, B., & Brundin, P. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq262 · Cited by 148
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Yunta, M., Nieto-Díaz, M., Esteban, F. J., Caballero-López, M., Navarro-Ruíz, R., Reigada, D., Pita-Thomas, D. W., Águila, Á. D., Muñoz-Galdeano, T., & Maza, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034534 · Cited by 122
Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia
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Joglekar, M. V., Parekh, V. S., Mehta, S. S., Bhonde, R. R., & Hardikar, A. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.008 · Cited by 148
Peng, J., Omran, A. G., Ashhab, M. U., Kong, H., Gan, N., He, F. P., & Yin, F. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9953-3 · Cited by 146
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Liu, S., Kumar, S., Lu, H., Liu, A., Yang, R., Pushparajan, A., Guo, W., & Xu, X. (2011) · The Journal of Pathology · doi:10.1002/path.2964 · Cited by 138
MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics
Nieto‐Díaz, M., Esteban, F. J., Reigada, D., Muñoz‐Galdeano, T., Yunta, M., Caballero-López, M. J., Navarro-Ruíz, R., del Águila, Á., & Maza, R. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00053 · Cited by 137
microRNAs: Innovative Targets for Cerebral Ischemia and Stroke
Ouyang, Y., Stary, C. M., Yang, G., & Giffard, R. G. (2012) · Current Drug Targets · doi:10.2174/138945013804806424 · Cited by 140
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
Fazi, F., & Nervi, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn151 · Cited by 139
Greco, S. J., & Rameshwar, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703037104 · Cited by 137
Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis
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Song, Y.-J., Tian, X.-B., Zhang, S., Zhang, Y.-X., Li, X., Li, D., Cheng, Y., Zhang, J.-N., Kang, C.-S., & Zhao, W. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.073 · Cited by 135
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Wang, H., Liu, J., Zong, Y., Xu, Y., Deng, W., Zhu, H., Liu, Y. M., Ma, C., Huang, L. J., Zhang, L., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.023 · Cited by 130
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Caputo, V., Sinibaldi, L., Fiorentino, A., Parisi, C., Catalanotto, C., Pasini, A., Cogoni, C., & Pizzuti, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028656 · Cited by 126
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Neo, W. H., Yap, K., Lee, S. H., Looi, L., Khandelia, P., Neo, S. X., Makeyev, E. V., & Su, I.-H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.525493 · Cited by 122
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Baudet, M., Zivraj, K. H., Abreu‐Goodger, C., Muldal, A., Armisen, J., Blenkiron, C., Goldstein, L. D., Miska, E. A., & Holt, C. E. (2011) · Nature Neuroscience · doi:10.1038/nn.2979 · Cited by 117
MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
Hollins, S. L., & Cairns, M. J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.005 · Cited by 119
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Stenvang, J., & Kauppinen, S. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.1.59 · Cited by 115
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Shaik, M. M., Tamargo, I. A., Abubakar, M. B., Kamal, M. A., Greig, N. H., & Gan, S. H. (2018) · Genes · doi:10.3390/genes9040174 · Cited by 117
Cheng, L., Quek, C. Y. J., Sun, X., Bellingham, S. A., & Hill, A. F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00150 · Cited by 113
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Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 115
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Peruzzi, P., Bronisz, A., Nowicki, M. O., Wang, Y., Ogawa, D., Price, R., Nakano, I., Kwon, C.-H., Hayes, J., Lawler, S. E., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not055 · Cited by 97
Brennan, G. P., Dey, D., Chen, Y., Patterson, K. P., Magnetta, E., Hall, A. M., Dubé, C. M., Mei, Y., & Baram, T. Z. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.042 · Cited by 116
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Beveridge, N. J., Tooney, P. A., Carroll, A. P., Tran, N., & Cairns, M. J. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.07.019 · Cited by 109
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Liang, C., Zhu, H., Xu, Y., Huang, L. J., Ma, C., Deng, W., Liu, Y. M., & Qin, C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.10.051 · Cited by 111
Petri, R., Malmevik, J., Fasching, L., Åkerblom, M., & Jakobsson, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.09.022 · Cited by 109
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Xu, S. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.003 · Cited by 110
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Emerging functions of microRNAs in glioblastoma
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Christensen, M., & Schratt, G. M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.043 · Cited by 113
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Gong, S., Li, Q., Jeter, C. R., Fan, Q., Tang, D. G., & Liu, B. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22340 · Cited by 105
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Lee, J. Y., Kim, S., Hwang, D. W., Jeong, J. M., Chung, J., Lee, M. C., & Lee, D. S. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.042507 · Cited by 103
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Zhao, H., Tao, Z., Wang, R., Liu, P., Yan, F., Li, J., Zhang, C., Ji, X., & Luo, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.055 · Cited by 102
Rash, J. E., Davidson, K. G. V., Kamasawa, N., Yasumura, T., Kamasawa, M., Zhang, C., Michaels, R., Restrepo, D., Ottersen, O. P., Olson, C. O., et al. (2005) · Journal of Neurocytology · doi:10.1007/s11068-005-8360-2 · Cited by 102
Muiños-Gimeno, M., Guidi, M., Kagerbauer, B., Martín‐Santos, R., Navinés, R., Alonso, P., Menchón, J. M., s, M. N. G., Estivill, X., & Espinosa‐Parrilla, Y. (2009) · Human Mutation · doi:10.1002/humu.21005 · Cited by 102
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Waller, R., Wyles, M., Heath, P. R., Kazoka, M., Wollff, H., Shaw, P. J., & Kirby, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00731 · Cited by 99
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Lee, H., Palkovits, M., & Young, W. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605781103 · Cited by 97
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Guidi, M., Muiños-Gimeno, M., Kagerbauer, B., Martí, E., Estivill, X., & Espinosa‐Parrilla, Y. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-95 · Cited by 95
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Metadata
- Authors
- Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- German Federal Institute for Risk Assessment (BfR) (DE)
- Corresponding author
- Wulczyn, F. Gregory
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2005-03
- Volume
- 21
- Issue
- 6
- Pages
- 1469-1477
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2116641097
- Cited by
- 707
- References
- 55
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 23 · 2022: 22 · 2021: 34 · 2020: 27 · 2019: 29 · 2018: 30 · 2017: 20 · 2016: 37 · 2015: 51 · 2014: 50 · 2013: 52 · 2012: 54
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- microRNA, brain development, miRNA expression regulation, astrocytes, embryonic neurons, miR-124, miR-128, miR-125, miR-23, miR-26, miR-29, miR-9, embryonic stem cell differentiation, temporal gene expression
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Cell Line, Neurons, Stem Cells, Gene Expression Regulation, Developmental, MicroRNAs, Mice
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