Parvalbumin‐containing neurons, perineuronal nets and experience‐dependent plasticity in murine barrel cortex
Abstract
The ability to undergo experience‐dependent plasticity in the neocortex is often limited to early development, but also to particular cortical loci and specific experience. In layers II–IV of the barrel cortex, plasticity evoked by removing all but one vibrissae (univibrissa rearing) does not have a time limit except for layer IV barrels, where it can only be induced during the first postnatal week. In contrast, deprivation of every second vibrissa (chessboard deprivation) removes time limits for plasticity. The mechanism permitting plasticity in response to chessboard deprivation and halting it in reply to univibrissa rearing is unknown. Condensation of chondroitin sulfate proteoglycans into perineuronal nets and an increase in intracortical inhibition mediated by parvalbumin‐containing interneurons are implicated in closing the critical period for ocular dominance plasticity. These factors could also be involved in setting up the critical period in barrels in a way that depends on a particular sensory experience. We therefore examined changes in density of parvalbumin‐containing cells and perineuronal nets during development of mouse barrel cortex and after brief univibrissa and chessboard experience in adolescence. We observed a progressive increase in the density of the two markers across cortical layers between postnatal day 10 and 20, which was especially pronounced in the barrels. Univibrissa rearing, but not chessboard deprivation, increased the density of perineuronal nets and parvalbumin‐containing cells in the deprived barrels, but only those that immediately neighbour the undeprived barrel. These data suggest the involvement of both tested factors in closing the critical period in barrels in an experience‐dependent manner.
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Once initiated, critical period plasticity rises, peaks, and terminates with a relatively fixed schedule, in part defined by molecular markers including PNNs.
“On the other hand, once initiated, critical period plasticity rises, peaks, and terminates with a rather fixed schedule (16), in part defined by several molecular markers including those that mark PNNs (29).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [29]
PV and PNN colocalization is correlated with critical period closure and reduced synaptic plasticity, particularly in sensory cortices.
“In fact, PV and PNN colocalization is correlated with critical period closure and reduced synaptic plasticity, particularly in sensory cortices (Nowicka et al., 2009; Beurdeley et al., 2012).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Nowicka et al., 2009
Absence of PNNs is associated with increased plasticity.
“As the absence of PNNs is associated with increased plasticity (Pizzorusso et al., 2002; Nowicka et al., 2009)”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Nowicka et al., 2009
Neuronal activity in sensory cortices during closure of a critical period is associated with both maturation of parvalbumin neurons and appearance of perineuronal nets.
“Consistent with this interpretation, neuronal activity in sensory cortices during the closure of a critical period is associated with both the maturation of PV neurons and the appearance of PNNs (Nowicka et al, 2009;Ye and Miao, 2013).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Nowicka et al, 2009
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- Authors
- Nowicka, D., Soulsby, S., Skangiel‐Kramska, J., & Glazewski, S.
- Affiliations
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Keele University (GB)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-11-30
- Volume
- 30
- Issue
- 11
- Pages
- 2053-2063
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2046833863
- Cited by
- 110
- References
- 60
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 12 · 2018: 4 · 2017: 13 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- parvalbumin interneurons, perineuronal nets, experience-dependent plasticity, critical period, barrel cortex, chessboard deprivation, chondroitin sulfate proteoglycans, intracortical inhibition, ocular dominance plasticity, postnatal development
- MeSH terms
- Afferent Pathways, Age Factors, Analysis of Variance, Animals, Animals, Newborn, Brain Mapping, Cerebral Cortex, Female, Indoles, Functional Laterality, Male, Nerve Net, Neuronal Plasticity, Neurons, Parvalbumins, Sensory Deprivation, Vibrissae, Receptors, N-Acetylglucosamine, Plant Lectins, Mice
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