Cited by 5,050Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsGut microbiota and health

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Microbial complexes in subgingival plaque

Socransky, S.S., Haffajee, A.D., Cugini, M.A., Smith, C., Kent, R. L.·1998·Journal of Clinical Periodontology

DOI 10.1111/j.1600-051x.1998.tb02419.x

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Abstract

Abstract. It has been recognized for some time that bacterial species exist in complexes in subgingival plaque. The purpose of the present investigation was to attempt to define such communities using data from large numbers of plaque samples and different clustering and ordination techniques. Subgingival plaque samples were taken from the mesial aspect of each tooth in 185 subjects (mean age 51 ± 16 years) with ( n = 160) or without ( n = 25) periodontitis. The presence and levels of 40 subgingival taxa were determined in 13.261 plaque samples using whole genomic DNA probes and checkerboard DNA‐DNA hybridization. Clinical assessments were made at 6 sites per tooth at each visit. Similarities between pairs of species were computed using phi coefficients and species clustered using an averaged unweighted linkage sort. Community ordination was performed using principal components analysis and correspondence analysis. 5 major complexes were consistently observed using any of the analytical methods. One complex consisted of the tightly related group: Bacteroides forsythus. Porphvromonas gingivalis and Treponema denticola. The 2nd complex consisted of a tightly related core group including members of the Fusobcterium nucleaturm/periodonticum subspecies, Prevotella intermedia. Prevotella nigrescens and Peptostreptucoccus micros. Species associated with this group included: Eubacterium nodatum, Campylobacter rectus, Campylobacter showae, Streptococcus constellatus and Campylobacter gracilis. The 3rd complex consisted of Streptococcus sanguis. S. oralis, S. mitis, S. gordonii and S. intermedius. The 4th complex was comprised of 3 Capnocytophaga species, Campylobacter concisus, Eikenella corrodens and Actinobacillus actinomycetemcomitans serotype a. The 5th complex consisted of Veillonella parvula and Actitwmyces odontotylicus. A. actinotnycetemcomitans serotype b, Selenomonas noxia and Actinomyces naeslundii genospecies 2 ( A. viscosus ) were outliers with little relation to each other and the 5 major complexes. The 1st complex related strikingly to clinical measures of periodontal disease particularly pocket depth and bleeding on probing.

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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Numerical Taxonomy: The Principles and Practice of Numerical Classification
Sneath, P. H. A., & Sokal, R. R. (1973) · CERN Document Server (European Organization for Nuclear Research) · Cited by 5,094
Microbial etiological agents of destructive periodontal diseases
Haffajee, A. D., & Socransky, S. S. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00020.x · Cited by 1,623
Self-citation
The bacteria of periodontal diseases
Moore, W. E., & Moore, L. V. H. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00019.x · Cited by 1,077
"Checkerboard" DNA-DNA hybridization.
Socransky, S. S., Smith, C., Martin, L., Paster, B. J., Dewhirst, F. E., & Levin, A. E. (1994) · PubMed · Cited by 725
Self-citation
Structure of the Microbial Flora Associated with Periodontal Health and Disease in Man: A Light and Electron Microscopic Study
Listgarten, M. A. (1976) · Journal of Periodontology · doi:10.1902/jop.1976.47.1.1 · Cited by 555
The effect of SRP on the clinical and microbiological parameters of periodontal diseases
Haffajee, A. D., Cugini, M., Dibart, S., Smith, C., Kent, R., & Socransky, S. S. (1997) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1997.tb00765.x · Cited by 506
Self-citation
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Sundqvist, G. (1992) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1992.tb00584.x · Cited by 425
Reduction of Background Problems in Nonradioactive Northern and Southern Blot Analyses Enables Higher Sensitivity Than 32P-Based Hybridizations
Engler-Blum, G., Meier, M., Frank, J., & Muller, G. A. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1189 · Cited by 407
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Self-citation

Show all 40 references

Research works printed but not linked: 2

Hosaka Y., 1994, Effect of initial therapy on dynamics of immunoglobulin G levels to some periodontopathic bacteria in serum and gingival crevicular fluid, Bulletin of Tokyo Denial College, 35, 207
Ludwig J. A., 1988, A primer on methods and computing, 223

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I nvasion of D entinal T ubules by O ral B acteria
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“This complex contained P. gingivalis, T. forsythia, and Treponema denticola and depended on earlier colonization of the pocket by the orange complex (Socransky & Haffajee, 2005, Socransky et al., 1998).”
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Authors: Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L.
Affiliations: The Forsyth Institute (US)
Corresponding author: Socransky, S.S.
Venue: Journal of Clinical Periodontology
Publisher: Wiley
Published: 1998-02
Volume: 25
Issue: 2
Pages: 134-144
ISSN: 0303-6979 (ISSN-L)
1600-051X
DOI: 10.1111/j.1600-051x.1998.tb02419.x
OpenAlex: W2157107389
Cited by: 5,050
References: 40
Citations by year: 2026: 189 · 2025: 267 · 2024: 296 · 2023: 262 · 2022: 289 · 2021: 353 · 2020: 291 · 2019: 261 · 2018: 216 · 2017: 243 · 2016: 211 · 2015: 248 · 2014: 250 · 2013: 211 · 2012: 191
FWCI: 51.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2880 d)
Locations: Journal Of Clinical Periodontology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE-10977, P50DE004881, R37DE010977, DE04881)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: subgingival plaque, periodontitis, bacterial community structure, Tannerella forsythia, Porphyromonas gingivalis, Treponema denticola, Fusobacterium nucleatum, Prevotella intermedia, Peptostreptococcus micros, Streptococcus sanguinis, Capnocytophaga, Aggregatibacter actinomycetemcomitans, Veillonella parvula, Actinomyces naeslundii, Selenomonas noxia, probing depth, bleeding on probing, periodontal disease
MeSH terms: Adult, Aged, Aged, 80 and over, Bacteria, Anaerobic, Dental Plaque, DNA, Bacterial, Female, Humans, Male, Middle Aged, Periodontal Index, Periodontal Pocket, Periodontitis, Regression Analysis, DNA Probes, Bacterial Typing Techniques, Cluster Analysis, Ecosystem, Statistics, Nonparametric

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Microbial complexes in subgingival plaque

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