Cited by 147Neuroendocrine regulation and behaviorAnimal Behavior and ReproductionOlfactory and Sensory Function Studies

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Partner Preference Development in Female Prairie Voles Is Facilitated by Mating or the Central Infusion of Oxytocina

WILLIAMS, JESSIE R., CARTER, C. SUE, INSEL, THOMAS·1992·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.1992.tb34393.x

Open this paper in CoChat — free account

Abstract

Results of these experiments indicate that females given at least 24 hours of cohabitation with a male develop a social preference for the familiar partner versus a stranger. Mating is not essential for the development of partner preferences, but clearly facilitates the onset of preferences. Females given six hours of cohabitation showed partner preferences only if they mated with the partner during cohabitation (Experiment 2) or if they received oxytocin (Experiment 3). Females that continued to mate during preference tests (Experiment 2, n = 4) mated exclusively with the partner. Oxytocin infusions, even in the absence of mating or estrogen priming, facilitated the development of partner preferences.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.1992.tb34393.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nebraska Symposium on Motivation, 1961
Whitehorn, J. C. (1963) · American Journal of Psychiatry · doi:10.1176/ajp.119.9.904 · Cited by 2,361
Central and peripheral effects of oxytocin administration in prairie voles (Microtus ochrogaster)
Witt, D. M., Carter, C. S., & Walton, D. M. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90042-g · Cited by 181
Central mechanisms underlying the neural and neuroendocrine determinants of maternal behaviour
Keverne, E. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90010-8 · Cited by 78
Social and Hormonal Determinants of Reproductive Patterns in the Prairie Vole
Carter, C. S., & Getz, L. L. (1985) · Proceedings in life sciences · doi:10.1007/978-3-642-87599-1_2 · Cited by 61

Show all 4 references

Sorted by citations

Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
“Indeed, oxytocin infused i.c. v. into both male and female prairie voles facilitates pair bond formation in the absence of mating (Cho et al., 1999; Williams et al., 1992).”
Background
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
“mating—which facilitates partner preference formation in females [228].”
The Concept of Stress and Its Relevance for Animal Behavior
von Holst, D. (1998) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60362-9 · Cited by 396
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
“following cohabitation with a male without mating, although this requires longer time periods (Williams et al., 1992).”
Background
The impact of early life family structure on adult social attachment, alloparental behavior, and the neuropeptide systems regulating affiliative behaviors in the monogamous prairie vole (Microtus ochrogaster)
Ahern, T. H. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.017.2009 · Cited by 239
“For example, oxytocin (OT) modulates spontaneous alloparental behavior and plays a central role in the formation of partner preferences (PP), the laboratory proxy of pair bonds, in female prairie voles (Williams et al., 1992; Insel and Hulihan, 1995; Olazábal and Young, 2006a).”
Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata
Smith, A. S., Ågmo, A., Birnie, A. K., & French, J. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.12.004 · Cited by 228
“The length of cohabitation required to form partner preferences is reduced in female prairie voles if the pair mates (Williams et al., 1992; Insel et al., 1995) or if exogenous OT is infused into the brain (Winslow et al., 1993b; Williams et al., 1994; Insel and Hulihan, 1995).”
Influential
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204
“Central OT administered to rodents facilitates social contact, maternal–infant attachment, and pair-bond formation (Pedersen et al., 1992; Williams et al., 1992; Witt et al., 1992).”
Background
Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles
Johnson, Z. V., Walum, H., Jamal, Y. A., Xiao, Y., Keebaugh, A. C., Inoue, K., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.11.011 · Cited by 190
“In the laboratory, pair bond formation is reflected through formation of a robust and enduring preference for the mating partner relative to a novel opposite sex individual, referred to as a “partner preference” (Williams et al., 1992a).”
Background
Anterior hypothalamic neural activation and neurochemical associations with aggression in pair-bonded male prairie voles
Gobrogge, K. L., Liu, Y., Jia, X., & Wang, Z. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21364 · Cited by 178
“…systems, including AVP, OXT, DA, GABA, and glutamate, have been implicated in partner preference formation in male and female prairie voles (Williams et al., 1992a; Winslow et al., 1993; Carter et al., 1995; Aragona et al., 2003; Liu and Wang, 2003; Lim et al., 2004a; Curtis and Wang,…”
Background
Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170
“Moreover, OXT signaling facilitates social preferences between adult monogamous rodents (Williams et al. 1992; Williams et al. 1994).”
Background
The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies
Young, K. A., Liu, Y., & Wang, Z. (2008) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.02.004 · Cited by 163
Increasing oxytocin receptor expression in the nucleus accumbens of pre-pubertal female prairie voles enhances alloparental responsiveness and partner preference formation as adults
Keebaugh, A. C., & Young, L. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.018 · Cited by 154
“In a partner preference test, the experimental female is placed in a neutral chamber of a three-chambered apparatus, in which the male “partner” is tethered to one side of the chamber and a novel “stranger” male is tethered in the other (Williams et al., 1992).”
RNAi knockdown of oxytocin receptor in the nucleus accumbens inhibits social attachment and parental care in monogamous female prairie voles
Keebaugh, A. C., Barrett, C. E., Laprairie, J. L., Jenkins, J. J., & Young, L. J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1040893 · Cited by 150
“All animals then underwent a 3- hour partner preference test as described previously (Williams et al., 1992).”
Method
Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context
Bredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 164
“Given the well-known role of OXT in facilitating pro-social behaviors (Williams et al., 1992; Feldman et al., 2007; Kojima and Alberts, 2011; Feldman, 2012) and reducing anxiety-like behaviors (Windle et al., 1997; Ring et al., 2006; Blume et al., 2008), we expected to find a facilitating effect of…”
Background
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156
Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
“Prairie voles, in particular, have been useful in revealing OT’s role in human sociality largely because they share with humans the tendency toward forming selective preferences for familiar conspecifics (Williams et al., 1992).”
Background
An investigation of plasma and salivary oxytocin responses in breast- and formula-feeding mothers of infants
Grewen, K. M., Davenport, R. E., & Light, K. C. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00968.x · Cited by 146
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143
“Centrally administered OT facilitates contact-seeking, attachment bond formation, and social memory in rodents (Ferguson et al., 2000; Williams et al., 1992; Witt et al., 1992).”
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction
Wessells, H., Gralnek, D. R., Dorr, R. T., Hruby, V. J., Hadley, M. E., & Levine, N. (2000) · Urology · doi:10.1016/s0090-4295(00)00680-4 · Cited by 137
What is a pair bond?
Bales, K. L., Ardekani, C. S., Baxter, A., Karaskiewicz, C. L., Kuske, J. X., Lau, A. R., Savidge, L. E., Sayler, K. R., & Witczak, L. R. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105062 · Cited by 108
κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance
Resendez, S. L., Kuhnmuench, M., Krzywosinski, T., & Aragona, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5779-11.2012 · Cited by 110
“Initial pair bond formation involves prosocial behaviors that are reliably assayed with the partner preference test (Williams et al., 1992).”
Parental division of labor, coordination, and the effects of family structure on parenting in monogamous prairie voles ( Microtus ochrogaster )
Ahern, T. H., Hammock, E. A. D., & Young, L. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20498 · Cited by 113
Oxytocin and same-sex social behavior in female meadow voles
Beery, A. K., & Zucker, I. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.023 · Cited by 108
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105
“…evidence that centrally administered OT could facilitate monogamous pair-bond formation in prairie voles and later that centrally administered OT could modulate social interaction, aggression, and sexual satiety in prairie voles (Carter et al., 1992; Williams et al., 1992; Witt et al., 1990, 1992).”
Background
Oxytocin and Social Bonds: The Role of Oxytocin in Perceptions of Romantic Partners’ Bonding Behavior
Algoe, S. B., Kurtz, L. E., & Grewen, K. (2017) · Psychological Science · doi:10.1177/0956797617716922 · Cited by 108
“Specifically, rather than focus on global evaluations of the relationship, we took a cue from original work (Williams et al., 1992) that examined proximal mechanisms for bonding, and we focused on the specific affective and relationship constructs involved in that process; in the future, such an approach may help addr…”
BackgroundResultInfluential
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus
Edsinger, E., & Dölen, G. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.061 · Cited by 104
Oxytocin Reverses Amphetamine-Induced Deficits in Social Bonding: Evidence for an Interaction with Nucleus Accumbens Dopamine
Young, K. A., Liu, Y., Gobrogge, K. L., Wang, H., & Wang, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4275-13.2014 · Cited by 99
“induces PP formation in female prairie voles (Williams et al., 1992; Insel and Hulihan, 1995).”
Background
Oxytocin inhibits ethanol consumption and ethanol‐induced dopamine release in the nucleus accumbens
Peters, S., Bowen, M. T., Bohrer, K., McGregor, I. S., & Neumann, I. D. (2016) · Addiction Biology · doi:10.1111/adb.12362 · Cited by 101
“2009) with centrally administered OXT facilitating monogamous pair bond formation in prairie voles (Williams et al. 1992).”
Background
μ-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms
Resendez, S. L., Dome, M., Gormley, G., Franco, D., Nevárez, N., Hamid, A. A., & Aragona, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4123-12.2013 · Cited by 93
“Motivation, the dorsal striatum, and partner preference formation Partner preference formation in prairie voles is facilitated by mating (Williams et al., 1992), and the present study demonstrates that blockade of neural systems that mediate this behavior, such as the endogenous opioid system…”
BackgroundResultInfluential
Salubrious effects of oxytocin on social stress-induced deficits
Smith, A. S., & Wang, Z. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.010 · Cited by 88
“…relationships (reviewed in Dunbar, 2010), the neuroendocrine systems that regulate these bond-promoting behavior such as the oxytocin system (e.g., Williams et al., 1992; Winslow et al., 1993; Williams et al., 1994; Insel and Hulihan, 1995; Cho et al., 1999; Ross et al., 2009; Smith et al., 2010;…”
Background
Melanocortin receptor agonists facilitate oxytocin-dependent partner preference formation in the Prairie Vole
Modi, M. E., Inoue, K., Barrett, C. E., Kittelberger, K. A., Smith, D. G., Landgraf, R., & Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.35 · Cited by 82
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 86
“In addition to maternal care, OXT modulates sexual behavior, social recognition, and affiliative behaviors (Caldwell et al., 1986; Insel and Winslow, 1991; Williams et al., 1992; Ferguson et al., 2001; Neumann and Landgraf, 2012).”
Background
Neuroscience: The hard science of oxytocin
Shen, H. H. (2015) · Nature · doi:10.1038/522410a · Cited by 80
Social bonding: regulation by neuropeptides
Lieberwirth, C., & Wang, Z. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00171 · Cited by 86
“…OT seems to be gender-specific as OT administration does not result in partner preference formation and selective OTR antagonist administration does not block partner preference formation in males (Williams et al., 1992a; Winslow et al., 1993; Insel and Hulihan, 1995; but see Cho et al., 1999).”
BackgroundInfluential
Antisocial oxytocin: Complex effects on social behavior
Beery, A. K. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.006 · Cited by 74
The neurobiology of pair bond formation, bond disruption, and social buffering
Lieberwirth, C., & Wang, Z. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.05.006 · Cited by 72
A neuronal signature for monogamous reunion
Scribner, J. L., Vance, E. A., Protter, D. S. W., Sheeran, W. M., Saslow, E., Cameron, R. T., Klein, E. M., Jimenez, J., Kheirbek, M. A., & Donaldson, Z. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917287117 · Cited by 68
Oxytocin and the salience of social cues
Averbeck, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004892107 · Cited by 64
Development of a partner preference test that differentiates between established pair bonds and other relationships in socially monogamous titi monkeys (Callicebus cupreus)
Carp, S. B., Rothwell, E. S., Bourdon, A., Freeman, S. M., Ferrer, E. E., & Bales, K. L. (2015) · American Journal of Primatology · doi:10.1002/ajp.22450 · Cited by 63
“The test subject is placed into the central “neutral” chamber and then allowed to move to spend time in, or adjacent to, the two outside chambers containing each stimulus animal or to remain in the neutral portion of the apparatus [Williams et al., 1992].”
BackgroundInfluential
Adaptive coding of the value of social cues with oxytocin, an fMRI study in autism spectrum disorder
Andari, E., Richard, N., Leboyer, M., & Sirigu, A. (2016) · Cortex · doi:10.1016/j.cortex.2015.12.010 · Cited by 62
Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60
Oxytocin and Social Cognition
Ebert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 66
Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59
“ogamous prairie vole [30,31].”
Biological Contribution to Social Influences on Alcohol Drinking: Evidence from Animal Models
Anacker, A. M. J., & Ryabinin, A. E. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7020473 · Cited by 59
“Oxytocin facilitates partner preference formation in female prairie voles [92], and has a number of addiction-related effects similar to vasopressin,”
Background
Sex differences in microglial colonization and vulnerabilities to endocrine disruption in the social brain
Rebuli, M. E., Gibson, P., Rhodes, C. L., Cushing, B. S., & Patisaul, H. B. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.04.018 · Cited by 58
Behavioural compatibility, extrapair copulation and mate switching in a socially monogamous parrot
Spoon, T. R., Millam, J. R., & Owings, D. H. (2007) · Animal Behaviour · doi:10.1016/j.anbehav.2006.10.010 · Cited by 56
A Neuroscientist’s Guide to the Vole
Kenkel, W. M., Gustison, M. L., & Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.175 · Cited by 52
Comparative Assessment of Familiarity/Novelty Preferences in Rodents
Beery, A. K., & Shambaugh, K. L. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.648830 · Cited by 50
“In early descriptions, partner preferences became evident in the 2nd hour and remained stable thereafter (Williams et al., 1992a).”
Background
Day length and estradiol affect same-sex affiliative behavior in the female meadow vole
Beery, A. K., Loo, T. J., & Zucker, I. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.007 · Cited by 50
“This contrasts to results obtained in opposite-sex prairie voles, where social behavior in LD is always high, but changes from non-specific to specific affiliation with increased housing time or sexual activity (Williams et al., 1992).”
Result
Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles
Gillera, S. E. A., Marinello, W. P., Horman, B. M., Phillips, A. L., Ruis, M. T., Stapleton, H. M., Reif, D. M., & Patisaul, H. B. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106840 · Cited by 48
“This length of time is sufficient to induce a pair bond even if mating does not occur (Williams et al., 1992).”
BackgroundMethodInfluential
Novel treatments for autism spectrum disorder based on genomics and systems biology
Baribeau, D. A., & Anagnostou, E. A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107939 · Cited by 51
BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior
Maynard, K. R., Hobbs, J. W., Phan, B. N., Gupta, A., Rajpurohit, S., Williams, C. A., Rajpurohit, A., Shin, J. H., Jaffe, A. E., & Martinowich, K. (2018) · eLife · doi:10.7554/elife.33676 · Cited by 47
Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior
Lu, Q., Lai, J., Du, Y., Huang, T., Prukpitikul, P., Xu, Y., & Hu, S. (2019) · Psychology Research and Behavior Management · doi:10.2147/prbm.s192951 · Cited by 47
“Facing opposite-sex cage mates, prairie voles exhibit familiar-partner preference in both males 30 – 32 and females 19,33,34 with OT injections intracranially.”
Background
The Discipline of Neurobehavioral Development: The Emerging Interface of Processes That Build Circuits and Skills
Hammock, E. A. D., & Levitt, P. R. (2006) · Human Development · doi:10.1159/000095581 · Cited by 46
A sexual arousability model involving steroid effects at the plasma membrane
Caldwell, J. D. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00035-5 · Cited by 44
Social selectivity and social motivation in voles
Beery, A. K., Lopez, S. A., Blandino, K. L., Lee, N. S., Bourdon, N. S., & Ahern, T. H. (2021) · eLife · doi:10.7554/elife.72684 · Cited by 53
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38
“Monogamy” in Primates: Variability, Trends, and Synthesis: Introduction to special issue on Primate Monogamy
Díaz‐Muñoz, S. L., & Bales, K. L. (2015) · American Journal of Primatology · doi:10.1002/ajp.22463 · Cited by 40
“A standardized partner preference test is widely used in the study of rodent monogamy, which has allowed comparisons across laboratories, across time, and across species [Williams et al., 1992, 1994; Millan & Bales, 2013], and this test uses similar parameters.”
Oxytocin synchrony between patients and therapists as a mechanism underlying effective psychotherapy for depression.
Zilcha‐Mano, S., Goldstein, P., Dolev‐Amit, T., & Shamay‐Tsoory, S. (2021) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000619 · Cited by 39
“Based on accumulating studies, it has been argued that OT serves as a biological mechanism by which bonds are formed and strengthened in various species (Algoe et al., 2017; Josef et al., 2019; Williams et al., 1992).”
Background
Lipopolysaccharide facilitates partner preference behaviors in female prairie voles
Bilbo, S. D., KLEIN, S., DEVRIES, A., & Nelson, R. J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00154-7 · Cited by 37
“Some labs report pair bonding in females within 3 h [18,19], although others report that females require >24 h for partner preferences to be expressed in the absence of mating [20, 21 ,35,36].”
Background
Familiarity and Mate Preference Assessment with the Partner Preference Test
Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.173 · Cited by 39
Oxytocin: A citation network analysis of 10 000 papers
Leng, G., & Leng, R. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13014 · Cited by 34
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles
Harbert, K. J., Pellegrini, M., Gordon, K. M., & Donaldson, Z. R. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104847 · Cited by 32
Ardipithecus ramidus and the evolution of language and singing: An early origin for hominin vocal capability
Clark, G., & Henneberg, M. (2017) · HOMO · doi:10.1016/j.jchb.2017.03.001 · Cited by 31
Prairie Voles as a Model for Understanding the Genetic and Epigenetic Regulation of Attachment Behaviors
Sadino, J. M., & Donaldson, Z. R. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00475 · Cited by 30
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Sadino, J. M., Bradeen, X., Kelly, C. J., Brusman, L. E., Walker, D. M., & Donaldson, Z. R. (2023) · eLife · doi:10.7554/elife.80517 · Cited by 29
“…voles will prefer to affiliate with their partner, display selective aggression towards non-partner individuals, and exhibit robust and organized biparental care ( Williams, 1992 ; Getz et al., 1981 ; Williams et al., 1992 ; Insel and Young, 2001 ; Carter et al., 1995 ; Winslow et al., 1993 ).”
Background
Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles
Anacker, A. M. J., Ahern, T. H., Hostetler, C. M., Dufour, B. D., Smith, M. L., Cocking, D. L., Li, J., Young, L. J., Loftis, J. M., & Ryabinin, A. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320879111 · Cited by 28
“Extensive literature implicates oxytocin and AVP in regulation of PP (28, 39, 40), and although we found some effects of alcohol or sex on these neuropeptide levels in a few brain regions (Table S1), there were no significant interactions to indicate a role for either of these neuropeptides in the sex-specific effects…”
BackgroundMethod
Neural Circuits Underlying Rodent Sociality: A Comparative Approach
Lee, N. S., & Beery, A. K. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_77 · Cited by 31
Neurophysiological mechanisms underlying affiliative social behavior: Insights from comparative research
Stoesz, B. M., Hare, J. F., & Snow, W. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.007 · Cited by 28
Variation in the stability of cockatiel (Nymphicus hollandicus) pair relationships: the roles of males, females, and mate compatibility
Millam, J. R., Spoon, T. R., & Owings, D. H. (2004) · Behaviour · doi:10.1163/1568539042729711 · Cited by 28
Natural variation in the oxytocin receptor gene and rearing interact to influence reproductive and nonreproductive social behavior and receptor binding
Ahern, T. H., Olsen, S., Tudino, R., & Beery, A. K. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105209 · Cited by 27
Genetics of Aggression in Voles
Gobrogge, K. L., & Wang, Z. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380858-5.00003-4 · Cited by 26
Gene Regulation as a Modulator of Social Preference in Voles
Hammock, E. A. D. (2007) · Advances in genetics · doi:10.1016/s0065-2660(07)59004-8 · Cited by 26
The role of oxytocin and vasopressin in conditioned mate guarding behavior in the female rat
Holley, A., Bellevue, S., Vosberg, D., Wenzel, K., Roorda, S., & Pfaus, J. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.039 · Cited by 28
“whenmale/female prairie voles mate guard the first mate they copulated with [5].”
Background
Alcohol Consumption Decreases Oxytocin Neurons in the Anterior Paraventricular Nucleus of the Hypothalamus in Prairie Voles
Stevenson, J. R., Young, K., Bohidar, A. E., Francomacaro, L. M., Fasold, T. R., Buirkle, J. M., Ndem‐Galbert, J. R., & Christian, S. C. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13430 · Cited by 25
Social stimuli cause changes of plasma oxytocin and behavior in guinea pigs
Wallner, B., Dittami, J., & Machatschke, I. H. (2006) · Biological Research · doi:10.4067/s0716-97602006000200007 · Cited by 23
Alcohol’s Effects on Pair-Bond Maintenance in Male Prairie Voles
Walcott, A. T., & Ryabinin, A. E. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00226 · Cited by 20
“Partner Preference Test Partner preference test was used as a standard way to test pair bonding in prairie voles (36, 37).”
Method
Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents.
Baribeau, D. A., & Anagnostou, E. A. (2014) · Europe PMC (PubMed Central) · Cited by 19
Exploring the role of intra-nasal oxytocin on the partner preference effect in humans
Liu, J. C., Guastella, A. J., & Dadds, M. R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.009 · Cited by 19
MECHANISMS AND TIME COURSE FOR INDUCTION OF PATERNAL BEHAVIOR IN PRAIRIE VOLES (MICROTUS OCHROGASTER)
Terleph, T. A., Jean‐Baptiste, N., & Bamshad, M. (2004) · Journal of Mammalogy · doi:10.1644/bns-108.1 · Cited by 19
“Cohabitation with or without mating induces partner preference in females (Williams et al. 1992), but the effect of cohabitation on partner preference in males is unknown.”
Oxytocin and vasopressin in non-human primates
Ragen, B., & Bales, K. L. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.019 · Cited by 18
Linking oxytocin and arginine vasopressin signaling abnormalities to social behavior impairments in Prader-Willi syndrome
Oztan, O., Zyga, O., Stafford, D. E. J., & Parker, K. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104870 · Cited by 18
“, 1987), and subsequently, pair bond formation in female prairie voles (Williams et al., 1992).”
Background
Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles
Gobrogge, K. L. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_264 · Cited by 16
“…such as corticotrophin releasing factor (CRF), steroid hormones, GABA, glutamate, and opioids have also been implicated in pair-bonding behavior (Williams et al. 1992, 1994; Winslow et al. 1993; Carter et al. 1995; Wang et al. 1998; Liu et al. 2001; Aragona et al. 2003; Liu and Wang 2003; Lim…”
Conditioned mate-guarding behavior in the female rat
Holley, A., Shalev, S., Bellevue, S., & Pfaus, J. G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.034 · Cited by 18
“, 1993), or when male/female prairie voles mate guard the first mate they copulated with (Williams et al., 1993).”
Emerging Frontiers in Social Neuroendocrinology and the Study of Nonapeptides
Ondrasek, N. R. (2016) · Ethology · doi:10.1111/eth.12493 · Cited by 19
Oxytocin and Brain Plasticity
Froemke, R. C., & Carcea, I. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00037-1 · Cited by 20
Romantic Love Is Associated with Enhanced Inhibitory Control in an Emotional Stop-Signal Task
Song, S., Zou, Z., Song, H., Wang, Y.-M., Uquillas, F. D., Wang, H., & Chen, H. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01574 · Cited by 18
“Studies show a critical role for oxytocin (OT) in promoting pair-bonding formation, and OT has been shown to modulate social interaction and sexual satiety in prairie voles (Carter, 1992; Williams et al., 1992; Witt et al., 1992).”
Background
Estrous phase alters social behavior in a polygynous but not a monogamous Peromyscus species
Karelina, K., Walton, J. C., Weil, Z. M., Norman, G. J., Nelson, R. J., & DeVries, A. C. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.022 · Cited by 15
“following exogenous administration of OT) induces a pro-social behavioral phenotype (Cho et al., 1999; Williams et al., 1992; Witt et al., 1992), thus, elevated endogenous OT prior to and during social interaction potentially contributed to increased affiliative social contact in P.”
BackgroundInfluential
Sex differences of oxytocin and vasopressin in social behaviors
Lu, Q., & Hu, S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00005-7 · Cited by 19
Chronic central oxytocin infusion impairs sociability in mandarin voles
Du, P., He, Z., Cai, Z., Hao, X., Dong, N., Yuan, W., Hou, W., Yang, J., Jia, R., & Tai, F. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.09.006 · Cited by 14
“to a stranger in female prairie voles (Williams et al., 1992).”
Influential
FireMaster® 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster
Krentzel, A. A., Kimble, L. C., Dorris, D. M., Horman, B. M., Meitzen, J., & Patisaul, H. B. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105019 · Cited by 14
Partner separation rescues pair bond-induced decreases in hypothalamic oxytocin neural densities
Fricker, B. A., Roshko, V. C., Jiang, J., & Kelly, A. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-32076-8 · Cited by 15
Everyday co-presence with a romantic partner is associated with lower C-reactive protein
Jolink, T. A., Way, B. M., Younge, A. N., Oveis, C., & Algoe, S. B. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.09.007 · Cited by 13
Effects of Alcohol Consumption on Pair Bond Maintenance and Potential Neural Substrates in Female Prairie Voles
Walcott, A. T., & Ryabinin, A. E. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz041 · Cited by 12
“PPT has been described previously (Williams et al., 1992; Ahern et al., 2009).”
The Role of Early Life Experience and Species Differences in Alcohol Intake in Microtine Rodents
Anacker, A. M. J., Ahern, T. H., Young, L. J., & Ryabinin, A. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039753 · Cited by 13
“[8,9,10,11,12].”
Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles
Gillera, S. E. A., Marinello, W. P., Nelson, M. A., Horman, B. M., & Patisaul, H. B. (2022) · Toxics · doi:10.3390/toxics10050268 · Cited by 11
Presence and Absence of Sex Differences in Structure and Function of the Brain Oxytocin System: Implications for Understanding the Regulation of Social Behavior
Dumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11
A test of the social behavior network reveals differential patterns of neural responses to social novelty in bonded, but not non-bonded, male prairie voles
Wallace, K. J., Chun, E. K., Manns, J. R., Ophir, A. G., & Kelly, A. M. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105362 · Cited by 9
“Like studies before (Williams et al., 1992; Winslow et al., 1993; Young et al., 2008), we found that non-bonded males were more pro-social across all contexts than pair bonded males, whereas pair bonded males were more aggressive.”
Oxytocin and object preferences in the male prairie vole
Madularu, D., Athanassiou, M., Yee, J. R., Kenkel, W. M., Carter, C. S., & Mumby, D. G. (2014) · Peptides · doi:10.1016/j.peptides.2014.08.015 · Cited by 11

Authors: WILLIAMS, J. R., CARTER, C. S., & INSEL, T.
Affiliations: University of Maryland, College Park (US)
National Institutes of Health (US)
ORCID: CARTER, C. SUE
INSEL, THOMAS
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 1992-06
Volume: 652
Issue: 1
Pages: 487-489
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.1992.tb34393.x
OpenAlex: W2047822585
Cited by: 147
References: 4
Citations by year: 2026: 4 · 2025: 2 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 4 · 2012: 6
FWCI: 0.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5312 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: mate preferences, Microtus ochrogaster, oxytocin, mating, female social behavior, cohabitation, social bonding, estradiol, monogamy
MeSH terms: Animals, Arvicolinae, Estradiol, Estrus, Female, Injections, Intraventricular, Male, Ovariectomy, Oxytocin, Pair Bond, Sexual Behavior, Animal, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Partner Preference Development in Female Prairie Voles Is Facilitated by Mating or the Central Infusion of Oxytocina

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks