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Cited by 556

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Staphylococcus aureus biofilm: a complex developmental organism

Open access
Moormeier, Derek E., Bayles, Kenneth W.·2017·Molecular Microbiology
DOI 10.1111/mmi.13634PMC PMC5397344
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Abstract

Summary: Chronic biofilm‐associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly‐defined, five‐stage model of biofilm development and the mechanisms required for each stage. Importantly, this model includes an alternate view of the processes involved in microcolony formation in S. aureus and suggests that these structures originate as a result of stochastically regulated metabolic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive process involving the release of cell clusters from a thick, unstructured biofilm. Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions.

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Research works printed but not linked: 93

  1. 10.1128/IAI.61.9.3879-3885.1993 · DOI · Paper page
  2. 10.1038/nrmicro3136 · DOI · Paper page
  3. 10.1128/IAI.06134-11 · DOI
  4. 10.1128/AEM.03065-09 · doi:10.1128/aem.03065-09
  5. 10.1111/j.1574-6968.2006.00281.x · DOI · Paper page
  6. 10.1371/journal.ppat.1000052 · DOI · Paper page
  7. 10.1371/journal.pone.0010146 · DOI · Paper page
  8. 10.1371/journal.pone.0042244 · DOI · Paper page
  9. 10.1371/journal.ppat.1004292 · DOI · Paper page
  10. 10.1128/JB.01946-14 · DOI
  11. 10.1146/annurev.mi.41.100187.002251 · DOI · Paper page
  12. 10.1128/IAI.67.10.5427-5433.1999 · DOI · Paper page
  13. 10.1128/IAI.69.6.4079-4085.2001 · DOI · Paper page
  14. 10.1128/JB.183.9.2888-2896.2001 · DOI · Paper page
  15. 10.1128/JB.00726-15 · DOI
  16. 10.1128/JB.183.24.7341-7353.2001 · DOI · Paper page
  17. 10.1128/mBio.00537-12 · DOI · Paper page
  18. 10.1128/JCM.43.4.1973-1976.2005 · DOI · Paper page
  19. 10.1073/pnas.1322125111 · DOI
  20. 10.1038/nrmicro2415 · DOI · Paper page
  21. 10.1038/nrmicro3161 · DOI · Paper page
  22. 10.1128/mBio.01667-14 · DOI · Paper page
  23. 10.1128/JB.00628-10 · DOI · Paper page
  24. 10.1038/mi.2011.27 · DOI · Paper page
  25. 10.1128/IAI.69.5.3423-3426.2001 · DOI · Paper page
  26. 10.1111/j.1461-0248.2011.01679.x · DOI · Paper page
  27. 10.1111/j.1365-2958.2005.05008.x · DOI · Paper page
  28. 10.1128/IAI.00364-10 · DOI · Paper page
  29. 10.1086/340123 · DOI
  30. 10.1099/00221287-144-12-3387 · DOI · Paper page
  31. 10.1099/jmm.0.45764-0 · DOI
  32. 10.1371/journal.pone.0095574 · DOI
  33. 10.1371/journal.pone.0026714 · DOI · Paper page
  34. Kim M.K., 2016, Local and global consequences of flow on bacterial quorum sensing, Nature Microbiology, 1, 15005, 10.1038/nmicrobiol.2015.5 · DOI · Paper page
  35. 10.1101/cshperspect.a010306 · DOI · Paper page
  36. 10.1128/IAI.01036-08 · DOI · Paper page
  37. 10.3389/fcimb.2014.00167 · DOI · Paper page
  38. 10.1111/mmi.12902 · DOI · Paper page
  39. 10.1371/journal.ppat.1000354 · DOI · Paper page
  40. 10.1186/1471-2180-9-61 · DOI
  41. 10.1371/journal.pone.0005822 · DOI · Paper page
  42. 10.1128/MMBR.70.1.192-221.2006 · DOI · Paper page
  43. 10.2217/fmb.14.64 · DOI · Paper page
  44. 10.1111/1574-6968.12424 · DOI · Paper page
  45. 10.1111/j.1365-2958.1994.tb00304.x · DOI · Paper page
  46. 10.1128/JB.01222-08 · DOI · Paper page
  47. 10.1099/mic.0.036673-0 · DOI
  48. 10.1128/mBio.01341-14 · DOI · Paper page
  49. 10.1128/AEM.00395-13 · DOI
  50. 10.1111/mmi.12943 · DOI · Paper page
  51. 10.1128/IAI.00377-13 · DOI
  52. 10.1371/journal.pone.0038453 · DOI · Paper page
  53. 10.1016/j.cell.2007.11.044 · DOI · Paper page
  54. 10.1111/j.1365-2958.1994.tb01271.x · DOI · Paper page
  55. 10.1128/IAI.68.4.2061-2068.2000 · DOI · Paper page
  56. 10.1046/j.1365-2958.1998.01050.x · DOI · Paper page
  57. 10.1146/annurev.genet.42.110807.091640 · DOI · Paper page
  58. 10.1046/j.1365-2958.2002.02935.x · DOI · Paper page
  59. 10.1111/j.1574-6968.2007.00688.x · DOI · Paper page
  60. 10.1128/JB.00167-08 · DOI · Paper page
  61. 10.1128/JCM.02280-06 · DOI · Paper page
  62. 10.1146/annurev.micro.54.1.49 · DOI · Paper page
  63. 10.1128/IAI.01242-12 · DOI · Paper page
  64. 10.1007/3-540-29916-5_10 · DOI · Paper page
  65. 10.1146/annurev-med-042711-140023 · DOI · Paper page
  66. 10.1016/j.arth.2010.04.011 · doi:10.1016/j.arth.2010.04.011
  67. 10.1073/pnas.1115006109 · DOI · Paper page
  68. 10.1038/nrmicro3110 · DOI · Paper page
  69. 10.1111/mmi.12018 · DOI
  70. 10.4161/biom.22905 · DOI · Paper page
  71. 10.1099/mic.0.26412-0 · DOI · Paper page
  72. 10.1016/j.biomaterials.2006.11.046 · DOI · Paper page
  73. 10.1016/j.mib.2011.12.010 · DOI
  74. 10.1093/femsle/fnv006 · DOI
  75. 10.1128/IAI.02177-14 · DOI
  76. 10.1371/journal.pone.0007567 · DOI · Paper page
  77. 10.1111/mmi.13219 · DOI
  78. 10.1371/journal.ppat.1002744 · DOI · Paper page
  79. 10.1086/649797 · DOI
  80. 10.3389/fcimb.2014.00171 · DOI · Paper page
  81. 10.2217/fmb.09.102 · DOI
  82. 10.1038/nrmicro1838 · DOI · Paper page
  83. 10.1371/journal.ppat.1004205 · DOI
  84. 10.4049/jimmunol.1002794 · DOI · Paper page
  85. 10.1128/JB.187.15.5318-5329.2005 · DOI · Paper page
  86. 10.1371/journal.pone.0003361 · DOI
  87. 10.1371/journal.pone.0104561 · DOI
  88. 10.1074/jbc.M110.214981 · DOI
  89. 10.1086/317606 · DOI · Paper page
  90. 10.1128/JB.129.2.798-802.1977 · DOI · Paper page
  91. 10.1128/JB.186.6.1838-1850.2004 · DOI · Paper page
  92. 10.1038/sj.emboj.7600888 · DOI · Paper page
  93. 10.1093/infdis/jiv319 · DOI

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Metadata

Authors
Moormeier, D. E., & Bayles, K. W.
Venue
Molecular Microbiology
Publisher
Wiley
Published
2017-03-08
Volume
104
Issue
3
Pages
365-376
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1111/mmi.13634
PMC
PMC5397344
OpenAlex
W2595011271
Cited by
556
References
8
FWCI
10.77
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
National Institutes of Health (PO1‐AI83211, RO1‐AI125589)

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CoChat. (2026). Citation check: Staphylococcus aureus biofilm: a complex developmental organism. https://app.cochat.ai/papers/10.1111/mmi.13634
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Moormeier, D. E., & Bayles, K. W. (2017). Staphylococcus aureus biofilm: a complex developmental organism. Molecular Microbiology. https://doi.org/10.1111/mmi.13634

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.