Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

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80. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
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83. Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
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84. Mechanisms regulating dendritic cell specification and development
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85. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
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86. A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
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87. Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery
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88. Mitochondrial Stat3, the need for design thinking
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89. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
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90. IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells
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91. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways
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92. Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling
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93. MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts
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94. The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
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96. The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation
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102. STAT3 promotes IFNγ/TNFα‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner
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103. STAT3-driven transcription depends upon the dimethylation of K49 by EZH2
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104. Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA
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106. Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy
     Jang‐Hyuk Yun, Sung Wook Park, Kyung‐Jin Kim, Jong‐Sup Bae, Eun Hui Lee, Sun Ha Paek, Seung Up Kim, Sang‐Kyu Ye, Jeong Hun Kim, Chung‐Hyun Cho · 2016 · Journal of Cellular Physiology
107. Transcriptional Inactivation of STAT3 by PPARγ Suppresses IL-6-Responsive Multiple Myeloma Cells
     Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Jiaqiang Huang, Jian Hou, Jie Li, Hong Xiong, Kelly Mihalic, Heming Zhu, Weihua Xiao et al. · 2004 · Immunity
108. The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions
     R. Ferrao, P. Lupardus · 2017 · Frontiers in Endocrinology
109. Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma
     Pan, Yunbao, Zhou, Fuling, Zhang, Ronghua, Claret, Francois X. · 2013 · PLoS ONE
110. STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses
     Lidia Avalle, Annalisa Camporeale, Giampaolo Morciano, Natascia Caroccia, Elena Ghetti, Valeria Orecchia, Daniele Viavattene, Carlotta Giorgi, Paolo Pinton, Valeria Poli · 2018 · Cell Death and Differentiation
111. Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration
     C P Lim, T-T Phan, I.J. Lim, Xinmin Cao · 2006 · Oncogene
112. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
     Siegel, Andrea M., Stone, Kelly D., Cruse, Glenn, Lawrence, Monica G., Olivera, Ana, Jung, Mi-yeon, Barber, John S., Freeman, Alexandra F., Holland, Steven M., O'Brien, Michelle et al. · 2013 · Journal of Allergy and Clinical Immunology
113. Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock
     Meng, Zhi Hong, Dyer, Kevin, Billiar, Timothy R., Tweardy, David J. · 2001 · American Journal of Physiology-Cell Physiology
114. STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism
     Yan S. Xu, Jinyuan J. Liang, Yumei Wang, Xiangzhong Zhao, Li Xu, Yeyang Xu, Quanli C. Zou, Junxun M. Zhang, Chenge Tu, Yange Cui et al. · 2016 · Scientific Reports
115. STAT signaling in mammary gland differentiation, cell survival and tumorigenesis
     Svasti Haricharan, Yi Li · 2013 · Molecular and Cellular Endocrinology
116. Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
     Xuejun Xu, Moses M. Kasembeli, Xueqing Jiang, Benjamin J. Tweardy, David John Tweardy · 2009 · PLoS ONE
117. STAT3 NH2-Terminal Acetylation Is Activated by the Hepatic Acute-Phase Response and Required for IL-6 Induction of Angiotensinogen
     Sutapa Ray, Istvan R. Boldogh, Allan R. Brasier · 2005 · Gastroenterology
118. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
     SMITH, R, SULEMAN, N, LACERDA, L, OPIE, L, AKIRA, S, CHIEN, K, SACK, M · 2004 · Cardiovascular Research
119. p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
     Katrin Ramsauer, Iwona Sadzak, Almudena Porrás, Andreas Pilz, Ángel R. Nebreda, Thomas Decker, Pavel Kovarik · 2002 · Proceedings of the National Academy of Sciences
120. Stat-3 is required for pulmonary homeostasis during hyperoxia
     Hokuto, Isamu, Ikegami, Machiko, Yoshida, Mitsuhiro, Takeda, Kiyoshi, Akira, Shizuo, Perl, Anne-Karina T., Hull, William M., Wert, Susan E., Whitsett, Jeffrey A. · 2004 · Journal of Clinical Investigation
121. Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
     Albert Lin, Anita Schildknecht, Linh T. Nguyen, Pamela S. Ohashi · 2009 · Immunology Letters
122. S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling
     Xie, Yi, Kole, Sutapa, Precht, Patricia, Pazin, Michael J., Bernier, Michel · 2009 · Endocrinology
123. Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
     Fredirick L. Mashili, Alexander Chibalin, Anna Krook, Juleen Rae Zierath · 2012 · Diabetes
124. Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
     Schuringa, Jan-Jacob, Schepers, Hein, Vellenga, Edo, Kruijer, Wiebe · 2001 · FEBS Letters
125. Multifunctional effects of a small-molecule STAT3 inhibitor on NASH and hepatocellular carcinoma in mice
     Jung, Kwang Hwa, Yoo, Wonbeak, Stevenson, Heather L., Deshpande, Dipti, Shen, Hong, Gagea, Mihai, Yoo, Suk-Young, Wang, Jing, Eckols, T. Kris, Bharadwaj, Uddalak et al. · 2017 · Clinical Cancer Research
126. Janus kinase deregulation in leukemia and lymphoma
     Chen, Edwin, Staudt, Louis M., Green, Anthony R. · 2012 · Immunity
127. Inflammatory Response to Pulmonary Ischemia–Reperfusion Injury
     Calvin S.H. Ng, Song Wan, Ahmed A. Arifi · 2006 · Surgery Today
128. Interleukin 21: a cytokine/cytokine receptor system that has come of age
     Leonard, Warren J, Zeng, Rong, Spolski, Rosanne · 2008 · Journal of Leukocyte Biology
129. Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1
     Sims, Jonathan T., Ganguly, Sourik S., Bennett, Holly, Friend, J. Woodrow, Tepe, Jessica, Plattner, Rina · 2013 · PLoS ONE
130. Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
     Naoko Ohtani, Eiji Hara · 2013 · Cancer Science
131. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3
     Ahmad, Rehan, Raina, Deepak, Meyer, Colin, Kufe, Donald · 2008 · Cancer Research
132. Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway
     Kimie Kondo, Hila Shaim, Philip A. Thompson, Jan A. Burger, Michael J. Keating, Zeev E. Estrov, David Harris, E Kim, Alessandra Ferrajoli, May Daher et al. · 2017 · Leukemia
133. Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance
     Saul J. Priceman, Maciej Kujawski, Shudan Shen, Gregory Allan Cherryholmes, Heehyoung Lee, Chunyan Zhang, Laura L. Kruper, Joanne E. Mortimer, Richard Jove, Arthur D. Riggs et al. · 2013 · Proceedings of the National Academy of Sciences
134. The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease
     Leonie C.S. De Vries, Manon E. Wildenberg, Wouter J. de Jonge, Geert D’Haens · 2017 · Journal of Crohn s and Colitis
135. Untitled work
     2014 · Dove Medical Press (Taylor and Francis Group)
136. Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3
     Szczepanek, Karol, Chen, Qun, Larner, Andrew C., Lesnefsky, Edward J. · 2012 · Mitochondrion
137. H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload
     Hongyu Qiu, Paulo L. Lizano, Lydie Laure, Xiangzhen Sui, Eman R. Rashed, Ji Yeon Park, Chull Hong, Shumin Gao, Eric Holle, Didier Morin et al. · 2011 · Circulation
138. Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
     Christian Hierholzer, Jörg C. Kalff, Laurel Omert, Katsuhiko Tsukada, J. Eric Loeffert, Simon C. Watkins, Timothy R. Billiar, David John Tweardy · 1998 · American Journal of Physiology-Lung Cellular and Molecular Physiology
139. OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
     Mi‐Jung Kim, Hyun-Jin Nam, Hwang‐Phill Kim, Sae‐Won Han, Seock‐Ah Im, Tae‐You Kim, Do‐Youn Oh, Yung‐Jue Bang · 2013 · Cancer Letters
140. Signal Transducers and Activators of Transcription 3 Signaling Pathway
     Alessandro Musso, Patrizia Dentelli, Alessandra Carlino, Luigi Chiusa, Alessandro Repici, Andreas Sturm, Claudio Fiocchi, Mario Rizzetto, Luigi Pegoraro, Carla Sategna-Guidetti et al. · 2005 · Inflammatory Bowel Diseases
141. Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
     Bendell, Johanna C., Hong, David S., Burris, Howard A., Naing, Aung, Jones, Suzanne F., Falchook, Gerald, Bricmont, Patricia, Elekes, Agnes, Rock, Edwin P., Kurzrock, Razelle · 2014 · Cancer Chemotherapy and Pharmacology
142. The Mitogen-activated Protein (MAP) Kinase p38 and Its Upstream Activator MAP Kinase Kinase 6 Are Involved in the Activation of Signal Transducer and Activator of Transcription by Hyperosmolarity*
     J. Bode, Petros Gatsios, S. Ludwig, U. Rapp, D. Häussinger, P. Heinrich, L. Graeve · 1999 · Journal of Biological Chemistry
143. STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model
     Gavino, A. C., Nahmod, K., Bharadwaj, U., Makedonas, G., Tweardy, D. J. · 2016 · Allergy
144. The dual function of hepatic SOCS3 in insulin resistance in vivo
     Takehiro Torisu, Naoichi Sato, Daigo Yoshiga, Takashi Kobayashi, Tomoko Yoshioka, Hiroyuki Mori, Mitsuo Iida, Akihiko Yoshimura · 2007 · Genes to Cells
145. Molecular pathways: cachexia signaling-A targeted approach to cancer treatment
     Miyamoto, Yuji, Hanna, Diana L., Zhang, Wu, Baba, Hideo, Lenz, Heinz-Josef · 2016 · Clinical Cancer Research
146. STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression
     Masao Saitoh, K Endo, S Furuya, M Minami, Akira Fukasawa, Takeshi Imamura, Keiji Miyazawa · 2015 · Oncogene
147. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
     Hayakawa, F, Sugimoto, K, Harada, Y, Hashimoto, N, Ohi, N, Kurahashi, S, Naoe, T · 2013 · Blood Cancer Journal
148. Phase I study of OPB ‐51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
     Michinori Ogura, Toshiki Uchida, Yasuhito Terui, Fumihiko Hayakawa, Yukio Kobayashi, Masafumi Taniwaki, Yasushi Takamatsu, Tomoki Naoe, Kensei Tobinai, Wataru Munakata et al. · 2015 · Cancer Science
149. Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
     Chung, Yang-Jo, Park, Bo-Bae, Kang, Young-Ju, Kim, Tae-min, Eaves, Connie J., Oh, Il-Hoan · 2006 · Blood
150. Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity
     Lufei, C, Koh, T H, Uchida, T, Cao, X · 2007 · Oncogene
151. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs
     Cheng, Fengdong, Lienlaf, Maritza, Wang, Hong-Wei, Perez-Villarroel, Patricio, Lee, Calvin, Woan, Karrune, Rock-Klotz, Jennifer, Sahakian, Eva, Woods, David, Pinilla-Ibarz, Javier et al. · 2014 · The Journal of Immunology
152. Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
     Ohkawara, Bisei, Shirakabe, Kyoko, Hyodo-Miura, Junko, Matsuo, Ritsuko, Ueno, Naoto, Matsumoto, Kunihiro, Shibuya, Hiroshi · 2004 · Genes &amp; Development
153. Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
     Genini, Davide, Brambilla, Lara, Laurini, Erik, Merulla, Jessica, Civenni, Gianluca, Pandit, Shusil, D'Antuono, Rocco, Perez, Laurent, Levy, David E., Pricl, Sabrina et al. · 2017 · Proceedings of the National Academy of Sciences
154. STAT3 modulates the DNA damage response pathway
     Barry, Seán P., Townsend, Paul A., Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., Stephanou, Anastasis · 2010 · International Journal of Experimental Pathology
155. STAT3 targets the regulatory regions of gluconeogenic genes in vivo
     Ramadoss, Preeti, Unger-Smith, Nathan E., Lam, Francis S., Hollenberg, Anthony N. · 2009 · Molecular Endocrinology
156. Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
     Yamada, Eijiro, Bastie, Claire C., Koga, Hiroshi, Wang, Yichen, Cuervo, Ana Maria, Pessin, Jeffrey E. · 2012 · Cell Reports
157. The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer
     Khan, Mohammad W., Saadalla, Abdulrahman, Ewida, Ahmed H., Al-Katranji, Khalid, Al-Saoudi, Ghadier, Giaccone, Zachary T., Gounari, Fotini, Zhang, Ming, Frank, David A., Khazaie, Khashayarsha · 2018 · Cancer Immunology, Immunotherapy
158. Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer
     N. Kettner, S. Vijayaraghavan, M. Durak, T. Bui, Mehrnoosh Kohansal, Jin-Yu Min, Bin Liu, Xia-Yu Rao, Jing Wang, M. Yi et al. · 2019 · Clinical Cancer Research
159. A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning
     Roberto Bolli, Adam Stein, Yiru Guo, Ou‐Li Wang, Gregg D. Rokosh, Buddhadeb Dawn, Jeffery D. Molkentin, Santosh K. Sanganalmath, Yanqing Zhu, Yu-Ting Xuan · 2011 · Journal of Molecular and Cellular Cardiology
160. STAT3 regulation by S-nitrosylation: implication for inflammatory disease
     Kim, Jinsu, Won, Je-Seong, Singh, Avtar K., Sharma, Anand K., Singh, Inderjit · 2014 · Antioxidants &amp; Redox Signaling
161. Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10
     Barbara Schaljo, Franz Kratochvill, Nina Gratz, Iwona Sadzak, Ines Sauer, Michael Hammer, Claus Vogl, Birgit Strobl, Mathias M. Müller, Perry J. Blackshear et al. · 2009 · The Journal of Immunology
162. STAT3 and the Hyper-IgE syndrome
     Trine Hyrup Mogensen · 2013 · JAK-STAT
163. PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
     Sun, Shishinn, Steinberg, Bettie M. · 2002 · Journal of General Virology
164. Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome‐proliferator‐activated receptor γ (PPARγ)
     Wang, Dongmei, Zhou, Yiran, Lei, Weiwei, Zhang, Kehua, Shi, Jian, Hu, Ying, Shu, Guangwen, Song, Jianguo · 2010 · Biology of the Cell
165. Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury
     Zhang, Xuchen, Shan, Peiying, Jiang, Ge, S‐M. Zhang, Samuel, Otterbein, Leo E., Fu, Xin‐Yuan, Le, Patty J., Zhang, Xuchen, Shan, Peiying, Jiang, Ge et al. · 2006 · The FASEB Journal
166. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
     U. Bharadwaj, T. K. Eckols, Xue-Jun Xu, M. Kasembeli, Yun-Yun Chen, M. Adachi, Yong-Cheng Song, Q. Mo, S. Lai, D. Tweardy · 2016 · OncoTarget
167. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
     Jasmine Lau, Shirin Ilkhanizadeh, Susan Wang, Yekaterina A. Miroshnikova, Nicolas A. Salvatierra, Robyn A. Wong, Christin Schmidt, Valerie Marie Weaver, William A. Weiss, Anders I. Persson · 2015 · Cancer Research
168. Lactic acidosis and other mitochondrial disorders
     Peter W. Stacpoole · 1997 · Metabolism
169. The Sin3a repressor complex is a master regulator of STAT transcriptional activity
     L. Icardi, Raffaele Mori, Viola Gesellchen, S. Eyckerman, L. De Cauwer, Judith Verhelst, K. Vercauteren, X. Saelens, P. Meuleman, G. Leroux-Roels et al. · 2012 · Proceedings of the National Academy of Sciences of the United States of America
170. Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45
     Wakahara, Ryohei, Kunimoto, Hiroyuki, Tanino, Kanae, Kojima, Hirotada, Inoue, Akira, Shintaku, Haruo, Nakajima, Koichi · 2012 · Genes to Cells
171. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer
     Rath, Kellie S., Naidu, Shan K., Lata, Pushpa, Bid, Hemant K., Rivera, Brian K., McCann, Georgia A., Tierney, Brent J., ElNaggar, Adam C., Bravo, Veronica, Leone, Gustavo et al. · 2014 · Cancer Research
172. Hitting the right spot: Mechanism of action of OPB‐31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
     Lara Brambilla, Davide Genini, Erik Laurini, Jessica Merulla, Laurent H. Perez, Maurizio Fermeglia, Giuseppina Maria Carbone, Sabrina Pricl, Carlo Vittorio Catapano · 2015 · Molecular Oncology
173. Cell Type-Specific and Tyrosine Phosphorylation-Independent Nuclear Presence of STAT1 and STAT3
     Thomas Meyer, Karsten Gavénis, Uwe Vinkemeier · 2002 · Experimental Cell Research
174. STAT3 positively regulates an early step in B-cell development
     Chou, Wei-Chun, Levy, David E., Lee, Chien-Kuo · 2006 · Blood
175. Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells
     Huang, Shuling, Chen, Min, Shen, Yonghua, Shen, Weidong, Guo, Huimin, Gao, Qian, Zou, Xiaoping · 2012 · Cancer Letters
176. Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric SarcomasIn vitroandIn vivo
     Shuang Yan, Z. Li, Carol J. Thiele · 2013 · Oncotarget
177. Hypothalamic leptin action is mediated by histone deacetylase 5
     Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García‐Cáceres, Sonja Charlotte Schriever, Verónica Casquero-García, Adam Fiseha Kebede, Esther Fuente-Martín, Chitrang J. Trivedi, Kristy M. Heppner, N. Henriette Uhlenhaut et al. · 2016 · Nature Communications
178. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
     Schmitz, Jochen, Dahmen, Heike, Grimm, Carsten, Gendo, Cornelia, Müller-Newen, Gerhard, Heinrich, Peter C, Schaper, Fred · 2000 · The Journal of Immunology
179. Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation
     Kim, Jeong-Ho, Yoon, Mee-Sup, Chen, Jie · 2009 · Journal of Biological Chemistry
180. The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
     Zhenxing Liang, Guiling Wu, Chongxi Fan, Jing Xu, Shuai Jiang, Xiaolong Yan, Shouyin Di, Zhiqiang Ma, Wei Hu, Yang Yang · 2015 · Progress in Neurobiology
181. Mitochondrial Ca2+ and membrane potential, an alternative pathway for interleukin 6 to regulate CD4 cell effector function
     Yang, Rui, Lirussi, Dario, Thornton, Tina M, Jelley-Gibbs, Dawn M, Diehl, Sean A, Case, Laure K, Madesh, Muniswamy, Taatjes, Douglas J, Teuscher, Cory, Haynes, Laura et al. · 2015 · eLife
182. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma
     Tiffany A. Doucette, Ling-Yuan Kong, Yuhui Yang, Sherise Desiree Ferguson, Jinbo Yang, Jun Wei, Wei Qiao, Gregory N. Fuller, Krishna Bhat, Kenneth Aldape et al. · 2012 · Neuro-Oncology
183. T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
     Atsushi Fukushima, Kim Loh, Sandra Galić, Barbara Christianne Fam, Ben Shields, Florian Wiede, Michel L. Tremblay, Matthew J. Watt, Sofianos Andrikopoulos, Tony Tiganis · 2010 · Diabetes
184. STAT3 in Skeletal Muscle Function and Disorders
     Eleonora Guadagnin, Davi A. G. Mázala, Yiwen Chen · 2018 · International Journal of Molecular Sciences
185. Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)
     Yang, Zhenggang, Hulver, Matthew, McMillan, Ryan P., Cai, Lingzhi, Kershaw, Erin E., Yu, Liqing, Xue, Bingzhong, Shi, Hang · 2012 · PLoS ONE
186. The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain*
     Tie-Ying Hou, Sutapa Ray, Chang Y. Lee, A. Brasier · 2008 · Journal of Biological Chemistry
187. Asthma phenotypes and endotypes
     Ting‐Yu Lin, Audrey H. Poon, Qutayba A. Hamid · 2012 · Current Opinion in Pulmonary Medicine
188. Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
     Karen T. Liby, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Anirban Maitra, Ralph H. Hruban, Michael B. Sporn · 2010 · Cancer Prevention Research
189. Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
     Sutapa Ray, C. Lee, Tieying Hou, Istvan R. Boldogh, Allan R. Brasier · 2008 · Nucleic Acids Research
190. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
     Haiyan S. Li, Cliff Y. Yang, Kalyan C. Nallaparaju, Huiyuan Zhang, Yong‐Jun Liu, Ananda W. Goldrath, Stephanie S. Watowich · 2012 · Blood
191. Effects of Ruxolitinib Treatment on Metabolic and Nutritional Parameters in Patients With Myelofibrosis From COMFORT-I
     Ruben A. Mesa, Srđan Verstovšek, Vikas K Gupta, John O Mascarenhas, Ehab L. Atallah, Timothy C. Burn, William Y. Sun, Victor A. Sandor, Jason R. Gotlib · 2014 · Clinical Lymphoma Myeloma & Leukemia
192. Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity
     Cernkovich, Erin R., Deng, Jianbei, Bond, Michael C., Combs, Terry P., Harp, Joyce B. · 2008 · Endocrinology
193. Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy
     Hong Yue, Wěi Li, Russell W. Desnoyer, Sadashiva S. Karnik · 2009 · Cardiovascular Research
194. A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3
     Steward-Tharp, Scott M., Laurence, Arian, Kanno, Yuka, Kotlyar, Alex, Villarino, Alejandro V., Sciume, Giuseppe, Kuchen, Stefan, Resch, Wolfgang, Wohlfert, Elizabeth A., Jiang, Kan et al. · 2014 · Blood
195. Activation of Signal Transducers and Activators of Transcription 1 and 3 by Leukemia Inhibitory Factor, Oncostatin-M, and Interferon-γ in Adipocytes
     Jacqueline M. Stephens, Steven J. Lumpkin, Jordan B. Fishman · 1998 · Journal of Biological Chemistry
196. Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H2O2-Induced Cell Death
     Aaron B. Waxman, Keyvan Mahboubi, Roy G. Knickelbein, Lin L. Mantell, Nicholas D. Manzo, Jordan S. Pober, Jack Angel Elias · 2003 · American Journal of Respiratory Cell and Molecular Biology
197. Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance
     Hoffmeister, Karin M., Falet, Hervé · 2016 · Thrombosis Research
198. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
     Tonino Alonzi · 2004 · Cytokine
199. Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock
     Gatsios, Petros, Terstegen, Lara, Schliess, Freimut, Häussinger, Dieter, Kerr, Ian M., Heinrich, Peter C., Graeve, Lutz · 1998 · Journal of Biological Chemistry
200. Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells
     Laubner, Katharina, Kieffer, Timothy J., Lam, Ni T., Niu, Xinjie, Jakob, Franz, Seufert, Jochen · 2005 · Diabetes